CA2913418C - Intracorps a chaine unique modifiant la degradation de la proteine mutante huntingtin - Google Patents

Intracorps a chaine unique modifiant la degradation de la proteine mutante huntingtin Download PDF

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Publication number
CA2913418C
CA2913418C CA2913418A CA2913418A CA2913418C CA 2913418 C CA2913418 C CA 2913418C CA 2913418 A CA2913418 A CA 2913418A CA 2913418 A CA2913418 A CA 2913418A CA 2913418 C CA2913418 C CA 2913418C
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CA
Canada
Prior art keywords
sequence
seq
variable light
intrabody
variable heavy
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Active
Application number
CA2913418A
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English (en)
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CA2913418A1 (fr
Inventor
Lee Alan Henderson
Irene Alexandra AMARO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vybion Inc
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Vybion Inc
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Publication date
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Publication of CA2913418A1 publication Critical patent/CA2913418A1/fr
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Publication of CA2913418C publication Critical patent/CA2913418C/fr
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/80—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des compositions et des méthodes d'utilisation d'intracorps se liant et modifiant les effets de l'agrégation de protéines poly-glutamate dans des maladies associées au poly-glutamate, telles que la maladie de Huntington. Les intracorps selon l'invention empêchent l'agrégation de poly-glutamate, la dérégulation de gènes et les effets négatifs de la maladie de Huntington.
CA2913418A 2013-05-29 2014-05-09 Intracorps a chaine unique modifiant la degradation de la proteine mutante huntingtin Active CA2913418C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361828625P 2013-05-29 2013-05-29
US61/828,625 2013-05-29
US201361871288P 2013-08-28 2013-08-28
US61/871,288 2013-08-28
PCT/US2014/037563 WO2014193632A2 (fr) 2013-05-29 2014-05-09 Intracorps à chaîne unique modifiant la dégradation de la protéine mutante huntingtin

Publications (2)

Publication Number Publication Date
CA2913418A1 CA2913418A1 (fr) 2014-12-04
CA2913418C true CA2913418C (fr) 2021-11-23

Family

ID=51989509

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2913418A Active CA2913418C (fr) 2013-05-29 2014-05-09 Intracorps a chaine unique modifiant la degradation de la proteine mutante huntingtin

Country Status (8)

Country Link
US (3) US9932394B2 (fr)
EP (2) EP3071598B1 (fr)
CN (2) CN111205369B (fr)
AU (2) AU2014272024B2 (fr)
CA (1) CA2913418C (fr)
DK (1) DK3071598T3 (fr)
HK (1) HK1223634A1 (fr)
WO (1) WO2014193632A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3071598B1 (fr) * 2013-05-29 2021-07-07 Vybion, Inc. Intracorps à chaîne unique modifiant la dégradation de la protéine mutante huntingtin
RU2021100991A (ru) 2014-07-10 2021-03-01 Аффирис Аг Вещества и способы для применения при предупреждении и/или лечении болезни гентингтона
KR102643395B1 (ko) * 2014-07-29 2024-03-11 뉴리뮨 홀딩 아게 인간-유래의 항-헌팅틴(htt) 항체 및 그의 용도

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
US5587308A (en) 1992-06-02 1996-12-24 The United States Of America As Represented By The Department Of Health & Human Services Modified adeno-associated virus vector capable of expression from a novel promoter
CA2145386A1 (fr) 1992-10-13 1994-04-28 Russel D. Leatherman Appareil d'execution de transactions
US5478745A (en) 1992-12-04 1995-12-26 University Of Pittsburgh Recombinant viral vector system
ATE198490T1 (de) * 1993-06-09 2001-01-15 Unilever Nv Verfahren zur herstellung von fusionsproteinen, die scfv fragmente enthalten, in transformierten schimmelpilzen
DK173897B1 (da) 1998-09-25 2002-02-04 Topsoe Haldor As Fremgangsmåde til autotermisk reforming af et carbonhydridfødemateriale indeholdende højere carbonhydrider
US7375194B2 (en) * 2002-01-28 2008-05-20 California Institute Of Technology Antibodies that bind to an epitope on the Huntington's disease protein
US7799986B2 (en) 2002-07-16 2010-09-21 Line 6, Inc. Stringed instrument for connection to a computer to implement DSP modeling
US20050226863A1 (en) * 2003-11-20 2005-10-13 Massachusetts Institute Of Technology Single-domain antibodies and uses thereof
WO2008040332A1 (fr) * 2006-09-25 2008-04-10 Forschungsverbund Berlin E.V. Structures mimétiques de peptides riches en proline, et leur utilisation pharmaceutique
US20100298280A1 (en) * 2007-06-13 2010-11-25 Petra Kioschis-Schneider Compounds for the Modulation of Huntingtin Aggregation, Methods and Means for Identifying Such Compounds
WO2013043669A1 (fr) * 2011-09-21 2013-03-28 The Board Of Regents Of The University Of Texas System Compositions peptoïdes pour le traitement de la maladie d'alzheimer et d'un trouble de l'expansion de polyglutamine
EP3071598B1 (fr) 2013-05-29 2021-07-07 Vybion, Inc. Intracorps à chaîne unique modifiant la dégradation de la protéine mutante huntingtin

Also Published As

Publication number Publication date
US20220064269A1 (en) 2022-03-03
EP3071598A4 (fr) 2017-06-14
DK3071598T3 (da) 2021-09-13
US20180319874A1 (en) 2018-11-08
EP3950712A1 (fr) 2022-02-09
AU2018204243B2 (en) 2020-10-15
AU2018204243A1 (en) 2018-07-05
AU2014272024B2 (en) 2018-03-15
WO2014193632A3 (fr) 2015-04-02
CN105531287B (zh) 2020-01-21
EP3071598B1 (fr) 2021-07-07
CN111205369B (zh) 2024-03-08
CN105531287A (zh) 2016-04-27
HK1223634A1 (zh) 2017-08-04
CN111205369A (zh) 2020-05-29
WO2014193632A2 (fr) 2014-12-04
US20170044241A1 (en) 2017-02-16
AU2014272024A1 (en) 2015-12-03
CA2913418A1 (fr) 2014-12-04
US9932394B2 (en) 2018-04-03
EP3071598A2 (fr) 2016-09-28
US11072650B2 (en) 2021-07-27

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Effective date: 20190508