CA2907657A1 - Derives de piperazine en tant qu'inhibiteurs de fasn - Google Patents
Derives de piperazine en tant qu'inhibiteurs de fasn Download PDFInfo
- Publication number
- CA2907657A1 CA2907657A1 CA2907657A CA2907657A CA2907657A1 CA 2907657 A1 CA2907657 A1 CA 2907657A1 CA 2907657 A CA2907657 A CA 2907657A CA 2907657 A CA2907657 A CA 2907657A CA 2907657 A1 CA2907657 A1 CA 2907657A1
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- Prior art keywords
- denotes
- atoms
- formula
- pharmaceutically acceptable
- stereoisomers
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
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- Biomedical Technology (AREA)
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- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13001462 | 2013-03-21 | ||
| EP13001462.4 | 2013-03-21 | ||
| PCT/EP2014/000478 WO2014146747A1 (fr) | 2013-03-21 | 2014-02-24 | Dérivés de pipérazine en tant qu'inhibiteurs de fasn |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2907657A1 true CA2907657A1 (fr) | 2014-09-25 |
Family
ID=47912880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2907657A Abandoned CA2907657A1 (fr) | 2013-03-21 | 2014-02-24 | Derives de piperazine en tant qu'inhibiteurs de fasn |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9809552B2 (fr) |
| EP (1) | EP2976328B2 (fr) |
| JP (2) | JP6412553B2 (fr) |
| CN (1) | CN105008329B (fr) |
| AR (1) | AR095707A1 (fr) |
| AU (1) | AU2014234721A1 (fr) |
| CA (1) | CA2907657A1 (fr) |
| ES (1) | ES2634875T3 (fr) |
| IL (1) | IL241513A0 (fr) |
| WO (1) | WO2014146747A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20160122A1 (es) | 2013-03-13 | 2016-02-12 | Forma Therapeutics Inc | Compuestos nobles y composiciones para la inhibicion de fasn |
| MX2017016669A (es) | 2015-06-18 | 2018-04-13 | Cephalon Inc | Derivados de piperidina 1,4-sustituidos. |
| EP3310773B1 (fr) | 2015-06-18 | 2020-12-02 | 89Bio Ltd. | Dérivés de 4-benzyl et 4-benzoyl-pipéridine substitués |
| ES2886935T3 (es) | 2016-04-25 | 2021-12-21 | Forma Therapeutics Inc | Inhibidores de FASN para su uso en el tratamiento de esteatohepatitis no alcohólica |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| CN113382633A (zh) | 2018-10-29 | 2021-09-10 | 福马治疗股份有限公司 | (4-(2-氟-4-(1-甲基-1H-苯并[d]咪唑-5-基)苯甲酰基)哌嗪-1-基)(1-羟基环丙基)甲酮的固体形式 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19743435A1 (de) | 1997-10-01 | 1999-04-08 | Merck Patent Gmbh | Benzamidinderivate |
| DE102007007751A1 (de) | 2007-02-16 | 2008-08-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| WO2009099736A2 (fr) | 2008-02-06 | 2009-08-13 | Lead Therapeutics, Inc. | Inhibiteurs à base de composés benzoxazole-carboxamide de l’activité poly(adp-ribose)polymérase (parp) |
| JP5744886B2 (ja) * | 2009-10-19 | 2015-07-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | シクロペンタンカルボキサミド誘導体、このような化合物を含む薬物及びそれらの使用 |
| KR101261702B1 (ko) * | 2011-01-07 | 2013-05-06 | 이화여자대학교 산학협력단 | 신규한 2-페닐퀴나졸린-4(3ｈ)-온 유도체, 그 제조방법 및 그 약학적 조성물 |
| CN102627610B (zh) * | 2012-04-11 | 2014-06-25 | 江苏先声药物研究有限公司 | 一类苯并咪唑类衍生物及其应用 |
| PE20160122A1 (es) | 2013-03-13 | 2016-02-12 | Forma Therapeutics Inc | Compuestos nobles y composiciones para la inhibicion de fasn |
-
2014
- 2014-02-24 US US14/778,253 patent/US9809552B2/en not_active Expired - Fee Related
- 2014-02-24 CN CN201480016107.3A patent/CN105008329B/zh not_active Expired - Fee Related
- 2014-02-24 WO PCT/EP2014/000478 patent/WO2014146747A1/fr active Application Filing
- 2014-02-24 EP EP14708800.9A patent/EP2976328B2/fr not_active Not-in-force
- 2014-02-24 CA CA2907657A patent/CA2907657A1/fr not_active Abandoned
- 2014-02-24 ES ES14708800.9T patent/ES2634875T3/es active Active
- 2014-02-24 AU AU2014234721A patent/AU2014234721A1/en not_active Abandoned
- 2014-02-24 JP JP2016504506A patent/JP6412553B2/ja not_active Expired - Fee Related
- 2014-03-21 AR ARP140101320A patent/AR095707A1/es unknown
-
2015
- 2015-09-10 IL IL241513A patent/IL241513A0/en unknown
-
2018
- 2018-07-09 JP JP2018129665A patent/JP2018188452A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014146747A1 (fr) | 2014-09-25 |
| JP6412553B2 (ja) | 2018-10-24 |
| US9809552B2 (en) | 2017-11-07 |
| CN105008329A (zh) | 2015-10-28 |
| EP2976328B1 (fr) | 2017-05-03 |
| ES2634875T3 (es) | 2017-09-29 |
| EP2976328B2 (fr) | 2019-07-03 |
| IL241513A0 (en) | 2015-11-30 |
| AU2014234721A1 (en) | 2015-11-05 |
| EP2976328A1 (fr) | 2016-01-27 |
| JP2016515550A (ja) | 2016-05-30 |
| AR095707A1 (es) | 2015-11-04 |
| JP2018188452A (ja) | 2018-11-29 |
| CN105008329B (zh) | 2018-01-05 |
| US20160280655A1 (en) | 2016-09-29 |
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| FZDE | Discontinued |
Effective date: 20180226 |