CA2903708C - A process for the preparation of 2-amino-1,3-propane diol compounds and salts thereof - Google Patents
A process for the preparation of 2-amino-1,3-propane diol compounds and salts thereof Download PDFInfo
- Publication number
- CA2903708C CA2903708C CA2903708A CA2903708A CA2903708C CA 2903708 C CA2903708 C CA 2903708C CA 2903708 A CA2903708 A CA 2903708A CA 2903708 A CA2903708 A CA 2903708A CA 2903708 C CA2903708 C CA 2903708C
- Authority
- CA
- Canada
- Prior art keywords
- formula
- amino
- propanediol
- ethyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN951/CHE/2013 | 2013-03-05 | ||
| IN951CH2013 | 2013-03-05 | ||
| PCT/IB2014/059423 WO2014136047A2 (en) | 2013-03-05 | 2014-03-04 | A process for the preparation of 2-amino-1,3-propane diol compounds and salts thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2903708A1 CA2903708A1 (en) | 2014-09-12 |
| CA2903708C true CA2903708C (en) | 2021-07-13 |
Family
ID=54198663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2903708A Active CA2903708C (en) | 2013-03-05 | 2014-03-04 | A process for the preparation of 2-amino-1,3-propane diol compounds and salts thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9815772B2 (https=) |
| EP (1) | EP2964210B1 (https=) |
| JP (2) | JP6484567B2 (https=) |
| KR (1) | KR102255357B1 (https=) |
| AU (1) | AU2014224237B2 (https=) |
| CA (1) | CA2903708C (https=) |
| ES (1) | ES2964891T3 (https=) |
| RU (1) | RU2663833C2 (https=) |
| WO (1) | WO2014136047A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2627691C1 (ru) * | 2016-07-06 | 2017-08-10 | Олег Ростиславович Михайлов | Кристаллическая η-модификация 2-амино-2-(2-(4-октилфенил)этил)пропан-1,3-диол гидрохлорида, способ её получения и фармацевтическая композиция на её основе |
| WO2020165672A1 (en) | 2019-02-15 | 2020-08-20 | Shivalik Rasayan Limited | Process for preparation of highly pure fingolimod hydrochloride |
| WO2021167770A1 (en) * | 2020-02-18 | 2021-08-26 | Octagon Therapeutics, Inc. | Immune cell modulators |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5604229A (en) * | 1992-10-21 | 1997-02-18 | Yoshitomi Pharmaceutical Industries, Ltd. | 2-amino-1,3-propanediol compound and immunosuppressant |
| GB9624038D0 (en) * | 1996-11-19 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| EP1457478B1 (en) * | 1998-11-11 | 2017-07-19 | Novartis AG | Production of 2-amino-2-[2-(4-alkyl-phenyl)ethyl]propane-1,3-diols |
| EP1937699A2 (en) * | 2005-10-18 | 2008-07-02 | Centre National De La Recherche Scientifique (Cnrs) | Hypophosphorous acid derivatives and their therapeutical applications |
| US20090176744A1 (en) * | 2007-11-02 | 2009-07-09 | Concert Pharmaceuticals, Inc. | Deuterated fingolimod |
| CA2743232C (en) * | 2008-11-11 | 2015-12-29 | Novartis Ag | Crystalline forms of fingolimod hcl |
| MX2011004924A (es) | 2008-11-11 | 2011-05-30 | Novartis Ag | Sales de fingolimod. |
| EP2400960B1 (en) * | 2009-02-24 | 2013-04-17 | Novartis AG | Ceramide-analogous metabolites |
| EP2456752A2 (en) * | 2009-07-24 | 2012-05-30 | ratiopharm GmbH | Process for producing fingolimod salts |
| WO2012041359A1 (en) * | 2010-10-01 | 2012-04-05 | Synthon B.V. | Process for making fingolimod |
| US9266816B2 (en) * | 2010-11-25 | 2016-02-23 | Shilpa Medicare Limited | Fingolimod polymorphs and their processes |
| EP2702034A4 (en) * | 2011-04-29 | 2015-03-25 | Reddys Lab Ltd Dr | PREPARATION OF FINGOLIMOD AND ITS SALTS |
| CN102796022B (zh) * | 2012-08-27 | 2015-03-25 | 南京华威医药科技开发有限公司 | 制备2-氨基-2-[2-(4-烷基苯基)乙基]-1,3-丙二醇盐酸盐的方法 |
-
2014
- 2014-03-04 US US14/772,739 patent/US9815772B2/en active Active
- 2014-03-04 AU AU2014224237A patent/AU2014224237B2/en active Active
- 2014-03-04 WO PCT/IB2014/059423 patent/WO2014136047A2/en not_active Ceased
- 2014-03-04 JP JP2015560826A patent/JP6484567B2/ja active Active
- 2014-03-04 ES ES14760844T patent/ES2964891T3/es active Active
- 2014-03-04 CA CA2903708A patent/CA2903708C/en active Active
- 2014-03-04 RU RU2015139293A patent/RU2663833C2/ru active
- 2014-03-04 EP EP14760844.2A patent/EP2964210B1/en active Active
- 2014-03-04 KR KR1020157026450A patent/KR102255357B1/ko active Active
-
2018
- 2018-10-16 JP JP2018194845A patent/JP2019023224A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| RU2015139293A (ru) | 2017-04-07 |
| JP2016513623A (ja) | 2016-05-16 |
| EP2964210A4 (en) | 2016-11-16 |
| US9815772B2 (en) | 2017-11-14 |
| RU2663833C2 (ru) | 2018-08-10 |
| JP6484567B2 (ja) | 2019-03-13 |
| EP2964210B1 (en) | 2023-10-04 |
| EP2964210A2 (en) | 2016-01-13 |
| KR20150126876A (ko) | 2015-11-13 |
| WO2014136047A2 (en) | 2014-09-12 |
| US20160009634A1 (en) | 2016-01-14 |
| CA2903708A1 (en) | 2014-09-12 |
| ES2964891T3 (es) | 2024-04-10 |
| AU2014224237B2 (en) | 2017-07-20 |
| WO2014136047A3 (en) | 2015-04-02 |
| KR102255357B1 (ko) | 2021-05-24 |
| JP2019023224A (ja) | 2019-02-14 |
| AU2014224237A1 (en) | 2015-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20190225 |
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| MPN | Maintenance fee for patent paid |
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| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20260129 |
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| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20260129 |