CA2901439C - Peptides for use in the topical treatment of retinal neurodegenerative diseases, in particular in early stages of diabetic retinopathy and other retinal diseases in which neurodegeneration plays an essential role - Google Patents

Peptides for use in the topical treatment of retinal neurodegenerative diseases, in particular in early stages of diabetic retinopathy and other retinal diseases in which neurodegeneration plays an essential role Download PDF

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Publication number
CA2901439C
CA2901439C CA2901439A CA2901439A CA2901439C CA 2901439 C CA2901439 C CA 2901439C CA 2901439 A CA2901439 A CA 2901439A CA 2901439 A CA2901439 A CA 2901439A CA 2901439 C CA2901439 C CA 2901439C
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Prior art keywords
peptide
amino acid
use according
group
acid sequence
Prior art date
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Active
Application number
CA2901439A
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English (en)
French (fr)
Other versions
CA2901439A1 (en
Inventor
Rafael Simo Canonge
Cristina Hernandez Pascual
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fundació Institut de Recerca Hospital Universitari Vall d'Hebron
Original Assignee
Fundació Institut de Recerca Hospital Universitari Vall d'Hebron
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Publication of CA2901439A1 publication Critical patent/CA2901439A1/en
Application granted granted Critical
Publication of CA2901439C publication Critical patent/CA2901439C/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CA2901439A 2013-03-01 2014-02-27 Peptides for use in the topical treatment of retinal neurodegenerative diseases, in particular in early stages of diabetic retinopathy and other retinal diseases in which neurodegeneration plays an essential role Active CA2901439C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13382063 2013-03-01
EP13382063.9 2013-03-01
PCT/EP2014/053787 WO2014131815A1 (en) 2013-03-01 2014-02-27 Peptides for use in the topical treatment of retinal neurodegenerative disesases, in particular in early stages of diabetic retinopathy and other retinal diseases in which neurodegeneration plays an essential role

Publications (2)

Publication Number Publication Date
CA2901439A1 CA2901439A1 (en) 2014-09-04
CA2901439C true CA2901439C (en) 2023-04-04

Family

ID=47901927

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2901439A Active CA2901439C (en) 2013-03-01 2014-02-27 Peptides for use in the topical treatment of retinal neurodegenerative diseases, in particular in early stages of diabetic retinopathy and other retinal diseases in which neurodegeneration plays an essential role

Country Status (14)

Country Link
US (1) US9707273B2 (enExample)
EP (1) EP2968471B1 (enExample)
JP (2) JP6368722B2 (enExample)
CN (1) CN105007931B (enExample)
CA (1) CA2901439C (enExample)
DK (1) DK2968471T3 (enExample)
ES (1) ES2644016T3 (enExample)
HR (1) HRP20171501T1 (enExample)
HU (1) HUE036542T2 (enExample)
MX (1) MX364911B (enExample)
PL (1) PL2968471T3 (enExample)
PT (1) PT2968471T (enExample)
SI (1) SI2968471T1 (enExample)
WO (1) WO2014131815A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10251462B2 (en) 2013-04-23 2019-04-09 Noxell Corporation Hair consultation tool arrangement and method
CN107206058A (zh) 2014-12-12 2017-09-26 赛诺菲-安万特德国有限公司 甘精胰岛素/利西拉来固定比率配制剂
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
AU2016379403B2 (en) 2015-12-23 2020-03-12 The Johns Hopkins University Long-acting GLP-1r agonist as a therapy of neurological and neurodegenerative conditions
US10973867B2 (en) 2015-12-30 2021-04-13 Marshall University Research Corporation Compositions and methods for treating retinopathy
WO2017186934A1 (en) * 2016-04-29 2017-11-02 Fundació Hospital Universitari Vall D'hebron - Institut De Recerca Dipeptidyl peptidase-4 inhibitors for topical eye treatment of retinal neurodegenerative diseases
CN106822182A (zh) * 2016-12-27 2017-06-13 广州姿生生物科技有限公司 一种细胞提取物及其用途
EP3443980A1 (en) * 2017-08-15 2019-02-20 Ciliocure Limited Compound for the treatment of patients with leptin-resistant obesity, bardet-biedl syndrome and other ciliopathies
MX2022009136A (es) * 2020-02-13 2022-08-22 Ferrer Int Composicion farmaceutica oftalmica y uso de la misma.
GB202014740D0 (en) * 2020-09-18 2020-11-04 Invex Therapeutics Ltd Method of reducing intraocular pressure
US20220193201A1 (en) * 2020-10-19 2022-06-23 The Trustees Of The University Of Pennsylvania Glp-1r agonist reduces retinal inflammation and neuron death secondary to ocular hypertension
IL302804A (en) * 2020-11-09 2023-07-01 Tel Hashomer Medical Res Infrastructure & Services Ltd Treatment of ocular diseases
EP4248985A1 (en) 2022-03-25 2023-09-27 Consejo Superior de Investigaciones Científicas (CSIC) Peptides for the treatment of retinitis pigmentosa
KR102587729B1 (ko) * 2023-02-27 2023-10-12 주식회사 아이바이오코리아 펩타이드를 포함하는 당뇨망막병증의 치료용 조성물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5424286A (en) 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
DE122009000079I2 (de) 1996-08-30 2011-06-16 Novo Nordisk As Novo Alle Glp-1 derivate
JP4798814B2 (ja) 1997-01-07 2011-10-19 アミリン・ファーマシューティカルズ，インコーポレイテッド 食物摂取低減用のエキセンジンおよびそのアゴニストの使用
WO2003059373A2 (en) 2002-01-16 2003-07-24 Ramot At Tel Aviv University Ltd. Compositions and their use for enhancing and inhibiting fertilization
US20120021980A1 (en) 2004-08-25 2012-01-26 Aegis Therapeutics, Inc. Compositions for drug administration
US8541413B2 (en) 2004-10-01 2013-09-24 Ramscor, Inc. Sustained release eye drop formulations
WO2007062434A2 (en) 2005-11-22 2007-05-31 Crestwave Technologies (Pty) Ltd A mineral recovery process
WO2010008831A2 (en) * 2008-06-24 2010-01-21 Irm Llc Compounds and methods for modulating g protein-coupled receptors
EP2251028A1 (en) * 2009-05-12 2010-11-17 Biocompatibles Uk Ltd. Treatment of eye diseases using encapsulated cells encoding and secreting an anti-angiogenic factor and/or a neuroprotective factor
ES2362604B1 (es) 2009-12-22 2012-06-28 Bcn Peptides, S.A. Formulación tópica oftálmica de péptidos.
CN102643339B (zh) * 2011-02-21 2014-04-09 天津药物研究院 一种glp-1类似物、制备方法及其应用

Also Published As

Publication number Publication date
WO2014131815A1 (en) 2014-09-04
EP2968471A1 (en) 2016-01-20
SI2968471T1 (sl) 2017-11-30
HRP20171501T1 (hr) 2017-11-17
CA2901439A1 (en) 2014-09-04
BR112015020143A2 (pt) 2017-08-29
MX364911B (es) 2019-05-13
US20160000882A1 (en) 2016-01-07
PL2968471T3 (pl) 2017-12-29
CN105007931B (zh) 2018-04-06
JP2016510728A (ja) 2016-04-11
US9707273B2 (en) 2017-07-18
PT2968471T (pt) 2017-10-24
JP6368722B2 (ja) 2018-08-01
JP2018111702A (ja) 2018-07-19
HUE036542T2 (hu) 2018-07-30
EP2968471B1 (en) 2017-07-19
CN105007931A (zh) 2015-10-28
DK2968471T3 (en) 2017-10-23
MX2015011243A (es) 2016-04-25
ES2644016T3 (es) 2017-11-27

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