JP6368722B2 - 網膜神経変性疾患の、特に、初期の糖尿病性網膜症及び神経変性が本質的な役割を果たす他の網膜疾患における局所治療における使用のためのペプチド - Google Patents

網膜神経変性疾患の、特に、初期の糖尿病性網膜症及び神経変性が本質的な役割を果たす他の網膜疾患における局所治療における使用のためのペプチド Download PDF

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JP6368722B2
JP6368722B2 JP2015559495A JP2015559495A JP6368722B2 JP 6368722 B2 JP6368722 B2 JP 6368722B2 JP 2015559495 A JP2015559495 A JP 2015559495A JP 2015559495 A JP2015559495 A JP 2015559495A JP 6368722 B2 JP6368722 B2 JP 6368722B2
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peptide
amino acid
glp
retinal
xaa
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JP2016510728A (ja
JP2016510728A5 (enExample
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カノンジュ， ラファエル シモ
カノンジュ， ラファエル シモ
パスクアル， クリスティーナ エルナンデス
パスクアル， クリスティーナ エルナンデス
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フンダシオ オスピタル ウニベルシタリ バル デブロン−インスティテュート デ レセルカ
フンダシオ オスピタル ウニベルシタリ バル デブロン−インスティテュート デ レセルカ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2015559495A 2013-03-01 2014-02-27 網膜神経変性疾患の、特に、初期の糖尿病性網膜症及び神経変性が本質的な役割を果たす他の網膜疾患における局所治療における使用のためのペプチド Active JP6368722B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13382063 2013-03-01
EP13382063.9 2013-03-01
PCT/EP2014/053787 WO2014131815A1 (en) 2013-03-01 2014-02-27 Peptides for use in the topical treatment of retinal neurodegenerative disesases, in particular in early stages of diabetic retinopathy and other retinal diseases in which neurodegeneration plays an essential role

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018029089A Division JP2018111702A (ja) 2013-03-01 2018-02-21 網膜神経変性疾患の、特に、初期の糖尿病性網膜症及び神経変性が本質的な役割を果たす他の網膜疾患における局所治療における使用のためのペプチド

Publications (3)

Publication Number Publication Date
JP2016510728A JP2016510728A (ja) 2016-04-11
JP2016510728A5 JP2016510728A5 (enExample) 2017-03-30
JP6368722B2 true JP6368722B2 (ja) 2018-08-01

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JP2015559495A Active JP6368722B2 (ja) 2013-03-01 2014-02-27 網膜神経変性疾患の、特に、初期の糖尿病性網膜症及び神経変性が本質的な役割を果たす他の網膜疾患における局所治療における使用のためのペプチド
JP2018029089A Pending JP2018111702A (ja) 2013-03-01 2018-02-21 網膜神経変性疾患の、特に、初期の糖尿病性網膜症及び神経変性が本質的な役割を果たす他の網膜疾患における局所治療における使用のためのペプチド

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JP2018029089A Pending JP2018111702A (ja) 2013-03-01 2018-02-21 網膜神経変性疾患の、特に、初期の糖尿病性網膜症及び神経変性が本質的な役割を果たす他の網膜疾患における局所治療における使用のためのペプチド

Country Status (14)

Country Link
US (1) US9707273B2 (enExample)
EP (1) EP2968471B1 (enExample)
JP (2) JP6368722B2 (enExample)
CN (1) CN105007931B (enExample)
CA (1) CA2901439C (enExample)
DK (1) DK2968471T3 (enExample)
ES (1) ES2644016T3 (enExample)
HR (1) HRP20171501T1 (enExample)
HU (1) HUE036542T2 (enExample)
MX (1) MX364911B (enExample)
PL (1) PL2968471T3 (enExample)
PT (1) PT2968471T (enExample)
SI (1) SI2968471T1 (enExample)
WO (1) WO2014131815A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015026910A2 (pt) 2013-04-23 2017-07-25 Procter & Gamble arranjo de ferramenta para consulta de cabelo e método
ES2949095T3 (es) 2014-12-12 2023-09-25 Sanofi Aventis Deutschland Formulación de relación fija de insulina glargina/lixisenatida
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
KR102508651B1 (ko) 2015-12-23 2023-03-13 더 존스 홉킨스 유니버시티 신경계 및 신경변성 상태의 요법으로서 장기간 작용하는 glf-1r 작용제
ES2903397T3 (es) 2015-12-30 2022-04-01 Marshall Univ Research Corporation Composiciones y métodos para tratar la retinopatía
DK3448388T3 (da) * 2016-04-29 2021-02-08 Fundacio Hospital Univ Vall D Hebron Institut De Recerca Dipeptidyl-peptidase-4-inhibitorer til topikal øjenbehandling af retinale neurodegenerative sygdomme
CN106822182A (zh) * 2016-12-27 2017-06-13 广州姿生生物科技有限公司 一种细胞提取物及其用途
EP3443980A1 (en) * 2017-08-15 2019-02-20 Ciliocure Limited Compound for the treatment of patients with leptin-resistant obesity, bardet-biedl syndrome and other ciliopathies
BR112022014543A2 (pt) 2020-02-13 2022-09-20 Ferrer Int Composição farmacêutica oftálmica e uso da mesma
GB202014740D0 (en) * 2020-09-18 2020-11-04 Invex Therapeutics Ltd Method of reducing intraocular pressure
US20220193201A1 (en) * 2020-10-19 2022-06-23 The Trustees Of The University Of Pennsylvania Glp-1r agonist reduces retinal inflammation and neuron death secondary to ocular hypertension
EP4240391A4 (en) * 2020-11-09 2024-09-11 Tel HaShomer Medical Research Infrastructure and Services Ltd. TREATMENT OF RETINAL DISORDERS
EP4248985A1 (en) 2022-03-25 2023-09-27 Consejo Superior de Investigaciones Científicas (CSIC) Peptides for the treatment of retinitis pigmentosa

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5424286A (en) 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
JP3149958B2 (ja) 1996-08-30 2001-03-26 ノボ ノルディスク アクティーゼルスカブ Ｇｌｐ―１誘導体
WO1998030231A1 (en) 1997-01-07 1998-07-16 Amylin Pharmaceuticals, Inc. Use of exendins and agonists thereof for the reduction of food intake
WO2003059373A2 (en) 2002-01-16 2003-07-24 Ramot At Tel Aviv University Ltd. Compositions and their use for enhancing and inhibiting fertilization
US20120021980A1 (en) 2004-08-25 2012-01-26 Aegis Therapeutics, Inc. Compositions for drug administration
US8541413B2 (en) 2004-10-01 2013-09-24 Ramscor, Inc. Sustained release eye drop formulations
WO2007062434A2 (en) 2005-11-22 2007-05-31 Crestwave Technologies (Pty) Ltd A mineral recovery process
US8362050B2 (en) * 2008-06-24 2013-01-29 Irm Llc Compounds and methods for modulating G protein-coupled receptors
EP2251028A1 (en) * 2009-05-12 2010-11-17 Biocompatibles Uk Ltd. Treatment of eye diseases using encapsulated cells encoding and secreting an anti-angiogenic factor and/or a neuroprotective factor
ES2362604B1 (es) 2009-12-22 2012-06-28 Bcn Peptides, S.A. Formulación tópica oftálmica de péptidos.
CN102643339B (zh) * 2011-02-21 2014-04-09 天津药物研究院 一种glp-1类似物、制备方法及其应用

Also Published As

Publication number Publication date
CN105007931A (zh) 2015-10-28
US20160000882A1 (en) 2016-01-07
PL2968471T3 (pl) 2017-12-29
BR112015020143A2 (pt) 2017-08-29
WO2014131815A1 (en) 2014-09-04
HUE036542T2 (hu) 2018-07-30
SI2968471T1 (sl) 2017-11-30
EP2968471A1 (en) 2016-01-20
JP2018111702A (ja) 2018-07-19
CA2901439C (en) 2023-04-04
DK2968471T3 (en) 2017-10-23
JP2016510728A (ja) 2016-04-11
MX364911B (es) 2019-05-13
CN105007931B (zh) 2018-04-06
ES2644016T3 (es) 2017-11-27
US9707273B2 (en) 2017-07-18
EP2968471B1 (en) 2017-07-19
PT2968471T (pt) 2017-10-24
MX2015011243A (es) 2016-04-25
HRP20171501T1 (hr) 2017-11-17
CA2901439A1 (en) 2014-09-04

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