CA2901379C - Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection - Google Patents
Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection Download PDFInfo
- Publication number
- CA2901379C CA2901379C CA2901379A CA2901379A CA2901379C CA 2901379 C CA2901379 C CA 2901379C CA 2901379 A CA2901379 A CA 2901379A CA 2901379 A CA2901379 A CA 2901379A CA 2901379 C CA2901379 C CA 2901379C
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- Prior art keywords
- alkylene
- compound
- alkyl
- optionally substituted
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000338 in vitro Methods 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title 1
- 238000011503 in vivo imaging Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000003384 imaging method Methods 0.000 abstract 2
- 239000000975 dye Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0816—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring comprising Si as a ring atom
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B11/00—Diaryl- or thriarylmethane dyes
- C09B11/28—Pyronines ; Xanthon, thioxanthon, selenoxanthan, telluroxanthon dyes
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/008—Dyes containing a substituent, which contains a silicium atom
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361794188P | 2013-03-15 | 2013-03-15 | |
| US61/794,188 | 2013-03-15 | ||
| PCT/US2014/029350 WO2014144793A1 (en) | 2013-03-15 | 2014-03-14 | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2901379A1 CA2901379A1 (en) | 2014-09-18 |
| CA2901379C true CA2901379C (en) | 2023-05-16 |
Family
ID=50721890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2901379A Active CA2901379C (en) | 2013-03-15 | 2014-03-14 | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9649389B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2970342B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6606487B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN105073761B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2014228504C1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2901379C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014144793A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2618361T3 (es) | 2005-09-02 | 2017-06-21 | Visen Medical, Inc. | Marcadores colorantes fluorescentes que contienen sulfonamida N,N-disustituida biocompatible |
| US9913917B2 (en) | 2005-12-22 | 2018-03-13 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| AU2009205950C1 (en) | 2008-01-18 | 2015-08-06 | Visen Medical, Inc. | Fluorescent imaging agents |
| JP6122840B2 (ja) | 2011-05-09 | 2017-04-26 | ビセン メディカル， インコーポレイテッド | 炭酸脱水酵素標的化剤およびそれの使用方法 |
| CA2901379C (en) | 2013-03-15 | 2023-05-16 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
| WO2014144702A2 (en) | 2013-03-15 | 2014-09-18 | Visen Medical, Inc. | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof |
| WO2015027176A1 (en) | 2013-08-22 | 2015-02-26 | Sony Corporation | Water soluble fluorescent or colored dyes and methods for their use |
| US10004815B2 (en) | 2013-12-04 | 2018-06-26 | The University Of Tokyo | Near-infrared quenching group |
| CA2944476C (en) * | 2014-04-01 | 2021-06-15 | Howard Hughes Medical Institute | Azetidine-substituted fluorescent compounds |
| EP3262055A4 (en) | 2015-02-26 | 2018-09-05 | Sony Corporation | Water soluble fluorescent or colored dyes comprising conjugating groups |
| CN108027314A (zh) * | 2015-07-28 | 2018-05-11 | 加利福尼亚大学董事会 | 长波长电压敏感染料 |
| JP2017149806A (ja) * | 2016-02-22 | 2017-08-31 | 富士フイルム株式会社 | 着色組成物、インクジェット用インク、及び捺染方法 |
| WO2017147015A1 (en) * | 2016-02-24 | 2017-08-31 | Saudi Arabian Oil Company | Detecting xanthan gum |
| CN114806218A (zh) | 2016-04-01 | 2022-07-29 | 索尼公司 | 超亮二聚或多聚染料 |
| WO2017173348A1 (en) | 2016-04-01 | 2017-10-05 | Sony Corporation | Ultra bright dimeric or polymeric dyes with rigid spacing groups |
| AU2017248165B2 (en) | 2016-04-06 | 2021-08-26 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes with spacing linker groups |
| EP3450963A4 (en) * | 2016-04-28 | 2020-01-29 | National University Corporation Nagoya University | FLUORESCENT PROBE, METHOD FOR DETECTING FLUORESCENCE AND METHOD OF USING FLUORESCENT PROBE |
| US11390754B2 (en) | 2016-05-10 | 2022-07-19 | Sony Corporation | Compositions comprising a polymeric dye and a cyclodextrin and uses thereof |
| WO2017196954A1 (en) | 2016-05-10 | 2017-11-16 | Sony Corporation | Ultra bright polymeric dyes with peptide backbones |
| JP7071286B2 (ja) | 2016-05-11 | 2022-05-18 | ソニーグループ株式会社 | 超明色ダイマーまたはポリマー染料 |
| US11377563B2 (en) | 2016-06-06 | 2022-07-05 | Sony Corporation | Ionic polymers comprising fluorescent or colored reporter groups |
| JP6919653B2 (ja) * | 2016-06-22 | 2021-08-18 | 富士フイルム和光純薬株式会社 | ケイ素含有複素環式化合物及び消光剤 |
| WO2018022925A1 (en) | 2016-07-29 | 2018-02-01 | Sony Corporation | Ultra bright dimeric or polymeric dyes and methods for preparation of the same |
| US20180193003A1 (en) * | 2016-12-07 | 2018-07-12 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
| WO2018151260A1 (ja) * | 2017-02-17 | 2018-08-23 | 国立大学法人 東京大学 | ペプチダーゼ活性検出用赤色蛍光プローブ |
| CN111093711A (zh) | 2017-10-05 | 2020-05-01 | 索尼公司 | 可编程的树枝状药物 |
| JP7551056B2 (ja) | 2017-10-05 | 2024-09-17 | ソニーグループ株式会社 | プログラマブルなポリマー薬物 |
| WO2019099789A1 (en) | 2017-11-16 | 2019-05-23 | Sony Corporation | Programmable polymeric drugs |
| CN111565756A (zh) | 2018-01-12 | 2020-08-21 | 索尼公司 | 包含生物活性化合物的具有刚性间隔基团的聚合物 |
| WO2019140227A1 (en) | 2018-01-12 | 2019-07-18 | Sony Corporation | Phosphoalkyl ribose polymers comprising biologically active compounds |
| JP2021520423A (ja) | 2018-03-19 | 2021-08-19 | ソニーグループ株式会社 | 蛍光シグナルを増強するための二価金属の使用 |
| JP7515786B2 (ja) | 2018-03-21 | 2024-07-16 | ソニーグループ株式会社 | リンカー基を有するポリマータンデム色素 |
| US11697736B2 (en) | 2018-05-18 | 2023-07-11 | Singular Genomics Systems, Inc. | Silicon containing detectable compounds |
| KR102228538B1 (ko) * | 2018-06-01 | 2021-03-15 | 주식회사 엘지화학 | 염료 화합물 및 포토폴리머 조성물 |
| KR102854332B1 (ko) | 2018-06-27 | 2025-09-03 | 소니그룹주식회사 | 디옥시리보오스를 포함하는 링커 군을 갖는 중합체성 염료 |
| US12258477B2 (en) | 2018-08-10 | 2025-03-25 | Life Technologies Corporation | Silicon-substituted rhodamine dyes and dye conjugates |
| US12030893B2 (en) | 2018-09-11 | 2024-07-09 | Oregon Health & Science University | Near-infrared nerve-sparing benzo[c]phenoxazine fluorophores |
| KR102283067B1 (ko) * | 2019-07-18 | 2021-07-28 | 아주대학교산학협력단 | 미토콘드리아를 표적으로 하는 신규한 근적외선 형광 프로브 및 이를 포함하는 종양 진단 및 치료 겸용 조성물 |
| WO2021062176A2 (en) | 2019-09-26 | 2021-04-01 | Sony Corporation | Polymeric tandem dyes with linker groups |
| EP4055023A4 (en) | 2019-11-07 | 2024-01-03 | Singular Genomics Systems, Inc. | SILICON-CONTAINING DETECTED COMPOUNDS AND USES THEREOF |
| EP4073175A1 (en) * | 2019-12-09 | 2022-10-19 | F. Hoffmann-La Roche AG | Dicationic fluorescent dyes |
| JP7481122B2 (ja) * | 2020-02-03 | 2024-05-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 蛍光色素及びその利用 |
| WO2022125564A1 (en) | 2020-12-07 | 2022-06-16 | Sony Group Corporation | Spacing linker group design for brightness enhancement in dimeric or polymeric dyes |
| CN113045599B (zh) * | 2021-03-17 | 2022-04-19 | 山西大学 | 一种高对比度区分癌细胞/组织的方法及荧光探针的制备 |
| US20240239823A1 (en) * | 2021-05-10 | 2024-07-18 | University Of Virginia Patent Foundation | Phosphinate ester-containing dyes having tunable properties and methods of making the same |
| CN113563298B (zh) * | 2021-07-20 | 2023-07-28 | 北京大学 | 一类含水溶性取代基罗丹明荧光染料其制备方法和应用 |
| JP7787670B2 (ja) * | 2021-08-31 | 2025-12-17 | 富士フイルム株式会社 | 化合物及びこれを用いた標識生体物質 |
| CN113801145B (zh) * | 2021-10-12 | 2022-06-07 | 南京大学 | 一种激活型近红外小分子荧光探针及其制备方法与应用 |
| CN114869227B (zh) * | 2022-04-02 | 2025-09-05 | 北京信息科技大学 | 一种可穿戴式微型活体流式图像细胞仪 |
| CN115322205B (zh) * | 2022-04-06 | 2025-09-26 | 大连理工大学 | 一类近红外二区荧光染料及制备方法与抗肿瘤应用 |
| US20250321537A1 (en) * | 2022-11-04 | 2025-10-16 | Lg Chem, Ltd. | Photopolymer composition, hologram recording medium, preparation method thereof and optical element comprising the same |
| JP2025515017A (ja) | 2022-11-04 | 2025-05-13 | エルジー・ケム・リミテッド | ホログラム記録媒体およびこれを含む光学素子 |
| JP2025514130A (ja) * | 2022-11-04 | 2025-05-02 | エルジー・ケム・リミテッド | ホログラム記録媒体、その製造方法およびこれを含む光学素子 |
| US12359068B2 (en) | 2023-02-10 | 2025-07-15 | Singular Genomics Systems, Inc. | Rhodamine fluorescent compounds and production methods thereof |
| WO2024225787A1 (ko) * | 2023-04-28 | 2024-10-31 | 에스에프씨 주식회사 | 신규한 화합물 및 이의 용도 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4219335A (en) | 1978-09-18 | 1980-08-26 | E. I. Du Pont De Nemours And Company | Immunochemical testing using tagged reagents |
| US6086737A (en) | 1984-03-29 | 2000-07-11 | Li-Cor, Inc. | Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor |
| US6048982A (en) | 1986-04-18 | 2000-04-11 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
| US5164297A (en) | 1990-05-03 | 1992-11-17 | Advanced Magnetics Inc. | Solvent mediated relaxation assay system |
| US5445970A (en) | 1992-03-20 | 1995-08-29 | Abbott Laboratories | Magnetically assisted binding assays using magnetically labeled binding members |
| DE69332952T2 (de) | 1992-09-04 | 2004-02-19 | The General Hospital Corp., Boston | Diagnostische und therapeutische Einheiten enthaltende biokompatible Polymere |
| DE4445065A1 (de) | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| IT1276833B1 (it) | 1995-10-09 | 1997-11-03 | Sorin Biomedica Cardio Spa | Coloranti fluorescenti della famiglia della solfo benz e indocianina |
| DE19717904A1 (de) | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
| US6046585A (en) | 1997-11-21 | 2000-04-04 | Quantum Design, Inc. | Method and apparatus for making quantitative measurements of localized accumulations of target particles having magnetic particles bound thereto |
| US6083486A (en) | 1998-05-14 | 2000-07-04 | The General Hospital Corporation | Intramolecularly-quenched near infrared fluorescent probes |
| US6592847B1 (en) | 1998-05-14 | 2003-07-15 | The General Hospital Corporation | Intramolecularly-quenched near infrared flourescent probes |
| US6399392B1 (en) | 1999-04-23 | 2002-06-04 | Molecular Probes, Inc. | Xanthene dyes and their application as luminescence quenching compounds |
| EP1491591B1 (en) | 1999-07-02 | 2009-07-01 | Visen Medical, Inc. | New fluorescence cyanine labels containing a sulfamido linker arm |
| ATE352586T2 (de) | 2000-09-29 | 2007-02-15 | Molecular Probes Inc | Modifizierte carbocyaninfarbstoffe und deren konjugate |
| AU2002236683A1 (en) | 2000-10-27 | 2002-05-21 | Beth Israel Deaconess Medical Center | Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates |
| US6615063B1 (en) | 2000-11-27 | 2003-09-02 | The General Hospital Corporation | Fluorescence-mediated molecular tomography |
| EP1209205A1 (en) | 2000-11-28 | 2002-05-29 | Innosense S.r.l. | Improved process and method for the preparation of asymetric monofunctionalised indocyanine labelling reagents and obtained compounds |
| EP1221465A1 (en) | 2001-01-03 | 2002-07-10 | Innosense S.r.l. | Symmetric, monofunctionalised polymethine dyes labelling reagents |
| US20030044353A1 (en) | 2001-01-05 | 2003-03-06 | Ralph Weissleder | Activatable imaging probes |
| EP1469989B1 (en) | 2002-01-02 | 2011-12-14 | Visen Medical, Inc. | Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates |
| WO2003061711A2 (en) | 2002-01-16 | 2003-07-31 | Visen Medical, Inc. | Chromophore probes for optical imaging |
| WO2003079015A1 (en) | 2002-03-11 | 2003-09-25 | Visen Medical, Inc. | Optical imaging probes |
| EP2410315B1 (en) | 2002-06-04 | 2020-04-01 | Visen Medical, Inc. | Imaging volumes with arbitrary geometries in contact and non-contact tomography |
| US7868147B2 (en) * | 2003-09-05 | 2011-01-11 | Tetsuo Nagano | Fluorescent probe |
| US20060239916A1 (en) | 2005-01-07 | 2006-10-26 | Kai Licha | Use of cyanine dyes for the diagnosis of proliferative diseases |
| US8173819B2 (en) | 2005-09-02 | 2012-05-08 | Visen Medical, Inc. | Nicotinic and picolinic acid derived near-infrared fluorophores |
| ES2618361T3 (es) | 2005-09-02 | 2017-06-21 | Visen Medical, Inc. | Marcadores colorantes fluorescentes que contienen sulfonamida N,N-disustituida biocompatible |
| DK1937676T3 (en) | 2005-09-02 | 2017-03-06 | Visen Medical Inc | Biocompatible fluorescent imaging compounds |
| US9913917B2 (en) | 2005-12-22 | 2018-03-13 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| CN100361999C (zh) * | 2006-03-03 | 2008-01-16 | 大连理工大学 | 含硅元素的阳离子发色团及其衍生物 |
| US20100189657A1 (en) | 2006-03-20 | 2010-07-29 | The General Hospital Corporation | Intramolecularly quenched fluorochrome conjugates and methods of use |
| WO2008100817A2 (en) | 2007-02-09 | 2008-08-21 | Visen Medical, Inc. | Polycyclo dyes and use thereof |
| WO2008109832A2 (en) | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
| AU2009205950C1 (en) | 2008-01-18 | 2015-08-06 | Visen Medical, Inc. | Fluorescent imaging agents |
| WO2009114776A2 (en) | 2008-03-14 | 2009-09-17 | Visen Medical, Inc. | Integrin targeting agents and methods of using same |
| US8864821B2 (en) | 2008-11-26 | 2014-10-21 | Visen Medical, Inc. | Methods and compositions for identifying subjects at risk of developing stent thrombosis |
| WO2010126077A1 (ja) * | 2009-04-30 | 2010-11-04 | 国立大学法人 東京大学 | 近赤外蛍光化合物 |
| US9429568B2 (en) * | 2010-12-16 | 2016-08-30 | Board Of Trustees Of Southern Illinois University On Behalf Of Southern Illinois University Carbondale | Silaanthracene as a red and near infrared sensor and a method to manufacture such a sensor |
| US9329184B2 (en) * | 2011-02-18 | 2016-05-03 | The University Of Tokyo | Fluorescent probe |
| US9180209B2 (en) | 2011-02-28 | 2015-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Non-peptidic quenched fluorescent imaging probes |
| JP6122840B2 (ja) | 2011-05-09 | 2017-04-26 | ビセン メディカル， インコーポレイテッド | 炭酸脱水酵素標的化剤およびそれの使用方法 |
| US9346957B2 (en) * | 2011-08-26 | 2016-05-24 | École Polytechnique Fédérale De Lausanne (Epfl) | Cell permeable, fluorescent dye |
| AU2013303233C1 (en) | 2012-08-15 | 2018-08-23 | Visen Medical, Inc. | Prostate specific antigen agents and methods of using same for prostate cancer imaging |
| CA2901379C (en) | 2013-03-15 | 2023-05-16 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
| WO2014144702A2 (en) | 2013-03-15 | 2014-09-18 | Visen Medical, Inc. | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof |
| WO2014152298A1 (en) * | 2013-03-15 | 2014-09-25 | Promega Corporation | New silicon and germanium dyes for use in genetic identity |
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2014
- 2014-03-14 CA CA2901379A patent/CA2901379C/en active Active
- 2014-03-14 EP EP14723931.3A patent/EP2970342B1/en active Active
- 2014-03-14 WO PCT/US2014/029350 patent/WO2014144793A1/en not_active Ceased
- 2014-03-14 CN CN201480016182.XA patent/CN105073761B/zh active Active
- 2014-03-14 JP JP2016503068A patent/JP6606487B2/ja active Active
- 2014-03-14 AU AU2014228504A patent/AU2014228504C1/en active Active
- 2014-03-17 US US14/215,979 patent/US9649389B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2901379A1 (en) | 2014-09-18 |
| CN105073761A (zh) | 2015-11-18 |
| EP2970342B1 (en) | 2024-01-24 |
| US20140314677A1 (en) | 2014-10-23 |
| AU2014228504A1 (en) | 2015-08-27 |
| JP6606487B2 (ja) | 2019-11-13 |
| AU2014228504B2 (en) | 2019-04-11 |
| EP2970342A1 (en) | 2016-01-20 |
| US9649389B2 (en) | 2017-05-16 |
| CN105073761B (zh) | 2020-10-20 |
| JP2016521254A (ja) | 2016-07-21 |
| AU2014228504C1 (en) | 2019-10-03 |
| WO2014144793A1 (en) | 2014-09-18 |
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| US20240393330A1 (en) | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof |
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