CA2901379C - Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection - Google Patents

Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection Download PDF

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Publication number
CA2901379C
CA2901379C CA2901379A CA2901379A CA2901379C CA 2901379 C CA2901379 C CA 2901379C CA 2901379 A CA2901379 A CA 2901379A CA 2901379 A CA2901379 A CA 2901379A CA 2901379 C CA2901379 C CA 2901379C
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alkylene
compound
alkyl
optionally substituted
group
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French (fr)
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CA2901379A1 (en
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Kevin Groves
Ryan BUFF
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Visen Medical Inc
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Visen Medical Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0816—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring comprising Si as a ring atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/28—Pyronines ; Xanthon, thioxanthon, selenoxanthan, telluroxanthon dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/008—Dyes containing a substituent, which contains a silicium atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Saccharide Compounds (AREA)
CA2901379A 2013-03-15 2014-03-14 Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection Active CA2901379C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361794188P 2013-03-15 2013-03-15
US61/794,188 2013-03-15
PCT/US2014/029350 WO2014144793A1 (en) 2013-03-15 2014-03-14 Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection

Publications (2)

Publication Number Publication Date
CA2901379A1 CA2901379A1 (en) 2014-09-18
CA2901379C true CA2901379C (en) 2023-05-16

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CA2901379A Active CA2901379C (en) 2013-03-15 2014-03-14 Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection

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US (1) US9649389B2 (cg-RX-API-DMAC10.html)
EP (1) EP2970342B1 (cg-RX-API-DMAC10.html)
JP (1) JP6606487B2 (cg-RX-API-DMAC10.html)
CN (1) CN105073761B (cg-RX-API-DMAC10.html)
AU (1) AU2014228504C1 (cg-RX-API-DMAC10.html)
CA (1) CA2901379C (cg-RX-API-DMAC10.html)
WO (1) WO2014144793A1 (cg-RX-API-DMAC10.html)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5106397B2 (ja) 2005-09-02 2012-12-26 ビセン メディカル， インコーポレイテッド 生体適合性ｎ，ｎ−二置換スルホンアミド含有蛍光色素標識
EP1973575B1 (en) 2005-12-22 2019-07-24 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
EP2244741B1 (en) 2008-01-18 2015-03-25 VisEn Medical, Inc. Fluorescent imaging agents
EP2707102B1 (en) 2011-05-09 2019-11-13 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
CN105073761B (zh) 2013-03-15 2020-10-20 文森医学公司 用于体外和体内成像和检测的取代的硅杂蒽阳离子红至近红外荧光染料
EP2970674B1 (en) 2013-03-15 2018-12-12 VisEn Medical, Inc. 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
EP3019559A4 (en) 2013-08-22 2017-04-05 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
WO2015083799A1 (ja) * 2013-12-04 2015-06-11 国立大学法人 東京大学 近赤外線消光団
WO2015153813A1 (en) * 2014-04-01 2015-10-08 Howard Hughes Medical Institute Azetidine-substituted fluorescent compounds
WO2016138461A1 (en) 2015-02-26 2016-09-01 Sony Corporation Water soluble fluorescent or colored dyes comprising conjugating groups
JP6898301B2 (ja) 2015-07-28 2021-07-07 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 長波長電圧感受性色素
JP2017149806A (ja) * 2016-02-22 2017-08-31 富士フイルム株式会社 着色組成物、インクジェット用インク、及び捺染方法
US20170240951A1 (en) * 2016-02-24 2017-08-24 Saudi Arabian Oil Company Detecting Xanthan Gum
BR112018070164B1 (pt) 2016-04-01 2022-09-27 Sony Corporation Of America Corantes diméricos ou poliméricos ultrabrilhantes
EP3436528B1 (en) 2016-04-01 2025-07-02 Sony Group Corporation Ultra bright dimeric or polymeric dyes with rigid spacing groups
CN109153860B (zh) 2016-04-06 2021-04-23 索尼公司 具有间隔连接体基团的超高亮二聚体或聚合物染料
JPWO2017187717A1 (ja) * 2016-04-28 2019-02-28 国立大学法人名古屋大学 蛍光プローブ、蛍光検出方法及び蛍光プローブの使用方法
JP7527537B2 (ja) * 2016-05-10 2024-08-05 ソニーグループ株式会社 ペプチド骨格を有する超明色ポリマー染料
US11390754B2 (en) 2016-05-10 2022-07-19 Sony Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
BR112018073199A2 (pt) 2016-05-11 2019-04-16 Sony Corporation corantes diméricos ou poliméricos ultrabrilhantes
EP3464477A1 (en) 2016-06-06 2019-04-10 Sony Corporation Ionic polymers comprising fluorescent or colored reporter groups
CN109071960B (zh) * 2016-06-22 2021-01-12 富士胶片和光纯药株式会社 含硅杂环消光剂、化合物以及聚合物
WO2018022925A1 (en) 2016-07-29 2018-02-01 Sony Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
CA3045944A1 (en) * 2016-12-07 2018-06-14 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
WO2018151260A1 (ja) * 2017-02-17 2018-08-23 国立大学法人 東京大学 ペプチダーゼ活性検出用赤色蛍光プローブ
KR20260011205A (ko) 2017-10-05 2026-01-22 소니그룹주식회사 프로그램가능한 중합체성 약물
US12290571B2 (en) 2017-10-05 2025-05-06 Sony Group Corporation Programmable dendritic drugs
CN111836645A (zh) 2017-11-16 2020-10-27 索尼公司 可编程的聚合药物
EP3737417B1 (en) 2018-01-12 2025-08-27 Sony Group Corporation Phosphoalkyl ribose polymers comprising biologically active compounds
WO2019140128A1 (en) 2018-01-12 2019-07-18 Sony Corporation Phosphoalkyl polymers comprising biologically active compounds
US12076407B2 (en) 2018-01-12 2024-09-03 Sony Group Corporation Polymers with rigid spacing groups comprising biologically active compounds
EP3769085B1 (en) 2018-03-19 2022-08-24 Sony Group Corporation Use of divalent metals for enhancement of fluorescent signals
KR102864292B1 (ko) 2018-03-21 2025-09-26 소니그룹주식회사 링커 군을 갖는 중합체성 텐덤 염료
US11697736B2 (en) 2018-05-18 2023-07-11 Singular Genomics Systems, Inc. Silicon containing detectable compounds
KR102228538B1 (ko) * 2018-06-01 2021-03-15 주식회사 엘지화학 염료 화합물 및 포토폴리머 조성물
JP7580689B2 (ja) 2018-06-27 2024-11-12 ソニーグループ株式会社 デオキシリボースを含むリンカー基を有するポリマー色素
US12578342B2 (en) 2018-07-13 2026-03-17 Sony Group Corporation Polymeric dyes having a backbone comprising organophosphate units
SG11202101282QA (en) * 2018-08-10 2021-03-30 Life Technologies Corp Silicon-substituted rhodamine dyes and dye conjugates
CN112804982B (zh) * 2018-09-11 2023-07-25 俄勒冈健康与科学大学 近红外保留神经用苯并[c]吩噁嗪荧光团
KR102283067B1 (ko) * 2019-07-18 2021-07-28 아주대학교산학협력단 미토콘드리아를 표적으로 하는 신규한 근적외선 형광 프로브 및 이를 포함하는 종양 진단 및 치료 겸용 조성물
EP3861074A2 (en) 2019-09-26 2021-08-11 Sony Group Corporation Polymeric tandem dyes with linker groups
EP4038081A1 (en) 2019-09-30 2022-08-10 Sony Group Corporation Nucleotide probes
EP4055023A4 (en) 2019-11-07 2024-01-03 Singular Genomics Systems, Inc. SILICON-CONTAINING DETECTED COMPOUNDS AND USES THEREOF
JP7794737B2 (ja) * 2019-12-09 2026-01-06 エフ． ホフマン－ラ ロシュ アーゲー ジカチオン性蛍光色素
JP7481122B2 (ja) * 2020-02-03 2024-05-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 蛍光色素及びその利用
EP4256078A1 (en) 2020-12-07 2023-10-11 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes
CN113045599B (zh) * 2021-03-17 2022-04-19 山西大学 一种高对比度区分癌细胞/组织的方法及荧光探针的制备
WO2022207534A1 (en) * 2021-04-01 2022-10-06 Agfa-Gevaert Nv Nir absorbing capsules
WO2022241418A1 (en) * 2021-05-10 2022-11-17 University Of Virginia Patent Foundation Phosphinate ester-containing dyes having tunable properties and methods of making the same
CN113563298B (zh) * 2021-07-20 2023-07-28 北京大学 一类含水溶性取代基罗丹明荧光染料其制备方法和应用
JP7787670B2 (ja) * 2021-08-31 2025-12-17 富士フイルム株式会社 化合物及びこれを用いた標識生体物質
CN113801145B (zh) * 2021-10-12 2022-06-07 南京大学 一种激活型近红外小分子荧光探针及其制备方法与应用
CN114869227B (zh) * 2022-04-02 2025-09-05 北京信息科技大学 一种可穿戴式微型活体流式图像细胞仪
CN115322205B (zh) * 2022-04-06 2025-09-26 大连理工大学 一类近红外二区荧光染料及制备方法与抗肿瘤应用
US20250321537A1 (en) * 2022-11-04 2025-10-16 Lg Chem, Ltd. Photopolymer composition, hologram recording medium, preparation method thereof and optical element comprising the same
US12473382B2 (en) 2022-11-04 2025-11-18 Lg Chem, Ltd. Hologram recording medium and optical element comprising the same
CN119095889A (zh) * 2022-11-04 2024-12-06 株式会社Lg化学 全息图记录介质、其制备方法及包括其的光学元件
US12359068B2 (en) 2023-02-10 2025-07-15 Singular Genomics Systems, Inc. Rhodamine fluorescent compounds and production methods thereof
WO2024225787A1 (ko) * 2023-04-28 2024-10-31 에스에프씨 주식회사 신규한 화합물 및 이의 용도
GB202415958D0 (en) * 2024-10-30 2024-12-11 Tocris Cookson Ltd Compounds

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4219335A (en) 1978-09-18 1980-08-26 E. I. Du Pont De Nemours And Company Immunochemical testing using tagged reagents
US6086737A (en) 1984-03-29 2000-07-11 Li-Cor, Inc. Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor
US6048982A (en) 1986-04-18 2000-04-11 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5164297A (en) 1990-05-03 1992-11-17 Advanced Magnetics Inc. Solvent mediated relaxation assay system
US5445970A (en) 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
JPH08501097A (ja) 1992-09-04 1996-02-06 ザ ゼネラル ホスピタル コーポレーション 臨床診断及び治療用部分を含む生体適合性ポリマー
DE4445065A1 (de) 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
IT1276833B1 (it) 1995-10-09 1997-11-03 Sorin Biomedica Cardio Spa Coloranti fluorescenti della famiglia della solfo benz e indocianina
DE19717904A1 (de) 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
US6046585A (en) 1997-11-21 2000-04-04 Quantum Design, Inc. Method and apparatus for making quantitative measurements of localized accumulations of target particles having magnetic particles bound thereto
US6592847B1 (en) 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US6083486A (en) 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
WO2000064988A1 (en) 1999-04-23 2000-11-02 Molecular Probes, Inc. Xanthene dyes and their application as luminescence quenching compounds
ATE284433T1 (de) 1999-07-02 2004-12-15 Visen Medical Inc Fluorescierende cyaninlabels mit einem sulphamidobrückenglied
EP2325263B1 (en) 2000-09-29 2013-01-23 Life Technologies Corporation Modified carbocyanine dyes and their conjugates
EP1341557A2 (en) 2000-10-27 2003-09-10 Beth Israel Deaconess Medical Center Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates
US6615063B1 (en) 2000-11-27 2003-09-02 The General Hospital Corporation Fluorescence-mediated molecular tomography
EP1209205A1 (en) 2000-11-28 2002-05-29 Innosense S.r.l. Improved process and method for the preparation of asymetric monofunctionalised indocyanine labelling reagents and obtained compounds
EP1221465A1 (en) 2001-01-03 2002-07-10 Innosense S.r.l. Symmetric, monofunctionalised polymethine dyes labelling reagents
US20030044353A1 (en) 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
ATE536993T1 (de) 2002-01-02 2011-12-15 Visen Medical Inc Aminfunktionalisierte superparamagnetisierte nanoteilchen für die synthese von biokonjugaten
WO2003061711A2 (en) 2002-01-16 2003-07-31 Visen Medical, Inc. Chromophore probes for optical imaging
AU2003225763A1 (en) 2002-03-11 2003-09-29 Visen Medical, Inc. Optical imaging probes
EP2410315B1 (en) 2002-06-04 2020-04-01 Visen Medical, Inc. Imaging volumes with arbitrary geometries in contact and non-contact tomography
US7868147B2 (en) * 2003-09-05 2011-01-11 Tetsuo Nagano Fluorescent probe
US20060239916A1 (en) 2005-01-07 2006-10-26 Kai Licha Use of cyanine dyes for the diagnosis of proliferative diseases
ES2612738T3 (es) 2005-09-02 2017-05-18 Visen Medical, Inc. Agentes de formación de imágenes fluorescentes biocompatibles
US8173819B2 (en) 2005-09-02 2012-05-08 Visen Medical, Inc. Nicotinic and picolinic acid derived near-infrared fluorophores
JP5106397B2 (ja) 2005-09-02 2012-12-26 ビセン メディカル， インコーポレイテッド 生体適合性ｎ，ｎ−二置換スルホンアミド含有蛍光色素標識
EP1973575B1 (en) 2005-12-22 2019-07-24 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
CN100361999C (zh) * 2006-03-03 2008-01-16 大连理工大学 含硅元素的阳离子发色团及其衍生物
WO2007109364A2 (en) 2006-03-20 2007-09-27 The General Hospital Corporation Intramolecularly quenched fluorochrome conjugates and methods of use
EP2118206B9 (en) 2007-02-09 2018-08-29 Visen Medical, Inc. Polycyclo dyes and use thereof
WO2008109832A2 (en) 2007-03-08 2008-09-12 Visen Medical, Inc. Viable near-infrared fluorochrome labeled cells and methods of making and using same
EP2244741B1 (en) 2008-01-18 2015-03-25 VisEn Medical, Inc. Fluorescent imaging agents
EP3673922A1 (en) 2008-03-14 2020-07-01 VisEn Medical, Inc. Integrin targeting agents and methods of using same
US8864821B2 (en) 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
WO2010126077A1 (ja) * 2009-04-30 2010-11-04 国立大学法人 東京大学 近赤外蛍光化合物
WO2012083064A1 (en) * 2010-12-16 2012-06-21 Southern Illinois University Carbondale Silaanthracene as a red and near infrared sensor and a method to manufacture such a sensor
JP5807025B2 (ja) * 2011-02-18 2015-11-10 国立大学法人 東京大学 蛍光プローブ
US9180209B2 (en) 2011-02-28 2015-11-10 The Board Of Trustees Of The Leland Stanford Junior University Non-peptidic quenched fluorescent imaging probes
EP2707102B1 (en) 2011-05-09 2019-11-13 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
WO2013029650A1 (en) * 2011-08-26 2013-03-07 Ecole Polytechnique Federale De Lausanne (Epfl) Cell permeable, fluorescent dye
WO2014028057A1 (en) 2012-08-15 2014-02-20 Visen Medical, Inc. Prostate specific antigen agents and methods of using same for prostate cancer imaging
WO2014152298A1 (en) * 2013-03-15 2014-09-25 Promega Corporation New silicon and germanium dyes for use in genetic identity
EP2970674B1 (en) 2013-03-15 2018-12-12 VisEn Medical, Inc. 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
CN105073761B (zh) 2013-03-15 2020-10-20 文森医学公司 用于体外和体内成像和检测的取代的硅杂蒽阳离子红至近红外荧光染料

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CN105073761B (zh) 2020-10-20
AU2014228504C1 (en) 2019-10-03
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AU2014228504B2 (en) 2019-04-11
JP6606487B2 (ja) 2019-11-13
CA2901379A1 (en) 2014-09-18
US20140314677A1 (en) 2014-10-23
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