CA2900435C - A novel composition for nonalcoholic fatty liver disease (nafld) - Google Patents
A novel composition for nonalcoholic fatty liver disease (nafld) Download PDFInfo
- Publication number
- CA2900435C CA2900435C CA2900435A CA2900435A CA2900435C CA 2900435 C CA2900435 C CA 2900435C CA 2900435 A CA2900435 A CA 2900435A CA 2900435 A CA2900435 A CA 2900435A CA 2900435 C CA2900435 C CA 2900435C
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- CA
- Canada
- Prior art keywords
- pharmaceutical composition
- sodium
- liver
- fatty liver
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 title claims abstract description 90
- 239000000203 mixture Substances 0.000 title claims abstract description 17
- 150000001875 compounds Chemical class 0.000 claims abstract description 63
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims abstract description 54
- 231100000240 steatosis hepatitis Toxicity 0.000 claims abstract description 33
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 23
- 208000004930 Fatty Liver Diseases 0.000 claims abstract description 22
- 208000010706 fatty liver disease Diseases 0.000 claims abstract description 22
- 210000004185 liver Anatomy 0.000 claims abstract description 21
- 206010019708 Hepatic steatosis Diseases 0.000 claims abstract description 20
- 206010016654 Fibrosis Diseases 0.000 claims abstract description 19
- 230000007882 cirrhosis Effects 0.000 claims abstract description 16
- 208000019425 cirrhosis of liver Diseases 0.000 claims abstract description 16
- 230000007863 steatosis Effects 0.000 claims abstract description 14
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 34
- 150000003839 salts Chemical class 0.000 claims description 29
- 201000010099 disease Diseases 0.000 claims description 17
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- 210000005229 liver cell Anatomy 0.000 claims description 14
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 12
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1468/MUM/2013 | 2013-04-22 | ||
| IN1468MU2013 IN2013MU01468A (2) | 2013-04-22 | 2013-06-25 | |
| PCT/IN2013/000391 WO2014174524A1 (en) | 2013-04-22 | 2013-06-25 | A novel composition for nonalcoholic fatty liver disease (nafld) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2900435A1 CA2900435A1 (en) | 2014-10-30 |
| CA2900435C true CA2900435C (en) | 2017-02-14 |
Family
ID=49253372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2900435A Expired - Fee Related CA2900435C (en) | 2013-04-22 | 2013-06-25 | A novel composition for nonalcoholic fatty liver disease (nafld) |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20160166539A1 (2) |
| EP (1) | EP2988736A1 (2) |
| JP (1) | JP6246895B2 (2) |
| KR (1) | KR101617812B1 (2) |
| CN (1) | CN105377246B (2) |
| AP (1) | AP2015008674A0 (2) |
| AU (1) | AU2013387996B2 (2) |
| BR (1) | BR112015020600A2 (2) |
| CA (1) | CA2900435C (2) |
| EA (1) | EA201592020A1 (2) |
| GE (1) | GEP201706663B (2) |
| HK (1) | HK1214968A1 (2) |
| IL (2) | IL240183A (2) |
| IN (1) | IN2013MU01468A (2) |
| MA (1) | MA38385A1 (2) |
| MX (1) | MX346943B (2) |
| MY (1) | MY180160A (2) |
| PH (1) | PH12015501795A1 (2) |
| SG (1) | SG11201506218UA (2) |
| UA (1) | UA114360C2 (2) |
| WO (1) | WO2014174524A1 (2) |
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| BR112019011740A2 (pt) | 2016-12-09 | 2019-10-29 | Cadila Healthcare Limited | composição farmacêutica e método para o tratamento de colangite biliar primária |
| PT3600309T (pt) | 2017-03-28 | 2022-10-03 | Gilead Sciences Inc | Combinações terapêuticas para o tratamento de doenças hepáticas |
| GB201710229D0 (en) * | 2017-06-27 | 2017-08-09 | Tdeltas Ltd | Compounds for new use |
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| CN109675016A (zh) * | 2017-10-18 | 2019-04-26 | 上海贺普药业股份有限公司 | 非酒精性脂肪性肝病的治疗药物 |
| CN110934866B (zh) * | 2018-09-25 | 2023-12-01 | 深圳微芯生物科技股份有限公司 | 西格列羧及其相关化合物的应用 |
| US12201609B2 (en) * | 2018-12-18 | 2025-01-21 | Zydus Lifesciences Limited | Saroglitazar for the treatment of hepatocellular carcinoma |
| WO2020165782A1 (en) * | 2019-02-13 | 2020-08-20 | Cadila Healthcare Limited | Treatment for polycystic ovarian syndrome (pcos) |
| CN116546981A (zh) * | 2020-12-18 | 2023-08-04 | 雀巢产品有限公司 | 使用至少一种甘氨酸或其衍生物和/或至少一种n-乙酰半胱氨酸或其衍生物以及至少一种百里酚和/或香芹酚的组合物和方法 |
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| MX346943B (es) | 2017-04-06 |
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| AU2013387996A1 (en) | 2015-09-24 |
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| IL247231A (en) | 2017-03-30 |
| EP2988736A1 (en) | 2016-03-02 |
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| WO2014174524A8 (en) | 2015-10-01 |
| CN105377246A (zh) | 2016-03-02 |
| US20170087127A1 (en) | 2017-03-30 |
| MY180160A (en) | 2020-11-23 |
| IL240183A (en) | 2016-08-31 |
| UA114360C2 (uk) | 2017-05-25 |
| EA201592020A1 (ru) | 2016-05-31 |
| KR101617812B1 (ko) | 2016-05-03 |
| MX2015010769A (es) | 2015-11-26 |
| BR112015020600A2 (pt) | 2017-07-18 |
| HK1214968A1 (zh) | 2016-08-12 |
| AU2013387996B2 (en) | 2015-12-10 |
| JP6246895B2 (ja) | 2017-12-13 |
| SG11201506218UA (en) | 2015-09-29 |
| JP2016515608A (ja) | 2016-05-30 |
| MA38385A1 (fr) | 2017-09-29 |
| PH12015501795A1 (en) | 2015-11-09 |
| GEP201706663B (en) | 2017-05-10 |
| CN105377246B (zh) | 2018-03-20 |
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