CA2899587C - Recombinant microorganisms comprising nadph dependent enzymes and methods of production thereof - Google Patents

Recombinant microorganisms comprising nadph dependent enzymes and methods of production thereof Download PDF

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Publication number
CA2899587C
CA2899587C CA2899587A CA2899587A CA2899587C CA 2899587 C CA2899587 C CA 2899587C CA 2899587 A CA2899587 A CA 2899587A CA 2899587 A CA2899587 A CA 2899587A CA 2899587 C CA2899587 C CA 2899587C
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CA
Canada
Prior art keywords
nadph
microorganism
nadh
dependent
clostridium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2899587A
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English (en)
French (fr)
Other versions
CA2899587A1 (en
Inventor
Alexander Mueller
Michael Koepke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lanzatech NZ Inc
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Lanzatech New Zealand Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of CA2899587A1 publication Critical patent/CA2899587A1/en
Application granted granted Critical
Publication of CA2899587C publication Critical patent/CA2899587C/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
CA2899587A 2013-01-30 2014-01-30 Recombinant microorganisms comprising nadph dependent enzymes and methods of production thereof Active CA2899587C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361758441P 2013-01-30 2013-01-30
US61/758,441 2013-01-30
US201361828675P 2013-05-29 2013-05-29
US61/828,675 2013-05-29
PCT/US2014/013712 WO2014120852A2 (en) 2013-01-30 2014-01-30 Recombinant microorganisms comprising nadph dependent enzymes and methods of production thereof

Publications (2)

Publication Number Publication Date
CA2899587A1 CA2899587A1 (en) 2014-08-07
CA2899587C true CA2899587C (en) 2019-09-17

Family

ID=51223347

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2899587A Active CA2899587C (en) 2013-01-30 2014-01-30 Recombinant microorganisms comprising nadph dependent enzymes and methods of production thereof

Country Status (11)

Country Link
US (1) US9422565B2 (enExample)
EP (1) EP2951286B1 (enExample)
JP (3) JP2016508718A (enExample)
KR (1) KR102290728B1 (enExample)
CN (1) CN104955938B (enExample)
AU (1) AU2014212462B2 (enExample)
CA (1) CA2899587C (enExample)
ES (1) ES2961674T3 (enExample)
FI (1) FI2951286T3 (enExample)
PT (1) PT2951286T (enExample)
WO (1) WO2014120852A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201507509D0 (en) * 2015-04-30 2015-06-17 Inside Biometrics Ltd Electrochemical Test Device
CN113684167B (zh) * 2015-05-27 2024-10-18 朗泽科技新西兰有限公司 用于制造分支酸衍生物的基因工程化微生物
CN107849575A (zh) * 2015-07-23 2018-03-27 达特默斯大学托管会 用于将木质纤维素生物质转化为乙醇的嗜热微生物
CN106635936A (zh) * 2015-11-04 2017-05-10 中国科学院青岛生物能源与过程研究所 一种联产琥珀酸和异戊二烯的基因工程菌及其构建方法
US10358661B2 (en) * 2015-12-28 2019-07-23 Lanzatech New Zealand Limited Microorganism with modified hydrogenase activity
CN108603178A (zh) * 2016-01-06 2018-09-28 株式会社西化学 Co水合酶以及使用其产生甲酸的方法
GB201707034D0 (en) 2017-05-03 2017-06-14 Gradley Michell Lorraine Modified microorganisms and methods for production of useful products
EP4399284A1 (en) * 2021-09-06 2024-07-17 Global Bioenergies Organisms producing less crotonic acid
CN114437981A (zh) * 2022-02-15 2022-05-06 科盛环保科技股份有限公司 一种快速培养硫自养反硝化细菌的发酵方法
JP7891382B2 (ja) 2022-07-21 2026-07-16 Tdk株式会社 回転角検知装置、及び回転角検知装置を用いたブレーキシステム
WO2024191356A1 (en) * 2023-03-14 2024-09-19 Vidyasirimedhi Institute Of Science And Technology A recombinant cell for generating energy-rich metabolites and a method for the same

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5173429A (en) 1990-11-09 1992-12-22 The Board Of Trustees Of The University Of Arkansas Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism
US5593886A (en) 1992-10-30 1997-01-14 Gaddy; James L. Clostridium stain which produces acetic acid from waste gases
UA72220C2 (uk) 1998-09-08 2005-02-15 Байоенджініерінг Рісорсиз, Інк. Незмішувана з водою суміш розчинник/співрозчинник для екстрагування оцтової кислоти, спосіб одержання оцтової кислоти (варіанти), спосіб анаеробного мікробного бродіння для одержання оцтової кислоти (варіанти), модифікований розчинник та спосіб його одержання
JP4883872B2 (ja) 2000-07-25 2012-02-22 エモース・フアンデーシヨン・インコーポレーテツド 微生物発酵によるエタノール生産を向上させる方法
US7704723B2 (en) 2006-08-31 2010-04-27 The Board Of Regents For Oklahoma State University Isolation and characterization of novel clostridial species
WO2009036095A1 (en) * 2007-09-10 2009-03-19 Joule Biotechnologies, Inc. Engineered light-harvesting organisms
KR101375029B1 (ko) 2007-11-13 2014-03-14 란자테크 뉴질랜드 리미티드 신규 세균 및 이의 이용 방법
US8986963B2 (en) * 2008-02-23 2015-03-24 James Weifu Lee Designer calvin-cycle-channeled production of butanol and related higher alcohols
US7981647B2 (en) * 2008-03-03 2011-07-19 Joule Unlimited, Inc. Engineered CO2 fixing microorganisms producing carbon-based products of interest
US8039239B2 (en) * 2008-12-16 2011-10-18 Coskata, Inc. Recombinant microorganisms having modified production of alcohols and acids
CA2783096A1 (en) * 2009-12-10 2011-06-16 Genomatica, Inc. Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol
JP2011160673A (ja) * 2010-02-04 2011-08-25 Fujirebio Inc 水素ガスの生産方法及びそのための微生物
US8143037B2 (en) 2010-03-19 2012-03-27 Coskata, Inc. Ethanologenic Clostridium species, Clostridium coskatii
US20110236941A1 (en) * 2010-10-22 2011-09-29 Lanzatech New Zealand Limited Recombinant microorganism and methods of production thereof

Also Published As

Publication number Publication date
EP2951286A2 (en) 2015-12-09
JP7525541B2 (ja) 2024-07-30
EP2951286A4 (en) 2016-08-10
US9422565B2 (en) 2016-08-23
EP2951286B1 (en) 2023-09-13
AU2014212462B2 (en) 2019-01-31
ES2961674T3 (es) 2024-03-13
KR20150110806A (ko) 2015-10-02
FI2951286T3 (fi) 2023-11-20
JP2022116003A (ja) 2022-08-09
US20140212976A1 (en) 2014-07-31
JP2020096602A (ja) 2020-06-25
CA2899587A1 (en) 2014-08-07
WO2014120852A3 (en) 2015-02-05
CN104955938A (zh) 2015-09-30
PT2951286T (pt) 2023-11-02
KR102290728B1 (ko) 2021-08-19
AU2014212462A1 (en) 2015-08-20
WO2014120852A2 (en) 2014-08-07
JP2016508718A (ja) 2016-03-24
CN104955938B (zh) 2018-03-02

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