CA2898431C - Compositions cellulaires issues de cellules reprogrammees dedifferenciees - Google Patents

Compositions cellulaires issues de cellules reprogrammees dedifferenciees Download PDF

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Publication number
CA2898431C
CA2898431C CA2898431A CA2898431A CA2898431C CA 2898431 C CA2898431 C CA 2898431C CA 2898431 A CA2898431 A CA 2898431A CA 2898431 A CA2898431 A CA 2898431A CA 2898431 C CA2898431 C CA 2898431C
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Canada
Prior art keywords
cells
cell
endoderm
heregulin
human
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2898431A
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English (en)
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CA2898431A1 (fr
Inventor
Alan D. Agulnick
Olivia Kelly
Yuki OHI
Allan Robins
Thomas Schultz
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Viacyte Inc
Original Assignee
Viacyte Inc
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Filing date
Publication date
Priority claimed from US13/761,078 external-priority patent/US9109245B2/en
Application filed by Viacyte Inc filed Critical Viacyte Inc
Priority to CA3212301A priority Critical patent/CA3212301A1/fr
Publication of CA2898431A1 publication Critical patent/CA2898431A1/fr
Application granted granted Critical
Publication of CA2898431C publication Critical patent/CA2898431C/fr
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases (EC 2.)
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne des compositions de culture cellulaire, par exemple des compositions de culture cellulaire pancréatique, issues de cellules souches pluripotentes reprogrammées humaines dédifférenciées, telles que des cellules souches pluripotentes induites (iPS) et des procédés de production et d'utilisation de telles compositions de culture cellulaire.
CA2898431A 2013-02-06 2014-02-06 Compositions cellulaires issues de cellules reprogrammees dedifferenciees Active CA2898431C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3212301A CA3212301A1 (fr) 2013-02-06 2014-02-06 Compositions cellulaires issues de cellules reprogrammees dedifferenciees

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/761,078 2013-02-06
US13/761,078 US9109245B2 (en) 2009-04-22 2013-02-06 Cell compositions derived from dedifferentiated reprogrammed cells
PCT/US2014/015156 WO2014124172A1 (fr) 2013-02-06 2014-02-06 Compositions cellulaires issues de cellules reprogrammées dédifférenciées

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3212301A Division CA3212301A1 (fr) 2013-02-06 2014-02-06 Compositions cellulaires issues de cellules reprogrammees dedifferenciees

Publications (2)

Publication Number Publication Date
CA2898431A1 CA2898431A1 (fr) 2014-08-14
CA2898431C true CA2898431C (fr) 2023-10-17

Family

ID=50239931

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2898431A Active CA2898431C (fr) 2013-02-06 2014-02-06 Compositions cellulaires issues de cellules reprogrammees dedifferenciees
CA3212301A Pending CA3212301A1 (fr) 2013-02-06 2014-02-06 Compositions cellulaires issues de cellules reprogrammees dedifferenciees

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3212301A Pending CA3212301A1 (fr) 2013-02-06 2014-02-06 Compositions cellulaires issues de cellules reprogrammees dedifferenciees

Country Status (8)

Country Link
EP (1) EP2954045A1 (fr)
JP (4) JP6517702B2 (fr)
AU (4) AU2014214879A1 (fr)
CA (2) CA2898431C (fr)
HK (1) HK1218139A1 (fr)
IL (4) IL290717B1 (fr)
RU (2) RU2754089C2 (fr)
WO (1) WO2014124172A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9109245B2 (en) 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
WO2016021734A1 (fr) 2014-08-04 2016-02-11 武田薬品工業株式会社 Procédé de multiplication de cellules progénitrices pancréatiques
MA45479A (fr) * 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
EP3460042B1 (fr) * 2016-05-18 2024-02-21 Keio University Milieu de culture cellulaire pour la culture d'un organoïde, procédé de culture et organoïde
US11746331B2 (en) 2017-01-27 2023-09-05 Kaneka Corporation Endodermal cell population, and method for producing cell population of any of three germ layers from pluripotent cell
JP7284948B2 (ja) 2017-06-14 2023-06-01 バーテックス ファーマシューティカルズ インコーポレイテッド 療法薬を送達するためのデバイスおよび方法
SG11202101098YA (en) * 2018-08-03 2021-03-30 Univ Kyoto Cell production method
JP7295576B2 (ja) * 2018-09-19 2023-06-21 オリヅルセラピューティクス株式会社 インスリン産生細胞
WO2020243668A1 (fr) 2019-05-31 2020-12-03 W. L. Gore & Associates, Inc. Dispositifs d'encapsulation de cellules présentant des distances de diffusion d'oxygène régulées
JP2022534545A (ja) 2019-05-31 2022-08-01 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティド 生体適合性メンブレン複合体
EP3975926A1 (fr) 2019-05-31 2022-04-06 W.L. Gore & Associates, Inc. Composite à membrane biocompatible
CA3139591C (fr) 2019-05-31 2024-01-16 Timothy M. BRUHN Composite a membrane biocompatible

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2307505T3 (es) * 1999-04-06 2008-12-01 Genentech, Inc. Utilizacion de ligandos receptores de erbb en el tratamiento de la diabetes.
US6759039B2 (en) * 2000-06-30 2004-07-06 Amcyte, Inc. Culturing pancreatic stem cells having a specified, intermediate stage of development
JP2005503759A (ja) * 2001-01-24 2005-02-10 アメリカ合衆国 幹細胞の膵臓内分泌細胞への分化方法
NZ567082A (en) * 2005-10-14 2012-08-31 Univ Minnesota Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype
US20090298169A1 (en) * 2006-06-02 2009-12-03 The University Of Georgia Research Foundation Pancreatic and Liver Endoderm Cells and Tissue by Differentiation of Definitive Endoderm Cells Obtained from Human Embryonic Stems
ES2932850T3 (es) 2008-11-14 2023-01-27 Viacyte Inc Encapsulación de células pancreáticas derivadas de células madre pluripotentes humanas
DK2421957T3 (da) * 2009-04-22 2021-01-25 Viacyte Inc Cellesammensætninger afledt af dedifferentierede omprogrammerede celler
WO2010129294A2 (fr) * 2009-04-27 2010-11-11 Schulz Thomas C Petites molécules supportant la croissance de cellules pluripotentes et procédés apparentés

Also Published As

Publication number Publication date
JP2016506736A (ja) 2016-03-07
JP7250731B2 (ja) 2023-04-03
AU2022200075B2 (en) 2023-02-02
HK1218139A1 (zh) 2017-02-03
IL239953B (en) 2021-05-31
JP2020178694A (ja) 2020-11-05
JP6517702B2 (ja) 2019-05-22
IL290717A (en) 2022-04-01
AU2014214879A1 (en) 2015-07-30
IL311689A (en) 2024-05-01
IL283088B (en) 2022-04-01
AU2022200075C1 (en) 2023-07-06
RU2015131279A (ru) 2017-03-13
JP6721752B2 (ja) 2020-07-15
EP2954045A1 (fr) 2015-12-16
WO2014124172A1 (fr) 2014-08-14
AU2022200075A1 (en) 2022-02-03
IL239953A0 (en) 2015-08-31
CA2898431A1 (fr) 2014-08-14
AU2019201314B2 (en) 2021-10-14
AU2023202507A1 (en) 2023-05-11
IL283088A (en) 2021-06-30
RU2018144412A3 (fr) 2020-02-14
IL290717B1 (en) 2024-06-01
RU2754089C2 (ru) 2021-08-26
RU2675928C2 (ru) 2018-12-25
JP2019146578A (ja) 2019-09-05
JP2023017838A (ja) 2023-02-07
AU2019201314A1 (en) 2019-03-14
CA3212301A1 (fr) 2014-08-14
RU2018144412A (ru) 2019-03-25

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AU2022200075B2 (en) Cell compositions derived from dedifferentiated reprogrammed cells
EP2421957B1 (fr) Compositions cellulaires issues de cellules reprogrammées dédifférenciées

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