CA2888479A1 - Novel .alpha.4.beta.7 peptide dimer antagonists - Google Patents
Novel .alpha.4.beta.7 peptide dimer antagonists Download PDFInfo
- Publication number
- CA2888479A1 CA2888479A1 CA2888479A CA2888479A CA2888479A1 CA 2888479 A1 CA2888479 A1 CA 2888479A1 CA 2888479 A CA2888479 A CA 2888479A CA 2888479 A CA2888479 A CA 2888479A CA 2888479 A1 CA2888479 A1 CA 2888479A1
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- Prior art keywords
- group
- lys
- asp
- acid
- peptide dimer
- Prior art date
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- General Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
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Applications Claiming Priority (7)
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| US201361807714P | 2013-04-02 | 2013-04-02 | |
| US61/807,714 | 2013-04-02 | ||
| US14/050,349 US9273093B2 (en) | 2012-10-11 | 2013-10-10 | α4β7 peptide dimer antagonists |
| US14/050,349 | 2013-10-10 | ||
| PCT/US2013/064439 WO2014059213A1 (en) | 2012-10-11 | 2013-10-11 | NOVEL α4ß7 PEPTIDE DIMER ANTAGONISTS |
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| CA2888479A1 true CA2888479A1 (en) | 2014-04-17 |
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| EP (1) | EP2906584B1 (forum.php) |
| JP (2) | JP6480865B2 (forum.php) |
| KR (1) | KR20150084808A (forum.php) |
| CN (1) | CN105102470A (forum.php) |
| AU (2) | AU2013329135B2 (forum.php) |
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| JP6501270B2 (ja) | 2013-03-14 | 2019-04-17 | ザ カリフォルニア インスティテュート フォー バイオメディカル リサーチ | 標的化剤抗体抱合体およびその使用 |
| HUE057168T2 (hu) | 2013-03-15 | 2022-04-28 | Protagonist Therapeutics Inc | A hepcidin analógjai és ezek alkalmazása |
| US20140294901A1 (en) * | 2013-04-02 | 2014-10-02 | Protagonist Therapeutics, Inc. | Novel a4b7 peptide dimer antagonists |
| WO2015038938A1 (en) | 2013-09-13 | 2015-03-19 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
| EP3082797A4 (en) | 2013-12-18 | 2017-12-13 | The California Institute for Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| KR20250043599A (ko) * | 2014-05-16 | 2025-03-28 | 프로타고니스트 테라퓨틱스, 인코포레이티드 | α4β7 인테그린 티오에테르 펩티드 길항제 |
| US9624268B2 (en) | 2014-07-17 | 2017-04-18 | Protagonist Therapeutics, Inc. | Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases |
| WO2016054445A1 (en) * | 2014-10-01 | 2016-04-07 | Protagonist Therapeutics, Inc. | Novel cyclic monomer and dimer peptides having integrin antagonist activity |
| EP3200812B8 (en) | 2014-10-01 | 2021-04-28 | Protagonist Therapeutics, Inc. | Novel alpha4beta7 peptide monomer and dimer antagonists |
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2013
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- 2013-10-11 EP EP13845982.1A patent/EP2906584B1/en active Active
- 2013-10-11 WO PCT/US2013/064439 patent/WO2014059213A1/en active Application Filing
- 2013-10-11 SG SG10201702979SA patent/SG10201702979SA/en unknown
- 2013-10-11 AU AU2013329135A patent/AU2013329135B2/en active Active
- 2013-10-11 HK HK16101620.8A patent/HK1213583A1/zh unknown
- 2013-10-11 CN CN201380064713.8A patent/CN105102470A/zh active Pending
- 2013-10-11 SG SG11201502812WA patent/SG11201502812WA/en unknown
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- 2013-10-11 KR KR1020157011369A patent/KR20150084808A/ko not_active Ceased
- 2013-10-11 NZ NZ706909A patent/NZ706909A/en unknown
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2015
- 2015-04-02 IL IL238123A patent/IL238123A0/en unknown
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2016
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2018
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2019
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| IN2015DN03039A (forum.php) | 2015-10-02 |
| US20190248870A1 (en) | 2019-08-15 |
| JP2015533833A (ja) | 2015-11-26 |
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| AU2018201599A1 (en) | 2018-03-29 |
| HK1213583A1 (zh) | 2016-07-08 |
| KR20150084808A (ko) | 2015-07-22 |
| EP2906584B1 (en) | 2019-11-20 |
| IL238123A0 (en) | 2015-05-31 |
| EP2906584A1 (en) | 2015-08-19 |
| US20140193465A1 (en) | 2014-07-10 |
| SG11201502812WA (en) | 2015-05-28 |
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| JP6480865B2 (ja) | 2019-03-13 |
| AU2013329135A1 (en) | 2015-04-30 |
| US20160368966A1 (en) | 2016-12-22 |
| WO2014059213A1 (en) | 2014-04-17 |
| JP2019001825A (ja) | 2019-01-10 |
| SG10201702979SA (en) | 2017-05-30 |
| CN105102470A (zh) | 2015-11-25 |
| US9273093B2 (en) | 2016-03-01 |
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