CA2886037C - Methodes de production d'un tube a utiliser dans la formation d'une endoprothese vasculaire et de tel tube - Google Patents
Methodes de production d'un tube a utiliser dans la formation d'une endoprothese vasculaire et de tel tube Download PDFInfo
- Publication number
- CA2886037C CA2886037C CA2886037A CA2886037A CA2886037C CA 2886037 C CA2886037 C CA 2886037C CA 2886037 A CA2886037 A CA 2886037A CA 2886037 A CA2886037 A CA 2886037A CA 2886037 C CA2886037 C CA 2886037C
- Authority
- CA
- Canada
- Prior art keywords
- tubing
- die
- mandrel
- poly
- tube
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims abstract description 195
- 230000015572 biosynthetic process Effects 0.000 title claims description 9
- 229920000642 polymer Polymers 0.000 claims abstract description 64
- 229920001169 thermoplastic Polymers 0.000 claims abstract description 56
- 230000007246 mechanism Effects 0.000 claims abstract description 15
- 239000007790 solid phase Substances 0.000 claims abstract description 11
- -1 poly(valerolactone) Polymers 0.000 claims description 89
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims description 56
- 229920001432 poly(L-lactide) Polymers 0.000 claims description 54
- 229920000954 Polyglycolide Polymers 0.000 claims description 32
- 239000004633 polyglycolic acid Substances 0.000 claims description 32
- 230000008569 process Effects 0.000 claims description 31
- 229920001577 copolymer Polymers 0.000 claims description 27
- 238000010438 heat treatment Methods 0.000 claims description 27
- 238000002844 melting Methods 0.000 claims description 25
- 230000008018 melting Effects 0.000 claims description 25
- 230000009477 glass transition Effects 0.000 claims description 20
- 229920001710 Polyorthoester Polymers 0.000 claims description 17
- 238000001816 cooling Methods 0.000 claims description 16
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims description 15
- 229920000071 poly(4-hydroxybutyrate) Polymers 0.000 claims description 13
- 229920002732 Polyanhydride Polymers 0.000 claims description 12
- 229920001279 poly(ester amides) Polymers 0.000 claims description 12
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 12
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 claims description 12
- 229920002627 poly(phosphazenes) Polymers 0.000 claims description 12
- 239000000622 polydioxanone Substances 0.000 claims description 12
- 239000004626 polylactic acid Substances 0.000 claims description 12
- 229920001308 poly(aminoacid) Polymers 0.000 claims description 11
- VPVXHAANQNHFSF-UHFFFAOYSA-N 1,4-dioxan-2-one Chemical compound O=C1COCCO1 VPVXHAANQNHFSF-UHFFFAOYSA-N 0.000 claims description 8
- 229920001610 polycaprolactone Polymers 0.000 claims description 8
- 239000004632 polycaprolactone Substances 0.000 claims description 8
- 230000002829 reductive effect Effects 0.000 claims description 8
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims description 7
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 6
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 6
- MZWUAKOSFJGPFZ-UHFFFAOYSA-N 2-hydroxybutanoic acid;2-hydroxypentanoic acid Chemical compound CCC(O)C(O)=O.CCCC(O)C(O)=O MZWUAKOSFJGPFZ-UHFFFAOYSA-N 0.000 claims description 6
- 102000009027 Albumins Human genes 0.000 claims description 6
- 108010088751 Albumins Proteins 0.000 claims description 6
- 229920001661 Chitosan Polymers 0.000 claims description 6
- 102000008186 Collagen Human genes 0.000 claims description 6
- 108010035532 Collagen Proteins 0.000 claims description 6
- 229920001651 Cyanoacrylate Polymers 0.000 claims description 6
- 229920002307 Dextran Polymers 0.000 claims description 6
- 108010049003 Fibrinogen Proteins 0.000 claims description 6
- 102000008946 Fibrinogen Human genes 0.000 claims description 6
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 6
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 6
- 239000005018 casein Substances 0.000 claims description 6
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 6
- 235000021240 caseins Nutrition 0.000 claims description 6
- 229920002678 cellulose Polymers 0.000 claims description 6
- 239000001913 cellulose Substances 0.000 claims description 6
- 235000010980 cellulose Nutrition 0.000 claims description 6
- 229920001436 collagen Polymers 0.000 claims description 6
- 229940012952 fibrinogen Drugs 0.000 claims description 6
- 229920000159 gelatin Polymers 0.000 claims description 6
- 235000019322 gelatine Nutrition 0.000 claims description 6
- 150000004676 glycans Chemical class 0.000 claims description 6
- 229920002674 hyaluronan Polymers 0.000 claims description 6
- 229960003160 hyaluronic acid Drugs 0.000 claims description 6
- 229920005583 poly(anhydride-co-imide) Polymers 0.000 claims description 6
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims description 6
- 229920000980 poly(hydroxybutyrate-co-hydroxyvalerate) Polymers 0.000 claims description 6
- 229920000218 poly(hydroxyvalerate) Polymers 0.000 claims description 6
- 229920001230 polyarylate Polymers 0.000 claims description 6
- 229920000515 polycarbonate Polymers 0.000 claims description 6
- 239000004417 polycarbonate Substances 0.000 claims description 6
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 6
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 6
- 229920001299 polypropylene fumarate Polymers 0.000 claims description 6
- 229920001282 polysaccharide Polymers 0.000 claims description 6
- 239000005017 polysaccharide Substances 0.000 claims description 6
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 6
- 239000000661 sodium alginate Substances 0.000 claims description 6
- 235000010413 sodium alginate Nutrition 0.000 claims description 6
- 229940005550 sodium alginate Drugs 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 6
- 108010010803 Gelatin Proteins 0.000 claims description 5
- 239000008273 gelatin Substances 0.000 claims description 5
- 235000011852 gelatine desserts Nutrition 0.000 claims description 5
- 239000002745 poly(ortho ester) Substances 0.000 claims description 5
- 238000011144 upstream manufacturing Methods 0.000 claims description 4
- 238000004513 sizing Methods 0.000 claims description 3
- 239000000463 material Substances 0.000 description 55
- 238000012360 testing method Methods 0.000 description 44
- 238000002474 experimental method Methods 0.000 description 24
- 239000003795 chemical substances by application Substances 0.000 description 20
- 238000009864 tensile test Methods 0.000 description 20
- 230000015556 catabolic process Effects 0.000 description 14
- 239000000203 mixture Substances 0.000 description 14
- 238000001125 extrusion Methods 0.000 description 13
- 230000002792 vascular Effects 0.000 description 13
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 description 12
- 239000002253 acid Substances 0.000 description 11
- 238000006731 degradation reaction Methods 0.000 description 10
- 239000002516 radical scavenger Substances 0.000 description 10
- 210000004204 blood vessel Anatomy 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 8
- 230000002093 peripheral effect Effects 0.000 description 8
- JOZPEVMCAKXSEY-UHFFFAOYSA-N pyrimido[5,4-d]pyrimidine Chemical group N1=CN=CC2=NC=NC=C21 JOZPEVMCAKXSEY-UHFFFAOYSA-N 0.000 description 8
- 239000013543 active substance Substances 0.000 description 7
- 238000000071 blow moulding Methods 0.000 description 7
- FOYWNSCCNCUEPU-UHFFFAOYSA-N mopidamol Chemical compound C12=NC(N(CCO)CCO)=NC=C2N=C(N(CCO)CCO)N=C1N1CCCCC1 FOYWNSCCNCUEPU-UHFFFAOYSA-N 0.000 description 7
- 229950010718 mopidamol Drugs 0.000 description 7
- 230000001028 anti-proliverative effect Effects 0.000 description 6
- 239000003146 anticoagulant agent Substances 0.000 description 6
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000002513 implantation Methods 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- 150000002739 metals Chemical class 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 description 5
- 229940127219 anticoagulant drug Drugs 0.000 description 5
- 229920002988 biodegradable polymer Polymers 0.000 description 5
- 239000004621 biodegradable polymer Substances 0.000 description 5
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000003112 inhibitor Substances 0.000 description 5
- 238000003698 laser cutting Methods 0.000 description 5
- 239000008188 pellet Substances 0.000 description 5
- 229920003023 plastic Polymers 0.000 description 5
- 239000004033 plastic Substances 0.000 description 5
- 238000007711 solidification Methods 0.000 description 5
- 230000008023 solidification Effects 0.000 description 5
- 239000004416 thermosoftening plastic Substances 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 239000005557 antagonist Substances 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 239000007857 degradation product Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 238000000113 differential scanning calorimetry Methods 0.000 description 4
- 229960002768 dipyridamole Drugs 0.000 description 4
- 238000002595 magnetic resonance imaging Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 4
- GNOGSFBXBWBTIG-UHFFFAOYSA-N Acetrizoic acid Chemical class CC(=O)NC1=C(I)C=C(I)C(C(O)=O)=C1I GNOGSFBXBWBTIG-UHFFFAOYSA-N 0.000 description 3
- XUHXFSYUBXNTHU-UHFFFAOYSA-N Iotrolan Chemical compound IC=1C(C(=O)NC(CO)C(O)CO)=C(I)C(C(=O)NC(CO)C(O)CO)=C(I)C=1N(C)C(=O)CC(=O)N(C)C1=C(I)C(C(=O)NC(CO)C(O)CO)=C(I)C(C(=O)NC(CO)C(O)CO)=C1I XUHXFSYUBXNTHU-UHFFFAOYSA-N 0.000 description 3
- AMDBBAQNWSUWGN-UHFFFAOYSA-N Ioversol Chemical compound OCCN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I AMDBBAQNWSUWGN-UHFFFAOYSA-N 0.000 description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
- FFINMCNLQNTKLU-UHFFFAOYSA-N adipiodone Chemical compound OC(=O)C1=C(I)C=C(I)C(NC(=O)CCCCC(=O)NC=2C(=C(C(O)=O)C(I)=CC=2I)I)=C1I FFINMCNLQNTKLU-UHFFFAOYSA-N 0.000 description 3
- YVPYQUNUQOZFHG-UHFFFAOYSA-N amidotrizoic acid Chemical compound CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I YVPYQUNUQOZFHG-UHFFFAOYSA-N 0.000 description 3
- 239000002260 anti-inflammatory agent Substances 0.000 description 3
- 229940121363 anti-inflammatory agent Drugs 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 3
- AYJRCSIUFZENHW-DEQYMQKBSA-L barium(2+);oxomethanediolate Chemical compound [Ba+2].[O-][14C]([O-])=O AYJRCSIUFZENHW-DEQYMQKBSA-L 0.000 description 3
- 229910000416 bismuth oxide Inorganic materials 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 230000000112 colonic effect Effects 0.000 description 3
- 239000003218 coronary vasodilator agent Substances 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 229940127089 cytotoxic agent Drugs 0.000 description 3
- 239000002254 cytotoxic agent Substances 0.000 description 3
- 231100000599 cytotoxic agent Toxicity 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 229920006237 degradable polymer Polymers 0.000 description 3
- TYIXMATWDRGMPF-UHFFFAOYSA-N dibismuth;oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Bi+3].[Bi+3] TYIXMATWDRGMPF-UHFFFAOYSA-N 0.000 description 3
- 230000002183 duodenal effect Effects 0.000 description 3
- 230000003628 erosive effect Effects 0.000 description 3
- 230000001747 exhibiting effect Effects 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 239000007943 implant Substances 0.000 description 3
- 229960004108 iobitridol Drugs 0.000 description 3
- YLPBXIKWXNRACS-UHFFFAOYSA-N iobitridol Chemical compound OCC(O)CN(C)C(=O)C1=C(I)C(NC(=O)C(CO)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I YLPBXIKWXNRACS-UHFFFAOYSA-N 0.000 description 3
- 229960004901 iodamide Drugs 0.000 description 3
- VVDGWALACJEJKG-UHFFFAOYSA-N iodamide Chemical compound CC(=O)NCC1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I VVDGWALACJEJKG-UHFFFAOYSA-N 0.000 description 3
- 229940029355 iodipamide Drugs 0.000 description 3
- 229960004359 iodixanol Drugs 0.000 description 3
- NBQNWMBBSKPBAY-UHFFFAOYSA-N iodixanol Chemical compound IC=1C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C(I)C=1N(C(=O)C)CC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NBQNWMBBSKPBAY-UHFFFAOYSA-N 0.000 description 3
- FZDZULUFHNDEDJ-UHFFFAOYSA-N ioglycamic acid Chemical compound OC(=O)C1=C(I)C=C(I)C(NC(=O)COCC(=O)NC=2C(=C(C(O)=O)C(I)=CC=2I)I)=C1I FZDZULUFHNDEDJ-UHFFFAOYSA-N 0.000 description 3
- 229960004876 ioglycamic acid Drugs 0.000 description 3
- 229960001025 iohexol Drugs 0.000 description 3
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 description 3
- 229960000780 iomeprol Drugs 0.000 description 3
- NJKDOADNQSYQEV-UHFFFAOYSA-N iomeprol Chemical compound OCC(=O)N(C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NJKDOADNQSYQEV-UHFFFAOYSA-N 0.000 description 3
- OLAOYPRJVHUHCF-UHFFFAOYSA-N iooxitalamic acid Chemical class CC(=O)NC1=C(I)C(C(O)=O)=C(I)C(C(=O)NCCO)=C1I OLAOYPRJVHUHCF-UHFFFAOYSA-N 0.000 description 3
- 229960004647 iopamidol Drugs 0.000 description 3
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 description 3
- 229960000824 iopentol Drugs 0.000 description 3
- IUNJANQVIJDFTQ-UHFFFAOYSA-N iopentol Chemical compound COCC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I IUNJANQVIJDFTQ-UHFFFAOYSA-N 0.000 description 3
- 229960002603 iopromide Drugs 0.000 description 3
- DGAIEPBNLOQYER-UHFFFAOYSA-N iopromide Chemical compound COCC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I DGAIEPBNLOQYER-UHFFFAOYSA-N 0.000 description 3
- 229960003182 iotrolan Drugs 0.000 description 3
- 229960004537 ioversol Drugs 0.000 description 3
- 229960002611 ioxilan Drugs 0.000 description 3
- UUMLTINZBQPNGF-UHFFFAOYSA-N ioxilan Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCCO)=C(I)C(C(=O)NCC(O)CO)=C1I UUMLTINZBQPNGF-UHFFFAOYSA-N 0.000 description 3
- 229910052749 magnesium Inorganic materials 0.000 description 3
- 239000011777 magnesium Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- GGGDNPWHMNJRFN-UHFFFAOYSA-N metrizoic acid Chemical class CC(=O)N(C)C1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I GGGDNPWHMNJRFN-UHFFFAOYSA-N 0.000 description 3
- 239000004005 microsphere Substances 0.000 description 3
- 230000000704 physical effect Effects 0.000 description 3
- 230000002285 radioactive effect Effects 0.000 description 3
- 238000001959 radiotherapy Methods 0.000 description 3
- 238000007655 standard test method Methods 0.000 description 3
- 229910052715 tantalum Inorganic materials 0.000 description 3
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 3
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 3
- 229910052721 tungsten Inorganic materials 0.000 description 3
- 239000010937 tungsten Substances 0.000 description 3
- 229940124549 vasodilator Drugs 0.000 description 3
- 239000003071 vasodilator agent Substances 0.000 description 3
- 238000012800 visualization Methods 0.000 description 3
- JJTUDXZGHPGLLC-ZXZARUISSA-N (3r,6s)-3,6-dimethyl-1,4-dioxane-2,5-dione Chemical compound C[C@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-ZXZARUISSA-N 0.000 description 2
- 239000005541 ACE inhibitor Substances 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- UXIGWFXRQKWHHA-UHFFFAOYSA-N Iotalamic acid Chemical class CNC(=O)C1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I UXIGWFXRQKWHHA-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 241001082241 Lythrum hyssopifolia Species 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229920001963 Synthetic biodegradable polymer Polymers 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 229940034982 antineoplastic agent Drugs 0.000 description 2
- 239000003972 antineoplastic antibiotic Substances 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 238000003486 chemical etching Methods 0.000 description 2
- 239000011247 coating layer Substances 0.000 description 2
- 238000010924 continuous production Methods 0.000 description 2
- 208000029078 coronary artery disease Diseases 0.000 description 2
- 210000004351 coronary vessel Anatomy 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000001595 flow curve Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000002427 irreversible effect Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 229910001092 metal group alloy Inorganic materials 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 238000013001 point bending Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000005482 strain hardening Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 229960000278 theophylline Drugs 0.000 description 2
- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 description 2
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 2
- AOLNDUQWRUPYGE-UHFFFAOYSA-N 1,4-dioxepan-5-one Chemical compound O=C1CCOCCO1 AOLNDUQWRUPYGE-UHFFFAOYSA-N 0.000 description 1
- QNKFHUMDHRWWES-UHFFFAOYSA-N 2,4,6,8-tetrachloropyrimido[5,4-d]pyrimidine Chemical compound N1=C(Cl)N=C(Cl)C2=NC(Cl)=NC(Cl)=C21 QNKFHUMDHRWWES-UHFFFAOYSA-N 0.000 description 1
- 102000015427 Angiotensins Human genes 0.000 description 1
- 108010064733 Angiotensins Proteins 0.000 description 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 229910000684 Cobalt-chrome Inorganic materials 0.000 description 1
- 206010048554 Endothelial dysfunction Diseases 0.000 description 1
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010024769 Local reaction Diseases 0.000 description 1
- 239000002616 MRI contrast agent Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229910000861 Mg alloy Inorganic materials 0.000 description 1
- HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 description 1
- 208000005764 Peripheral Arterial Disease Diseases 0.000 description 1
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 description 1
- 229940122388 Thrombin inhibitor Drugs 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 108010069102 Thromboxane-A synthase Proteins 0.000 description 1
- 206010047139 Vasoconstriction Diseases 0.000 description 1
- WAIPAZQMEIHHTJ-UHFFFAOYSA-N [Cr].[Co] Chemical compound [Cr].[Co] WAIPAZQMEIHHTJ-UHFFFAOYSA-N 0.000 description 1
- IYKJEILNJZQJPU-UHFFFAOYSA-N acetic acid;butanedioic acid Chemical compound CC(O)=O.OC(=O)CCC(O)=O IYKJEILNJZQJPU-UHFFFAOYSA-N 0.000 description 1
- 229960005305 adenosine Drugs 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 239000002168 alkylating agent Substances 0.000 description 1
- 229940100198 alkylating agent Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 229920006125 amorphous polymer Polymers 0.000 description 1
- 230000000340 anti-metabolite Effects 0.000 description 1
- 230000000702 anti-platelet effect Effects 0.000 description 1
- 229940100197 antimetabolite Drugs 0.000 description 1
- 239000002256 antimetabolite Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000013533 biodegradable additive Substances 0.000 description 1
- 229920000229 biodegradable polyester Polymers 0.000 description 1
- 239000004622 biodegradable polyester Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000003114 blood coagulation factor Substances 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 229940124630 bronchodilator Drugs 0.000 description 1
- 239000000168 bronchodilator agent Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 239000010952 cobalt-chrome Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 238000002788 crimping Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229960005223 diatrizoic acid Drugs 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000008694 endothelial dysfunction Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229960005167 everolimus Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000002594 fluoroscopy Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- RJOJUSXNYCILHH-UHFFFAOYSA-N gadolinium(3+) Chemical compound [Gd+3] RJOJUSXNYCILHH-UHFFFAOYSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000000266 injurious effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 125000002346 iodo group Chemical group I* 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 230000000394 mitotic effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- MENOBBYDZHOWLE-UHFFFAOYSA-N morpholine-2,3-dione Chemical compound O=C1NCCOC1=O MENOBBYDZHOWLE-UHFFFAOYSA-N 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 1
- 229910001000 nickel titanium Inorganic materials 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920002959 polymer blend Polymers 0.000 description 1
- 229920005594 polymer fiber Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000003303 reheating Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 229940121356 serotonin receptor antagonist Drugs 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 229960002930 sirolimus Drugs 0.000 description 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
- 229940075620 somatostatin analogue Drugs 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 229910001256 stainless steel alloy Inorganic materials 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000007892 surgical revascularization Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 125000001302 tertiary amino group Chemical group 0.000 description 1
- 239000003868 thrombin inhibitor Substances 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C55/00—Shaping by stretching, e.g. drawing through a die; Apparatus therefor
- B29C55/22—Shaping by stretching, e.g. drawing through a die; Apparatus therefor of tubes
- B29C55/26—Shaping by stretching, e.g. drawing through a die; Apparatus therefor of tubes biaxial
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
- B29C48/09—Articles with cross-sections having partially or fully enclosed cavities, e.g. pipes or channels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/15—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor incorporating preformed parts or layers, e.g. extrusion moulding around inserts
- B29C48/151—Coating hollow articles
- B29C48/152—Coating hollow articles the inner surfaces thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C55/00—Shaping by stretching, e.g. drawing through a die; Apparatus therefor
- B29C55/30—Drawing through a die
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C55/00—Shaping by stretching, e.g. drawing through a die; Apparatus therefor
- B29C55/22—Shaping by stretching, e.g. drawing through a die; Apparatus therefor of tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C55/00—Shaping by stretching, e.g. drawing through a die; Apparatus therefor
- B29C55/22—Shaping by stretching, e.g. drawing through a die; Apparatus therefor of tubes
- B29C55/24—Shaping by stretching, e.g. drawing through a die; Apparatus therefor of tubes radial
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C70/00—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts
- B29C70/04—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts comprising reinforcements only, e.g. self-reinforcing plastics
- B29C70/28—Shaping operations therefor
- B29C70/40—Shaping or impregnating by compression not applied
- B29C70/50—Shaping or impregnating by compression not applied for producing articles of indefinite length, e.g. prepregs, sheet moulding compounds [SMC] or cross moulding compounds [XMC]
- B29C70/52—Pultrusion, i.e. forming and compressing by continuously pulling through a die
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D23/00—Producing tubular articles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
- B29K2995/0037—Other properties
- B29K2995/0059—Degradable
- B29K2995/006—Bio-degradable, e.g. bioabsorbable, bioresorbable or bioerodible
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2023/00—Tubular articles
- B29L2023/005—Hoses, i.e. flexible
- B29L2023/007—Medical tubes other than catheters
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
L'invention porte sur des tubes polymères biorésorbables appropriés pour être utilisés dans une endoprothèse du type de celles qui ont déjà été produites en utilisant une technique d'étirage à filière, comprenant : - la déformation d'un tube polymère thermoplastique orientable (4) dans la phase solide par étirage de celui-ci sur un mandrin (1) et/ou à travers une filière (3), le mandrin (1) ayant une extrémité de tête et une extrémité de sortie et la filière (3) ayant un côté d'entrée et un côté de sortie, un mécanisme d'étirage appliquant une tension d'étirage au tube (4) à partir de l'extrémité de sortie du mandrin (1) et/ou du côté de sortie de la filière (3), ladite tension étant insuffisante pour provoquer une rupture du tube par tension, mais suffisante pour déformer le tube, en étirant ainsi le tube sur le mandrin (1) et/ou à travers la filière (3), dans la phase solide, pour induire une orientation uniaxiale ou biaxiale du polymère ; et - la collecte du tube déformé provenant de l'extrémité de sortie du mandrin (1) et/ou du côté de sortie de la filière (3).
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261704795P | 2012-09-24 | 2012-09-24 | |
GB1217018.9 | 2012-09-24 | ||
US61/704,795 | 2012-09-24 | ||
GB1217018.9A GB2512016A (en) | 2012-09-24 | 2012-09-24 | Methods |
PCT/GB2013/052499 WO2014045068A1 (fr) | 2012-09-24 | 2013-09-24 | Procédé de production d'un tube destiné à être utilisé dans la formation d'une endoprothèse, et tube |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2886037A1 CA2886037A1 (fr) | 2014-03-27 |
CA2886037C true CA2886037C (fr) | 2020-10-06 |
Family
ID=47190502
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2886037A Active CA2886037C (fr) | 2012-09-24 | 2013-09-24 | Methodes de production d'un tube a utiliser dans la formation d'une endoprothese vasculaire et de tel tube |
Country Status (14)
Country | Link |
---|---|
US (1) | US10299944B2 (fr) |
EP (2) | EP2909003B1 (fr) |
JP (2) | JP2015530157A (fr) |
CN (1) | CN105121132B (fr) |
AU (1) | AU2013319946B2 (fr) |
CA (1) | CA2886037C (fr) |
ES (2) | ES2674119T3 (fr) |
GB (1) | GB2512016A (fr) |
HK (1) | HK1250690A1 (fr) |
IN (1) | IN2015DN03328A (fr) |
MY (1) | MY179760A (fr) |
NZ (1) | NZ707348A (fr) |
SG (2) | SG10201702366WA (fr) |
WO (1) | WO2014045068A1 (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8814930B2 (en) | 2007-01-19 | 2014-08-26 | Elixir Medical Corporation | Biodegradable endoprosthesis and methods for their fabrication |
KR101489263B1 (ko) * | 2014-02-26 | 2015-02-04 | 썬텍 주식회사 | 고분자 스텐트의 제조방법 및 폴리락트산 고분자 스텐트 |
US10010436B2 (en) | 2012-09-20 | 2018-07-03 | Dotter Intellectual Pte, Ltd. | Polymeric stent and methods of manufacturing the same |
US9750622B2 (en) | 2014-06-17 | 2017-09-05 | Abbott Cardiovascular Systems Inc. | High molecular weight polylactide and polycaprolactone copolymer and blends for bioresorbable vascular scaffolds |
US10022906B2 (en) * | 2014-07-30 | 2018-07-17 | Abbott Cardiovascular Systems Inc. | Methods for solid phase processing of tubes and medical devices made from the processed tubes |
US9730819B2 (en) | 2014-08-15 | 2017-08-15 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
US9855156B2 (en) | 2014-08-15 | 2018-01-02 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
US20160175084A1 (en) * | 2014-12-19 | 2016-06-23 | Volcano Corporation | Biodegradable filter and support frame |
US10099431B2 (en) * | 2015-08-21 | 2018-10-16 | Abbott Cardiovascular Systems Inc. | Method to increase radial strength of a bioresorbable scaffold |
CN109561955B (zh) | 2016-05-16 | 2021-04-16 | 万能医药公司 | 撑开支架 |
US11622872B2 (en) | 2016-05-16 | 2023-04-11 | Elixir Medical Corporation | Uncaging stent |
CN108472064B (zh) * | 2016-06-03 | 2022-01-11 | Q3医疗设备有限公司 | 支架 |
CN106729952B (zh) * | 2016-12-23 | 2020-05-22 | 西安交通大学 | Ppf/ppf-da光固化材料骨胶带 |
CN108272481A (zh) * | 2016-12-30 | 2018-07-13 | 香港科技大学深圳研究院 | 一种自适应支架及其制造方法 |
CN106891558A (zh) * | 2017-02-27 | 2017-06-27 | 柳州市人民医院 | 抽血保护装置的生产方法 |
EP3381501B1 (fr) * | 2017-03-30 | 2024-05-29 | PFM Medical AG | Dispositif d'accès implantable pour accéder au système vasculaire d'un corps humain ou animal |
US11040170B2 (en) | 2017-05-25 | 2021-06-22 | Tepha, Inc. | Continuous formation of tubes of poly-4-hydroxybutyrate and copolymers thereof |
CN107350305B (zh) * | 2017-07-03 | 2019-04-02 | 中北大学 | 一种高性能镁合金薄壁管的挤压拉伸成形方法 |
KR102493851B1 (ko) * | 2017-09-08 | 2023-01-31 | 제우스 컴퍼니 인크. | 제어된 배향을 갖는 중합체 튜브 |
RU177450U1 (ru) * | 2017-11-07 | 2018-02-21 | Антон Михайлович Чернышев | Устройство для изготовления теплоизолированных труб |
CN110962340A (zh) * | 2019-12-18 | 2020-04-07 | 北京工业大学 | 一种光固化3d打印编织网状海藻酸钠水凝胶血管支架的制备方法 |
CN114953544B (zh) * | 2022-05-26 | 2024-03-08 | 山东中鲁管业有限公司 | 一种耐磨损的高分子管材生产工艺及装置 |
Family Cites Families (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2561569A (en) * | 1947-01-10 | 1951-07-24 | Wardlyn Corp | Method of making catheters |
US3201827A (en) * | 1963-04-08 | 1965-08-24 | Anaconda Wire & Cable Co | Tube-stretching mandrel |
GB1506565A (en) | 1974-03-05 | 1978-04-05 | Nat Res Dev | Production of polyethylene filaments |
US4528832A (en) * | 1983-01-26 | 1985-07-16 | Fuchs Jr Francis J | Methods and apparatus for increasing the efficiency of tubing extrusion |
GB8408336D0 (en) * | 1984-03-30 | 1984-05-10 | Ward I M | Tubular materials |
EP0157601B1 (fr) * | 1984-03-30 | 1991-05-08 | National Research Development Corporation | Produits tubulaires |
GB8827967D0 (en) * | 1988-11-30 | 1989-01-05 | Ward I M | Die-free drawing |
SE468666B (sv) * | 1990-09-27 | 1993-03-01 | Plm Ab | Saett och anordning foer att kristallisera amorft plastmaterial i ett aemne |
US5401257A (en) * | 1993-04-27 | 1995-03-28 | Boston Scientific Corporation | Ureteral stents, drainage tubes and the like |
NL9400453A (nl) * | 1994-03-22 | 1995-11-01 | Wavin Bv | Werkwijze en inrichting voor het vervaardigen van biaxiaal georiënteerde buis uit thermoplastisch kunststofmateriaal. |
NL9400451A (nl) * | 1994-03-22 | 1995-11-01 | Wavin Bv | Werkwijze en inrichting voor het vervaardigen van biaxiaal georiënteerde buis uit thermoplastisch kunststofmateriaal. |
NL9400738A (nl) * | 1994-05-04 | 1995-12-01 | Wavin Bv | Werkwijze en inrichting voor het vervaardigen van biaxiaal georiënteerde buis uit thermoplastisch kunststofmateriaal. |
US5609605A (en) * | 1994-08-25 | 1997-03-11 | Ethicon, Inc. | Combination arterial stent |
NL1001259C2 (nl) * | 1995-05-03 | 1996-11-05 | Wavin Bv | Werkwijze voor het behandelen van een geëxtrudeerd kunststof profiel en extrusie-installatie daarvoor. |
US5702656A (en) * | 1995-06-07 | 1997-12-30 | United States Surgical Corporation | Process for making polymeric articles |
GB9522477D0 (en) * | 1995-11-02 | 1996-01-03 | Howmedica | Method of improving the wear quality of ultra-high molecular weight polyethylene |
JPH09241412A (ja) | 1996-03-07 | 1997-09-16 | Sumitomo Electric Ind Ltd | 延伸ポリテトラフルオロエチレンチューブとその製造方法 |
US5928279A (en) | 1996-07-03 | 1999-07-27 | Baxter International Inc. | Stented, radially expandable, tubular PTFE grafts |
DE19728345A1 (de) * | 1997-07-03 | 1999-01-07 | Asea Brown Boveri | Kraft- und formschlüssige Verbindung von rotierenden Bauteilen |
US6626939B1 (en) | 1997-12-18 | 2003-09-30 | Boston Scientific Scimed, Inc. | Stent-graft with bioabsorbable structural support |
JP2000167922A (ja) * | 1998-12-01 | 2000-06-20 | Mitsubishi Chemicals Corp | 樹脂管状体の製造方法及び装置 |
US6187054B1 (en) * | 1999-02-04 | 2001-02-13 | Endomed Inc. | Method of making large diameter vascular prosteheses and a vascular prosthesis made by said method |
NL1012032C2 (nl) * | 1999-03-05 | 2000-09-06 | Wavin Bv | Werkwijze voor het vervaardigen van een buis van biaxiaal georiënteerd thermoplastisch kunststofmateriaal. |
FR2806956B1 (fr) * | 2000-03-29 | 2003-05-09 | Alphacan Sa | Procede et ligne de fabrication en continu de tubes en matiere plastique avec etirage bi-axial, et tube en matiere plastique obtenu |
EP1341483B1 (fr) * | 2000-11-22 | 2008-08-27 | Bard Peripheral Vascular, Inc. | Procede pour la fabrication d'une structure tubulaire en polytetrafluorethylene expanse haute densite a microparoi |
JP2002249555A (ja) * | 2001-02-23 | 2002-09-06 | Nippon Zeon Co Ltd | 管状成形品 |
EP1539038A2 (fr) * | 2002-09-13 | 2005-06-15 | Linvatec Corporation | Stent etendu etire |
US7025745B2 (en) * | 2002-10-07 | 2006-04-11 | Advanced Cardiovascular Systems, Inc. | Method of making a catheter balloon using a tapered mandrel |
US7763063B2 (en) * | 2003-09-03 | 2010-07-27 | Bolton Medical, Inc. | Self-aligning stent graft delivery system, kit, and method |
US8292943B2 (en) | 2003-09-03 | 2012-10-23 | Bolton Medical, Inc. | Stent graft with longitudinal support member |
US20050137678A1 (en) | 2003-12-22 | 2005-06-23 | Medtronic Vascular, Inc. | Low profile resorbable stent |
US20050149172A1 (en) | 2003-12-22 | 2005-07-07 | Ashish Varma | Minimal injury resorbable stent |
US8012402B2 (en) | 2008-08-04 | 2011-09-06 | Abbott Cardiovascular Systems Inc. | Tube expansion process for semicrystalline polymers to maximize fracture toughness |
US7971333B2 (en) | 2006-05-30 | 2011-07-05 | Advanced Cardiovascular Systems, Inc. | Manufacturing process for polymetric stents |
US8501079B2 (en) * | 2009-09-14 | 2013-08-06 | Abbott Cardiovascular Systems Inc. | Controlling crystalline morphology of a bioabsorbable stent |
US7731890B2 (en) * | 2006-06-15 | 2010-06-08 | Advanced Cardiovascular Systems, Inc. | Methods of fabricating stents with enhanced fracture toughness |
US20060020330A1 (en) * | 2004-07-26 | 2006-01-26 | Bin Huang | Method of fabricating an implantable medical device with biaxially oriented polymers |
US20060041102A1 (en) | 2004-08-23 | 2006-02-23 | Advanced Cardiovascular Systems, Inc. | Implantable devices comprising biologically absorbable polymers having constant rate of degradation and methods for fabricating the same |
EP1793331A4 (fr) * | 2004-09-21 | 2010-09-08 | Panasonic Corp | Carte memoire a semi-conducteur |
US8585753B2 (en) * | 2006-03-04 | 2013-11-19 | John James Scanlon | Fibrillated biodegradable prosthesis |
US20090076594A1 (en) | 2006-03-14 | 2009-03-19 | Patrick Sabaria | Method of monitoring positioning of polymer stents |
US7594928B2 (en) * | 2006-05-17 | 2009-09-29 | Boston Scientific Scimed, Inc. | Bioabsorbable stents with reinforced filaments |
US20070288080A1 (en) * | 2006-06-07 | 2007-12-13 | Maccollum Michael W | Stent expanding device |
EP3061791B1 (fr) | 2006-07-20 | 2019-01-16 | OrbusNeich Medical, Inc. | Composition polymère bioabsorbable pour un dispositif médical |
US8394488B2 (en) | 2006-10-06 | 2013-03-12 | Cordis Corporation | Bioabsorbable device having composite structure for accelerating degradation |
JP5593070B2 (ja) | 2006-10-20 | 2014-09-17 | エリクシアー メディカル コーポレイション | 管腔内人工装具および管腔内人工装具を被膜するための方法 |
US20080103584A1 (en) | 2006-10-25 | 2008-05-01 | Biosensors International Group | Temporal Intraluminal Stent, Methods of Making and Using |
CA2668283A1 (fr) | 2006-11-10 | 2008-05-15 | Dow Global Technologies Inc. | Moule d'etirement sensiblement proportionnel pour des compositions a base de polymere |
US20080177373A1 (en) | 2007-01-19 | 2008-07-24 | Elixir Medical Corporation | Endoprosthesis structures having supporting features |
US7704275B2 (en) * | 2007-01-26 | 2010-04-27 | Reva Medical, Inc. | Circumferentially nested expandable device |
FR2916439B1 (fr) * | 2007-05-23 | 2010-09-10 | Commissariat Energie Atomique | Procede de fabrication d'une vermiculite fortement exfoliee ne necessitant pas l'utilisation de liant organique ou d'additif organique pour etre mis en forme |
EP2160153A1 (fr) | 2007-06-11 | 2010-03-10 | Nanovasc, Inc. | Stents |
US8317857B2 (en) | 2008-01-10 | 2012-11-27 | Telesis Research, Llc | Biodegradable self-expanding prosthesis |
US8206635B2 (en) * | 2008-06-20 | 2012-06-26 | Amaranth Medical Pte. | Stent fabrication via tubular casting processes |
US9119906B2 (en) * | 2008-09-24 | 2015-09-01 | Integran Technologies, Inc. | In-vivo biodegradable medical implant |
US20100244334A1 (en) * | 2009-03-24 | 2010-09-30 | Contiliano Joseph H | Method of manufacturing a polymeric stent having a circumferential ring configuration |
US8545742B2 (en) | 2009-08-28 | 2013-10-01 | Abbott Cardiovascular Systems Inc. | Method of fabricating a low crystallinity poly(L-lactide) tube |
CN201551421U (zh) | 2009-11-06 | 2010-08-18 | 易生科技(北京)有限公司 | 一种血管支架 |
US8568471B2 (en) | 2010-01-30 | 2013-10-29 | Abbott Cardiovascular Systems Inc. | Crush recoverable polymer scaffolds |
US8496865B2 (en) | 2010-10-15 | 2013-07-30 | Abbott Cardiovascular Systems Inc. | Method to minimize chain scission and monomer generation in processing of poly(L-lactide) stent |
WO2013003644A1 (fr) * | 2011-06-30 | 2013-01-03 | Elixir Medical Corporation | Endoprothèses biodégradables et leurs procédés de fabrication |
-
2012
- 2012-09-24 GB GB1217018.9A patent/GB2512016A/en not_active Withdrawn
-
2013
- 2013-09-24 SG SG10201702366WA patent/SG10201702366WA/en unknown
- 2013-09-24 AU AU2013319946A patent/AU2013319946B2/en active Active
- 2013-09-24 CA CA2886037A patent/CA2886037C/fr active Active
- 2013-09-24 SG SG11201502284UA patent/SG11201502284UA/en unknown
- 2013-09-24 MY MYPI2015000736A patent/MY179760A/en unknown
- 2013-09-24 US US14/430,497 patent/US10299944B2/en active Active
- 2013-09-24 NZ NZ707348A patent/NZ707348A/en unknown
- 2013-09-24 WO PCT/GB2013/052499 patent/WO2014045068A1/fr active Application Filing
- 2013-09-24 CN CN201380059970.2A patent/CN105121132B/zh active Active
- 2013-09-24 ES ES13771185.9T patent/ES2674119T3/es active Active
- 2013-09-24 ES ES18158541T patent/ES2788392T3/es active Active
- 2013-09-24 IN IN3328DEN2015 patent/IN2015DN03328A/en unknown
- 2013-09-24 JP JP2015532511A patent/JP2015530157A/ja active Pending
- 2013-09-24 EP EP13771185.9A patent/EP2909003B1/fr active Active
- 2013-09-24 EP EP18158541.5A patent/EP3345739B1/fr active Active
-
2018
- 2018-08-07 HK HK18110139.1A patent/HK1250690A1/zh unknown
-
2019
- 2019-01-08 JP JP2019001338A patent/JP7034104B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
US10299944B2 (en) | 2019-05-28 |
SG10201702366WA (en) | 2017-04-27 |
CN105121132B (zh) | 2019-09-13 |
HK1250690A1 (zh) | 2019-01-11 |
JP7034104B2 (ja) | 2022-03-11 |
NZ707348A (en) | 2018-07-27 |
CN105121132A (zh) | 2015-12-02 |
EP2909003A1 (fr) | 2015-08-26 |
EP3345739A2 (fr) | 2018-07-11 |
JP2019051399A (ja) | 2019-04-04 |
AU2013319946A1 (en) | 2015-05-14 |
MY179760A (en) | 2020-11-12 |
GB201217018D0 (en) | 2012-11-07 |
IN2015DN03328A (fr) | 2015-10-09 |
GB2512016A (en) | 2014-09-24 |
AU2013319946B2 (en) | 2018-03-08 |
EP3345739B1 (fr) | 2020-02-19 |
SG11201502284UA (en) | 2015-05-28 |
CA2886037A1 (fr) | 2014-03-27 |
ES2674119T3 (es) | 2018-06-27 |
JP2015530157A (ja) | 2015-10-15 |
WO2014045068A1 (fr) | 2014-03-27 |
US20150230946A1 (en) | 2015-08-20 |
EP2909003B1 (fr) | 2018-03-21 |
ES2788392T3 (es) | 2020-10-21 |
EP3345739A3 (fr) | 2018-09-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2886037C (fr) | Methodes de production d'un tube a utiliser dans la formation d'une endoprothese vasculaire et de tel tube | |
US8747878B2 (en) | Method of fabricating an implantable medical device by controlling crystalline structure | |
US9216238B2 (en) | Implantable medical device having reduced chance of late inflammatory response | |
CA2627059C (fr) | Endoprotheses a base de composite bioresorbable comprenant un polymere bioresorbable | |
JP5833543B2 (ja) | 非晶質のポリマーまたは結晶度が非常に低いポリマーのコンストラクトからの埋込式医療機器(デバイス)の製造方法 | |
US20080243228A1 (en) | Implantable medical devices fabricated from block copolymers | |
JP2007313327A (ja) | フープの選定された領域に、改変された分子構造を有するポリマーステント、および、破断点伸びを増大させる方法 | |
JP2007313324A (ja) | 可撓性コネクターとフープの半径方向円弧部材とに、改変された分子構造を有するポリマーステント | |
JP2008012912A (ja) | フープの選定された領域に、改変された分子構造を有するポリマーステント、および、それの製造方法 | |
JP2007313328A (ja) | 可撓性コネクターの選択された領域に改変された分子構造を有するポリマーステント | |
CN107073179B (zh) | 用于生物可再吸收血管支架结构的聚交酯和聚已内酯共聚物和共混物 | |
JP2007325921A (ja) | 可撓性コネクターとフープの半径方向ストラットとに、改変された分子構造を有するポリマーステント | |
US10099431B2 (en) | Method to increase radial strength of a bioresorbable scaffold | |
JP2007325923A (ja) | フープと可撓性コネクターの選定された部分との両方に、改変された分子構造を有するポリマーステント |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20180726 |