CA2884299A1 - Novel drug-protein conjugates - Google Patents
Novel drug-protein conjugates Download PDFInfo
- Publication number
- CA2884299A1 CA2884299A1 CA2884299A CA2884299A CA2884299A1 CA 2884299 A1 CA2884299 A1 CA 2884299A1 CA 2884299 A CA2884299 A CA 2884299A CA 2884299 A CA2884299 A CA 2884299A CA 2884299 A1 CA2884299 A1 CA 2884299A1
- Authority
- CA
- Canada
- Prior art keywords
- group
- conjugate
- linker
- auristatin
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Molecular Biology (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
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| US201261717743P | 2012-10-24 | 2012-10-24 | |
| US201261717710P | 2012-10-24 | 2012-10-24 | |
| US61/717,743 | 2012-10-24 | ||
| US61/717,710 | 2012-10-24 | ||
| US201361811285P | 2013-04-12 | 2013-04-12 | |
| US61/811,285 | 2013-04-12 | ||
| PCT/GB2013/051593 WO2013190292A2 (en) | 2012-06-19 | 2013-06-19 | Novel process for preparation of antibody conjugates and novel antibody conjugates |
| GBPCT/GB2013/051593 | 2013-06-19 | ||
| PCT/GB2013/052661 WO2014064423A1 (en) | 2012-10-24 | 2013-10-11 | Drug-protein conjugates |
Publications (1)
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|---|---|
| CA2884299A1 true CA2884299A1 (en) | 2014-05-01 |
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| CA2884299A Abandoned CA2884299A1 (en) | 2012-10-24 | 2013-10-11 | Novel drug-protein conjugates |
Country Status (18)
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105658240A (zh) | 2013-06-04 | 2016-06-08 | 西托姆克斯治疗公司 | 用于缀合可活化抗体的组合物和方法 |
| SI3057585T1 (sl) | 2013-10-15 | 2020-12-31 | Seagen Inc. | Pegilirani linkerji zdravila za izboljšano farmakokinetiko konjugata ligand-zdravilo |
| ES2792598T3 (es) * | 2014-05-23 | 2020-11-11 | Novartis Ag | Métodos para preparar conjugados a partir de proteínas que contienen disulfuro |
| US10357472B2 (en) * | 2014-06-12 | 2019-07-23 | Cspc Dophen Corporation | Homogenous antibody drug conjugates via enzymatic methods |
| EP3218009B1 (en) * | 2014-10-14 | 2021-04-07 | Polytherics Limited | Process for the conjugation of a peptide or protein with a reagent comprising a leaving group including a portion of peg |
| JP6612860B2 (ja) * | 2014-10-24 | 2019-11-27 | ポリセリックス・リミテッド | コンジュゲート及びコンジュゲート試薬 |
| GB201419108D0 (en) | 2014-10-27 | 2014-12-10 | Glythera Ltd | Materials and methods relating to linkers for use in antibody drug conjugates |
| EP3165237B1 (en) | 2015-11-03 | 2018-12-19 | Industrial Technology Research Institute | Antibody-drug conjugate (adc) and method for forming the same |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| ES2919323T3 (es) | 2015-12-04 | 2022-07-26 | Seagen Inc | Conjugados de compuestos de tubulisina cuaternizados |
| WO2017161206A1 (en) | 2016-03-16 | 2017-09-21 | Halozyme, Inc. | Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use |
| US11844839B2 (en) | 2016-03-25 | 2023-12-19 | Seagen Inc. | Process for the preparation of pegylated drug-linkers and intermediates thereof |
| EP3442595A1 (en) | 2016-04-14 | 2019-02-20 | Polytherics Limited | Conjugates and conjugating reagents comprising a linker that includes at least two (-ch2-ch2-0-) units in a ring |
| GB201608936D0 (en) * | 2016-05-20 | 2016-07-06 | Polytherics Ltd | Novel conjugates and novel conjugating reagents |
| CN109311996B (zh) * | 2016-06-06 | 2023-11-28 | 阿布泽纳(英国)有限公司 | 抗体、其用途及其缀合物 |
| GB201614162D0 (en) * | 2016-08-18 | 2016-10-05 | Polytherics Ltd | Antibodies, uses thereof and conjugates thereof |
| SG11201908325PA (en) | 2017-03-24 | 2019-10-30 | Seattle Genetics Inc | Process for the preparation of glucuronide drug-linkers and intermediates thereof |
| GB201820864D0 (en) * | 2018-12-20 | 2019-02-06 | J A Kemp | Antibody-drug conjugates |
| AU2021256223B2 (en) * | 2020-04-15 | 2024-04-18 | Shenzhen Enduring Biotech, Ltd. | Antibody-drug conjugate |
| KR20230159463A (ko) * | 2021-03-19 | 2023-11-21 | 선전 엔듀어링 바이오테크 리미티드 | Cd3 및 cd19에 대해 이중 특이성을 갖는 페길화된 t 세포 인게이저 |
| WO2023141855A1 (en) * | 2022-01-27 | 2023-08-03 | Glyco-Therapy Biotechnology Co., Ltd. | Protein conjugates with multiple payloads and methods for making the same |
| TW202444426A (zh) * | 2023-03-29 | 2024-11-16 | 美商艾克塞里克斯公司 | Amhrii抗體-藥物結合物及其用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| CN107213469A (zh) | 2003-11-06 | 2017-09-29 | 西雅图基因公司 | 能够与配体偶联的单甲基缬氨酸化合物 |
| AU2006294554B2 (en) * | 2005-09-26 | 2013-03-21 | E. R. Squibb & Sons, L.L.C. | Antibody-drug conjugates and methods of use |
| DK2211904T3 (en) * | 2007-10-19 | 2016-10-24 | Seattle Genetics Inc | Cd19-binding agents and uses thereof |
| WO2009117531A1 (en) | 2008-03-18 | 2009-09-24 | Seattle Genetics, Inc. | Auristatin drug linker conjugates |
| WO2009134952A2 (en) * | 2008-04-30 | 2009-11-05 | Immunogen, Inc | Potent conjugates and hydrophilic linkers |
| WO2010100430A1 (en) | 2009-03-04 | 2010-09-10 | Polytherics Limited | Conjugated proteins and peptides |
| EP2414399A1 (en) * | 2009-04-01 | 2012-02-08 | F. Hoffmann-La Roche AG | Anti-fcrh5 antibodies and immunoconjugates and methods of use |
| UY32913A (es) * | 2009-10-02 | 2011-04-29 | Sanofi Aventis | Nuevos maitansinoides y el uso de dichos maitansinoides para preparar conjugados con un anticuero |
| RU2620864C2 (ru) * | 2012-04-25 | 2017-05-30 | Конинклейке Филипс Н.В. | Система и способ для определения местоположения градиентной катушки |
| JP2015521615A (ja) * | 2012-06-19 | 2015-07-30 | ポリセリックス・リミテッド | 抗体コンジュゲートの調製のための新規方法及び新規抗体コンジュゲート |
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2013
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- 2013-10-11 MY MYPI2015701285A patent/MY169147A/en unknown
- 2013-10-11 EP EP16203350.0A patent/EP3159013A1/en not_active Withdrawn
- 2013-10-11 EP EP13786530.9A patent/EP2911700B1/en active Active
- 2013-10-11 US US14/437,537 patent/US20150290342A1/en not_active Abandoned
- 2013-10-11 KR KR1020157011427A patent/KR102209395B1/ko active Active
- 2013-10-11 BR BR112015008376A patent/BR112015008376A2/pt not_active Application Discontinuation
- 2013-10-11 WO PCT/GB2013/052661 patent/WO2014064423A1/en active Application Filing
- 2013-10-11 CA CA2884299A patent/CA2884299A1/en not_active Abandoned
- 2013-10-11 CN CN201380055880.6A patent/CN104870021B/zh active Active
- 2013-10-11 JP JP2015538560A patent/JP6328648B2/ja active Active
- 2013-10-11 SG SG11201501618WA patent/SG11201501618WA/en unknown
- 2013-10-11 RU RU2015119561A patent/RU2015119561A/ru unknown
- 2013-10-11 IN IN2349DEN2015 patent/IN2015DN02349A/en unknown
- 2013-10-11 DK DK13786530.9T patent/DK2911700T5/en active
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2015
- 2015-03-10 ZA ZA2015/01642A patent/ZA201501642B/en unknown
- 2015-03-11 IL IL237672A patent/IL237672B/en active IP Right Grant
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2021
- 2021-09-17 US US17/477,565 patent/US20220062436A1/en active Pending
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| EP2911700A1 (en) | 2015-09-02 |
| KR102209395B1 (ko) | 2021-01-28 |
| US20150290342A1 (en) | 2015-10-15 |
| CN104870021B (zh) | 2018-03-13 |
| EP3159013A1 (en) | 2017-04-26 |
| MY169147A (en) | 2019-02-18 |
| JP6328648B2 (ja) | 2018-05-23 |
| IL237672A0 (en) | 2015-04-30 |
| US20220062436A1 (en) | 2022-03-03 |
| EP2911700B1 (en) | 2017-02-08 |
| IN2015DN02349A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-08-28 |
| ES2623209T3 (es) | 2017-07-10 |
| RU2015119561A (ru) | 2016-12-20 |
| IL237672B (en) | 2018-02-28 |
| SG11201501618WA (en) | 2015-04-29 |
| AU2013336409B2 (en) | 2017-08-03 |
| BR112015008376A2 (pt) | 2017-09-26 |
| JP2015533847A (ja) | 2015-11-26 |
| MX2015005122A (es) | 2015-10-29 |
| ZA201501642B (en) | 2016-01-27 |
| DK2911700T5 (en) | 2017-05-22 |
| DK2911700T3 (en) | 2017-05-15 |
| KR20150103656A (ko) | 2015-09-11 |
| HK1208187A1 (en) | 2016-02-26 |
| AU2013336409A1 (en) | 2015-04-02 |
| CN104870021A (zh) | 2015-08-26 |
| WO2014064423A1 (en) | 2014-05-01 |
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| FZDE | Discontinued |
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