CA2882489A1 - Antibodies to paliperidone haptens and use thereof - Google Patents
Antibodies to paliperidone haptens and use thereof Download PDFInfo
- Publication number
- CA2882489A1 CA2882489A1 CA2882489A CA2882489A CA2882489A1 CA 2882489 A1 CA2882489 A1 CA 2882489A1 CA 2882489 A CA2882489 A CA 2882489A CA 2882489 A CA2882489 A CA 2882489A CA 2882489 A1 CA2882489 A1 CA 2882489A1
- Authority
- CA
- Canada
- Prior art keywords
- paliperidone
- antibody
- sample
- labeled
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- PMXMIIMHBWHSKN-UHFFFAOYSA-N 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCC(O)C4=NC=3C)=NOC2=C1 PMXMIIMHBWHSKN-UHFFFAOYSA-N 0.000 title claims abstract description 113
- 229960001057 paliperidone Drugs 0.000 title claims abstract description 112
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- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 claims abstract description 73
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- CCHPRJNLMUPGSW-UHFFFAOYSA-N n,n'-dicyclohexylmethanediimine;n,n'-di(propan-2-yl)methanediimine Chemical compound CC(C)N=C=NC(C)C.C1CCCCC1N=C=NC1CCCCC1 CCHPRJNLMUPGSW-UHFFFAOYSA-N 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
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- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- RFIOZSIHFNEKFF-UHFFFAOYSA-M piperazine-1-carboxylate Chemical compound [O-]C(=O)N1CCNCC1 RFIOZSIHFNEKFF-UHFFFAOYSA-M 0.000 description 1
- XIPFMBOWZXULIA-UHFFFAOYSA-N pivalamide Chemical compound CC(C)(C)C(N)=O XIPFMBOWZXULIA-UHFFFAOYSA-N 0.000 description 1
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- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 description 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261691634P | 2012-08-21 | 2012-08-21 | |
| US61/691,634 | 2012-08-21 | ||
| PCT/US2013/055733 WO2014031603A1 (en) | 2012-08-21 | 2013-08-20 | Antibodies to paliperidone haptens and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2882489A1 true CA2882489A1 (en) | 2014-02-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2882489A Abandoned CA2882489A1 (en) | 2012-08-21 | 2013-08-20 | Antibodies to paliperidone haptens and use thereof |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20140057297A1 (enExample) |
| EP (1) | EP2888287A4 (enExample) |
| JP (2) | JP2015529199A (enExample) |
| CN (1) | CN104736566A (enExample) |
| AU (3) | AU2013305938B2 (enExample) |
| CA (1) | CA2882489A1 (enExample) |
| HK (1) | HK1211956A1 (enExample) |
| WO (1) | WO2014031603A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2888284T (pt) | 2012-08-21 | 2022-11-18 | Janssen Pharmaceutica Nv | Anticorpos dirigidos contra haptenos de risperidona e a sua utilização |
| JP6270845B2 (ja) | 2012-08-21 | 2018-01-31 | ヤンセン ファーマシューティカ エヌ．ベー． | アリピプラゾールに対する抗体及びその使用 |
| CN104736564B (zh) | 2012-08-21 | 2019-02-05 | 詹森药业有限公司 | 喹硫平半抗原的抗体及其用途 |
| EP2888277A4 (en) | 2012-08-21 | 2016-05-18 | Ortho Clinical Diagnostics Inc | ANTIBODIES AGAINST PALIPERIDONE AND USE THEREOF |
| PT2888593T (pt) | 2012-08-21 | 2018-12-12 | Janssen Pharmaceutica Nv | Anticorpos contra risperidona e utilizações dos mesmos |
| CA2882489A1 (en) * | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc. | Antibodies to paliperidone haptens and use thereof |
| CA2882595C (en) | 2012-08-21 | 2019-06-04 | Ortho-Clinical Diagnostics, Inc. | Antibodies to olanzapine haptens and use thereof |
| PT3321254T (pt) | 2012-08-21 | 2020-10-20 | Janssen Pharmaceutica Nv | Haptenos de aripiprazol e seu uso em imunoensaios |
| WO2014031662A2 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to olanzapine and use thereof |
| CN110054694B (zh) | 2012-08-21 | 2024-02-20 | 詹森药业有限公司 | 阿立哌唑半抗原的抗体及其用途 |
| PL2888592T3 (pl) | 2012-08-21 | 2018-03-30 | Janssen Pharmaceutica Nv | Przeciwciała względem kwetiapiny i ich zastosowania |
| WO2017106501A1 (en) | 2015-12-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Antibodies to risperidone and use thereof |
| JP6994461B2 (ja) | 2015-12-17 | 2022-02-04 | ヤンセン ファーマシューティカ エヌ．ベー． | クエチアピンに対する抗体及びその使用 |
| CN107137715B (zh) * | 2017-04-26 | 2019-02-19 | 石家庄蒎格医药科技有限公司 | 一种帕利哌酮聚乙二醇缀合前药及制备 |
| CN112730825B (zh) * | 2020-12-17 | 2022-09-06 | 北京丹大生物技术有限公司 | 一种用于检测利培酮和/或9-羟基利培酮的检测试剂和检测试剂盒 |
| CN112608310B (zh) * | 2020-12-17 | 2022-03-29 | 北京丹大生物技术有限公司 | 一种利培酮和9-羟基利培酮半抗原、抗原和抗体以及其应用 |
Family Cites Families (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
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2013
- 2013-08-20 CA CA2882489A patent/CA2882489A1/en not_active Abandoned
- 2013-08-20 US US13/971,387 patent/US20140057297A1/en not_active Abandoned
- 2013-08-20 HK HK15112826.8A patent/HK1211956A1/xx unknown
- 2013-08-20 JP JP2015528574A patent/JP2015529199A/ja active Pending
- 2013-08-20 CN CN201380054967.1A patent/CN104736566A/zh active Pending
- 2013-08-20 WO PCT/US2013/055733 patent/WO2014031603A1/en not_active Ceased
- 2013-08-20 AU AU2013305938A patent/AU2013305938B2/en not_active Ceased
- 2013-08-20 EP EP13831062.8A patent/EP2888287A4/en not_active Withdrawn
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2017
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2018
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2019
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|---|---|
| JP2018118972A (ja) | 2018-08-02 |
| US20190338047A1 (en) | 2019-11-07 |
| WO2014031603A1 (en) | 2014-02-27 |
| US20170129968A1 (en) | 2017-05-11 |
| US11225527B2 (en) | 2022-01-18 |
| EP2888287A1 (en) | 2015-07-01 |
| AU2019284029B2 (en) | 2022-03-10 |
| EP2888287A4 (en) | 2016-04-20 |
| HK1211956A1 (en) | 2016-06-03 |
| AU2013305938A1 (en) | 2015-03-05 |
| US20140057297A1 (en) | 2014-02-27 |
| AU2013305938B2 (en) | 2017-08-17 |
| US20170298147A1 (en) | 2017-10-19 |
| AU2017261585A1 (en) | 2017-12-07 |
| AU2019284029A1 (en) | 2020-01-23 |
| JP2015529199A (ja) | 2015-10-05 |
| US10370457B2 (en) | 2019-08-06 |
| AU2017261585B2 (en) | 2019-09-26 |
| CN104736566A (zh) | 2015-06-24 |
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