CA2881361C - Antimicrobial compositions comprising glyceryl nitrates - Google Patents

Antimicrobial compositions comprising glyceryl nitrates Download PDF

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Publication number
CA2881361C
CA2881361C CA2881361A CA2881361A CA2881361C CA 2881361 C CA2881361 C CA 2881361C CA 2881361 A CA2881361 A CA 2881361A CA 2881361 A CA2881361 A CA 2881361A CA 2881361 C CA2881361 C CA 2881361C
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Prior art keywords
solution
acid
chelator
glyceryl
citrate
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CA2881361A
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English (en)
French (fr)
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CA2881361A1 (en
Inventor
Issam Raad
Joel Rosenblatt
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The University of Texas System
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The University of Texas System
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
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    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
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    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3947—Liquid compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/26—Organic compounds containing oxygen
    • C11D7/261—Alcohols; Phenols
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/26—Organic compounds containing oxygen
    • C11D7/265—Carboxylic acids or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials
    • A61L2103/06—The human body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/65—Personal protective equipment, e.g. facial masks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
    • C11D2111/10—Objects to be cleaned
    • C11D2111/14—Hard surfaces
    • C11D2111/20—Industrial or commercial equipment, e.g. reactors, tubes or engines

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Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8778387B2 (en) 2009-09-02 2014-07-15 Hyprotek, Inc. Antimicrobial medical dressings and protecting wounds and catheter sites
SG182452A1 (en) * 2010-01-22 2012-08-30 Hyprotek Inc Antimicrobial agent comprising peroxide, alcohol and chelating agent
US9192443B2 (en) 2012-02-06 2015-11-24 Hyprotek, Inc. Combined cap applicators
DK2882433T3 (da) * 2012-08-08 2019-05-27 Univ Texas Antimikrobielle sammensætninger omfattende glycerylnitrater
US10021876B2 (en) * 2013-05-02 2018-07-17 Next Science IP Holdings Pty Ltd High osmolarity antimicrobial composition containing one or more organic solvents
WO2015077798A1 (en) * 2013-11-25 2015-05-28 Excelsior Medical Corporation Catheter lock solution formulations
MX2017002916A (es) 2014-09-09 2017-05-30 Lonza Ag Composicion de desinfectante que contiene compuestos de amonio cuaternario.
RU2017134391A (ru) 2015-03-18 2019-04-05 Ром Энд Хаас Компани Устойчивые к замораживанию композиции сульфата тетракис(гидроксиметил)фосфония
EP3413942B1 (en) * 2016-02-12 2023-01-11 Medical Components, Inc. Catheter locking solution and catheter locking therapy
WO2017147067A1 (en) * 2016-02-22 2017-08-31 Board Of Regents, The University Of Texas System Antimicrobial compositions and uses thereof
DE102017200310B3 (de) * 2017-01-10 2017-11-02 Axagarius Gmbh & Co. Kg Test zur Bestimmung der Sulfatkonzentration
AU2018338194B2 (en) 2017-09-22 2021-07-08 Becton, Dickinson And Company 4% trisodium citrate solution for use as a catheter lock solution
EP3713608A4 (en) * 2017-11-25 2021-08-25 Ash Access Technology, Inc. CATHETER RINSING SOLUTION INCLUDING SODIUM CITRATE AND BENZYL ALCOHOL
US11612403B2 (en) * 2018-10-03 2023-03-28 Covidien Lp Multi-function surgical transection instrument
WO2021229574A1 (en) * 2020-05-13 2021-11-18 Corolabs Ltd. Compositions for inhalation and uses thereof for disinfecting the upper respiratory airways
WO2022046668A1 (en) * 2020-08-22 2022-03-03 Luc Montagnier Compositions and methods for reducing the transmissivity of illnesses
CN112604176B (zh) * 2021-01-14 2022-01-25 中南大学湘雅医院 一种颌骨缺损个性化修复后适应装置
EP4326063A4 (en) * 2021-04-23 2025-01-08 Solugen, Inc. IMPROVED BIOCIDE COMPOSITIONS

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0039999A1 (en) * 1980-05-09 1981-11-18 Warner-Lambert Company Nitroglycerin infusion set
JPH0645538B2 (ja) * 1987-09-30 1994-06-15 日本化薬株式会社 ニトログリセリンスプレー剤
US5217493A (en) 1992-03-11 1993-06-08 Board Of Regents, The University Of Texas System Antibacterial coated medical implants
US5814666A (en) 1992-04-13 1998-09-29 The United States As Represented By The Department Of Health And Human Services Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents
US5624704A (en) 1995-04-24 1997-04-29 Baylor College Of Medicine Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent
EP1017427B1 (en) 1997-08-26 2006-04-26 Board of Regents, The University of Texas System Use of a composition comprising a chelating agent and an antimicrobial compound for the treatment of biofilms
AU2727701A (en) * 1999-12-15 2001-06-25 Cellegy Pharmaceuticals, Inc. Nitroglycerin ointment for treatment of pain associated with anal disease
WO2002082907A1 (en) 2001-01-12 2002-10-24 Board Of Regents, The University Of Texas System Novel antiseptic derivatives with broad spectrum antimicrobial activity for the impregnation of surfaces
DK1644024T3 (da) 2003-06-06 2019-10-07 Univ Texas Antimikrobielle skylleopløsninger
CA2552911A1 (en) 2004-01-20 2005-08-11 Board Of Regents, The University Of Texas System Methods for coating and impregnating medical devices with antiseptic compositions
WO2007062306A2 (en) 2005-11-18 2007-05-31 The Board Of Regents Of The University Of Texas System Methods for coating surfaces with antimicrobial agents
US20090312279A1 (en) 2005-12-23 2009-12-17 Sterilex Technologies, Llc Antimicrobial compositions
US8426044B2 (en) 2009-03-20 2013-04-23 Board Of Regents, The University Of Texas System Method for imparting antimicrobial activity to a medical device
US9072296B2 (en) * 2009-03-26 2015-07-07 Organic Medical Ventures, L.L.C. Transdermal venous access locking solutions
DK2882433T3 (da) * 2012-08-08 2019-05-27 Univ Texas Antimikrobielle sammensætninger omfattende glycerylnitrater

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EP2882433B1 (en) 2019-03-13
EP2882433A1 (en) 2015-06-17
US9457002B2 (en) 2016-10-04
AU2013299575B2 (en) 2017-11-16
WO2014025994A1 (en) 2014-02-13
ES2729968T3 (es) 2019-11-07
US20150196523A1 (en) 2015-07-16
CA2881361A1 (en) 2014-02-13
US9913820B2 (en) 2018-03-13
AU2013299575A1 (en) 2015-02-26
JP2015525801A (ja) 2015-09-07
JP6175140B2 (ja) 2017-08-02
DK2882433T3 (da) 2019-05-27
US20160374978A1 (en) 2016-12-29

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