CA2878729C - Improved apparatus and method for mineralising biological material - Google Patents
Improved apparatus and method for mineralising biological material Download PDFInfo
- Publication number
- CA2878729C CA2878729C CA2878729A CA2878729A CA2878729C CA 2878729 C CA2878729 C CA 2878729C CA 2878729 A CA2878729 A CA 2878729A CA 2878729 A CA2878729 A CA 2878729A CA 2878729 C CA2878729 C CA 2878729C
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- Prior art keywords
- mineralising
- agent
- probe
- operable
- biological material
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- 239000012620 biological material Substances 0.000 title claims abstract description 58
- 238000000034 method Methods 0.000 title abstract description 71
- 239000000523 sample Substances 0.000 claims abstract description 74
- 239000003795 chemical substances by application Substances 0.000 claims description 161
- 230000004044 response Effects 0.000 claims description 59
- 230000003750 conditioning effect Effects 0.000 claims description 38
- 102000004169 proteins and genes Human genes 0.000 claims description 29
- 108090000623 proteins and genes Proteins 0.000 claims description 29
- 210000001519 tissue Anatomy 0.000 claims description 29
- 150000002632 lipids Chemical class 0.000 claims description 18
- 238000012546 transfer Methods 0.000 claims description 16
- 210000000988 bone and bone Anatomy 0.000 claims description 11
- 230000004048 modification Effects 0.000 claims description 8
- 238000012986 modification Methods 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 6
- 239000007800 oxidant agent Substances 0.000 claims description 4
- 238000002604 ultrasonography Methods 0.000 abstract description 36
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 36
- 239000011575 calcium Substances 0.000 description 33
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 30
- 229910052791 calcium Inorganic materials 0.000 description 30
- 208000002925 dental caries Diseases 0.000 description 28
- 235000018102 proteins Nutrition 0.000 description 28
- 229910052500 inorganic mineral Inorganic materials 0.000 description 27
- 239000011707 mineral Substances 0.000 description 27
- 235000010755 mineral Nutrition 0.000 description 27
- 229910019142 PO4 Inorganic materials 0.000 description 25
- 239000010452 phosphate Substances 0.000 description 25
- 230000003902 lesion Effects 0.000 description 22
- 238000011282 treatment Methods 0.000 description 20
- 230000008569 process Effects 0.000 description 18
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 16
- 239000003623 enhancer Substances 0.000 description 14
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 13
- -1 hydroxyl ions Chemical class 0.000 description 12
- 239000002105 nanoparticle Substances 0.000 description 12
- 239000001506 calcium phosphate Substances 0.000 description 11
- 239000007864 aqueous solution Substances 0.000 description 10
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 10
- 239000000463 material Substances 0.000 description 10
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 9
- 229910000389 calcium phosphate Inorganic materials 0.000 description 9
- 235000011010 calcium phosphates Nutrition 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 8
- 229910001424 calcium ion Inorganic materials 0.000 description 8
- 239000005018 casein Substances 0.000 description 8
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 8
- 235000021240 caseins Nutrition 0.000 description 8
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 6
- 239000007844 bleaching agent Substances 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 210000004268 dentin Anatomy 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 238000010603 microCT Methods 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 235000011007 phosphoric acid Nutrition 0.000 description 5
- 102000035195 Peptidases Human genes 0.000 description 4
- 108091005804 Peptidases Proteins 0.000 description 4
- 108010001441 Phosphopeptides Proteins 0.000 description 4
- 239000005708 Sodium hypochlorite Substances 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- GUYBGCBOZOALMT-UHFFFAOYSA-J dicalcium;fluoride;phosphate Chemical compound [F-].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O GUYBGCBOZOALMT-UHFFFAOYSA-J 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 229910052587 fluorapatite Inorganic materials 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 4
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 4
- 229910052712 strontium Inorganic materials 0.000 description 4
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 230000033558 biomineral tissue development Effects 0.000 description 3
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 3
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 3
- 230000002950 deficient Effects 0.000 description 3
- 238000005115 demineralization Methods 0.000 description 3
- 210000004262 dental pulp cavity Anatomy 0.000 description 3
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 description 3
- 238000010191 image analysis Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 2
- 102000005593 Endopeptidases Human genes 0.000 description 2
- 108010059378 Endopeptidases Proteins 0.000 description 2
- 102000018389 Exopeptidases Human genes 0.000 description 2
- 108010091443 Exopeptidases Proteins 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 238000000029 amperostatic coulometry Methods 0.000 description 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 2
- 239000000920 calcium hydroxide Substances 0.000 description 2
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 2
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 230000003196 chaotropic effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 210000003298 dental enamel Anatomy 0.000 description 2
- 239000005548 dental material Substances 0.000 description 2
- 201000002170 dentin sensitivity Diseases 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 2
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 2
- 229940038472 dicalcium phosphate Drugs 0.000 description 2
- 229940066758 endopeptidases Drugs 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- 229940077441 fluorapatite Drugs 0.000 description 2
- 230000003301 hydrolyzing effect Effects 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000011368 organic material Substances 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 235000019833 protease Nutrition 0.000 description 2
- 230000011218 segmentation Effects 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 230000002123 temporal effect Effects 0.000 description 2
- YIGWVOWKHUSYER-UHFFFAOYSA-F tetracalcium;hydrogen phosphate;diphosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O YIGWVOWKHUSYER-UHFFFAOYSA-F 0.000 description 2
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 description 2
- 238000013271 transdermal drug delivery Methods 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- 229910001312 Amalgam (dentistry) Inorganic materials 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 241000195940 Bryophyta Species 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 208000029725 Metabolic bone disease Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 206010049088 Osteopenia Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 description 1
- 206010072665 Tooth demineralisation Diseases 0.000 description 1
- 230000001594 aberrant effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000012867 bioactive agent Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 238000000970 chrono-amperometry Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000000448 dental amalgam Substances 0.000 description 1
- 208000004042 dental fluorosis Diseases 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000008713 feedback mechanism Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
- 239000004137 magnesium phosphate Substances 0.000 description 1
- 229910000157 magnesium phosphate Inorganic materials 0.000 description 1
- 229960002261 magnesium phosphate Drugs 0.000 description 1
- 235000010994 magnesium phosphates Nutrition 0.000 description 1
- 238000007620 mathematical function Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 235000011929 mousse Nutrition 0.000 description 1
- 229910000392 octacalcium phosphate Inorganic materials 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000001205 potentiostatic coulometry Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000005316 response function Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C19/00—Dental auxiliary appliances
- A61C19/06—Implements for therapeutic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C1/00—Dental machines for boring or cutting ; General features of dental machines or apparatus, e.g. hand-piece design
- A61C1/0007—Control devices or systems
- A61C1/0015—Electrical systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
- A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/455—Phosphates containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4732—Casein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Dentistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medical Informatics (AREA)
- Dermatology (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Water Supply & Treatment (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Electrotherapy Devices (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
- Surgical Instruments (AREA)
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| GB1212222.2 | 2012-07-10 | ||
| GB201212222A GB201212222D0 (en) | 2012-07-10 | 2012-07-10 | Improved apparatus and method for mineralising biological materials |
| PCT/GB2013/000296 WO2014009682A2 (en) | 2012-07-10 | 2013-07-09 | Improved apparatus and method for mineralising biological material |
Publications (2)
| Publication Number | Publication Date |
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| CA2878729A1 CA2878729A1 (en) | 2014-01-16 |
| CA2878729C true CA2878729C (en) | 2022-05-17 |
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| CA2878729A Active CA2878729C (en) | 2012-07-10 | 2013-07-09 | Improved apparatus and method for mineralising biological material |
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| EP (1) | EP2872213A2 (enExample) |
| JP (1) | JP6548574B2 (enExample) |
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| BR (1) | BR112015000550B1 (enExample) |
| CA (1) | CA2878729C (enExample) |
| GB (1) | GB201212222D0 (enExample) |
| MX (1) | MX360251B (enExample) |
| WO (1) | WO2014009682A2 (enExample) |
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| US20160113745A1 (en) * | 2014-10-27 | 2016-04-28 | TCD Consulting LLC | Ultrasonic tooth cleaning apparatus and method |
| US20170189149A1 (en) * | 2014-10-27 | 2017-07-06 | TCD Consulting LLC | Ultrasonic tooth cleaning apparatus and method |
| EP3347081B1 (en) * | 2015-09-09 | 2020-03-04 | Revenio Research OY | Apparatus for delivery of substances into bone |
| EP3380436B1 (en) | 2015-11-25 | 2023-07-26 | Corning Incorporated | Porous silicon alloy compositions, methods for making them and devices thereof |
| US10797221B2 (en) * | 2017-02-24 | 2020-10-06 | Baker Hughes, A Ge Company, Llc | Method for manufacturing an assembly for an ultrasonic probe |
| CN108938131A (zh) * | 2018-06-08 | 2018-12-07 | 南京医科大学附属口腔医院 | 一种用于治疗牙本质敏感的试剂盒 |
| EP3991690A1 (en) | 2020-10-27 | 2022-05-04 | Koninklijke Philips N.V. | Tooth remineralization |
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| US3019787A (en) * | 1960-10-05 | 1962-02-06 | Joe J Simmons | Apparatus for electrolytic dental desensitization |
| JPS5935208Y2 (ja) * | 1976-03-24 | 1984-09-29 | ライオン株式会社 | 超音波振動体 |
| JPS5347192A (en) * | 1976-10-13 | 1978-04-27 | Matsushita Electric Industrial Co Ltd | Device for introducing fluorine ion to tooth |
| GB9610101D0 (en) * | 1996-05-15 | 1996-07-24 | Univ Dundee | Methods and apparatus for the detection of dental caries |
| AUPO566297A0 (en) * | 1997-03-13 | 1997-04-10 | University Of Melbourne, The | Calcium phosphopeptide complexes |
| DE19714167B4 (de) * | 1997-04-07 | 2010-01-28 | Hahn, Rainer, Dr. | Gerät zum Zuführen von Behandlungsmedium in Hartgewebe und Verwendung eines solchen |
| US6946142B2 (en) * | 2001-06-23 | 2005-09-20 | Lg Household & Healthcare Ltd. | Multi-layer patches for teeth whitening |
| US6801804B2 (en) * | 2002-05-03 | 2004-10-05 | Aciont, Inc. | Device and method for monitoring and controlling electrical resistance at a tissue site undergoing iontophoresis |
| CN1972642A (zh) * | 2004-07-09 | 2007-05-30 | 宝洁公司 | 口腔护理装置 |
| US20060008767A1 (en) * | 2004-07-09 | 2006-01-12 | The Procter & Gamble Company | Oral care devices |
| CN101115527A (zh) * | 2004-12-09 | 2008-01-30 | 帕洛玛医疗技术公司 | 具有传热机构的口腔器具 |
| CN101212924B (zh) * | 2005-05-03 | 2010-10-13 | 乌尔特里奥公司 | 采用声波导波管的口腔卫生装置 |
| PL2705826T3 (pl) | 2006-02-09 | 2020-11-02 | The University Of Melbourne | Kompozycja fluorku i sposoby mineralizacji zębów |
| US20090209899A1 (en) * | 2006-06-15 | 2009-08-20 | Harry Unger | Delivery system and process |
| BRPI0720183B1 (pt) * | 2006-12-05 | 2019-03-26 | Unilever N.V. | Produto para tratamento bucal, produto que compreende uma primeira composição e uso de uma primeira composição. |
| KR100870232B1 (ko) | 2006-12-07 | 2008-11-24 | 재단법인서울대학교산학협력재단 | 치아용 미백기능성 물질 전달시스템 |
| GB0807224D0 (en) * | 2008-04-21 | 2008-05-28 | Univ Dundee | Remineralisation of calcified tissue |
| GB0815051D0 (en) * | 2008-08-18 | 2008-09-24 | Univ Dundee | Apparatus and method for mineralising biological materials |
| US8795637B2 (en) | 2008-11-25 | 2014-08-05 | The Procter & Gamble Company | Oral care compositions with fused silica |
| JP2010155786A (ja) * | 2008-12-26 | 2010-07-15 | Nsp:Kk | 歯牙の再石灰化剤及び再石灰化方法 |
| US20120252046A1 (en) * | 2009-12-17 | 2012-10-04 | Bayer Healthcare Llc | Transdermal systems, devices, and methods for biological analysis |
| US9327105B2 (en) * | 2010-03-26 | 2016-05-03 | Itrace Biomedical Inc. | Active transdermal drug delivery system and the method thereof |
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2012
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- 2013-07-09 MX MX2015000375A patent/MX360251B/es active IP Right Grant
- 2013-07-09 BR BR112015000550-0A patent/BR112015000550B1/pt not_active IP Right Cessation
- 2013-07-09 EP EP13745153.0A patent/EP2872213A2/en not_active Ceased
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- 2013-07-09 WO PCT/GB2013/000296 patent/WO2014009682A2/en not_active Ceased
- 2013-07-09 CN CN201380046224.XA patent/CN104602756B/zh not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
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| CN104602756B (zh) | 2018-10-19 |
| WO2014009682A8 (en) | 2014-05-22 |
| US10076392B2 (en) | 2018-09-18 |
| CA2878729A1 (en) | 2014-01-16 |
| MX2015000375A (es) | 2015-11-23 |
| JP2015521931A (ja) | 2015-08-03 |
| BR112015000550B1 (pt) | 2021-07-27 |
| CN104602756A (zh) | 2015-05-06 |
| WO2014009682A3 (en) | 2014-03-20 |
| WO2014009682A2 (en) | 2014-01-16 |
| JP6548574B2 (ja) | 2019-07-24 |
| GB201212222D0 (en) | 2012-08-22 |
| US20150125808A1 (en) | 2015-05-07 |
| EP2872213A2 (en) | 2015-05-20 |
| BR112015000550A2 (pt) | 2018-02-06 |
| MX360251B (es) | 2018-10-26 |
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