CA2877578A1 - Pro-drug compounds - Google Patents
Pro-drug compounds Download PDFInfo
- Publication number
- CA2877578A1 CA2877578A1 CA2877578A CA2877578A CA2877578A1 CA 2877578 A1 CA2877578 A1 CA 2877578A1 CA 2877578 A CA2877578 A CA 2877578A CA 2877578 A CA2877578 A CA 2877578A CA 2877578 A1 CA2877578 A1 CA 2877578A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- benzopyran
- dihydro
- chloro
- acetyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- XLIIRNOPGJTBJD-ROUUACIJSA-N n-[(3s,4s)-6-acetyl-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-3-chloro-4-fluorobenzamide Chemical compound N([C@@H]1[C@H](O)C(C)(C)OC2=CC=C(C=C21)C(=O)C)C(=O)C1=CC=C(F)C(Cl)=C1 XLIIRNOPGJTBJD-ROUUACIJSA-N 0.000 claims description 33
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- WHRNULOCNSKMGB-UHFFFAOYSA-N tetrahydrofuran thf Chemical compound C1CCOC1.C1CCOC1 WHRNULOCNSKMGB-UHFFFAOYSA-N 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 229940034208 thyroxine Drugs 0.000 description 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
- C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1211788.3 | 2012-07-03 | ||
| GBGB1211788.3A GB201211788D0 (en) | 2012-07-03 | 2012-07-03 | Pro-drug compounds |
| GB1304812.9 | 2013-03-15 | ||
| GBGB1304812.9A GB201304812D0 (en) | 2013-03-15 | 2013-03-15 | Pro-drug compounds |
| PCT/GB2013/051767 WO2014006407A1 (en) | 2012-07-03 | 2013-07-03 | Pro-drug compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2877578A1 true CA2877578A1 (en) | 2014-01-09 |
Family
ID=48782540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2877578A Abandoned CA2877578A1 (en) | 2012-07-03 | 2013-07-03 | Pro-drug compounds |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20140011773A1 (en:Method) |
| EP (1) | EP2870148A1 (en:Method) |
| AU (1) | AU2013285164A1 (en:Method) |
| CA (1) | CA2877578A1 (en:Method) |
| IN (1) | IN2014DN10669A (en:Method) |
| WO (1) | WO2014006407A1 (en:Method) |
| ZA (1) | ZA201409213B (en:Method) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013285164A1 (en) | 2012-07-03 | 2015-01-22 | Proximagen Limited | Pro-drug compounds |
| GB201304814D0 (en) * | 2013-03-15 | 2013-05-01 | Proximagen Ltd | Pro-drug compounds |
| GB201322932D0 (en) * | 2013-12-23 | 2014-02-12 | Proximagen Ltd | Pro-drug compounds |
| GB201322934D0 (en) * | 2013-12-23 | 2014-02-12 | Proximagen Ltd | Prodrug compounds |
| CN107109410B (zh) * | 2014-08-22 | 2021-11-02 | 奥克兰联合服务有限公司 | 通道调节剂 |
| US11717506B2 (en) | 2019-05-07 | 2023-08-08 | The Johns Hopkins University | Neuroprotective compounds for amyotrophic lateral sclerosis |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3479726D1 (de) | 1983-05-18 | 1989-10-19 | Beecham Group Plc | Benzopyran derivatives. |
| EP0139992B1 (en) | 1983-09-01 | 1988-12-28 | Beecham Group Plc | Chromanol derivatives |
| EP0301713A3 (en) | 1987-07-07 | 1990-05-02 | Beecham Group Plc | Chroman derivatives for treatment of pulmonary hypertension |
| SG49907A1 (en) | 1992-12-11 | 1998-06-15 | Smithkline Beecham Corp | Pharmaceutical composition containing bicyclic type compounds |
| NZ258610A (en) | 1992-12-11 | 1997-05-26 | Smithkline Beecham Plc | Various 4-acylamino-2h-benzo[b]pyran-3-ol derivatives;use in preparation of medicaments |
| DE69532849T2 (de) | 1994-02-04 | 2005-04-28 | Smithkline Beecham Plc, Brentford | Verfahren zum Epoxidieren prochiraler Olefine |
| SG67930A1 (en) | 1994-06-10 | 1999-10-19 | Smithkline Beecham Plc | Benzopyrans and their use as therapeutic agents |
| GB9411635D0 (en) | 1994-06-10 | 1994-08-03 | Smithkline Beecham Plc | Novel treatment |
| GB9813949D0 (en) | 1998-06-29 | 1998-08-26 | Smithkline Beecham Plc | Novel compounds |
| US7619110B2 (en) | 2004-12-23 | 2009-11-17 | Xenoport, Inc. | Amino acid derived prodrugs of propofol, compositions, uses and crystalline forms thereof |
| EP2296646A2 (en) | 2008-06-05 | 2011-03-23 | Minster Research Limited | Novel treatments |
| MX2010013313A (es) | 2008-06-05 | 2011-05-30 | Minster Res Ltd | Tratamientos novedosos. |
| WO2011067607A1 (en) | 2009-12-03 | 2011-06-09 | Minster Research Ltd | Treatment of infectious diseases |
| WO2011067608A1 (en) | 2009-12-03 | 2011-06-09 | Minster Research Ltd | Treatment of allodynia and hyperalgesia |
| AU2013285164A1 (en) | 2012-07-03 | 2015-01-22 | Proximagen Limited | Pro-drug compounds |
| GB201304814D0 (en) | 2013-03-15 | 2013-05-01 | Proximagen Ltd | Pro-drug compounds |
-
2013
- 2013-07-03 AU AU2013285164A patent/AU2013285164A1/en not_active Abandoned
- 2013-07-03 EP EP13735378.5A patent/EP2870148A1/en not_active Withdrawn
- 2013-07-03 WO PCT/GB2013/051767 patent/WO2014006407A1/en active Application Filing
- 2013-07-03 US US13/934,665 patent/US20140011773A1/en not_active Abandoned
- 2013-07-03 CA CA2877578A patent/CA2877578A1/en not_active Abandoned
- 2013-07-03 US US14/410,234 patent/US9499510B2/en not_active Expired - Fee Related
- 2013-07-03 IN IN10669DEN2014 patent/IN2014DN10669A/en unknown
-
2014
- 2014-12-15 ZA ZA2014/09213A patent/ZA201409213B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013285164A1 (en) | 2015-01-22 |
| ZA201409213B (en) | 2016-07-27 |
| US20140011773A1 (en) | 2014-01-09 |
| IN2014DN10669A (en:Method) | 2015-08-28 |
| US20150322034A1 (en) | 2015-11-12 |
| EP2870148A1 (en) | 2015-05-13 |
| US9499510B2 (en) | 2016-11-22 |
| WO2014006407A1 (en) | 2014-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |
Effective date: 20180704 |