IN2014DN10669A - - Google Patents

Info

Publication number
IN2014DN10669A
IN2014DN10669A IN10669DEN2014A IN2014DN10669A IN 2014DN10669 A IN2014DN10669 A IN 2014DN10669A IN 10669DEN2014 A IN10669DEN2014 A IN 10669DEN2014A IN 2014DN10669 A IN2014DN10669 A IN 2014DN10669A
Authority
IN
India
Prior art keywords
compound
formula
pharmaceutically acceptable
acceptable salt
salt
Prior art date
Application number
Inventor
Edward Savory
Martyn Pritchard
Mike Ashwood
Original Assignee
Proximagen Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1211788.3A external-priority patent/GB201211788D0/en
Priority claimed from GBGB1304812.9A external-priority patent/GB201304812D0/en
Application filed by Proximagen Ltd filed Critical Proximagen Ltd
Publication of IN2014DN10669A publication Critical patent/IN2014DN10669A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A compound of formula (I), or a pharmaceutically acceptable salt thereof: wherein Z1, Z2, and Z , Q, R2, A, and R1 are as defined in the claims.
IN10669DEN2014 2012-07-03 2013-07-03 IN2014DN10669A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1211788.3A GB201211788D0 (en) 2012-07-03 2012-07-03 Pro-drug compounds
GBGB1304812.9A GB201304812D0 (en) 2013-03-15 2013-03-15 Pro-drug compounds
PCT/GB2013/051767 WO2014006407A1 (en) 2012-07-03 2013-07-03 Pro-drug compounds

Publications (1)

Publication Number Publication Date
IN2014DN10669A true IN2014DN10669A (en) 2015-08-28

Family

ID=48782540

Family Applications (1)

Application Number Title Priority Date Filing Date
IN10669DEN2014 IN2014DN10669A (en) 2012-07-03 2013-07-03

Country Status (7)

Country Link
US (2) US9499510B2 (en)
EP (1) EP2870148A1 (en)
AU (1) AU2013285164A1 (en)
CA (1) CA2877578A1 (en)
IN (1) IN2014DN10669A (en)
WO (1) WO2014006407A1 (en)
ZA (1) ZA201409213B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9499510B2 (en) 2012-07-03 2016-11-22 Proximagen Limited Pro-drug compounds
GB201304814D0 (en) * 2013-03-15 2013-05-01 Proximagen Ltd Pro-drug compounds
GB201322934D0 (en) * 2013-12-23 2014-02-12 Proximagen Ltd Prodrug compounds
GB201322932D0 (en) * 2013-12-23 2014-02-12 Proximagen Ltd Pro-drug compounds
CA2958879A1 (en) 2014-08-22 2016-02-25 Auckland Uniservices Limited Channel modulators
US11717506B2 (en) * 2019-05-07 2023-08-08 The Johns Hopkins University Neuroprotective compounds for amyotrophic lateral sclerosis

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3479726D1 (en) 1983-05-18 1989-10-19 Beecham Group Plc BENZOPYRAN DERIVATIVES.
EP0139992B1 (en) 1983-09-01 1988-12-28 Beecham Group Plc Chromanol derivatives
EP0301713A3 (en) 1987-07-07 1990-05-02 Beecham Group Plc Chroman derivatives for treatment of pulmonary hypertension
DE69327965T2 (en) 1992-12-11 2000-10-19 Smithkline Beecham Corp., Philadelphia PHARMACEUTICAL COMPILATION CONTAINING BIZYCLIC TYPE COMPOUNDS
AU679475B2 (en) 1992-12-11 1997-07-03 Smithkline Beecham Corporation Bicyclic compounds with pharmaceutical activity
PL315786A1 (en) 1994-02-04 1996-12-09 Smithkline Beecham Plc Method of epoxydising prochiral olefins, catalyst for use in this method and intermediate products for obtaining such catalyst
PT764157E (en) 1994-06-10 2002-06-28 Smithkline Beecham Plc BENZOPYRANES AND THEIR USE AS THERAPEUTIC AGENTS
GB9411635D0 (en) * 1994-06-10 1994-08-03 Smithkline Beecham Plc Novel treatment
GB9813949D0 (en) 1998-06-29 1998-08-26 Smithkline Beecham Plc Novel compounds
EP1844000B1 (en) 2004-12-23 2010-01-27 Xenoport, Inc. Serine amino acid derived prodrugs of propofol, compositions, uses and crystalline forms thereof
EP2296646A2 (en) 2008-06-05 2011-03-23 Minster Research Limited Novel treatments
EP2307004A1 (en) 2008-06-05 2011-04-13 Minster Research Limited Novel treatments
CN102770134A (en) 2009-12-03 2012-11-07 普罗克西梅根有限公司 Treatment of infectious diseases
AU2010325756A1 (en) 2009-12-03 2012-06-21 Proximagen Ltd Treatment of allodynia and hyperalgesia
US9499510B2 (en) 2012-07-03 2016-11-22 Proximagen Limited Pro-drug compounds
GB201304814D0 (en) 2013-03-15 2013-05-01 Proximagen Ltd Pro-drug compounds

Also Published As

Publication number Publication date
WO2014006407A1 (en) 2014-01-09
CA2877578A1 (en) 2014-01-09
US20140011773A1 (en) 2014-01-09
EP2870148A1 (en) 2015-05-13
US20150322034A1 (en) 2015-11-12
US9499510B2 (en) 2016-11-22
ZA201409213B (en) 2016-07-27
AU2013285164A1 (en) 2015-01-22

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