CA2877048A1 - Substituted hetero-azepinones - Google Patents

Info

Publication number

CA2877048A1

CA2877048A1 CA2877048A CA2877048A CA2877048A1 CA 2877048 A1 CA2877048 A1 CA 2877048A1 CA 2877048 A CA2877048 A CA 2877048A CA 2877048 A CA2877048 A CA 2877048A CA 2877048 A1 CA2877048 A1 CA 2877048A1

Authority

CA

Canada

Prior art keywords

alkyl

methyl

oxo

methylamino

aryl

Prior art date

2012-08-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 150000001875 compounds Chemical class 0.000 claims abstract description 302
• 206010028980 Neoplasm Diseases 0.000 claims abstract description 21
• 201000011510 cancer Diseases 0.000 claims abstract description 19
• 238000011282 treatment Methods 0.000 claims abstract description 17
• -1 polycyclic heteroaromatics Chemical class 0.000 claims description 286
• KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims description 140
• 125000003118 aryl group Chemical group 0.000 claims description 135
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 125
• 125000005605 benzo group Chemical group 0.000 claims description 115
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 110
• DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims description 100
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 87
• 229910052739 hydrogen Inorganic materials 0.000 claims description 85
• 125000005843 halogen group Chemical group 0.000 claims description 77
• 229910052731 fluorine Inorganic materials 0.000 claims description 54
• 125000002252 acyl group Chemical group 0.000 claims description 53
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 53
• 125000000623 heterocyclic group Chemical group 0.000 claims description 52
• 150000003839 salts Chemical class 0.000 claims description 49
• 125000001072 heteroaryl group Chemical group 0.000 claims description 42
• SOWBFZRMHSNYGE-UHFFFAOYSA-N Monoamide-Oxalic acid Natural products NC(=O)C(O)=O SOWBFZRMHSNYGE-UHFFFAOYSA-N 0.000 claims description 39
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 37
• 229910052799 carbon Inorganic materials 0.000 claims description 34
• 125000000217 alkyl group Chemical group 0.000 claims description 32
• QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 claims description 32
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 31
• 238000002360 preparation method Methods 0.000 claims description 30
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 26
• 239000001257 hydrogen Substances 0.000 claims description 26
• 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 25
• 125000003367 polycyclic group Chemical group 0.000 claims description 21
• 229940080818 propionamide Drugs 0.000 claims description 20
• 238000000034 method Methods 0.000 claims description 18
• 229910052757 nitrogen Inorganic materials 0.000 claims description 18
• 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims description 17
• 150000002431 hydrogen Chemical class 0.000 claims description 16
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 16
• 125000003545 alkoxy group Chemical group 0.000 claims description 15
• 125000004549 quinolin-4-yl group Chemical group N1=CC=C(C2=CC=CC=C12)* 0.000 claims description 15
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 15
• 125000001424 substituent group Chemical group 0.000 claims description 13
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 11
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 10
• 229910052760 oxygen Inorganic materials 0.000 claims description 9
• 229910052717 sulfur Inorganic materials 0.000 claims description 9
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 8
• 125000001624 naphthyl group Chemical group 0.000 claims description 8
• 238000011321 prophylaxis Methods 0.000 claims description 8
• 239000008194 pharmaceutical composition Substances 0.000 claims description 7
• 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 6
• 239000003814 drug Substances 0.000 claims description 6
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 5
• DNUGQDABWRSBDP-RJEJWSCMSA-N 6-methoxy-5-[[(3s)-3-[[(2s)-2-(methylamino)propanoyl]amino]-4-oxospiro[3h-1,5-benzoxazepine-2,4'-oxane]-5-yl]methyl]naphthalene-2-carboxylic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.O=C([C@H]1NC(=O)[C@H](C)NC)N(CC=2C3=CC=C(C=C3C=CC=2OC)C(O)=O)C2=CC=CC=C2OC11CCOCC1 DNUGQDABWRSBDP-RJEJWSCMSA-N 0.000 claims description 4
• BMBANPOHPFKVTA-UHFFFAOYSA-N benzamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.NC(=O)C1=CC=CC=C1 BMBANPOHPFKVTA-UHFFFAOYSA-N 0.000 claims description 4
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 4
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 4
• QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 claims description 3
• XEVHDYXWAWPUBT-QNNMEKCMSA-N 6-methoxy-5-[[(3s)-3-[[(2s)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]naphthalene-2-carboxylic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.O=C1[C@@H](NC(=O)[C@H](C)NC)COC2=CC=CC=C2N1CC1=C(OC)C=CC2=CC(C(O)=O)=CC=C12 XEVHDYXWAWPUBT-QNNMEKCMSA-N 0.000 claims description 3
• SZPWXAOBLNYOHY-UHFFFAOYSA-N [C]1=CC=NC2=CC=CC=C12 Chemical group [C]1=CC=NC2=CC=CC=C12 SZPWXAOBLNYOHY-UHFFFAOYSA-N 0.000 claims description 3
• 239000013543 active substance Substances 0.000 claims description 3
• 125000005842 heteroatom Chemical group 0.000 claims description 3
• BWRGUZDODPWMOB-ZOEDVAEJSA-N (2s)-2-(methylamino)-n-[(3s)-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-9-(trifluoromethyl)-2,3-dihydro-1,5-benzoxazepin-3-yl]propanamide;hydrochloride Chemical compound Cl.CC=1C=CC2=CC=CC=C2C=1CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)COC2=C1C=CC=C2C(F)(F)F BWRGUZDODPWMOB-ZOEDVAEJSA-N 0.000 claims description 2
• XVRXCRGYPZBSBD-KKSFZXQISA-N methyl 6-methoxy-5-[[(3s)-3-[[(2s)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]naphthalene-2-carboxylate Chemical compound O=C1[C@@H](NC(=O)[C@H](C)NC)COC2=CC=CC=C2N1CC1=C(OC)C=CC2=CC(C(=O)OC)=CC=C12 XVRXCRGYPZBSBD-KKSFZXQISA-N 0.000 claims description 2
• 125000006299 oxetan-3-yl group Chemical group [H]C1([H])OC([H])([H])C1([H])* 0.000 claims description 2
• 125000000896 monocarboxylic acid group Chemical group 0.000 claims 8
• 125000004043 oxo group Chemical group O=* 0.000 claims 4
• RAHZWNYVWXNFOC-UHFFFAOYSA-N sulfur dioxide Inorganic materials O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 claims 4
• 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
• YHYBLFYAIRQTQG-WYCLLJLCSA-N (2S)-N-[(3R)-5-[[2-(difluoromethoxy)naphthalen-1-yl]methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide hydrochloride Chemical compound Cl.FC(OC1=C(C2=CC=CC=C2C=C1)CN1C2=C(OC3([C@H](C1=O)NC([C@H](C)NC)=O)CCOCC3)C=CC=C2)F YHYBLFYAIRQTQG-WYCLLJLCSA-N 0.000 claims 1
• KPKSKMHWRZUNQJ-AUALFVNHSA-N (2r)-n-[(3s)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-2,2-dimethyl-4-oxo-3h-1,5-benzothiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Chemical compound Cl.C12=CC=CC=C2SC(C)(C)[C@@H](NC(=O)[C@@H](C)NC)C(=O)N1CC1=C(OC)C=CC2=CC(Br)=CC=C12 KPKSKMHWRZUNQJ-AUALFVNHSA-N 0.000 claims 1
• PMTGJZLNFRQBBN-UWJYYQICSA-N (2s)-2-(methylamino)-n-[(3s)-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]propanamide Chemical compound O=C1[C@@H](NC(=O)[C@H](C)NC)COC2=CC=CC=C2N1CC1=C(C)C=CC2=CC=CC=C12 PMTGJZLNFRQBBN-UWJYYQICSA-N 0.000 claims 1
• LNMFEBUCTRGDLI-XRZIKPEHSA-N (2s)-2-(methylamino)-n-[1,1,4-trioxo-5-(4-phenylbutyl)-2,3-dihydro-1$l^{6},5-benzothiazepin-3-yl]propanamide;hydrochloride Chemical compound Cl.O=C1C(NC(=O)[C@H](C)NC)CS(=O)(=O)C2=CC=CC=C2N1CCCCC1=CC=CC=C1 LNMFEBUCTRGDLI-XRZIKPEHSA-N 0.000 claims 1
• JWDWSWYEQALIBS-LPVSMQOSSA-N (2s)-2-(methylamino)-n-[4-oxo-5-[(3-phenylphenyl)methyl]-2,3-dihydro-1,5-benzothiazepin-3-yl]propanamide;hydrochloride Chemical compound Cl.O=C1C(NC(=O)[C@H](C)NC)CSC2=CC=CC=C2N1CC(C=1)=CC=CC=1C1=CC=CC=C1 JWDWSWYEQALIBS-LPVSMQOSSA-N 0.000 claims 1
• AGIOLCPUBSPMLM-UWJYYQICSA-N (2s)-2-amino-n-[(3s)-5-[[1-(2-cyanophenyl)indazol-3-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]propanamide Chemical compound C([C@@H](C1=O)NC(=O)[C@@H](N)C)OC2=CC=CC=C2N1CC(C1=CC=CC=C11)=NN1C1=CC=CC=C1C#N AGIOLCPUBSPMLM-UWJYYQICSA-N 0.000 claims 1
• IDIOSLWBPCKHDR-HBYWCBEISA-N (2s)-n-(5-benzyl-1,1,4-trioxo-2,3-dihydro-1$l^{6},5-benzothiazepin-3-yl)-2-(methylamino)propanamide;hydrochloride Chemical compound Cl.O=C1C(NC(=O)[C@H](C)NC)CS(=O)(=O)C2=CC=CC=C2N1CC1=CC=CC=C1 IDIOSLWBPCKHDR-HBYWCBEISA-N 0.000 claims 1
• XQHYGDOJDYACHI-HBYWCBEISA-N (2s)-n-(5-benzyl-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl)-2-(methylamino)propanamide;hydrochloride Chemical compound Cl.O=C1C(NC(=O)[C@H](C)NC)CSC2=CC=CC=C2N1CC1=CC=CC=C1 XQHYGDOJDYACHI-HBYWCBEISA-N 0.000 claims 1
• UCPNNXHSWNEGMJ-IKULFRCJSA-N (2s)-n-[(2s,3s)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-2,8-dimethyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.O=C1[C@@H](NC(=O)[C@H](C)NC)[C@H](C)OC2=CC(C)=CC=C2N1CC1=C(OC)C=CC2=CC(Br)=CC=C12 UCPNNXHSWNEGMJ-IKULFRCJSA-N 0.000 claims 1
• YELONRPULJTYQX-DYRPNGKOSA-N (2s)-n-[(2s,3s)-5-[[1-(2-cyanophenyl)indazol-3-yl]methyl]-2-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(ethylamino)propanamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.O([C@@H](C)[C@@H](C1=O)NC(=O)[C@H](C)NCC)C2=CC=CC=C2N1CC(C1=CC=CC=C11)=NN1C1=CC=CC=C1C#N YELONRPULJTYQX-DYRPNGKOSA-N 0.000 claims 1
• SHNZFKCUMBXLLA-LPBFERMMSA-N (2s)-n-[(2s,3s)-5-[[2-cyano-1-(2-cyanophenyl)indol-3-yl]methyl]-2-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(ethylamino)propanamide Chemical compound O([C@@H](C)[C@@H](C1=O)NC(=O)[C@H](C)NCC)C2=CC=CC=C2N1CC(C1=CC=CC=C11)=C(C#N)N1C1=CC=CC=C1C#N SHNZFKCUMBXLLA-LPBFERMMSA-N 0.000 claims 1
• ZMVUSVSRGQJRHC-SGHJWQDXSA-N (2s)-n-[(2s,3s)-5-[[2-cyano-1-(2-cyanophenyl)indol-3-yl]methyl]-2-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Chemical compound O([C@@H](C)[C@@H](C1=O)NC(=O)[C@H](C)NC)C2=CC=CC=C2N1CC(C1=CC=CC=C11)=C(C#N)N1C1=CC=CC=C1C#N ZMVUSVSRGQJRHC-SGHJWQDXSA-N 0.000 claims 1
• QTAWNOXGLQMROR-QMTYFTJSSA-N (2s)-n-[(3r)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-8,9-difluoro-4-oxospiro[3h-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide Chemical compound O=C([C@@H]1NC(=O)[C@H](C)NC)N(CC=2C3=CC=C(Br)C=C3C=CC=2OC)C2=CC=C(F)C(F)=C2OC11CCOCC1 QTAWNOXGLQMROR-QMTYFTJSSA-N 0.000 claims 1
• XGAFAULUGFKPHN-HOFKKMOUSA-N (2s)-n-[(3r)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-9-fluoro-4-oxospiro[3h-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)butanamide Chemical compound O=C([C@@H]1NC(=O)[C@@H](NC)CC)N(CC=2C3=CC=C(Br)C=C3C=CC=2OC)C2=CC=CC(F)=C2OC11CCOCC1 XGAFAULUGFKPHN-HOFKKMOUSA-N 0.000 claims 1
• MXULZNXDARNAFL-QLXKLKPCSA-N (2s)-n-[(3r)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-9-fluoro-4-oxospiro[3h-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide Chemical compound O=C([C@@H]1NC(=O)[C@H](C)NC)N(CC=2C3=CC=C(Br)C=C3C=CC=2OC)C2=CC=CC(F)=C2OC11CCOCC1 MXULZNXDARNAFL-QLXKLKPCSA-N 0.000 claims 1
• BQBDDHDYHVMPRZ-URAOTHONSA-N (2s)-n-[(3r)-5-[[2-cyano-1-(2-cyanophenyl)indol-3-yl]methyl]-2,2-dimethyl-4-oxo-3h-1,5-benzothiazepin-3-yl]-2-(ethylamino)propanamide Chemical compound O=C([C@H](C(SC1=CC=CC=C11)(C)C)NC(=O)[C@H](C)NCC)N1CC(C1=CC=CC=C11)=C(C#N)N1C1=CC=CC=C1C#N BQBDDHDYHVMPRZ-URAOTHONSA-N 0.000 claims 1
• ASSRMYVHRGCEJC-RIAYWLAYSA-N (2s)-n-[(3r)-9-[[2-(2-methoxyethoxy)acetyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Chemical compound Cl.O=C1[C@@H](NC(=O)[C@H](C)NC)CSC2=C(NC(=O)COCCOC)C=CC=C2N1CC1=CC=CC2=CC=CC=C12 ASSRMYVHRGCEJC-RIAYWLAYSA-N 0.000 claims 1
• RRRZHUQUSBVQNZ-QNNMEKCMSA-N (2s)-n-[(3r)-9-amino-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Chemical compound Cl.O=C1[C@@H](NC(=O)[C@H](C)NC)CSC2=C(N)C=CC=C2N1CC1=CC=CC2=CC=CC=C12 RRRZHUQUSBVQNZ-QNNMEKCMSA-N 0.000 claims 1
• JFRHIUWPOYUWIZ-MIRNQTQTSA-N (2s)-n-[(3s)-5-(1,2-benzoxazol-3-ylmethyl)-4-oxo-9-(trifluoromethyl)-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Chemical compound Cl.N=1OC2=CC=CC=C2C=1CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)COC2=C1C=CC=C2C(F)(F)F JFRHIUWPOYUWIZ-MIRNQTQTSA-N 0.000 claims 1
• RSDSFJJWCNSGER-JXVZSMLKSA-N (2s)-n-[(3s)-5-(1,2-benzoxazol-3-ylmethyl)-4-oxospiro[3h-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide;hydrochloride Chemical compound Cl.O=C([C@H]1NC(=O)[C@H](C)NC)N(CC=2C3=CC=CC=C3ON=2)C2=CC=CC=C2OC11CCOCC1 RSDSFJJWCNSGER-JXVZSMLKSA-N 0.000 claims 1
• FJKGNKQMJJKBRW-YJBOKZPZSA-N (2s)-n-[(3s)-5-[(1-ethyl-2-oxo-3h-indol-4-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Chemical compound CCN1C(=O)CC2=C1C=CC=C2CN1C2=CC=CC=C2OC[C@H](NC(=O)[C@H](C)NC)C1=O FJKGNKQMJJKBRW-YJBOKZPZSA-N 0.000 claims 1
• GIKBDINPWKIYJA-BBRMVZONSA-N (2s)-n-[(3s)-5-[(2-chlorophenyl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Chemical compound C([C@@H](C1=O)NC(=O)[C@H](C)NC)OC2=CC=CC=C2N1CC1=CC=CC=C1Cl GIKBDINPWKIYJA-BBRMVZONSA-N 0.000 claims 1
• PQRLHLPVCHREAB-BBRMVZONSA-N (2s)-n-[(3s)-5-[(3-chlorophenyl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Chemical compound C([C@@H](C1=O)NC(=O)[C@H](C)NC)OC2=CC=CC=C2N1CC1=CC=CC(Cl)=C1 PQRLHLPVCHREAB-BBRMVZONSA-N 0.000 claims 1
• VLWUWJOMYZATBO-FNZWTVRRSA-N (2s)-n-[(3s)-5-[(4-bromonaphthalen-1-yl)methyl]-9-[4-(2-hydroxyethyl)piperazine-1-carbonyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Chemical compound C([C@@H](C(N1CC=2C3=CC=CC=C3C(Br)=CC=2)=O)NC(=O)[C@H](C)NC)OC2=C1C=CC=C2C(=O)N1CCN(CCO)CC1 VLWUWJOMYZATBO-FNZWTVRRSA-N 0.000 claims 1
• FTLFWECWQDBFNU-IDISGSTGSA-N (2s)-n-[(3s)-5-[(4-bromonaphthalen-1-yl)methyl]-9-[4-(3-hydroxypropyl)piperazine-1-carbonyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Chemical compound C([C@@H](C(N1CC=2C3=CC=CC=C3C(Br)=CC=2)=O)NC(=O)[C@H](C)NC)OC2=C1C=CC=C2C(=O)N1CCN(CCCO)CC1 FTLFWECWQDBFNU-IDISGSTGSA-N 0.000 claims 1
• NZGXRNHLIKDWHR-BBRMVZONSA-N (2s)-n-[(3s)-5-[(4-chlorophenyl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Chemical compound C([C@@H](C1=O)NC(=O)[C@H](C)NC)OC2=CC=CC=C2N1CC1=CC=C(Cl)C=C1 NZGXRNHLIKDWHR-BBRMVZONSA-N 0.000 claims 1
• KSFINHMSJUNSAO-VROPFNGYSA-N (2s)-n-[(3s)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(2-hydroxyethylamino)butanamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.O=C1[C@@H](NC(=O)[C@@H](NCCO)CC)COC2=CC=CC=C2N1CC1=C(OC)C=CC2=CC(Br)=CC=C12 KSFINHMSJUNSAO-VROPFNGYSA-N 0.000 claims 1
• PYGNINGYNZYWBV-GUTACTQSSA-N (2s)-n-[(3s)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)butanamide;hydrochloride Chemical compound Cl.O=C1[C@@H](NC(=O)[C@@H](NC)CC)COC2=CC=CC=C2N1CC1=C(OC)C=CC2=CC(Br)=CC=C12 PYGNINGYNZYWBV-GUTACTQSSA-N 0.000 claims 1
• GGXKCOCFMZACLS-QNNMEKCMSA-N (2s)-n-[(3s)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.O=C1[C@@H](NC(=O)[C@H](C)NC)COC2=CC=CC=C2N1CC1=C(OC)C=CC2=CC(Br)=CC=C12 GGXKCOCFMZACLS-QNNMEKCMSA-N 0.000 claims 1
• OBDDSOJZRSMWMC-NRGKXMCZSA-N (2s)-n-[(3s)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxo-7-(trifluoromethyl)-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.O=C1[C@@H](NC(=O)[C@H](C)NC)COC2=CC=C(C(F)(F)F)C=C2N1CC1=C(OC)C=CC2=CC(Br)=CC=C12 OBDDSOJZRSMWMC-NRGKXMCZSA-N 0.000 claims 1
• UQAZLIYWFGWOKP-NRGKXMCZSA-N (2s)-n-[(3s)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxo-9-(trifluoromethyl)-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Chemical compound Cl.COC=1C=CC2=CC(Br)=CC=C2C=1CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)COC2=C1C=CC=C2C(F)(F)F UQAZLIYWFGWOKP-NRGKXMCZSA-N 0.000 claims 1
• IXLKSKYSBRKVBV-SHVSPDIESA-N (2s)-n-[(3s)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3h-1,5-benzoxazepine-2,1'-cyclohexane]-3-yl]-2-(methylamino)propanamide;hydrochloride Chemical compound Cl.O=C([C@H]1NC(=O)[C@H](C)NC)N(CC=2C3=CC=C(Br)C=C3C=CC=2OC)C2=CC=CC=C2OC11CCCCC1 IXLKSKYSBRKVBV-SHVSPDIESA-N 0.000 claims 1
• UFSIJETWBAPLMM-UZTOHYMASA-N (2s)-n-[(3s)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3h-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(2-hydroxyethylamino)propanamide Chemical compound COC1=CC=C2C=C(Br)C=CC2=C1CN(C([C@H]1NC(=O)[C@H](C)NCCO)=O)C2=CC=CC=C2OC21CCOCC2 UFSIJETWBAPLMM-UZTOHYMASA-N 0.000 claims 1
• POHXLIGBDVISNP-SOSFJDLHSA-N (2s)-n-[(3s)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3h-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(trideuteriomethylamino)propanamide;hydrochloride Chemical compound Cl.O=C([C@H]1NC(=O)[C@H](C)NC([2H])([2H])[2H])N(CC=2C3=CC=C(Br)C=C3C=CC=2OC)C2=CC=CC=C2OC11CCOCC1 POHXLIGBDVISNP-SOSFJDLHSA-N 0.000 claims 1
• WONACKBJIGSDAN-WNCULLNHSA-N (2s)-n-[(3s)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-8-fluoro-4-oxospiro[3h-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)butanamide Chemical compound O=C([C@H]1NC(=O)[C@@H](NC)CC)N(CC=2C3=CC=C(Br)C=C3C=CC=2OC)C2=CC=C(F)C=C2OC11CCOCC1 WONACKBJIGSDAN-WNCULLNHSA-N 0.000 claims 1
• TWMNYKOLSDMFBC-MRDQGFSESA-N (2s)-n-[(3s)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-8-fluoro-4-oxospiro[3h-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide Chemical compound O=C([C@H]1NC(=O)[C@H](C)NC)N(CC=2C3=CC=C(Br)C=C3C=CC=2OC)C2=CC=C(F)C=C2OC11CCOCC1 TWMNYKOLSDMFBC-MRDQGFSESA-N 0.000 claims 1
• PSXAZFWBGYDPBQ-NRGKXMCZSA-N (2s)-n-[(3s)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-9-fluoro-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Chemical compound Cl.O=C1[C@@H](NC(=O)[C@H](C)NC)COC2=C(F)C=CC=C2N1CC1=C(OC)C=CC2=CC(Br)=CC=C12 PSXAZFWBGYDPBQ-NRGKXMCZSA-N 0.000 claims 1
• XGAFAULUGFKPHN-WNCULLNHSA-N (2s)-n-[(3s)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-9-fluoro-4-oxospiro[3h-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)butanamide Chemical compound O=C([C@H]1NC(=O)[C@@H](NC)CC)N(CC=2C3=CC=C(Br)C=C3C=CC=2OC)C2=CC=CC(F)=C2OC11CCOCC1 XGAFAULUGFKPHN-WNCULLNHSA-N 0.000 claims 1
• MXULZNXDARNAFL-MRDQGFSESA-N (2s)-n-[(3s)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-9-fluoro-4-oxospiro[3h-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide Chemical compound O=C([C@H]1NC(=O)[C@H](C)NC)N(CC=2C3=CC=C(Br)C=C3C=CC=2OC)C2=CC=CC(F)=C2OC11CCOCC1 MXULZNXDARNAFL-MRDQGFSESA-N 0.000 claims 1
• PMDXADUCFFKNBG-KSSFIOAISA-N (2s)-n-[(3s)-5-[(6-fluoro-1-methyl-2-oxoquinolin-4-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Chemical compound O=C1[C@@H](NC(=O)[C@H](C)NC)COC2=CC=CC=C2N1CC1=CC(=O)N(C)C2=CC=C(F)C=C12 PMDXADUCFFKNBG-KSSFIOAISA-N 0.000 claims 1
• HCSLWAKAKAIBTE-ZOEDVAEJSA-N (2s)-n-[(3s)-5-[(7-bromo-3-methoxynaphthalen-2-yl)methyl]-8-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.O=C1[C@@H](NC(=O)[C@H](C)NC)COC2=CC(C)=CC=C2N1CC1=CC2=CC(Br)=CC=C2C=C1OC HCSLWAKAKAIBTE-ZOEDVAEJSA-N 0.000 claims 1
• FJBROFACOLBQCW-MBSDFSHPSA-N (2s)-n-[(3s)-5-[[1-(2-cyanophenyl)-6-fluoroindazol-3-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(ethylamino)propanamide Chemical compound C([C@@H](C1=O)NC(=O)[C@H](C)NCC)OC2=CC=CC=C2N1CC(C1=CC=C(F)C=C11)=NN1C1=CC=CC=C1C#N FJBROFACOLBQCW-MBSDFSHPSA-N 0.000 claims 1
• FOYTWIGWFDGUIA-UPEFVECSSA-N (2s)-n-[(3s)-5-[[1-(2-cyanophenyl)indazol-3-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(1,1,2,2,2-pentadeuterioethylamino)propanamide Chemical compound C([C@@H](C1=O)NC(=O)[C@H](C)NC([2H])([2H])C([2H])([2H])[2H])OC2=CC=CC=C2N1CC(C1=CC=CC=C11)=NN1C1=CC=CC=C1C#N FOYTWIGWFDGUIA-UPEFVECSSA-N 0.000 claims 1
• MIJCTPVXXYDPMK-CVDCTZTESA-N (2s)-n-[(3s)-5-[[1-(2-cyanophenyl)indazol-3-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(2-hydroxyethylamino)propanamide Chemical compound C([C@@H](C1=O)NC(=O)[C@@H](NCCO)C)OC2=CC=CC=C2N1CC(C1=CC=CC=C11)=NN1C1=CC=CC=C1C#N MIJCTPVXXYDPMK-CVDCTZTESA-N 0.000 claims 1
• PGJMPWDEKYBAAZ-CYFREDJKSA-N (2s)-n-[(3s)-5-[[1-(2-cyanophenyl)indazol-3-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(oxetan-3-ylamino)propanamide Chemical compound N([C@@H](C)C(=O)N[C@@H]1C(N(CC=2C3=CC=CC=C3N(C=3C(=CC=CC=3)C#N)N=2)C2=CC=CC=C2OC1)=O)C1COC1 PGJMPWDEKYBAAZ-CYFREDJKSA-N 0.000 claims 1
• CHTDNPIBDHVSHN-RDPSFJRHSA-N (2s)-n-[(3s)-5-[[1-(2-cyanophenyl)indazol-3-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-[(2-hydroxy-2-methylpropyl)amino]propanamide Chemical compound C([C@@H](C1=O)NC(=O)[C@@H](NCC(C)(C)O)C)OC2=CC=CC=C2N1CC(C1=CC=CC=C11)=NN1C1=CC=CC=C1C#N CHTDNPIBDHVSHN-RDPSFJRHSA-N 0.000 claims 1
• YDIPFRDEORVQAS-KCWXNJEJSA-N (2s)-n-[(3s)-5-[[1-(2-cyanophenyl)indazol-3-yl]methyl]-4-oxospiro[3h-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide Chemical compound O=C([C@H](C1(CCOCC1)OC1=CC=CC=C11)NC(=O)[C@H](C)NC)N1CC(C1=CC=CC=C11)=NN1C1=CC=CC=C1C#N YDIPFRDEORVQAS-KCWXNJEJSA-N 0.000 claims 1
• XVSPJSXQUDWMJL-CVDCTZTESA-N (2s)-n-[(3s)-5-[[1-(2-cyanophenyl)indol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Chemical compound C([C@@H](C1=O)NC(=O)[C@H](C)NC)OC2=CC=CC=C2N1CC(C=1C=C2)=CC=CC=1N2C1=CC=CC=C1C#N XVSPJSXQUDWMJL-CVDCTZTESA-N 0.000 claims 1
• OWLACGCWCXSYAA-AVRDEDQJSA-N (2s)-n-[(3s)-5-[[1-(benzenesulfonyl)-2-chloroindol-3-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Chemical compound C([C@@H](C1=O)NC(=O)[C@H](C)NC)OC2=CC=CC=C2N1CC(C1=CC=CC=C11)=C(Cl)N1S(=O)(=O)C1=CC=CC=C1 OWLACGCWCXSYAA-AVRDEDQJSA-N 0.000 claims 1
• NNTKWKIMKMYXDE-COBSGTNCSA-N (2s)-n-[(3s)-5-[[1-(benzenesulfonyl)-2-chloroindol-3-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Chemical compound Cl.C([C@@H](C1=O)NC(=O)[C@H](C)NC)OC2=CC=CC=C2N1CC(C1=CC=CC=C11)=C(Cl)N1S(=O)(=O)C1=CC=CC=C1 NNTKWKIMKMYXDE-COBSGTNCSA-N 0.000 claims 1
• YHYBLFYAIRQTQG-CDAQVASYSA-N (2s)-n-[(3s)-5-[[2-(difluoromethoxy)naphthalen-1-yl]methyl]-4-oxospiro[3h-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide;hydrochloride Chemical compound Cl.O=C([C@H]1NC(=O)[C@H](C)NC)N(CC=2C3=CC=CC=C3C=CC=2OC(F)F)C2=CC=CC=C2OC11CCOCC1 YHYBLFYAIRQTQG-CDAQVASYSA-N 0.000 claims 1
• IHVOEWKFQHMHHV-AVRDEDQJSA-N (2s)-n-[(3s)-5-[[2-chloro-1-(2-cyanophenyl)indol-3-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Chemical compound C([C@@H](C1=O)NC(=O)[C@H](C)NC)OC2=CC=CC=C2N1CC(C1=CC=CC=C11)=C(Cl)N1C1=CC=CC=C1C#N IHVOEWKFQHMHHV-AVRDEDQJSA-N 0.000 claims 1
• HAYDMSLHIKTULD-ZWHLOQRUSA-N (2s)-n-[(3s)-5-[[2-cyano-1-(2-cyanophenyl)indol-3-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C([C@@H](C1=O)NC(=O)[C@H](C)NC)OC2=CC=CC=C2N1CC(C1=CC=CC=C11)=C(C#N)N1C1=CC=CC=C1C#N HAYDMSLHIKTULD-ZWHLOQRUSA-N 0.000 claims 1
• CWXNEODDUDWHDU-WKRVVKTRSA-N (2s)-n-[(3s)-5-[[2-cyano-1-(2-cyanophenyl)indol-3-yl]methyl]-4-oxospiro[3h-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide Chemical compound O=C([C@H](C1(CCOCC1)OC1=CC=CC=C11)NC(=O)[C@H](C)NC)N1CC(C1=CC=CC=C11)=C(C#N)N1C1=CC=CC=C1C#N CWXNEODDUDWHDU-WKRVVKTRSA-N 0.000 claims 1
• ZMJBDMKLOKFUNJ-MXNNDABQSA-N (2s)-n-[(3s)-8-bromo-5-[[1-(2-cyanophenyl)indazol-3-yl]methyl]-4-oxospiro[3h-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.O=C([C@H](C1(CCOCC1)OC1=CC(Br)=CC=C11)NC(=O)[C@H](C)NC)N1CC(C1=CC=CC=C11)=NN1C1=CC=CC=C1C#N ZMJBDMKLOKFUNJ-MXNNDABQSA-N 0.000 claims 1
• LNLNIMBNEDGMAL-JBGRJTRNSA-N (2s)-n-[(3s)-8-cyano-5-[[1-(2-cyanophenyl)indazol-3-yl]methyl]-4-oxospiro[3h-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.O=C([C@H](C1(CCOCC1)OC1=CC(=CC=C11)C#N)NC(=O)[C@H](C)NC)N1CC(C1=CC=CC=C11)=NN1C1=CC=CC=C1C#N LNLNIMBNEDGMAL-JBGRJTRNSA-N 0.000 claims 1
• QZEFMDYLLZEKEG-XJVRPQCWSA-N (2s,3r)-2-amino-n-[(3s)-5-[(7-bromo-3-methoxynaphthalen-2-yl)methyl]-8-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-3-hydroxybutanamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.COC1=CC2=CC=C(Br)C=C2C=C1CN1C2=CC=C(C)C=C2OC[C@H](NC(=O)[C@@H](N)[C@@H](C)O)C1=O QZEFMDYLLZEKEG-XJVRPQCWSA-N 0.000 claims 1
• MTZXIAIZCKUTPJ-ZNHLNBOCSA-N (2s,3s)-2-amino-n-[(2s,3s)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-2,8-dimethyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-3-hydroxybutanamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.COC1=CC=C2C=C(Br)C=CC2=C1CN1C2=CC=C(C)C=C2O[C@@H](C)[C@H](NC(=O)[C@@H](N)[C@H](C)O)C1=O MTZXIAIZCKUTPJ-ZNHLNBOCSA-N 0.000 claims 1
• QZEFMDYLLZEKEG-AMWQFRPASA-N (2s,3s)-2-amino-n-[(3s)-5-[(7-bromo-3-methoxynaphthalen-2-yl)methyl]-8-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-3-hydroxybutanamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.COC1=CC2=CC=C(Br)C=C2C=C1CN1C2=CC=C(C)C=C2OC[C@H](NC(=O)[C@@H](N)[C@H](C)O)C1=O QZEFMDYLLZEKEG-AMWQFRPASA-N 0.000 claims 1
• BLBSANONMVYAIK-NRGKXMCZSA-N (3s)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-3-[[(2s)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepine-9-carboxylic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.COC=1C=CC2=CC(Br)=CC=C2C=1CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)COC2=C1C=CC=C2C(O)=O BLBSANONMVYAIK-NRGKXMCZSA-N 0.000 claims 1
• IXRBQTFZRUOBFE-NRGKXMCZSA-N (3s)-5-[(6-carboxy-2-methoxynaphthalen-1-yl)methyl]-3-[[(2s)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepine-9-carboxylic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.COC=1C=CC2=CC(C(O)=O)=CC=C2C=1CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)COC2=C1C=CC=C2C(O)=O IXRBQTFZRUOBFE-NRGKXMCZSA-N 0.000 claims 1
• LYSWNDFUEAGSOY-DCFHFQCYSA-N 1-acetyl-n-[(3r)-3-[[(2s)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]piperidine-4-carboxamide Chemical compound C([C@@H](C(N(CC=1C2=CC=CC=C2C=CC=1)C1=CC=C2)=O)NC(=O)[C@H](C)NC)SC1=C2NC(=O)C1CCN(C(C)=O)CC1 LYSWNDFUEAGSOY-DCFHFQCYSA-N 0.000 claims 1
• RCQFDAMHGMCSFG-UHFFFAOYSA-N 2-(4-methylindol-1-yl)benzonitrile Chemical compound C1=CC=2C(C)=CC=CC=2N1C1=CC=CC=C1C#N RCQFDAMHGMCSFG-UHFFFAOYSA-N 0.000 claims 1
• GMEVWRNNKLKAQK-QDMMYLPHSA-N 3,4,5-trimethoxy-n-[(3r)-3-[[(2s)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]benzamide;hydrochloride Chemical compound Cl.C([C@@H](C(N(CC=1C2=CC=CC=C2C=CC=1)C1=CC=C2)=O)NC(=O)[C@H](C)NC)SC1=C2NC(=O)C1=CC(OC)=C(OC)C(OC)=C1 GMEVWRNNKLKAQK-QDMMYLPHSA-N 0.000 claims 1
• MPBPQSWNZLSBFW-VPRHZQQDSA-N 3-[[(3s)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-3-[[(2s)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepine-9-carbonyl]amino]propanoic acid;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.COC=1C=CC2=CC(Br)=CC=C2C=1CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)COC2=C1C=CC=C2C(=O)NCCC(O)=O MPBPQSWNZLSBFW-VPRHZQQDSA-N 0.000 claims 1
• PXXOAXMZDDMIBF-FXXKCHFVSA-N 3-cyano-4-[3-[[(2S,3S)-2-methyl-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]indazol-1-yl]benzoic acid 2,2,2-trifluoroacetic acid Chemical compound FC(C(=O)O)(F)F.C(#N)C=1C=C(C(=O)O)C=CC1N1N=C(C2=CC=CC=C12)CN1C2=C(O[C@H]([C@@H](C1=O)NC([C@H](C)NC)=O)C)C=CC=C2 PXXOAXMZDDMIBF-FXXKCHFVSA-N 0.000 claims 1
• HHTAFBNBMVLKDJ-SHVSPDIESA-N 6-methoxy-5-[[(3s)-3-[[(2s)-2-(methylamino)propanoyl]amino]-4-oxospiro[3h-1,5-benzoxazepine-2,4'-oxane]-5-yl]methyl]-n-methylsulfonylnaphthalene-2-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.O=C([C@H]1NC(=O)[C@H](C)NC)N(CC=2C3=CC=C(C=C3C=CC=2OC)C(=O)NS(C)(=O)=O)C2=CC=CC=C2OC11CCOCC1 HHTAFBNBMVLKDJ-SHVSPDIESA-N 0.000 claims 1
• AMMRZWVVBRQWKK-ZLLYMXMVSA-N 6-methoxy-n,n-dimethyl-7-[[(3s)-3-[[(2s)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]naphthalene-2-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.O=C1[C@@H](NC(=O)[C@H](C)NC)COC2=CC=CC=C2N1CC1=CC2=CC(C(=O)N(C)C)=CC=C2C=C1OC AMMRZWVVBRQWKK-ZLLYMXMVSA-N 0.000 claims 1
• BLONQRBSZCSXHN-MMTVBGGISA-N methyl 4-[[[(3s)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-3-[[(2s)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepine-9-carbonyl]amino]methyl]benzoate Chemical compound C([C@@H](C(N1CC=2C3=CC=C(Br)C=C3C=CC=2OC)=O)NC(=O)[C@H](C)NC)OC2=C1C=CC=C2C(=O)NCC1=CC=C(C(=O)OC)C=C1 BLONQRBSZCSXHN-MMTVBGGISA-N 0.000 claims 1
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