CA2875331C - Methods for diagnosing chronic valvular disease - Google Patents

Methods for diagnosing chronic valvular disease Download PDF

Info

Publication number
CA2875331C
CA2875331C CA2875331A CA2875331A CA2875331C CA 2875331 C CA2875331 C CA 2875331C CA 2875331 A CA2875331 A CA 2875331A CA 2875331 A CA2875331 A CA 2875331A CA 2875331 C CA2875331 C CA 2875331C
Authority
CA
Canada
Prior art keywords
sample
amount
valvular disease
metabolite
animal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2875331A
Other languages
English (en)
French (fr)
Other versions
CA2875331A1 (en
Inventor
Qinghong LI
Dorothy P. Laflamme
Steven S. Hannah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe des Produits Nestle SA
Original Assignee
Societe des Produits Nestle SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe des Produits Nestle SA filed Critical Societe des Produits Nestle SA
Publication of CA2875331A1 publication Critical patent/CA2875331A1/en
Application granted granted Critical
Publication of CA2875331C publication Critical patent/CA2875331C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G01N33/5758—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/326—Arrhythmias, e.g. ventricular fibrillation, tachycardia, atrioventricular block, torsade de pointes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/16—Phosphorus containing
    • Y10T436/163333—Organic [e.g., chemical warfare agents, insecticides, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/200833—Carbonyl, ether, aldehyde or ketone containing
    • Y10T436/201666—Carboxylic acid

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Ecology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
CA2875331A 2012-06-05 2013-06-04 Methods for diagnosing chronic valvular disease Active CA2875331C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261655704P 2012-06-05 2012-06-05
US61/655,704 2012-06-05
PCT/US2013/044008 WO2013184628A1 (en) 2012-06-05 2013-06-04 Methods for diagnosing chronic valvular disease

Publications (2)

Publication Number Publication Date
CA2875331A1 CA2875331A1 (en) 2013-12-12
CA2875331C true CA2875331C (en) 2022-11-29

Family

ID=48626663

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2875331A Active CA2875331C (en) 2012-06-05 2013-06-04 Methods for diagnosing chronic valvular disease

Country Status (12)

Country Link
US (1) US20150153353A1 (enExample)
EP (1) EP2856170B1 (enExample)
JP (1) JP6174689B2 (enExample)
CN (1) CN104364658B (enExample)
AU (1) AU2013271879B2 (enExample)
BR (1) BR112014030243B1 (enExample)
CA (1) CA2875331C (enExample)
ES (1) ES2687979T3 (enExample)
IN (1) IN2014DN10127A (enExample)
MX (1) MX358561B (enExample)
RU (1) RU2667634C2 (enExample)
WO (1) WO2013184628A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10184932B2 (en) * 2015-12-07 2019-01-22 Zora Biosciences Oy Use of ceramides and LPLs in diagnosing CVD

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060257943A1 (en) * 2005-01-25 2006-11-16 Cis Biotech, Inc. Ischemic biomarkers and their use to predict adverse neurological events from surgery
EP2164977B1 (en) * 2007-07-17 2013-10-30 Metabolon, Inc. Biomarkers for pre-diabetes and methods using the same
CA2705325C (en) * 2007-11-09 2016-11-01 The Board Of Regents Of The University Of Texas System Micro-rnas of the mir-15 family modulate cardiomyocyte survival and cardiac repair
EP2283358B1 (en) * 2008-04-29 2015-04-22 Immunexcite, Inc. Immunomodulating compositions and methods of use thereof
PL2271933T3 (pl) * 2008-05-07 2013-05-31 Univ Strathclyde System i sposób charakteryzowania komórek
RU2011135768A (ru) * 2009-01-29 2013-03-10 Эбботт Лэборетриз Белки, связывающие il-1
MX2013000917A (es) * 2010-07-23 2013-07-05 Harvard College Metodos para detectar las enfermedades o condiciones usando celulas fagociticas.

Also Published As

Publication number Publication date
ES2687979T3 (es) 2018-10-30
RU2014153109A (ru) 2016-08-10
JP6174689B2 (ja) 2017-08-02
MX2014014791A (es) 2015-02-24
CN104364658B (zh) 2017-06-30
AU2013271879B2 (en) 2019-03-28
RU2667634C2 (ru) 2018-09-21
CA2875331A1 (en) 2013-12-12
WO2013184628A1 (en) 2013-12-12
AU2013271879A1 (en) 2014-12-18
IN2014DN10127A (enExample) 2015-08-21
BR112014030243B1 (pt) 2022-07-05
US20150153353A1 (en) 2015-06-04
EP2856170B1 (en) 2018-07-25
BR112014030243A2 (pt) 2017-06-27
MX358561B (es) 2018-08-24
JP2015524066A (ja) 2015-08-20
CN104364658A (zh) 2015-02-18
EP2856170A1 (en) 2015-04-08

Similar Documents

Publication Publication Date Title
Chen et al. Metabolome analysis for investigating host-gut microbiota interactions
Maniscalco et al. Clinical metabolomics of exhaled breath condensate in chronic respiratory diseases
Bouatra et al. The human urine metabolome
Snowden et al. Application of metabolomics approaches to the study of respiratory diseases
AU2014265669B2 (en) Biomarkers related to kidney function and methods using the same
US20050101023A1 (en) Methods for diagnosing urinary tract and prostatic disorders
Kouremenos et al. Metabolic profiling of infant urine using comprehensive two-dimensional gas chromatography: application to the diagnosis of organic acidurias and biomarker discovery
German et al. Serum biomarkers for Alzheimer's disease: proteomic discovery
US20140235503A1 (en) Prediction method of glomerular filtration rate from urine samples after kidney transplantation
Lind et al. The use of mass spectrometry for analysing metabolite biomarkers in epidemiology: methodological and statistical considerations for application to large numbers of biological samples
Vogl et al. Evaluation of dilution and normalization strategies to correct for urinary output in HPLC-HRTOFMS metabolomics
US20150056605A1 (en) Identification of blood based metabolite biomarkers of pancreatic cancer
US20200173996A1 (en) Device for diagnosing colorectal cancer and method for providing colorectal cancer diagnosis information
US20150276764A1 (en) Determining disease states using biomarker profiles
Krishnan et al. Circulating metabolite biomarkers: A game changer in the human prostate cancer diagnosis
Deda et al. GC-MS-based metabolic phenotyping
CN109946411B (zh) 用于胸椎黄韧带骨化诊断的生物标记物及其筛选方法
JP2011085427A (ja) 代謝物の異常度の取得方法、代謝異常の判定方法、及びそのプログラム、並びに、代謝物の異常度の取得装置、及び代謝異常の判定に基づく診断プログラム
US20240352542A1 (en) Means and methods for diagnosing a viral infection or a disease associated therewith
CA2875331C (en) Methods for diagnosing chronic valvular disease
Chekmeneva et al. Development of nanoelectrospray high resolution isotope dilution mass spectrometry for targeted quantitative analysis of urinary metabolites: application to population profiling and clinical studies
JP2009020037A (ja) メタボローム解析による同定方法、薬物代謝物の同定方法、およびこれらのスクリーニング方法
Creech et al. Mass spectrometry-based approaches for clinical biomarker discovery in traumatic brain injury
Li et al. A simple dilute and shoot approach incorporated with pentafluorophenyl (PFP) column based LC-MS/MS assay for the simultaneous determination of trimethylamine N-oxide and trimethylamine in spot urine samples with high throughput
Kiyonami et al. Selected reaction monitoring applied to quantitative proteomics

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180530

EEER Examination request

Effective date: 20180530

EEER Examination request

Effective date: 20180530

EEER Examination request

Effective date: 20180530