CA2874860C - Pharmaceutical combinations of a cdk4/6 inhibitor and a b-raf inhibitor - Google Patents
Pharmaceutical combinations of a cdk4/6 inhibitor and a b-raf inhibitor Download PDFInfo
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- CA2874860C CA2874860C CA2874860A CA2874860A CA2874860C CA 2874860 C CA2874860 C CA 2874860C CA 2874860 A CA2874860 A CA 2874860A CA 2874860 A CA2874860 A CA 2874860A CA 2874860 C CA2874860 C CA 2874860C
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| EP2976106B1 (en) | 2013-03-21 | 2021-04-14 | Array BioPharma Inc. | Combination therapy comprising a b-raf inhibitor and a second inhibitor |
| EP3236948A4 (en) * | 2014-12-23 | 2018-10-03 | Millennium Pharmaceuticals, Inc. | Combination of raf inhibitors and aurora kinase inhibitors |
| US10323035B2 (en) * | 2015-04-01 | 2019-06-18 | Crystal Pharmatech Co., Ltd. | Co-crystal of a CDK inhibitor and an MEK inhibitor and process of preparation thereof |
| CN105753869B (zh) * | 2015-04-01 | 2018-09-25 | 苏州晶云药物科技有限公司 | 一种cdk抑制剂和mek抑制剂的共晶及其制备方法 |
| WO2017037574A1 (en) * | 2015-08-28 | 2017-03-09 | Novartis Ag | Combinations of the cdk4/6 inhibitor lee011 and the mek1/2 inhibitor trametinib, optionally further comprising the pi3k inhibitor byl719 to treat cancer |
| CN105732642B (zh) * | 2015-11-18 | 2018-09-25 | 苏州晶云药物科技有限公司 | 一种cdk抑制剂和mek抑制剂的共晶及其制备方法 |
| RU2759669C2 (ru) * | 2016-06-03 | 2021-11-16 | Аррэй Байофарма Инк. | Фармацевтические комбинации |
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| WO2018081211A1 (en) * | 2016-10-26 | 2018-05-03 | Li George Y | Deuterated 7-cyclopentyl-n, n-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7h-pyrrolo[2,3-d]pyrimdine-6-carboxamide |
| US11395821B2 (en) | 2017-01-30 | 2022-07-26 | G1 Therapeutics, Inc. | Treatment of EGFR-driven cancer with fewer side effects |
| CN110494166B (zh) * | 2017-05-02 | 2022-11-08 | 诺华股份有限公司 | 组合疗法 |
| WO2018218633A1 (en) | 2017-06-02 | 2018-12-06 | Beijing Percans Oncology Co. Ltd. | Combination therapies for treating cancers |
| EP3738084A4 (en) | 2018-01-08 | 2021-11-17 | G1 Therapeutics, Inc. | G1T38 SUPERIOR DOSAGE RATES |
| US11174252B2 (en) | 2018-02-15 | 2021-11-16 | Nuvation Bio Inc. | Heterocyclic compounds as kinase inhibitors |
| WO2019195959A1 (en) * | 2018-04-08 | 2019-10-17 | Cothera Biosciences, Inc. | Combination therapy for cancers with braf mutation |
| WO2020010280A1 (en) * | 2018-07-06 | 2020-01-09 | Memorial Sloan Kettering Cancer Center | Combination therapy with mek inhibitor and cdk4/6 inhibitor to treat pancreatic cancer |
| AU2019407159A1 (en) * | 2018-12-20 | 2021-07-15 | Novartis Ag | Combination therapy with a Raf inhibitor and a CKD4/6 inhibitor for use in the treatment of cancer |
| AU2020276695A1 (en) | 2019-05-13 | 2021-12-23 | Novartis Ag | New crystalline forms of N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2 (trifluoromethyl)isonicotinamide as Raf inhibitors for the treatment of cancer |
| WO2021047573A1 (zh) * | 2019-09-11 | 2021-03-18 | 江苏恒瑞医药股份有限公司 | 一种mek抑制剂与cdk4/6抑制剂联合在制备治疗肿瘤的药物中的用途 |
| KR102836833B1 (ko) | 2019-12-10 | 2025-07-22 | 에프. 호프만-라 로슈 아게 | 신규 메틸퀴나졸리논 유도체 |
| CN115551509A (zh) * | 2020-05-12 | 2022-12-30 | 诺华股份有限公司 | 包含craf抑制剂的治疗组合 |
| WO2023230554A1 (en) | 2022-05-25 | 2023-11-30 | Pfizer Inc. | Combination of a braf inhibitor, an egfr inhibitor, and a pd-1 antagonist for the treatment of braf v600e-mutant, msi-h/dmmr colorectal cancer |
| WO2025003956A1 (en) | 2023-06-30 | 2025-01-02 | Pfizer Inc. | High drug loading formulations of encorafenib |
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|---|---|
| US20150164897A1 (en) | 2015-06-18 |
| MX360045B (es) | 2018-10-19 |
| WO2014018725A1 (en) | 2014-01-30 |
| RU2015106524A (ru) | 2016-09-20 |
| KR102113363B1 (ko) | 2020-05-21 |
| IN2015DN00376A (en:Method) | 2015-06-12 |
| JO3776B1 (ar) | 2021-01-31 |
| EP2877174A1 (en) | 2015-06-03 |
| EP2877174B1 (en) | 2020-01-01 |
| KR20150036146A (ko) | 2015-04-07 |
| CA2874860A1 (en) | 2014-01-30 |
| AU2013295771B2 (en) | 2016-08-11 |
| US9700557B2 (en) | 2017-07-11 |
| AR091876A1 (es) | 2015-03-04 |
| AU2013295771A1 (en) | 2014-12-11 |
| HK1210721A1 (en) | 2016-05-06 |
| BR112014033118A8 (pt) | 2023-01-31 |
| CN104507474A (zh) | 2015-04-08 |
| TWI599357B (zh) | 2017-09-21 |
| MX2015001122A (es) | 2015-04-08 |
| BR112014033118A2 (pt) | 2017-06-27 |
| RU2685250C2 (ru) | 2019-04-17 |
| CN104507474B (zh) | 2018-01-02 |
| JP2015523397A (ja) | 2015-08-13 |
| JP6320379B2 (ja) | 2018-05-09 |
| TW201412316A (zh) | 2014-04-01 |
| ES2778059T3 (es) | 2020-08-07 |
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