CA2874860C - Pharmaceutical combinations of a cdk4/6 inhibitor and a b-raf inhibitor - Google Patents
Pharmaceutical combinations of a cdk4/6 inhibitor and a b-raf inhibitor Download PDFInfo
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- CA2874860C CA2874860C CA2874860A CA2874860A CA2874860C CA 2874860 C CA2874860 C CA 2874860C CA 2874860 A CA2874860 A CA 2874860A CA 2874860 A CA2874860 A CA 2874860A CA 2874860 C CA2874860 C CA 2874860C
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Landscapes
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| PCT/US2013/051990 WO2014018725A1 (en) | 2012-07-26 | 2013-07-25 | Pharmaceutical combinations of a cdk4/6 inhibitor and a b-raf inhibitor |
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| WO2014097125A1 (en) * | 2012-12-20 | 2014-06-26 | Novartis Ag | Pharmaceutical combination comprising binimetinib |
| EP3696276A1 (en) * | 2013-02-25 | 2020-08-19 | Novartis AG | Novel androgen receptor mutation |
| NZ712184A (en) | 2013-03-21 | 2020-01-31 | Array Biopharma Inc | Combination therapy comprising a b-raf inhibitor and a second inhibitor |
| CA2972076A1 (en) * | 2014-12-23 | 2016-06-30 | Millennium Pharmaceuticals, Inc. | Combination of raf inhibitors and aurora kinase inhibitors |
| CN105753869B (zh) * | 2015-04-01 | 2018-09-25 | 苏州晶云药物科技有限公司 | 一种cdk抑制剂和mek抑制剂的共晶及其制备方法 |
| US10323035B2 (en) * | 2015-04-01 | 2019-06-18 | Crystal Pharmatech Co., Ltd. | Co-crystal of a CDK inhibitor and an MEK inhibitor and process of preparation thereof |
| EP3340991A1 (en) * | 2015-08-28 | 2018-07-04 | Novartis AG | Combinations of the cdk4/6 inhibitor lee011 and the mek1/2 inhibitor trametinib, optionally further comprising the pi3k inhibitor byl719 to treat cancer |
| CN105732642B (zh) * | 2015-11-18 | 2018-09-25 | 苏州晶云药物科技有限公司 | 一种cdk抑制剂和mek抑制剂的共晶及其制备方法 |
| CR20190002A (es) * | 2016-06-03 | 2019-06-10 | Zhu Alexander Cao | Combinaciones farmacéuticas |
| BR112019003722A2 (pt) * | 2016-08-23 | 2019-05-28 | Eisai R&D Man Co Ltd | terapias de combinação para o tratamento de carcinoma hepatocelular |
| US10973829B2 (en) * | 2016-09-19 | 2021-04-13 | Novartis Ag | Therapeutic uses of a C-RAF inhibitor |
| WO2018081211A1 (en) * | 2016-10-26 | 2018-05-03 | Li George Y | Deuterated 7-cyclopentyl-n, n-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7h-pyrrolo[2,3-d]pyrimdine-6-carboxamide |
| US11395821B2 (en) | 2017-01-30 | 2022-07-26 | G1 Therapeutics, Inc. | Treatment of EGFR-driven cancer with fewer side effects |
| DK3618875T3 (da) * | 2017-05-02 | 2023-07-10 | Novartis Ag | Kombinationsterapi omfattende en raf-inhibitor og trametinib |
| WO2018218633A1 (en) | 2017-06-02 | 2018-12-06 | Beijing Percans Oncology Co. Ltd. | Combination therapies for treating cancers |
| KR20200108867A (ko) | 2018-01-08 | 2020-09-21 | 쥐원 쎄라퓨틱스, 인크. | G1t38 우수한 투여 요법 |
| KR20200131246A (ko) | 2018-02-15 | 2020-11-23 | 누베이션 바이오 인크. | 키나제 억제제로서의 헤테로시클릭 화합물 |
| WO2019195959A1 (en) * | 2018-04-08 | 2019-10-17 | Cothera Biosciences, Inc. | Combination therapy for cancers with braf mutation |
| US11633401B2 (en) * | 2018-07-06 | 2023-04-25 | Memorial Sloan Kettering Cancer Center | Combination therapy with MEK inhibitor and CDK4/6 inhibitor to treat pancreatic cancer |
| BR112021011699A2 (pt) * | 2018-12-20 | 2021-09-08 | Novartis Ag | Terapia de combinação com um inibidor de raf e um inibidor de cdk4/6 para uso no tratamento contra câncer |
| US12187703B2 (en) | 2019-05-13 | 2025-01-07 | Novartis Ag | Crystalline forms of N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2 (trifluoromethyl)isonicotinamide as Raf inhibitors for the treatment of cancer |
| WO2021047573A1 (zh) * | 2019-09-11 | 2021-03-18 | 江苏恒瑞医药股份有限公司 | 一种mek抑制剂与cdk4/6抑制剂联合在制备治疗肿瘤的药物中的用途 |
| DK4073065T3 (da) | 2019-12-10 | 2025-04-22 | Hoffmann La Roche | Hidtil ukendte methylquinazolinonderivativer |
| EP4149472A1 (en) * | 2020-05-12 | 2023-03-22 | Novartis AG | Therapeutic combinations comprising a craf inhibitor |
| WO2023230554A1 (en) | 2022-05-25 | 2023-11-30 | Pfizer Inc. | Combination of a braf inhibitor, an egfr inhibitor, and a pd-1 antagonist for the treatment of braf v600e-mutant, msi-h/dmmr colorectal cancer |
| WO2025003956A1 (en) | 2023-06-30 | 2025-01-02 | Pfizer Inc. | High drug loading formulations of encorafenib |
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| US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| CN100519539C (zh) * | 2002-03-13 | 2009-07-29 | 阵列生物制药公司 | 作为mek抑制剂的n3烷基化苯并咪唑衍生物 |
| BRPI0509580A (pt) | 2004-03-30 | 2007-11-27 | Pfizer Prod Inc | combinações de inibidores de transdução de sinal |
| JP2011527703A (ja) | 2008-07-11 | 2011-11-04 | ノバルティス アーゲー | （ａ）ホスホイノシタイド３−キナーゼ阻害剤および（ｂ）Ｒａｓ／Ｒａｆ／Ｍｅｋ経路のモジュレーターの配合物 |
| JO2924B1 (en) * | 2008-08-22 | 2015-09-15 | نوفارتيس ايه جي | Pyroloperimidine compounds and their uses |
| JO3002B1 (ar) * | 2009-08-28 | 2016-09-05 | Irm Llc | مركبات و تركيبات كمثبطات كيناز بروتين |
| CN102869358B (zh) * | 2010-04-13 | 2016-03-23 | 诺华股份有限公司 | 用于治疗癌症的包含细胞周期蛋白依赖性激酶4或细胞周期蛋白依赖性激酶6(CDK4/6)抑制剂和mTOR抑制剂的组合 |
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- 2013-07-25 TW TW102126726A patent/TWI599357B/zh active
- 2013-07-25 KR KR1020157001594A patent/KR102113363B1/ko active Active
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| RU2685250C2 (ru) | 2019-04-17 |
| KR20150036146A (ko) | 2015-04-07 |
| HK1210721A1 (en) | 2016-05-06 |
| EP2877174A1 (en) | 2015-06-03 |
| AU2013295771B2 (en) | 2016-08-11 |
| IN2015DN00376A (en:Method) | 2015-06-12 |
| CN104507474B (zh) | 2018-01-02 |
| JP2015523397A (ja) | 2015-08-13 |
| EP2877174B1 (en) | 2020-01-01 |
| AU2013295771A1 (en) | 2014-12-11 |
| JP6320379B2 (ja) | 2018-05-09 |
| RU2015106524A (ru) | 2016-09-20 |
| MX2015001122A (es) | 2015-04-08 |
| US20150164897A1 (en) | 2015-06-18 |
| TW201412316A (zh) | 2014-04-01 |
| TWI599357B (zh) | 2017-09-21 |
| CN104507474A (zh) | 2015-04-08 |
| BR112014033118A2 (pt) | 2017-06-27 |
| KR102113363B1 (ko) | 2020-05-21 |
| BR112014033118A8 (pt) | 2023-01-31 |
| CA2874860A1 (en) | 2014-01-30 |
| MX360045B (es) | 2018-10-19 |
| US9700557B2 (en) | 2017-07-11 |
| JO3776B1 (ar) | 2021-01-31 |
| ES2778059T3 (es) | 2020-08-07 |
| AR091876A1 (es) | 2015-03-04 |
| WO2014018725A1 (en) | 2014-01-30 |
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