CA2872528C - Cannabis plant isolate comprising .delta.9-tetrahydrocannabinol and a method for preparing such an isolate - Google Patents

Cannabis plant isolate comprising .delta.9-tetrahydrocannabinol and a method for preparing such an isolate Download PDF

Info

Publication number
CA2872528C
CA2872528C CA2872528A CA2872528A CA2872528C CA 2872528 C CA2872528 C CA 2872528C CA 2872528 A CA2872528 A CA 2872528A CA 2872528 A CA2872528 A CA 2872528A CA 2872528 C CA2872528 C CA 2872528C
Authority
CA
Canada
Prior art keywords
thc
weight
dry matter
cannabis plant
isolate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2872528A
Other languages
English (en)
French (fr)
Other versions
CA2872528A1 (en
Inventor
Maria Vanesa Fernandez Cid
Dennis VAN HOUTEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Echo Pharmaceuticals BV
Original Assignee
Echo Pharmaceuticals BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Echo Pharmaceuticals BV filed Critical Echo Pharmaceuticals BV
Publication of CA2872528A1 publication Critical patent/CA2872528A1/en
Application granted granted Critical
Publication of CA2872528C publication Critical patent/CA2872528C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
CA2872528A 2012-05-03 2013-05-03 Cannabis plant isolate comprising .delta.9-tetrahydrocannabinol and a method for preparing such an isolate Active CA2872528C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12166661.4 2012-05-03
EP12166661 2012-05-03
PCT/NL2013/050339 WO2013165251A1 (en) 2012-05-03 2013-05-03 Cannabis plant isolate comprising /\9-tetrahydrocannabinol and a method for preparing such an isolate

Publications (2)

Publication Number Publication Date
CA2872528A1 CA2872528A1 (en) 2013-11-07
CA2872528C true CA2872528C (en) 2021-01-05

Family

ID=48468725

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2872528A Active CA2872528C (en) 2012-05-03 2013-05-03 Cannabis plant isolate comprising .delta.9-tetrahydrocannabinol and a method for preparing such an isolate

Country Status (13)

Country Link
US (1) US20150126754A1 (OSRAM)
EP (1) EP2844243B8 (OSRAM)
JP (1) JP2015515977A (OSRAM)
CN (1) CN104619318A (OSRAM)
AU (1) AU2013257322A1 (OSRAM)
CA (1) CA2872528C (OSRAM)
DK (1) DK2844243T3 (OSRAM)
ES (1) ES2769794T3 (OSRAM)
IN (1) IN2014DN09507A (OSRAM)
PL (1) PL2844243T3 (OSRAM)
PT (1) PT2844243T (OSRAM)
SI (1) SI2844243T1 (OSRAM)
WO (1) WO2013165251A1 (OSRAM)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9155767B2 (en) 2012-10-18 2015-10-13 Andrew D. Hospodor Essential element management
BR112015020332A2 (pt) 2013-02-28 2017-07-18 Full Spectrum Laboratories Ltd processos de engenharia química e aparelhos para a síntese de compostos
GB2536150A (en) * 2013-11-11 2016-09-07 The Werc Shop Llc Solvent-free processing, system and methods
CA2942867C (en) * 2014-03-18 2022-08-30 Izun Pharmaceuticals Corp. Protein-bound cannabinoid compositions
US20160000843A1 (en) * 2014-07-01 2016-01-07 MJAR Holdings, LLC High cannabidiol cannabis strains
CN106922153B (zh) 2014-08-25 2018-11-02 蒂威诺特科技有限公司 用于大麻素化合物的同时生产的设备和方法
US9730911B2 (en) * 2014-10-21 2017-08-15 United Cannabis Corp. Cannabis extracts and methods of preparing and using same
US9808494B2 (en) * 2015-01-22 2017-11-07 Rm3 Labs, Llc Process for the extraction of cannabinoids from cannabis using lipids as an extraction solvent
WO2016123475A1 (en) * 2015-01-31 2016-08-04 Constance Therapeutics, Inc. Methods for preparation of cannabis oil extracts and compositions
US10238745B2 (en) 2015-01-31 2019-03-26 Constance Therapeutics, Inc. Cannabinoid composition and products including α-tocopherol
US10059684B2 (en) 2015-05-07 2018-08-28 Axim Biotechnologies, Inc. Process to extract and purify Δ9-tetrahydrocannabinol
CA2985332C (en) * 2015-05-18 2023-01-03 5071, Inc. Homogenous cannabis compositions and methods of making the same
WO2016205923A1 (en) * 2015-06-25 2016-12-29 Compressed Perforated Puck Technologies Inc. Ingestible plant source pill and method
EP3150264A1 (de) * 2015-09-30 2017-04-05 Bionorica Ethics GmbH Vakuumdestillation zur anreicherung von cbd
IL299047A (en) 2015-11-24 2023-02-01 Constance Therapeutics Inc Cannabis fat preparations and methods for their preparation
WO2017180707A1 (en) 2016-04-12 2017-10-19 Schaneville Scott Ingestible films having substances from hemp or cannabis
ES2946991T3 (es) * 2016-04-18 2023-07-31 Gene Pool Tech Inc Aislamiento de extractos de plantas
WO2017185038A1 (en) 2016-04-22 2017-10-26 Receptor Life Sciences Fast-acting plant-based medicinal compounds and nutritional supplements
US10499584B2 (en) 2016-05-27 2019-12-10 New West Genetics Industrial hemp Cannabis cultivars and seeds with stable cannabinoid profiles
PT3474844T (pt) 2016-06-28 2022-11-08 Trichomeshell Ltd Uma forma de dosagem para ser vaporizada e fumada
AU2017290107A1 (en) * 2016-06-29 2019-01-17 CannScience Innovations Inc. Decarboxylated cannabis resins, uses thereof and methods of making same
KR20210013645A (ko) 2016-08-03 2021-02-04 젤다 테라퓨틱스 오퍼레이션즈 피티와이 엘티디 카나비스 조성물
JP2019523282A (ja) * 2016-08-03 2019-08-22 ゼルダ セラピューティクス オペレーションズ ピーティーワイ リミテッド 大麻組成物
KR102447510B1 (ko) * 2016-08-03 2022-09-27 젤리라 테라퓨틱스 오퍼레이션즈 피티와이 엘티디 카나비스 조성물
IL248150B (en) * 2016-09-29 2018-05-31 Garti Nissim Method for selective extraction of cannabinoids from a plant source
IL248148B (en) 2016-09-29 2021-09-30 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd A method for extracting a compound from plant origin
IL248149B (en) 2016-09-29 2020-03-31 Garti Nissim Formulations of dilutable cannabinoids and processes for their preparation
EA201892396A1 (ru) 2016-12-02 2019-04-30 Ресептор Лайф Сайенсиз, Инк. Быстродействующие растительные лекарственные соединения и биологически активные добавки
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
US10773184B2 (en) 2016-12-30 2020-09-15 X Traxion, Llc Extraction of compounds from cannabis
CA3055692A1 (en) 2017-03-09 2018-09-13 Izun Pharmaceuticals Corp. Stabilized protein-bound cannabinoid compositions
US10034907B1 (en) 2017-04-07 2018-07-31 Gerald Echavarry Flavored and edible cannabinoid composition and method of manufacturing
US11759724B2 (en) 2017-04-18 2023-09-19 Jose Rivas Method and apparatus for preparation of pharmacologically-relevant compounds from botanical sources
US10828341B2 (en) * 2017-04-18 2020-11-10 Jose Rivas Method for preparation of pharmacologically-relevant compounds from botanical sources
US11845022B2 (en) 2017-04-18 2023-12-19 Premium Extracts, Inc. Method and apparatus for dehydration and decarboxylation of cannabis
PE20201163A1 (es) 2017-06-19 2020-10-28 Zelda Therapeutics Operations Pty Ltd Composiciones y tratamientos para el trastorno del sueno
US10189762B1 (en) * 2017-07-07 2019-01-29 Orochem Technologies, Inc. Process for purification and separation of cannabinoids, from dried hemp and cannabis leaves
US10272360B2 (en) 2017-08-05 2019-04-30 Priya Naturals, Inc. Phytochemical extraction system and methods to extract phytochemicals from plants including plants of the family Cannabaceae sensu stricto
AU2018325465A1 (en) * 2017-09-02 2020-05-28 Scientific Holdings, Llc Tetrahydrocannabinol modulators
EP3453397A1 (en) 2017-09-12 2019-03-13 Albert Jan Dijkstra Processes for the isolation of a cannabinoid extract and product from cannabis plant material
US10406453B2 (en) * 2017-09-29 2019-09-10 NextLeaf Solutions Ltd. Cannabinoid extraction process using brine
US9987567B1 (en) 2017-09-29 2018-06-05 NextLeaf Solutions Ltd. Cannabinoid extraction process and system
US11202771B2 (en) 2018-01-31 2021-12-21 Treehouse Biotech, Inc. Hemp powder
WO2020028198A1 (en) 2018-08-03 2020-02-06 Biomass Oil Separation Solutions, Llc Processes and apparatus for extraction of substances and enriched extracts from plant material
US11254633B2 (en) 2018-10-05 2022-02-22 Jonas Alcirdas Navickas Cannabis thin layer decarboxylation
US11324718B2 (en) 2018-10-09 2022-05-10 Sartorius Chromatography Equipment Method for purifying cannabinoids
US11040932B2 (en) 2018-10-10 2021-06-22 Treehouse Biotech, Inc. Synthesis of cannabigerol
CA3117347A1 (en) * 2018-10-31 2020-05-07 Enantia, S.L. Solid compositions of cocrystals of cannabinoids
AU2019385420A1 (en) 2018-11-19 2021-07-08 Spoke Sciences, Inc. N-acylated fatty amino acids to reduce absorption variability in cannabinoid based compositions
US10765966B2 (en) 2019-02-06 2020-09-08 Heinkel Filtering Systems. Inc. Biomass extraction and centrifugation systems and methods
US10493377B1 (en) 2019-02-06 2019-12-03 Heinkel Filtering Systems, Inc. Biomass extraction and centrifugation systems and methods
US12220396B2 (en) 2019-05-03 2025-02-11 Zyus Life Sciences Inc. Formulation for pain management
US12178797B2 (en) 2019-05-03 2024-12-31 Zyus Life Sciences Inc. Formulation for pain management
CA3102473C (en) 2019-05-03 2021-07-06 Zyus Life Sciences Inc. Formulation for pain management
US10799546B1 (en) 2019-07-26 2020-10-13 Biomass Oil Separation Solutions, Llc Modular, integrated process and apparatus for extracting, refining and remediating active substances from plant material
US10717056B1 (en) 2019-09-09 2020-07-21 Michael Cem Gokay Method and apparatus for purification of cannabinoid extracts
US20210213082A1 (en) * 2019-10-24 2021-07-15 Fermented Farmer, LLC Botanical Synergistic Activated/Native and Equivalents Thereof
US10751640B1 (en) 2019-10-30 2020-08-25 Heinkel Filtering Systems, Inc. Cannabidiol isolate production systems and methods
US10858303B1 (en) 2019-10-30 2020-12-08 Heinkel Filtering Systems, Inc. Cannabidiol isolate production systems and methods
US11291699B1 (en) 2019-12-13 2022-04-05 Delmarva Hemp, LLC Method for solvent-free extraction and concentration of full spectrum of cannabinoids in a carrier oil
US20230398080A1 (en) * 2020-01-02 2023-12-14 Yissum Research Development Comp Any Of The Hebrew University Of Jerusalem Ltd. Floating drug delivery systems comprising cannabinoids
EP4087592A1 (en) 2020-01-10 2022-11-16 Real Isolates, LLC Methods for obtaining compounds from a plant or fungus material, respective compositions, and uses thereof
CN111239293A (zh) * 2020-03-02 2020-06-05 福建省中科生物股份有限公司 一种萜酚有关物质的hplc-pda检测方法
US20220395546A1 (en) * 2021-06-11 2022-12-15 eHempHouse Corp. Methods and compositions for the extraction of phytochemicals from plant material
KR20240121723A (ko) 2021-10-26 2024-08-09 에코파이버 유에스에이 인코포레이티드 대마 추출물을 사용하여 자궁내막암을 치료하는 방법
JP2024540176A (ja) 2021-10-26 2024-10-31 ザ ユニバーシティ オブ ニューカッスル 子宮内膜症及び他の非がん性婦人科疾患を麻抽出物で治療する方法
JP2024539988A (ja) 2021-10-26 2024-10-31 エコファイバー ユーエスエイ インコーポレイテッド ヘンプ抽出物及び組成物を生成するためのシステム及び方法
US12122757B2 (en) * 2021-11-24 2024-10-22 CLS Labs, Inc. Cannabidiol extraction and conversion process
MX2024009157A (es) 2022-01-28 2024-08-06 Vertanical GmbH Metodo para la produccion de un extracto vegetal.
CN115228135B (zh) * 2022-06-25 2024-02-20 永胜三可口生物开发有限责任公司 一种降低火麻油中四氢大麻酚含量的装置系统
US12011451B2 (en) 2022-10-26 2024-06-18 Ecofibre USA Inc. Stabilized compositions comprising cannabidiol
IL320517A (en) 2022-10-26 2025-06-01 Ecofibre Usa Inc Methods for treating estrogen-sensitive diseases with cannabis extract
EP4591855A1 (en) 2024-01-23 2025-07-30 Echo Pharmaceuticals B.V. Stable dronabinol compositions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020039795A1 (en) * 1998-10-26 2002-04-04 Elsohly Et Al Method of preparing delta-9-tetrahydrocannabinol
NZ534430A (en) * 2002-02-01 2007-09-28 Resolution Chemicals Ltd Production of delta 9 tetrahydrocannabinol from plant material
GB2408978B (en) * 2002-09-23 2006-04-05 Gw Pharma Ltd Methods of preparing delta-9 tetrahydrocannabinol from plant material
GB0222077D0 (en) * 2002-09-23 2002-10-30 Gw Pharma Ltd Methods of preparing cannabinoids from plant material

Also Published As

Publication number Publication date
SI2844243T1 (sl) 2020-02-28
ES2769794T3 (es) 2020-06-29
DK2844243T3 (da) 2020-02-03
EP2844243B8 (en) 2019-12-18
PT2844243T (pt) 2020-01-17
CN104619318A (zh) 2015-05-13
AU2013257322A1 (en) 2014-11-20
CA2872528A1 (en) 2013-11-07
EP2844243A1 (en) 2015-03-11
WO2013165251A1 (en) 2013-11-07
EP2844243B1 (en) 2019-11-13
IN2014DN09507A (OSRAM) 2015-07-17
JP2015515977A (ja) 2015-06-04
PL2844243T3 (pl) 2020-05-18
US20150126754A1 (en) 2015-05-07

Similar Documents

Publication Publication Date Title
CA2872528C (en) Cannabis plant isolate comprising .delta.9-tetrahydrocannabinol and a method for preparing such an isolate
EP3274321B1 (en) Cannabidiol isolate from industrial-hemp and use thereof in pharmaceutical and/or cosmetic preparations
US20210017145A1 (en) Process for producing an extract containing tetrahydrocannabinol and cannabidiol from cannabis plant material, and cannabis extracts
US11040295B2 (en) Method and apparatus for extracting plant oils using ethanol water
US20210362074A1 (en) Cold extraction method for cannabinoids and terpenes from cannabis by organic solvents
US6403126B1 (en) Cannabinoid extraction method
US20180344785A1 (en) Methods for Extraction and Isolation of Isoprenoid and Terpene Compounds from Biological Extracts
HK1251197A1 (zh) 用於富集大麻二酚的真空蒸馏
CA3010636A1 (en) Decarboxylated cannabis resins, uses thereof and methods of making same
WO2007109804A2 (en) Extracts and methods comprising cinnamon species
KR20090010172A (ko) 녹차 종을 포함하는 추출물 및 방법
US11148988B2 (en) Cannabinoid processing methods and systems
CN116322339A (zh) 包含欧夹竹桃苷的提取物及其生产方法
WO2010128243A1 (fr) Procédé de préparation d'extraits polyphénoliques à partir de feuilles d'épinards
KR20250134118A (ko) 신경퇴행성 질환 또는 장애 및 암 치료에 있어서의 칸나비노이드 조성물 및 이의 용도
US20220211789A1 (en) Extraction of cannabinoids from biomass
KR20240122436A (ko) 대마 추출물을 생성하기 위한 시스템 및 방법과 조성물
EP4431169A1 (en) Method of purifying cannabinoid components from plant extracts
JP2025537657A (ja) カンナビジオールの新規液体経口製剤

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180418