CA2872304C - Organic compositions to treat kras-related diseases - Google Patents
Organic compositions to treat kras-related diseases Download PDFInfo
- Publication number
- CA2872304C CA2872304C CA2872304A CA2872304A CA2872304C CA 2872304 C CA2872304 C CA 2872304C CA 2872304 A CA2872304 A CA 2872304A CA 2872304 A CA2872304 A CA 2872304A CA 2872304 C CA2872304 C CA 2872304C
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- Prior art keywords
- strand
- rnai agent
- kras
- modified
- seq
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA3173610A CA3173610A1 (en) | 2012-05-02 | 2013-04-30 | Organic compositions to treat kras-related diseases |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261641588P | 2012-05-02 | 2012-05-02 | |
| US61/641,588 | 2012-05-02 | ||
| PCT/US2013/038847 WO2013166004A2 (en) | 2012-05-02 | 2013-04-30 | Organic compositions to treat kras-related diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3173610A Division CA3173610A1 (en) | 2012-05-02 | 2013-04-30 | Organic compositions to treat kras-related diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2872304A1 CA2872304A1 (en) | 2013-11-07 |
| CA2872304C true CA2872304C (en) | 2022-12-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2872304A Active CA2872304C (en) | 2012-05-02 | 2013-04-30 | Organic compositions to treat kras-related diseases |
| CA3173610A Pending CA3173610A1 (en) | 2012-05-02 | 2013-04-30 | Organic compositions to treat kras-related diseases |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3173610A Pending CA3173610A1 (en) | 2012-05-02 | 2013-04-30 | Organic compositions to treat kras-related diseases |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20150238515A1 (OSRAM) |
| EP (3) | EP3272868A1 (OSRAM) |
| JP (1) | JP2015517466A (OSRAM) |
| KR (1) | KR20150004414A (OSRAM) |
| CN (2) | CN104583406A (OSRAM) |
| AU (5) | AU2013256471A1 (OSRAM) |
| BR (1) | BR112014027337A2 (OSRAM) |
| CA (2) | CA2872304C (OSRAM) |
| EA (1) | EA201492004A1 (OSRAM) |
| HK (1) | HK1206387A1 (OSRAM) |
| MX (1) | MX2014013367A (OSRAM) |
| WO (1) | WO2013166004A2 (OSRAM) |
Families Citing this family (15)
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| TW201620525A (zh) * | 2014-03-14 | 2016-06-16 | 波士頓生醫公司 | 使ｋ－ｒａｓ靜默之非對稱干擾ｒｎａ組成物及其使用方法 |
| MX377654B (es) | 2014-05-14 | 2025-03-11 | Targimmune Tharapeutics Ag | Vectores mejorados de polietilenimina polietilenglicol. |
| US11180759B2 (en) * | 2016-01-19 | 2021-11-23 | The University Of North Carolina At Chapel Hill | Methods and compositions using RNA interference and antisense oligonucleotides for inhibition of KRAS |
| MA45470A (fr) * | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Acides nucléiques kras et leurs utilisations |
| MA45328A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Compositions acide nucléique-polypeptide et utilisations de celles-ci |
| KR102543645B1 (ko) * | 2016-07-20 | 2023-06-16 | 주식회사 지씨지놈 | 유전성 발달장애 진단용 조성물 및 이의 용도 |
| JP7506601B2 (ja) | 2017-12-06 | 2024-06-26 | アビディティー バイオサイエンシーズ，インク． | 筋萎縮症と筋緊張性ジストロフィーを処置するための組成物および方法 |
| AU2020287343A1 (en) * | 2019-06-05 | 2021-12-09 | Southern Research Institute | Thiarabine- and thiarabine prodrug-based treatments |
| EP4058152A4 (en) * | 2019-11-14 | 2024-05-08 | The Board of Regents of the University of Oklahoma | PROSTATE CANCER TREATMENTS USING OLIGONUCLEOTIDES INTERFERENCE |
| CA3172111A1 (en) | 2020-03-19 | 2021-09-23 | Barbora MALECOVA | Compositions and methods of treating facioscapulohumeral muscular dystrophy |
| EP4100530A4 (en) * | 2020-04-07 | 2024-05-22 | The University of North Carolina at Chapel Hill | METHODS AND COMPOSITIONS USING RNA INTERFERENCE AND ANTISENSE OLIGONUCLEOTIDES FOR INHIBITION OF KRAS |
| WO2023034537A1 (en) * | 2021-09-02 | 2023-03-09 | Molecular Axiom, Llc | Compositions and methods for modulating kras expression |
| CN118265544A (zh) | 2021-09-16 | 2024-06-28 | 艾维迪提生物科学公司 | 治疗面肩肱型肌营养不良的组合物和方法 |
| WO2024155770A2 (en) * | 2023-01-18 | 2024-07-25 | Molecular Axiom, Llc | Compositions for modulating kras expression and uses thereof |
| EP4669752A1 (en) * | 2023-02-22 | 2025-12-31 | Altamira Therapeutics AG | KRAS COMPOSITIONS AND INHIBITION METHODS FOR THE TREATMENT OF A DISEASE |
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| US5030453A (en) | 1983-03-24 | 1991-07-09 | The Liposome Company, Inc. | Stable plurilamellar vesicles |
| US6977244B2 (en) | 1996-10-04 | 2005-12-20 | Board Of Regents, The University Of Texas Systems | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
| US5891467A (en) | 1997-01-31 | 1999-04-06 | Depotech Corporation | Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes |
| EP2314700A1 (en) | 1999-01-28 | 2011-04-27 | Medical College of Georgia Research Institute, Inc | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| CA2403397A1 (en) | 2000-03-16 | 2001-09-20 | Genetica, Inc. | Methods and compositions for rna interference |
| US6680068B2 (en) | 2000-07-06 | 2004-01-20 | The General Hospital Corporation | Drug delivery formulations and targeting |
| US20040234586A1 (en) | 2001-06-11 | 2004-11-25 | Sylvain Meloche | Compositions and methods for enhancing nucleic acid transfer into cells |
| ATE468861T1 (de) | 2001-08-16 | 2010-06-15 | Univ Pennsylvania | Synthese und verwendung von reagenzien für die verbesserte dna-lipofektion und/oder prodrug- und arzneimitteltherapien mit langsamer freisetzung |
| ATE485031T1 (de) | 2002-06-28 | 2010-11-15 | Protiva Biotherapeutics Inc | Verfahren und vorrichtung zur herstellung von liposomen |
| EP1658304A4 (en) | 2002-09-28 | 2009-01-14 | Massachusetts Inst Technology | THERAPY ANTIGRIPPALE |
| EP1560931B1 (en) * | 2002-11-14 | 2011-07-27 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| ES2343318T3 (es) | 2002-11-26 | 2010-07-28 | University Of Massachusetts | Administracion de arnsis. |
| WO2004064731A2 (en) | 2003-01-14 | 2004-08-05 | University Of Washington | Lipid-drug formulations and methods for targeted delivery of lipid-drug complexes to lymlplhoid tissues |
| ES2559828T3 (es) | 2003-07-16 | 2016-02-16 | Protiva Biotherapeutics Inc. | ARN de interferencia encapsulado en lípidos |
| EP2489737A1 (en) | 2003-08-28 | 2012-08-22 | Novartis AG | Interfering RNA duplex having blunt-ends and 3'-modifications |
| EP1682661A2 (en) * | 2003-10-23 | 2006-07-26 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina) |
| EP1714970A1 (en) * | 2005-04-22 | 2006-10-25 | Universität des Saarlandes | Use of inhibitors of RNAse A-family enzymes for stabilizing oligonucleotides having RNA interfering activity |
| CA2628300C (en) | 2005-11-02 | 2018-04-17 | Protiva Biotherapeutics, Inc. | Modified sirna molecules and uses thereof |
| DK2002004T3 (en) | 2006-03-23 | 2015-11-30 | Roche Innovation Ct Copenhagen As | LITTLE INTERNAL SEGMENTED INTERFERENCE RNA |
| GB0608838D0 (en) | 2006-05-04 | 2006-06-14 | Novartis Ag | Organic compounds |
| AU2007299705B2 (en) * | 2006-09-22 | 2012-09-06 | Dharmacon, Inc. | Duplex oligonucleotide complexes and methods for gene silencing by RNA interference |
| EP2121925A2 (en) * | 2007-03-02 | 2009-11-25 | MDRNA, Inc. | Nucleic acid compounds for inhibiting ras gene expression and uses thereof |
| MX2009012568A (es) | 2007-05-22 | 2009-12-08 | Mdrna Inc | Oligonucleotidos de acido ribonucleico sustituidos con hidroximetilo y complejos de acido ribonucleico. |
| CA2704737A1 (en) * | 2007-09-18 | 2009-09-03 | Intradigm Corporation | Compositions comprising k-ras sirna and methods of use |
| WO2009062199A1 (en) * | 2007-11-09 | 2009-05-14 | Fox Chase Cancer Center | EGFR/NEDD9/TGF-β LNTERACTOME AND METHODS OF USE THEREOF FOR THE IDENTIFICATION OF AGENTS HAVING EFFICACY IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS |
| ES2535419T3 (es) | 2007-12-27 | 2015-05-11 | Protiva Biotherapeutics Inc. | Silenciamiento de expresión de quinasa tipo polo usando ARN interferente |
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| US20110218334A1 (en) * | 2008-07-11 | 2011-09-08 | Alnylam Pharmaceuticals, Inc. | PHOSPHOROTHIOATE OLIGONUCLEOTIDES AND NON-NUCLEOSIDIC PHOSPHOROTHIOATES AS DELIVERY AGENTS FOR iRNA AGENTS |
| ES2921573T3 (es) * | 2009-04-03 | 2022-08-29 | Dicerna Pharmaceuticals Inc | Métodos y composiciones para la inhibición específica de KRAS por RNA bicatenario asimétrico |
| WO2010115202A2 (en) * | 2009-04-03 | 2010-10-07 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of kras by blunt ended double-stranded rna |
| SG181904A1 (en) | 2009-12-23 | 2012-07-30 | Novartis Ag | Lipids, lipid compositions, and methods of using them |
| EP2544671A2 (en) * | 2010-03-12 | 2013-01-16 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Pharmaceutical composition for the treatment of chlamydial infection |
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2013
- 2013-04-30 MX MX2014013367A patent/MX2014013367A/es unknown
- 2013-04-30 KR KR20147033421A patent/KR20150004414A/ko not_active Withdrawn
- 2013-04-30 BR BR112014027337A patent/BR112014027337A2/pt not_active IP Right Cessation
- 2013-04-30 CN CN201380035099.2A patent/CN104583406A/zh active Pending
- 2013-04-30 EP EP17187348.2A patent/EP3272868A1/en not_active Ceased
- 2013-04-30 EA EA201492004A patent/EA201492004A1/ru unknown
- 2013-04-30 CA CA2872304A patent/CA2872304C/en active Active
- 2013-04-30 AU AU2013256471A patent/AU2013256471A1/en not_active Abandoned
- 2013-04-30 JP JP2015510380A patent/JP2015517466A/ja active Pending
- 2013-04-30 CN CN201811456141.9A patent/CN109481455A/zh active Pending
- 2013-04-30 WO PCT/US2013/038847 patent/WO2013166004A2/en not_active Ceased
- 2013-04-30 CA CA3173610A patent/CA3173610A1/en active Pending
- 2013-04-30 EP EP13721578.6A patent/EP2844757A2/en not_active Withdrawn
- 2013-04-30 HK HK15106884.9A patent/HK1206387A1/xx unknown
- 2013-04-30 EP EP20178501.1A patent/EP3736333A1/en active Pending
- 2013-04-30 US US14/397,815 patent/US20150238515A1/en not_active Abandoned
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2016
- 2016-07-11 AU AU2016204832A patent/AU2016204832A1/en not_active Abandoned
- 2016-09-07 US US15/258,042 patent/US20180153919A1/en not_active Abandoned
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2017
- 2017-11-14 AU AU2017261481A patent/AU2017261481A1/en not_active Abandoned
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2020
- 2020-01-14 AU AU2020200247A patent/AU2020200247A1/en not_active Abandoned
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2022
- 2022-05-04 AU AU2022202991A patent/AU2022202991A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013166004A2 (en) | 2013-11-07 |
| EP3736333A1 (en) | 2020-11-11 |
| JP2015517466A (ja) | 2015-06-22 |
| EP3272868A1 (en) | 2018-01-24 |
| HK1206387A1 (en) | 2016-01-08 |
| CN109481455A (zh) | 2019-03-19 |
| CA3173610A1 (en) | 2013-11-07 |
| KR20150004414A (ko) | 2015-01-12 |
| AU2017261481A1 (en) | 2017-11-30 |
| US20180153919A1 (en) | 2018-06-07 |
| AU2013256471A1 (en) | 2014-11-13 |
| WO2013166004A3 (en) | 2014-01-03 |
| CA2872304A1 (en) | 2013-11-07 |
| EA201492004A1 (ru) | 2015-08-31 |
| AU2020200247A1 (en) | 2020-02-06 |
| AU2016204832A1 (en) | 2016-07-28 |
| BR112014027337A2 (pt) | 2017-07-18 |
| US20150238515A1 (en) | 2015-08-27 |
| MX2014013367A (es) | 2014-12-08 |
| CN104583406A (zh) | 2015-04-29 |
| EP2844757A2 (en) | 2015-03-11 |
| AU2022202991A1 (en) | 2022-05-26 |
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