CA2866405A1 - Identification of channelopsin-2 (chop2) mutations and methods of use - Google Patents

Identification of channelopsin-2 (chop2) mutations and methods of use Download PDF

Info

Publication number
CA2866405A1
CA2866405A1 CA2866405A CA2866405A CA2866405A1 CA 2866405 A1 CA2866405 A1 CA 2866405A1 CA 2866405 A CA2866405 A CA 2866405A CA 2866405 A CA2866405 A CA 2866405A CA 2866405 A1 CA2866405 A1 CA 2866405A1
Authority
CA
Canada
Prior art keywords
molecule
amino acid
cell
polypeptide molecule
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2866405A
Other languages
English (en)
French (fr)
Inventor
Zhuo-Hua Pan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wayne State University
Original Assignee
Wayne State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wayne State University filed Critical Wayne State University
Publication of CA2866405A1 publication Critical patent/CA2866405A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2866405A 2012-03-05 2013-03-05 Identification of channelopsin-2 (chop2) mutations and methods of use Pending CA2866405A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261606663P 2012-03-05 2012-03-05
US61/606,663 2012-03-05
PCT/US2013/029171 WO2013134295A1 (en) 2012-03-05 2013-03-05 Identification of channelrhodopsin-2 (chop2) mutations and methods of use

Publications (1)

Publication Number Publication Date
CA2866405A1 true CA2866405A1 (en) 2013-09-12

Family

ID=47892055

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2866405A Pending CA2866405A1 (en) 2012-03-05 2013-03-05 Identification of channelopsin-2 (chop2) mutations and methods of use

Country Status (16)

Country Link
US (3) US10947281B2 (cg-RX-API-DMAC10.html)
EP (1) EP2822964B1 (cg-RX-API-DMAC10.html)
JP (3) JP6395611B2 (cg-RX-API-DMAC10.html)
KR (1) KR102137717B1 (cg-RX-API-DMAC10.html)
CN (2) CN104334575A (cg-RX-API-DMAC10.html)
AU (4) AU2013230112A1 (cg-RX-API-DMAC10.html)
CA (1) CA2866405A1 (cg-RX-API-DMAC10.html)
DK (1) DK2822964T3 (cg-RX-API-DMAC10.html)
EA (1) EA201491643A1 (cg-RX-API-DMAC10.html)
ES (1) ES2703324T3 (cg-RX-API-DMAC10.html)
HU (1) HUE040487T2 (cg-RX-API-DMAC10.html)
MX (1) MX360085B (cg-RX-API-DMAC10.html)
NZ (1) NZ629843A (cg-RX-API-DMAC10.html)
PL (1) PL2822964T3 (cg-RX-API-DMAC10.html)
PT (1) PT2822964T (cg-RX-API-DMAC10.html)
WO (1) WO2013134295A1 (cg-RX-API-DMAC10.html)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8470790B2 (en) 2006-05-04 2013-06-25 Wayne State University Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids
WO2011140279A1 (en) 2010-05-04 2011-11-10 Wayne State University Aav-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells
EA201491643A1 (ru) 2012-03-05 2015-02-27 Уэйн Стейт Юниверсити Идентификация мутаций канал-опсина-2 (chop2) и способы применения
AU2014243925B2 (en) 2013-03-14 2018-12-06 Wayne State University Method of enhancing delivery of therapeutic compounds to the eye
JP6469669B2 (ja) 2013-07-08 2019-02-13 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ オキシムエステル光開始剤
US10307492B2 (en) 2014-03-11 2019-06-04 Wayne State University Modified MGLUR6 promoter and methods of use
EP3452067A1 (en) 2016-05-03 2019-03-13 Wayne State University Method of enhancing viral-mediated gene delivery in the eye using proteosome inhibitors
EP3464341A1 (en) * 2016-06-03 2019-04-10 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Mutant light-inducible ion channel of channelrhodopsin
WO2018044912A1 (en) * 2016-08-29 2018-03-08 Wayne State University Identification of mutations in channelopsin variants having improved light sensitivity and methods of use thereof
EP3535282A4 (en) * 2016-11-06 2020-04-08 Nanoscope Technologies LLC OPTOGENETIC MODULATION BY OPSINS WITH MULTIPLE CHARACTERISTICS FOR RESTORATION OF VISION AND OTHER ASSOCIATED APPLICATIONS
US20200115419A1 (en) * 2017-04-12 2020-04-16 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. New optogenetic tool
PL3720428T3 (pl) * 2017-12-04 2023-05-08 Laboratorios Salvat, S.A. Kompozycja oftalmiczna do podawania miejscowego zawierająca kwas dobezylowy do leczenia chorób tylnego odcinka oka
JP6567153B1 (ja) * 2018-09-28 2019-08-28 学校法人東北工業大学 対象化合物の特性の予測を行うための方法、コンピュータシステム、プログラム
WO2024226667A2 (en) * 2023-04-24 2024-10-31 Nanoscope Therapeutics Inc. Optogenetic modulation by multi-characteristic opsins for vision restoration and other applications thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4498919A (en) 1983-10-31 1985-02-12 Corning Glass Works Method for making colored photochromic prescription ophthalmic lenses
US6610287B1 (en) 1990-04-16 2003-08-26 The General Hospital Corporation Transfer and expression of gene sequences into nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication
US5827702A (en) 1994-10-31 1998-10-27 Genentech, Inc. Ocular gene therapy
EP0977880A2 (en) 1997-04-21 2000-02-09 University Of Florida Materials and methods for treatment of retinal diseases
CA2346262A1 (en) 1998-09-17 2000-03-23 University Of Florida Methods for treatment of degenerative retinal diseases
JP2004514407A (ja) 2000-04-28 2004-05-20 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 異種キャプシド中にシュードタイピングされたａａｖ５キャプシドおよびａａｖ５ベクターを含む組換えａａｖベクター
CA2442670A1 (en) 2001-04-13 2002-10-24 The Trustees Of The University Of Pennsylvania Method of treating or retarding the development of blindness
AU2002323210A1 (en) 2001-08-16 2003-03-03 Sloan Kettering Institute For Cancer Research Bio-synthetic photostimulators and methods of use
DE10216005A1 (de) 2002-04-11 2003-10-30 Max Planck Gesellschaft Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle
AU2003249318A1 (en) 2002-07-18 2004-02-09 The General Hospital Corp. Method for augmenting vision in persons suffering from photoreceptor cell degeneration
US7186699B2 (en) 2003-06-03 2007-03-06 Cell Genesys, Inc. Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes
WO2005044096A2 (en) 2003-11-05 2005-05-19 Neurovision, Inc. Method for improving visual perception
JP2009502140A (ja) 2005-07-22 2009-01-29 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 光活性化陽イオンチャネルおよびその使用
US8470790B2 (en) 2006-05-04 2013-06-25 Wayne State University Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids
WO2011140279A1 (en) * 2010-05-04 2011-11-10 Wayne State University Aav-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells
HRP20150846T1 (hr) * 2010-09-08 2015-09-11 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Mutirani kalanski rodopsin 2
EA201491643A1 (ru) * 2012-03-05 2015-02-27 Уэйн Стейт Юниверсити Идентификация мутаций канал-опсина-2 (chop2) и способы применения
KR101639859B1 (ko) * 2014-03-06 2016-07-14 포항공과대학교 산학협력단 광 자극에 의한 미토콘드리아 활성의 시공간적 가역 조절 방법

Also Published As

Publication number Publication date
HK1205744A1 (en) 2015-12-24
DK2822964T3 (en) 2018-12-10
CN111378020A (zh) 2020-07-07
US10947281B2 (en) 2021-03-16
MX360085B (es) 2018-10-10
HUE040487T2 (hu) 2019-03-28
EP2822964A1 (en) 2015-01-14
KR102137717B1 (ko) 2020-07-27
AU2021245195B2 (en) 2023-09-28
JP2015510759A (ja) 2015-04-13
US20220033449A1 (en) 2022-02-03
NZ629843A (en) 2017-03-31
AU2017239601B2 (en) 2019-05-16
AU2019216638B2 (en) 2021-07-08
US20250066431A1 (en) 2025-02-27
MX2014010664A (es) 2015-03-06
WO2013134295A1 (en) 2013-09-12
EA201491643A1 (ru) 2015-02-27
PL2822964T3 (pl) 2019-05-31
US20150044181A1 (en) 2015-02-12
AU2013230112A1 (en) 2014-09-25
AU2017239601A1 (en) 2017-10-26
JP6395611B2 (ja) 2018-09-26
AU2021245195A1 (en) 2021-11-04
PT2822964T (pt) 2018-11-29
AU2019216638A1 (en) 2019-09-05
JP2019193656A (ja) 2019-11-07
KR20140132401A (ko) 2014-11-17
NZ727041A (en) 2022-01-28
CN104334575A (zh) 2015-02-04
ES2703324T3 (es) 2019-03-08
JP2018134098A (ja) 2018-08-30
EP2822964B1 (en) 2018-08-22

Similar Documents

Publication Publication Date Title
AU2021245195B2 (en) Identification of Channelopsin-2 (Chop2) mutations and methods of use
US20240165198A1 (en) Optogenetic visual restoration using chrimson
JP2009536219A (ja) ロドプシン拡散のインビボ送達による視覚応答の回復
US10745453B2 (en) Compositions and methods for enhancing visual function
MX2010012592A (es) Vectores para la administracion de proteinas sensibles a la luz y metodos de uso de las mismas.
KR20140039281A (ko) 감광성 키메라 gpcr 단백질
US20230159609A1 (en) G-protein-gated-k+ channel-mediated enhancements in light sensitivity in rod-cone dystrophy (rcd)
EP3892738A1 (en) G-protein-gated-k+ channel-mediated enhancements in light sensitivity in rod-cone dystrophy (rcd)
KR20230160967A (ko) 프로테오좀 억제제를 사용하여 눈에서 바이러스 매개 유전자 전달을 향상시키는 방법
EA043449B1 (ru) ИДЕНТИФИКАЦИЯ МУТАЦИЙ КАНАЛ-ОПСИНА-2 (Chop2) И СПОСОБЫ ПРИМЕНЕНИЯ
HK1205744B (en) Identification of channelrhodopsin-2 (chop2) mutations and methods of use
NZ727041B2 (en) Identification of channelrhodopsin-2 (chop2) mutations and methods of use
US20230338581A1 (en) G-protein-gated-k+ channel-mediated enhancements in light sensitivity in rod-cone dystrophy (rcd)
US20260048089A1 (en) G-protein-gated-k+ channel-mediated enhancements in light sensitivity in rod-cone dystrophy (rcd)

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180305

D15 Examination report completed

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT

Effective date: 20240827

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 12TH ANNIV.) - STANDARD

Year of fee payment: 12

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20241220

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20241220

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20241220

B12 Application deemed to be withdrawn, abandoned or lapsed

Free format text: ST27 STATUS EVENT CODE: N-2-6-B10-B12-B303 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: DEEMED ABANDONED - FAILURE TO RESPOND TO AN EXAMINER'S REQUISITION

Effective date: 20241227