CA2865652C - Pharmaceutical compositions and topical use thereof - Google Patents
Pharmaceutical compositions and topical use thereof Download PDFInfo
- Publication number
- CA2865652C CA2865652C CA2865652A CA2865652A CA2865652C CA 2865652 C CA2865652 C CA 2865652C CA 2865652 A CA2865652 A CA 2865652A CA 2865652 A CA2865652 A CA 2865652A CA 2865652 C CA2865652 C CA 2865652C
- Authority
- CA
- Canada
- Prior art keywords
- adipose tissue
- derived
- cells
- secretions
- adipocytes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000000699 topical effect Effects 0.000 title claims abstract description 24
- 239000008194 pharmaceutical composition Substances 0.000 title abstract description 42
- 210000000577 adipose tissue Anatomy 0.000 claims abstract description 285
- 230000028327 secretion Effects 0.000 claims abstract description 139
- 239000000203 mixture Substances 0.000 claims abstract description 106
- 206010000496 acne Diseases 0.000 claims abstract description 79
- 208000002874 Acne Vulgaris Diseases 0.000 claims abstract description 67
- 238000011282 treatment Methods 0.000 claims abstract description 55
- 241000283690 Bos taurus Species 0.000 claims abstract description 51
- 210000001789 adipocyte Anatomy 0.000 claims description 151
- 210000004027 cell Anatomy 0.000 claims description 150
- 239000006285 cell suspension Substances 0.000 claims description 84
- 239000003814 drug Substances 0.000 claims description 15
- 239000006228 supernatant Substances 0.000 claims description 15
- 238000004519 manufacturing process Methods 0.000 claims description 12
- 238000004108 freeze drying Methods 0.000 claims description 11
- 239000000725 suspension Substances 0.000 claims description 10
- 238000004115 adherent culture Methods 0.000 claims description 9
- 206010000503 Acne cystic Diseases 0.000 claims description 6
- 238000000034 method Methods 0.000 abstract description 54
- 238000002360 preparation method Methods 0.000 abstract description 42
- 230000004968 inflammatory condition Effects 0.000 abstract description 9
- 230000003779 hair growth Effects 0.000 abstract description 6
- 230000000638 stimulation Effects 0.000 abstract description 5
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 54
- 210000003491 skin Anatomy 0.000 description 47
- 239000006071 cream Substances 0.000 description 44
- 239000002609 medium Substances 0.000 description 41
- 239000000523 sample Substances 0.000 description 38
- 238000007667 floating Methods 0.000 description 36
- 210000001519 tissue Anatomy 0.000 description 33
- 241000282414 Homo sapiens Species 0.000 description 32
- 210000002966 serum Anatomy 0.000 description 25
- 102000029816 Collagenase Human genes 0.000 description 23
- 108060005980 Collagenase Proteins 0.000 description 23
- 229960002424 collagenase Drugs 0.000 description 23
- 150000002632 lipids Chemical class 0.000 description 23
- 241001465754 Metazoa Species 0.000 description 22
- 238000012258 culturing Methods 0.000 description 17
- 239000008188 pellet Substances 0.000 description 17
- 239000007788 liquid Substances 0.000 description 16
- 238000005119 centrifugation Methods 0.000 description 15
- 210000004209 hair Anatomy 0.000 description 15
- 241000282465 Canis Species 0.000 description 13
- 239000003085 diluting agent Substances 0.000 description 13
- 208000027866 inflammatory disease Diseases 0.000 description 13
- 201000004384 Alopecia Diseases 0.000 description 12
- 241000894007 species Species 0.000 description 11
- 210000002268 wool Anatomy 0.000 description 11
- 230000002354 daily effect Effects 0.000 description 10
- 230000006872 improvement Effects 0.000 description 10
- 230000002265 prevention Effects 0.000 description 10
- 102000035195 Peptidases Human genes 0.000 description 9
- 108091005804 Peptidases Proteins 0.000 description 9
- 239000003937 drug carrier Substances 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 241000283073 Equus caballus Species 0.000 description 8
- 238000010494 dissociation reaction Methods 0.000 description 8
- 230000005593 dissociations Effects 0.000 description 8
- 230000004936 stimulating effect Effects 0.000 description 8
- 241000282472 Canis lupus familiaris Species 0.000 description 7
- 238000001914 filtration Methods 0.000 description 7
- 231100000241 scar Toxicity 0.000 description 7
- 238000011200 topical administration Methods 0.000 description 7
- 206010061218 Inflammation Diseases 0.000 description 6
- 230000029087 digestion Effects 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 208000035475 disorder Diseases 0.000 description 6
- 208000024963 hair loss Diseases 0.000 description 6
- 230000003676 hair loss Effects 0.000 description 6
- 230000002757 inflammatory effect Effects 0.000 description 6
- 230000004054 inflammatory process Effects 0.000 description 6
- 239000011148 porous material Substances 0.000 description 6
- 230000002829 reductive effect Effects 0.000 description 6
- 230000037390 scarring Effects 0.000 description 6
- 241001635598 Enicostema Species 0.000 description 5
- 241000282324 Felis Species 0.000 description 5
- 206010027626 Milia Diseases 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 206010042496 Sunburn Diseases 0.000 description 5
- 230000001464 adherent effect Effects 0.000 description 5
- 238000004113 cell culture Methods 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000005722 itchiness Effects 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 230000004083 survival effect Effects 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 5
- 201000004647 tinea pedis Diseases 0.000 description 5
- 206010003399 Arthropod bite Diseases 0.000 description 4
- 208000006877 Insect Bites and Stings Diseases 0.000 description 4
- 208000003251 Pruritus Diseases 0.000 description 4
- 206010064127 Solar lentigo Diseases 0.000 description 4
- 208000000260 Warts Diseases 0.000 description 4
- 230000000735 allogeneic effect Effects 0.000 description 4
- 206010068168 androgenetic alopecia Diseases 0.000 description 4
- 230000009089 cytolysis Effects 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 238000003306 harvesting Methods 0.000 description 4
- 238000006703 hydration reaction Methods 0.000 description 4
- 238000000386 microscopy Methods 0.000 description 4
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 4
- 201000010153 skin papilloma Diseases 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 206010054107 Nodule Diseases 0.000 description 3
- 241000283984 Rodentia Species 0.000 description 3
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 3
- 210000004504 adult stem cell Anatomy 0.000 description 3
- 238000013019 agitation Methods 0.000 description 3
- 208000031513 cyst Diseases 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 210000004013 groin Anatomy 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 201000004303 plantar wart Diseases 0.000 description 3
- 230000000717 retained effect Effects 0.000 description 3
- 230000036561 sun exposure Effects 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 239000003104 tissue culture media Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- 241000283086 Equidae Species 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 206010040925 Skin striae Diseases 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 208000031439 Striae Distensae Diseases 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 231100000360 alopecia Toxicity 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000007975 buffered saline Substances 0.000 description 2
- 239000013592 cell lysate Substances 0.000 description 2
- 230000006037 cell lysis Effects 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 2
- 238000005336 cracking Methods 0.000 description 2
- 210000000805 cytoplasm Anatomy 0.000 description 2
- 230000037336 dry skin Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 210000000245 forearm Anatomy 0.000 description 2
- 210000004907 gland Anatomy 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000000644 isotonic solution Substances 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 230000002934 lysing effect Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 238000011176 pooling Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 210000004003 subcutaneous fat Anatomy 0.000 description 2
- 230000037317 transdermal delivery Effects 0.000 description 2
- 210000005167 vascular cell Anatomy 0.000 description 2
- BHKKSKOHRFHHIN-MRVPVSSYSA-N 1-[[2-[(1R)-1-aminoethyl]-4-chlorophenyl]methyl]-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-4-one Chemical compound N[C@H](C)C1=C(CN2C(NC(C3=C2C=CN3)=O)=S)C=CC(=C1)Cl BHKKSKOHRFHHIN-MRVPVSSYSA-N 0.000 description 1
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 235000002198 Annona diversifolia Nutrition 0.000 description 1
- 208000034309 Bacterial disease carrier Diseases 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 241000282832 Camelidae Species 0.000 description 1
- 241000282421 Canidae Species 0.000 description 1
- 241000283153 Cetacea Species 0.000 description 1
- 241000186427 Cutibacterium acnes Species 0.000 description 1
- 241000283074 Equus asinus Species 0.000 description 1
- 241000282323 Felidae Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 208000009329 Graft vs Host Disease Diseases 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 241000282858 Hyracoidea Species 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 241000282838 Lama Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241001147389 Panthera uncia Species 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 241000283089 Perissodactyla Species 0.000 description 1
- 101100070542 Podospora anserina het-s gene Proteins 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 241000283080 Proboscidea <mammal> Species 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 206010039580 Scar Diseases 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 241000283083 Sirenia Species 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 241001493546 Suina Species 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 241000282866 Tubulidentata Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 241001416177 Vicugna pacos Species 0.000 description 1
- 208000035472 Zoonoses Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 210000000593 adipose tissue white Anatomy 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 229940030486 androgens Drugs 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000000607 artificial tear Substances 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940064804 betadine Drugs 0.000 description 1
- 239000008366 buffered solution Substances 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 208000015100 cartilage disease Diseases 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 238000003570 cell viability assay Methods 0.000 description 1
- 230000005754 cellular signaling Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000012468 concentrated sample Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000779 depleting effect Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 208000024908 graft versus host disease Diseases 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 230000003659 hair regrowth Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 238000007443 liposuction Methods 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 208000035824 paresthesia Diseases 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000002135 phase contrast microscopy Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 230000004800 psychological effect Effects 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229940091258 selenium supplement Drugs 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000012679 serum free medium Substances 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 210000003371 toe Anatomy 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 206010048282 zoonosis Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2011900932 | 2011-03-15 | ||
| AU2011900932A AU2011900932A0 (en) | 2011-03-15 | Pharmaceutical compositions and topical use thereof | |
| AU2012900140 | 2012-01-13 | ||
| AU2012900140A AU2012900140A0 (en) | 2012-01-13 | Pharmaceutical compositions and topical use thereof | |
| PCT/AU2012/000274 WO2012122604A1 (en) | 2011-03-15 | 2012-03-15 | Pharmaceutical compositions and topical use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2865652A1 CA2865652A1 (en) | 2012-09-20 |
| CA2865652C true CA2865652C (en) | 2020-12-29 |
Family
ID=46829963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2865652A Active CA2865652C (en) | 2011-03-15 | 2012-03-15 | Pharmaceutical compositions and topical use thereof |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9730964B2 (enExample) |
| EP (2) | EP2685993B9 (enExample) |
| JP (3) | JP6038821B2 (enExample) |
| CN (2) | CN106581067B (enExample) |
| AU (1) | AU2012229890B2 (enExample) |
| CA (1) | CA2865652C (enExample) |
| DK (1) | DK3156060T3 (enExample) |
| WO (1) | WO2012122604A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201606745XA (en) * | 2011-09-23 | 2016-10-28 | Cell Ideas Pty Ltd | Therapeutics using adipose cells and cell secretions |
| JP2023002772A (ja) * | 2011-09-23 | 2023-01-10 | レジニアス リミテッド | 脂肪細胞および細胞分泌物を使用する治療 |
| WO2015038951A1 (en) * | 2013-09-12 | 2015-03-19 | Ohio State Innovation Foundation | Topical compounds containing adipose-derived hormones for the rejuvenation of skin |
| JP5991687B2 (ja) * | 2014-07-23 | 2016-09-14 | 学校法人日本大学 | 脱分化脂肪細胞の製造方法 |
| IT201700102994A1 (it) * | 2017-09-14 | 2019-03-14 | Genlife Sagl | Catalizzatore rigenerativo di tessuti e relativo procedimento di realizzazione |
| MX2019014426A (es) | 2017-10-02 | 2020-02-05 | Fukuoka Hirotaro | Composicion farmaceutica para usarse en la mejora de la calidad del cuero cabelludo y la piel, de la cicatrizacion de heridas o mejora de la calidad del cabello. |
| KR102646145B1 (ko) * | 2018-05-31 | 2024-03-11 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 모공 축소용 조성물 |
| WO2024151321A2 (en) * | 2022-08-05 | 2024-07-18 | Trustees Of Tufts College | Systems and methods for commercial scale cultured adipose tissue production |
| WO2024145258A1 (en) | 2022-12-27 | 2024-07-04 | AVITA Medical Americas, LLC | System for automated preparation of a regenerative epidermal suspension and related methods of use |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4296099A (en) | 1976-11-30 | 1981-10-20 | L'oreal | Process for extracting embryonic calf skin and pharmaceutical compositions containing the same |
| US5762947A (en) * | 1997-05-09 | 1998-06-09 | Elizabeth Arden Co., Division Of Conopco, Inc. | Cosmetic skin conditioning compositions containing a salicyloxy α-carboxy acid |
| CN1352696A (zh) * | 1999-03-10 | 2002-06-05 | 匹兹堡大学联邦制高等教育 | 脂肪来源的干细胞和网格 |
| IT1309453B1 (it) * | 1999-10-01 | 2002-01-23 | Consorzio Per Gli Studi Uni | Substrato bioartificiale per la realizzazione di tessuti e organianimali, in particolare umani. |
| CA2472180A1 (en) | 2001-12-31 | 2003-07-17 | Isolagen Technologies, Inc. | Hair follicle growth |
| WO2005013885A2 (en) * | 2003-08-07 | 2005-02-17 | Healor Ltd. | Pharmaceutical compositions and methods for accelerating wound healing |
| EP2450433A3 (en) | 2003-10-08 | 2012-08-08 | Vet-Stem Inc | Methods of preparing and using stem cell compositions and kits comprising the same |
| WO2007026356A2 (en) | 2005-08-29 | 2007-03-08 | Healor Ltd. | Methods and compositions for prevention and treatment of diabetic and aged skin |
| FR2894961B1 (fr) * | 2005-12-16 | 2008-05-16 | Oreal | Utilisation de ceramides pour depigmenter la peau |
| CN101400787B (zh) * | 2006-01-27 | 2013-01-23 | 株式会社Prostemics | 采用脂肪来源成体干细胞大量制造生长因子的方法 |
| JP5240715B2 (ja) * | 2006-08-08 | 2013-07-17 | 国立大学法人名古屋大学 | 脂肪組織由来多分化能幹細胞を含有する細胞製剤 |
| US8835170B2 (en) * | 2006-10-06 | 2014-09-16 | University Of Virginia Patent Foundation | Methods and compositions useful for diabetic wound healing |
| KR101220239B1 (ko) | 2008-04-01 | 2013-01-09 | 바이오스펙트럼 주식회사 | 식물성 펩톤을 포함하는 줄기세포 증식 촉진용 조성물 |
| KR100994133B1 (ko) | 2008-04-15 | 2010-11-15 | 송신혜 | 문양이 삽입된 유리 제품 및 이의 제조 방법 |
| FR2938334A1 (fr) | 2008-11-13 | 2010-05-14 | Galderma Res & Dev | Modulateurs de l'adfp dans le traitement de l'acne, d'une dermatite seborrheique ou de l'hyperseborrhee |
| AU2009201915C1 (en) | 2008-08-22 | 2015-02-26 | Regeneus Ltd | Therapeutic methods |
| JP5633859B2 (ja) * | 2009-10-08 | 2014-12-03 | 国立大学法人名古屋大学 | 脂肪組織由来間葉系幹細胞を含有する免疫抑制剤及びその用途 |
| AU2009251017A1 (en) | 2009-12-17 | 2011-07-07 | Regeneus Ltd. | Therapeutic methods |
| KR100995133B1 (ko) | 2010-02-10 | 2010-11-18 | 허쉬바이오주식회사 | 지방조직 유래 줄기세포 및 단핵구로부터 세포성장인자의 생산방법 및 그 이용 |
| KR101749218B1 (ko) | 2010-04-26 | 2017-06-20 | (주)프로스테믹스 | 양모 효과를 가지는 인간 지방유래 줄기세포의 조건 배지 및 이의 용도 |
| WO2012047733A2 (en) * | 2010-09-29 | 2012-04-12 | Aidan Research And Consulting, Llc. | Treatment of acne by conditioned media |
-
2012
- 2012-03-15 CN CN201611149524.2A patent/CN106581067B/zh not_active Expired - Fee Related
- 2012-03-15 EP EP12757105.7A patent/EP2685993B9/en not_active Not-in-force
- 2012-03-15 EP EP16184030.1A patent/EP3156060B1/en active Active
- 2012-03-15 AU AU2012229890A patent/AU2012229890B2/en not_active Ceased
- 2012-03-15 CA CA2865652A patent/CA2865652C/en active Active
- 2012-03-15 CN CN201280022199.7A patent/CN103596577B/zh not_active Expired - Fee Related
- 2012-03-15 JP JP2013558271A patent/JP6038821B2/ja not_active Expired - Fee Related
- 2012-03-15 US US14/005,269 patent/US9730964B2/en not_active Expired - Fee Related
- 2012-03-15 WO PCT/AU2012/000274 patent/WO2012122604A1/en not_active Ceased
- 2012-03-15 DK DK16184030T patent/DK3156060T3/da active
-
2016
- 2016-11-02 JP JP2016215032A patent/JP2017031214A/ja active Pending
-
2017
- 2017-07-11 US US15/647,081 patent/US10967008B2/en not_active Expired - Fee Related
-
2018
- 2018-01-30 JP JP2018013476A patent/JP6621853B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP6621853B2 (ja) | 2019-12-18 |
| US20180169151A1 (en) | 2018-06-21 |
| EP2685993B9 (en) | 2017-04-05 |
| DK3156060T3 (da) | 2019-11-25 |
| EP2685993B8 (en) | 2016-10-19 |
| US9730964B2 (en) | 2017-08-15 |
| US20140087001A1 (en) | 2014-03-27 |
| AU2012229890B2 (en) | 2015-02-26 |
| AU2012229890A1 (en) | 2013-05-02 |
| CN103596577B (zh) | 2017-02-15 |
| WO2012122604A1 (en) | 2012-09-20 |
| EP2685993A1 (en) | 2014-01-22 |
| CN106581067B (zh) | 2021-07-23 |
| HK1191557A1 (zh) | 2014-08-01 |
| US10967008B2 (en) | 2021-04-06 |
| CN103596577A (zh) | 2014-02-19 |
| JP2018080205A (ja) | 2018-05-24 |
| JP2014511827A (ja) | 2014-05-19 |
| EP3156060A1 (en) | 2017-04-19 |
| CN106581067A (zh) | 2017-04-26 |
| CA2865652A1 (en) | 2012-09-20 |
| JP2017031214A (ja) | 2017-02-09 |
| EP2685993A4 (en) | 2014-11-19 |
| JP6038821B2 (ja) | 2016-12-07 |
| EP2685993B1 (en) | 2016-08-17 |
| EP3156060B1 (en) | 2019-11-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10967008B2 (en) | Pharmaceutical compositions and topical use thereof | |
| JP6177750B2 (ja) | 若返り用の細胞および細胞抽出物の投与 | |
| US9486401B2 (en) | Use of cellular extracts for skin rejuvenation | |
| EP2744892A1 (en) | Therapeutics using adipose cells and cell secretions | |
| AU2015201116B2 (en) | Use of cellular extracts for skin rejuvenation | |
| AU2015202776B2 (en) | Pharmaceutical compositions and topical use thereof | |
| AU2013203164B8 (en) | Therapeutics for skin conditions | |
| HK1236414A1 (en) | Pharmaceutical compositions and topical use thereof | |
| HK1236414A (en) | Pharmaceutical compositions and topical use thereof | |
| HK1236414B (en) | Pharmaceutical compositions and topical use thereof | |
| HK1191557B (en) | Composition adipose tissue-derived secretions for use in the topical treatment or prevention of acne | |
| TW201238595A (en) | Bamboo growth factor extraction method and its hair restoring liquid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20170202 |