CA2865504A1 - Compositions and methods for inhibition of cathepsins - Google Patents

Info

Publication number

CA2865504A1

CA2865504A1 CA2865504A CA2865504A CA2865504A1 CA 2865504 A1 CA2865504 A1 CA 2865504A1 CA 2865504 A CA2865504 A CA 2865504A CA 2865504 A CA2865504 A CA 2865504A CA 2865504 A1 CA2865504 A1 CA 2865504A1

Authority

CA

Canada

Prior art keywords

compound

cathepsin

compound according

group

compounds

Prior art date

2012-03-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

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• 108010084457 Cathepsins Proteins 0.000 title claims abstract description 35
• 238000000034 method Methods 0.000 title claims abstract description 35
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• 230000005764 inhibitory process Effects 0.000 title description 5
• 150000001875 compounds Chemical class 0.000 claims abstract description 149
• 108090000624 Cathepsin L Proteins 0.000 claims abstract description 19
• 102000004172 Cathepsin L Human genes 0.000 claims abstract description 19
• 108090000625 Cathepsin K Proteins 0.000 claims abstract description 16
• 102000004171 Cathepsin K Human genes 0.000 claims abstract description 16
• 150000003839 salts Chemical class 0.000 claims description 45
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 29
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• 239000008194 pharmaceutical composition Substances 0.000 claims description 19
• 125000003118 aryl group Chemical group 0.000 claims description 15
• 229910052739 hydrogen Inorganic materials 0.000 claims description 15
• 239000001257 hydrogen Substances 0.000 claims description 14
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• 125000002252 acyl group Chemical group 0.000 claims description 12
• 230000002401 inhibitory effect Effects 0.000 claims description 12
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