AU2013235729B2 - Compositions and methods for inhibition of cathepsins - Google Patents

Compositions and methods for inhibition of cathepsins Download PDF

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Publication number
AU2013235729B2
AU2013235729B2 AU2013235729A AU2013235729A AU2013235729B2 AU 2013235729 B2 AU2013235729 B2 AU 2013235729B2 AU 2013235729 A AU2013235729 A AU 2013235729A AU 2013235729 A AU2013235729 A AU 2013235729A AU 2013235729 B2 AU2013235729 B2 AU 2013235729B2
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AU
Australia
Prior art keywords
compound
cathepsin
compound according
group
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013235729A
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English (en)
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AU2013235729A1 (en
Inventor
David J. Chaplin
Kishore Kumar Gaddale Devanna
Erica PARKER
Kevin G. Pinney
Jiangli SONG
Mary L. Trawick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor University
Mateon Therapeutics Inc
Original Assignee
Baylor University
Mateon Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor University, Mateon Therapeutics Inc filed Critical Baylor University
Publication of AU2013235729A1 publication Critical patent/AU2013235729A1/en
Assigned to BAYLOR UNIVERSITY, MATEON THERAPEUTICS, INC. reassignment BAYLOR UNIVERSITY Amend patent request/document other than specification (104) Assignors: BAYLOR UNIVERSITY, OXIGENE, INC.
Application granted granted Critical
Publication of AU2013235729B2 publication Critical patent/AU2013235729B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C337/00—Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
    • C07C337/08—Compounds containing any of the groups, e.g. thiosemicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. thiosemicarbazones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/784—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic with all keto groups bound to a non-condensed ring
    • C07C49/786—Benzophenone

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2013235729A 2012-03-23 2013-03-05 Compositions and methods for inhibition of cathepsins Ceased AU2013235729B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261615091P 2012-03-23 2012-03-23
US61/615,091 2012-03-23
PCT/US2013/029106 WO2013142038A2 (en) 2012-03-23 2013-03-05 Compositions and methods for inhibition of cathepsins

Publications (2)

Publication Number Publication Date
AU2013235729A1 AU2013235729A1 (en) 2014-10-09
AU2013235729B2 true AU2013235729B2 (en) 2017-06-01

Family

ID=49223437

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013235729A Ceased AU2013235729B2 (en) 2012-03-23 2013-03-05 Compositions and methods for inhibition of cathepsins

Country Status (7)

Country Link
US (3) US8877967B2 (enExample)
EP (1) EP2828241B1 (enExample)
JP (1) JP6231548B2 (enExample)
AU (1) AU2013235729B2 (enExample)
CA (1) CA2865504A1 (enExample)
NZ (1) NZ629898A (enExample)
WO (1) WO2013142038A2 (enExample)

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* Cited by examiner, † Cited by third party
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JP6231548B2 (ja) * 2012-03-23 2017-11-15 マテオン セラピューティクス， インコーポレイテッド カテプシンの阻害のための組成物および方法
US9884719B2 (en) 2014-12-12 2018-02-06 Symbotic, LLC Storage and retrieval system
US11059937B2 (en) 2016-07-25 2021-07-13 The Boeing Company Epoxy resin
CN110267935B (zh) * 2016-12-21 2022-11-25 索尔维特殊聚合物美国有限责任公司 用于降低包含双(苯甲酰基)苯的单体组合物中的金属浓度的方法
US20180198740A1 (en) * 2017-01-06 2018-07-12 David Rademacher System and method for sharing and updating contact information
US10758559B1 (en) 2017-09-01 2020-09-01 University Of Wyoming Targeting cathepsin K to facilitate wound healing
US11766467B2 (en) 2017-09-01 2023-09-26 University Of Wyoming Methods of treating wounds using cathepsin K inhibitors
US10487057B1 (en) * 2018-07-05 2019-11-26 Landos Biopharma, Inc. NLRX1 ligands
CN110857267B (zh) * 2018-08-22 2022-12-09 昱镭光电科技股份有限公司 芳香酮化合物及其有机发光器件
US11329823B2 (en) 2019-09-26 2022-05-10 Bank Of America Corporation User authentication using tokens
US11303629B2 (en) 2019-09-26 2022-04-12 Bank Of America Corporation User authentication using tokens

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110305632A1 (en) * 2008-12-12 2011-12-15 The University Of Melbourne Process for the preparation of asymmetrical bis(thiosemicarbazones)

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Patent Citations (1)

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Also Published As

Publication number Publication date
WO2013142038A2 (en) 2013-09-26
NZ629898A (en) 2016-04-29
US8877967B2 (en) 2014-11-04
WO2013142038A3 (en) 2015-06-18
US9458103B2 (en) 2016-10-04
EP2828241A4 (en) 2016-06-29
JP2015521156A (ja) 2015-07-27
US20150031915A1 (en) 2015-01-29
US9873668B2 (en) 2018-01-23
EP2828241A2 (en) 2015-01-28
US20160368869A1 (en) 2016-12-22
EP2828241B1 (en) 2018-09-12
JP6231548B2 (ja) 2017-11-15
US20130296605A1 (en) 2013-11-07
AU2013235729A1 (en) 2014-10-09
CA2865504A1 (en) 2013-09-26

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired