CA2864797C - Methods of treating amyotrophic lateral sclerosis - Google Patents

Methods of treating amyotrophic lateral sclerosis Download PDF

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Publication number
CA2864797C
CA2864797C CA2864797A CA2864797A CA2864797C CA 2864797 C CA2864797 C CA 2864797C CA 2864797 A CA2864797 A CA 2864797A CA 2864797 A CA2864797 A CA 2864797A CA 2864797 C CA2864797 C CA 2864797C
Authority
CA
Canada
Prior art keywords
compound
als
administration
oxidative stress
stress associated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2864797A
Other languages
English (en)
French (fr)
Other versions
CA2864797A1 (en
Inventor
Per Gjorstrup
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ANIDA PHARMA Inc
Original Assignee
ANIDA PHARMA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ANIDA PHARMA Inc filed Critical ANIDA PHARMA Inc
Publication of CA2864797A1 publication Critical patent/CA2864797A1/en
Application granted granted Critical
Publication of CA2864797C publication Critical patent/CA2864797C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/42Unsaturated compounds containing hydroxy or O-metal groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2864797A 2012-02-15 2013-02-15 Methods of treating amyotrophic lateral sclerosis Active CA2864797C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261599096P 2012-02-15 2012-02-15
US61/599,096 2012-02-15
PCT/US2013/026284 WO2013123290A1 (en) 2012-02-15 2013-02-15 Methods of treating amyotrophic lateral sclerosis

Publications (2)

Publication Number Publication Date
CA2864797A1 CA2864797A1 (en) 2013-08-22
CA2864797C true CA2864797C (en) 2022-03-22

Family

ID=48984729

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2864797A Active CA2864797C (en) 2012-02-15 2013-02-15 Methods of treating amyotrophic lateral sclerosis

Country Status (5)

Country Link
US (1) US9340483B2 (enExample)
EP (1) EP2814479B1 (enExample)
JP (1) JP6173352B2 (enExample)
CA (1) CA2864797C (enExample)
WO (1) WO2013123290A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3050572A1 (en) * 2017-01-18 2018-07-26 Universitat Autonoma De Barcelona Specialized pro-resolving lipid mediators for use in the treatment of neurodegenerative diseases and/or autoimmune diseases
WO2019016580A1 (en) 2017-07-20 2019-01-24 Universitat Autonoma De Barcelona MARESINS FOR USE IN THE TREATMENT OF CNS INJURIES
US10322114B2 (en) 2017-07-31 2019-06-18 Above And Beyond Nb, Llc Formulation of a riluzole solution with beta-cyclodextrins
US20250381161A1 (en) * 2022-06-21 2025-12-18 Anida Pharma Inc. Compositions and methods for treating hearing and ocular disorders

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1202068C (zh) 2000-02-16 2005-05-18 布里格姆及妇女医院股份有限公司 阿司匹林触发的脂质介体
AU2002343609B2 (en) * 2001-11-16 2008-12-11 Als Therapy Development Foundation, Inc. Treatment of neurodegenerative disorders through the modulation of the polyamine pathway
US7759395B2 (en) 2002-08-12 2010-07-20 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
WO2004093802A2 (en) * 2003-04-17 2004-11-04 The Board Of Trustees Of The Leland Stanford Junior University Prevention of deficits in neurogenesis with anti-inflammatory agents
EP1660069A4 (en) * 2003-08-05 2009-03-18 Univ Louisiana State NEUROPROTECTION AGAINST CELL APOPTOSIS, NEURAL STROKES, ALZHEIMER DISEASE AND RETINAL DEGENERATION
DK1691814T3 (da) * 2003-12-01 2012-10-29 Cambridge Entpr Ltd Antiinflammatoriske midler
WO2007041440A2 (en) * 2005-10-03 2007-04-12 The Brigham And Women's Hospital, Inc. Anti-inflammatory actions of neuroprotectin d1/protectin d1 and its natural stereoisomers
US20110190389A1 (en) 2007-02-20 2011-08-04 Linda Arterburn Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same
WO2009018333A2 (en) 2007-07-30 2009-02-05 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Dha and pedf, a therapeutic composition for nerve and retinal pigment epithelial cells
GB2452696B (en) * 2007-08-02 2009-09-23 Cambridge Entpr Ltd 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
US20090137527A1 (en) 2007-09-14 2009-05-28 Resolvyx Pharmaceuticals, Inc. Compositions and methods for modulating immune function
WO2009056983A1 (en) 2007-10-31 2009-05-07 Pronova Biopharma Norge As New dha derivatives and their use as medicaments
US7782152B2 (en) 2008-08-14 2010-08-24 Broadcom Corporation Monotonic frequency tuning technique for DCXO in cellular applications
US20120122816A1 (en) 2009-02-05 2012-05-17 Resolvyx Pharmaceuticals, Inc. Compositions and methods for organ preservation
US9468620B2 (en) * 2013-02-28 2016-10-18 Andida Pharma, Inc. Methods of treating ototoxicity

Also Published As

Publication number Publication date
WO2013123290A1 (en) 2013-08-22
CA2864797A1 (en) 2013-08-22
JP6173352B2 (ja) 2017-08-02
EP2814479A1 (en) 2014-12-24
EP2814479A4 (en) 2015-07-01
US9340483B2 (en) 2016-05-17
JP2015510517A (ja) 2015-04-09
US20150010549A1 (en) 2015-01-08
WO2013123290A9 (en) 2014-09-12
EP2814479B1 (en) 2019-09-04

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Effective date: 20180215