CA2863723C - 8-substituted 2-amino-[1,2,4]triazolo[1,5-a]pyrazines as syk tryrosine kinase inhibitors and gcn2 serin kinase inhibitors - Google Patents

8-substituted 2-amino-[1,2,4]triazolo[1,5-a]pyrazines as syk tryrosine kinase inhibitors and gcn2 serin kinase inhibitors Download PDF

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Publication number
CA2863723C
CA2863723C CA2863723A CA2863723A CA2863723C CA 2863723 C CA2863723 C CA 2863723C CA 2863723 A CA2863723 A CA 2863723A CA 2863723 A CA2863723 A CA 2863723A CA 2863723 C CA2863723 C CA 2863723C
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Prior art keywords
pyrazin
triazolo
spiro
dihydro
ylamino
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French (fr)
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CA2863723A1 (en
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Carl Deutsch
Daniel Kuhn
Tatjana Ross
Lars Burgdorf
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Merck Patent GmbH
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Merck Patent GmbH
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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CA2863723A 2012-02-21 2013-01-22 8-substituted 2-amino-[1,2,4]triazolo[1,5-a]pyrazines as syk tryrosine kinase inhibitors and gcn2 serin kinase inhibitors Active CA2863723C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12001153 2012-02-21
EP12001153.1 2012-02-21
PCT/EP2013/000189 WO2013124026A1 (en) 2012-02-21 2013-01-22 8 - substituted 2 -amino - [1,2,4] triazolo [1, 5 -a] pyrazines as syk tryrosine kinase inhibitors and gcn2 serin kinase inhibitors

Publications (2)

Publication Number Publication Date
CA2863723A1 CA2863723A1 (en) 2013-08-29
CA2863723C true CA2863723C (en) 2020-09-22

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CA2863723A Active CA2863723C (en) 2012-02-21 2013-01-22 8-substituted 2-amino-[1,2,4]triazolo[1,5-a]pyrazines as syk tryrosine kinase inhibitors and gcn2 serin kinase inhibitors

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US (1) US9120804B2 (OSRAM)
EP (1) EP2817310B1 (OSRAM)
JP (2) JP6479476B2 (OSRAM)
CN (1) CN104114557B (OSRAM)
AR (1) AR090104A1 (OSRAM)
AU (1) AU2013224421B2 (OSRAM)
CA (1) CA2863723C (OSRAM)
ES (1) ES2674451T3 (OSRAM)
IL (1) IL233982A (OSRAM)
TW (1) TW201339165A (OSRAM)
WO (1) WO2013124026A1 (OSRAM)

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KR20210142154A (ko) 2019-03-21 2021-11-24 옹쎄오 암 치료를 위한 키나제 억제제와 조합된 dbait 분자
JP2023500906A (ja) 2019-11-08 2023-01-11 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
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JP2024518530A (ja) * 2021-05-14 2024-05-01 ビーエム ファーマ コンサルティング ピーティーワイ リミテッド ウイルス感染の予防及び治療のための二環式複素環化合物
WO2022271684A1 (en) * 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
KR102659126B1 (ko) * 2022-03-24 2024-04-19 충남대학교산학협력단 항결핵 약학조성물
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