CA2862485C - Peptide agents for cancer therapy - Google Patents

Peptide agents for cancer therapy Download PDF

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Publication number
CA2862485C
CA2862485C CA2862485A CA2862485A CA2862485C CA 2862485 C CA2862485 C CA 2862485C CA 2862485 A CA2862485 A CA 2862485A CA 2862485 A CA2862485 A CA 2862485A CA 2862485 C CA2862485 C CA 2862485C
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CA
Canada
Prior art keywords
peptide
seq
amino acid
cell
cancer
Prior art date
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Active
Application number
CA2862485A
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English (en)
French (fr)
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CA2862485A1 (en
Inventor
Michael Valentine Agrez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
InterK Peptide Therapeutics Ltd
Original Assignee
InterK Peptide Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2012900259A external-priority patent/AU2012900259A0/en
Application filed by InterK Peptide Therapeutics Ltd filed Critical InterK Peptide Therapeutics Ltd
Publication of CA2862485A1 publication Critical patent/CA2862485A1/en
Application granted granted Critical
Publication of CA2862485C publication Critical patent/CA2862485C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/005Enzyme inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546Integrin superfamily
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2862485A 2012-01-24 2013-01-24 Peptide agents for cancer therapy Active CA2862485C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AU2012900259A AU2012900259A0 (en) 2012-01-24 Agents for use in cancer therapy
AU2012900259 2012-01-24
AU2012904368A AU2012904368A0 (en) 2012-10-06 Anti-cancer peptides
AU2012904368 2012-10-06
PCT/AU2013/000045 WO2013110120A1 (en) 2012-01-24 2013-01-24 Peptide agents for cancer therapy

Publications (2)

Publication Number Publication Date
CA2862485A1 CA2862485A1 (en) 2013-08-01
CA2862485C true CA2862485C (en) 2021-05-11

Family

ID=48872819

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2862485A Active CA2862485C (en) 2012-01-24 2013-01-24 Peptide agents for cancer therapy

Country Status (7)

Country Link
US (1) US9403877B2 (https=)
EP (1) EP2807180B1 (https=)
JP (1) JP6249447B2 (https=)
CN (1) CN104271590B (https=)
AU (1) AU2013202137B2 (https=)
CA (1) CA2862485C (https=)
WO (1) WO2013110120A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101644982B1 (ko) * 2015-07-23 2016-08-02 주식회사 엔솔바이오사이언스 신규 펩타이드 및 그 용도
CN105294839A (zh) * 2015-10-28 2016-02-03 上海大学 对新生血管形成有阻断功能的多肽化合物及其应用
CN106084012A (zh) * 2016-07-09 2016-11-09 青岛大学 具有抑制癌细胞生长活性的肽及其应用
CN106167513A (zh) * 2016-07-09 2016-11-30 青岛大学 具有抑制癌细胞生长活性的肽及其应用
CN105936642A (zh) * 2016-07-09 2016-09-14 青岛大学 具有抑制癌细胞生长活性的肽及其应用
CN106146620A (zh) * 2016-07-09 2016-11-23 青岛大学 具有抑制癌细胞生长活性的肽及其应用
CN105936643A (zh) * 2016-07-09 2016-09-14 青岛大学 具有抑制癌细胞生长活性的肽及其应用
GB201706472D0 (en) * 2017-04-24 2017-06-07 Cancer Res Tech Ltd Tumour-targeting peptide variants
CN111094324B (zh) * 2018-03-14 2023-10-10 武汉博威德生物技术有限公司 一种溶瘤病毒、合成dna序列及其应用
US11912789B2 (en) 2018-05-15 2024-02-27 Interk Peptide Therapeutics Limited Peptide activating agent
CN112368293A (zh) * 2018-05-15 2021-02-12 英特肽治疗有限公司 活化剂
CA3120624A1 (en) * 2018-11-30 2020-06-04 Interk Peptide Therapeutics Limited Polypeptides and methods for improving skin conditions
CN110893236A (zh) * 2019-10-09 2020-03-20 中山大学 溶酶体靶向的抗体药物偶联物及其应用
CN112646018B (zh) * 2021-01-25 2023-04-28 井冈山大学 一种抑制肿瘤细胞增殖和转移的生物活性肽及其应用
JP2024532850A (ja) * 2021-08-20 2024-09-10 インテルク ペプチド セラピューティクス リミテッド がん及びがん療法に関連する自己免疫を含む、自己免疫を処置するための組成物及び方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030162956A1 (en) 1997-04-07 2003-08-28 Human Genome Sciences, Inc. Leukocyte regulatory factors 1 and 2
DE60037970T2 (de) * 1999-06-28 2008-08-21 Inter-K Pty. Ltd., Newcastle Verfahren zur modulierung von integrin-vermittelter zellaktivitaet und hierfuer geeignete reagenzien
CN1254234C (zh) 2000-06-09 2006-05-03 莱古伦公司 质粒dna(lipogenestm)和含细胞核定位信号/促融合肽缀合物的治疗剂包封到定向脂质体复合体中
US6696546B1 (en) 2000-11-06 2004-02-24 The Trustees Of Columbia University In The City Of New York Peptide that kills growing but not stationary cells
AUPR230500A0 (en) 2000-12-22 2001-01-25 University Of Newcastle Research Associates Limited, The A method of modulating map kinase mediated cellular activity and agents useful in same
WO2002053726A2 (en) 2001-01-02 2002-07-11 Hybrigenics Protein-protein interactions in adipocyte cells
US20030194798A1 (en) 2001-05-24 2003-10-16 Surber Mark W. Minicell compositions and methods
ATE541940T1 (de) 2001-10-15 2012-02-15 Engeneic Molecular Delivery Pty Ltd Intakte minizellen als vektoren für dna-transfer und gentherapie in vitro und in vivo
JP5105696B2 (ja) * 2001-11-16 2012-12-26 ジェネンテック, インコーポレイテッド アンジオポエチン様タンパク質3Angptl3含有組成物とその使用方法
US7611885B2 (en) 2003-06-24 2009-11-03 Engeneic Molecular Delivery Pty, Ltd. Pharmaceutically compatible method for purifying intact bacterial minicells
WO2005009346A2 (en) 2003-06-24 2005-02-03 Mirus Corporation Inhibition of gene function by delivery of polynucleotide-based gene expression inhibitors to mammalian cells in vivo
WO2005037308A1 (en) * 2003-10-17 2005-04-28 Inter-K Pty Limited Methods and agents for the treatment of cancer
WO2005105837A2 (en) 2004-04-14 2005-11-10 Brigham And Women's Hospital, Inc. Use of the ribosomal protein rpl41 to treat infections and inhibit cancer
US20060194319A1 (en) 2004-09-02 2006-08-31 Webb Carol F Promoter substitution for immunoglobulin therapy
DK2229956T3 (da) 2004-09-13 2013-07-29 Genzyme Corp Multimere konstruktioner
WO2006029981A1 (en) 2004-09-13 2006-03-23 Vib Vzw Abin-mediated protection against lung inflammatory disease
US7429481B2 (en) 2004-09-14 2008-09-30 University Of Pittsburgh Targeting viruses using a modified sindbis glycoprotein
GB0520068D0 (en) 2005-10-03 2005-11-09 Cancer Res Technology av peptide ligand
US7912214B2 (en) 2007-07-20 2011-03-22 Amadeus S.A.S. Method and system for generating and controlling the distribution and use of personal promotion codes by targeted customers
JP2011512364A (ja) * 2008-02-22 2011-04-21 インター−ケイ ピーティーワイ リミテッド 治療用ペプチド
EP2254592B1 (en) * 2008-02-28 2019-06-05 Dako Denmark A/S Mhc multimers in borrelia diagnostics and disease
EP2362909A4 (en) * 2008-09-30 2012-10-10 Zirus Inc MAMMALIAN GENES INVOLVED IN INFECTION
WO2010094085A1 (en) 2009-02-23 2010-08-26 Inter-K Pty Limited Inhibition of multiple cell activation pathways

Also Published As

Publication number Publication date
WO2013110120A1 (en) 2013-08-01
JP6249447B2 (ja) 2017-12-20
AU2013202137B2 (en) 2015-09-10
US9403877B2 (en) 2016-08-02
CA2862485A1 (en) 2013-08-01
EP2807180B1 (en) 2018-03-28
CN104271590A (zh) 2015-01-07
CN104271590B (zh) 2018-06-05
EP2807180A4 (en) 2016-01-06
JP2015510393A (ja) 2015-04-09
US20150110744A1 (en) 2015-04-23
EP2807180A1 (en) 2014-12-03

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