CA2858105A1 - Derives d'isoquinuclidene reunis par fusion a de l'indole et du benzofurane et leurs procedes de preparation - Google Patents

Derives d'isoquinuclidene reunis par fusion a de l'indole et du benzofurane et leurs procedes de preparation Download PDF

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Publication number
CA2858105A1
CA2858105A1 CA2858105A CA2858105A CA2858105A1 CA 2858105 A1 CA2858105 A1 CA 2858105A1 CA 2858105 A CA2858105 A CA 2858105A CA 2858105 A CA2858105 A CA 2858105A CA 2858105 A1 CA2858105 A1 CA 2858105A1
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CA
Canada
Prior art keywords
group
compound
alkyl
formula
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2858105A
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English (en)
Inventor
Robert M. Moriarty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DemeRx Inc
Original Assignee
DemeRx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2012/022787 external-priority patent/WO2013112163A1/fr
Application filed by DemeRx Inc filed Critical DemeRx Inc
Publication of CA2858105A1 publication Critical patent/CA2858105A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des dérivés d'isoquinuclidène réunis par fusion à de l'indole et du benzofurane. Elle concerne églement des procédés, de préférence des procédés à énantiosélectivité, permettant de préparer de tels dérivés, comprenant des procédés de préparation de noribogaïne (-) et (+) ou un sel associé, dans des formes sensiblement pures d'un point de vue énantiomérique.
CA2858105A 2012-01-25 2013-01-24 Derives d'isoquinuclidene reunis par fusion a de l'indole et du benzofurane et leurs procedes de preparation Abandoned CA2858105A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201261741798P 2012-01-25 2012-01-25
US201261590740P 2012-01-25 2012-01-25
US61/590,740 2012-01-25
US61/741,798 2012-01-25
US201261591258P 2012-01-26 2012-01-26
USPCT/US12/22787 2012-01-26
PCT/US2012/022787 WO2013112163A1 (fr) 2012-01-25 2012-01-26 Dérivés d'isoquinuclidène fusionnés à de l'indole et du benzofurane et procédés de préparation de ceux-ci
US61/591,258 2012-01-26
PCT/US2013/023017 WO2013112757A1 (fr) 2012-01-25 2013-01-24 Dérivés d'isoquinuclidène réunis par fusion à de l'indole et du benzofurane et leurs procédés de préparation

Publications (1)

Publication Number Publication Date
CA2858105A1 true CA2858105A1 (fr) 2013-08-01

Family

ID=48873918

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2858105A Abandoned CA2858105A1 (fr) 2012-01-25 2013-01-24 Derives d'isoquinuclidene reunis par fusion a de l'indole et du benzofurane et leurs procedes de preparation

Country Status (3)

Country Link
EP (1) EP2807167A4 (fr)
CA (1) CA2858105A1 (fr)
WO (1) WO2013112757A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11840541B2 (en) * 2014-11-26 2023-12-12 The Trustees Of Columbia University In The City Of New York Opioid receptor modulators
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
EP3955936A1 (fr) 2019-04-17 2022-02-23 COMPASS Pathfinder Limited Traitement de la dépression et de divers autres troubles au moyen de psilocybine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220737B1 (en) * 1997-09-04 2007-05-22 Novoneuron, Inc Noribogaine in the treatment of pain and drug addiction
JP5542972B2 (ja) * 2010-02-22 2014-07-09 ザ スクリプス リサーチ インスティテュート Ｍｄｒがん細胞に対する強化された生物活性を提供する１０’−フッ素化ビンカアルカロイド
US9358237B2 (en) * 2010-07-23 2016-06-07 Demerx, Inc. Noribogaine compositions
IN2014CN04160A (fr) * 2011-12-08 2015-07-17 Demerx Inc
US8877921B2 (en) * 2012-01-25 2014-11-04 Demerx, Inc. Synthetic voacangine

Also Published As

Publication number Publication date
EP2807167A4 (fr) 2016-01-20
EP2807167A1 (fr) 2014-12-03
WO2013112757A1 (fr) 2013-08-01

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180123

FZDE Discontinued

Effective date: 20210831