EP2807167A4 - Dérivés d'isoquinuclidène réunis par fusion à de l'indole et du benzofurane et leurs procédés de préparation - Google Patents

Dérivés d'isoquinuclidène réunis par fusion à de l'indole et du benzofurane et leurs procédés de préparation

Info

Publication number
EP2807167A4
EP2807167A4 EP13741381.1A EP13741381A EP2807167A4 EP 2807167 A4 EP2807167 A4 EP 2807167A4 EP 13741381 A EP13741381 A EP 13741381A EP 2807167 A4 EP2807167 A4 EP 2807167A4
Authority
EP
European Patent Office
Prior art keywords
indole
preparing
processes
isoquinuclidene
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP13741381.1A
Other languages
German (de)
English (en)
Other versions
EP2807167A1 (fr
Inventor
Robert M Moriarty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DemeRx Inc
Original Assignee
DemeRx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2012/022787 external-priority patent/WO2013112163A1/fr
Application filed by DemeRx Inc filed Critical DemeRx Inc
Publication of EP2807167A1 publication Critical patent/EP2807167A1/fr
Publication of EP2807167A4 publication Critical patent/EP2807167A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
EP13741381.1A 2012-01-25 2013-01-24 Dérivés d'isoquinuclidène réunis par fusion à de l'indole et du benzofurane et leurs procédés de préparation Withdrawn EP2807167A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261741798P 2012-01-25 2012-01-25
US201261590740P 2012-01-25 2012-01-25
US201261591258P 2012-01-26 2012-01-26
PCT/US2012/022787 WO2013112163A1 (fr) 2012-01-25 2012-01-26 Dérivés d'isoquinuclidène fusionnés à de l'indole et du benzofurane et procédés de préparation de ceux-ci
PCT/US2013/023017 WO2013112757A1 (fr) 2012-01-25 2013-01-24 Dérivés d'isoquinuclidène réunis par fusion à de l'indole et du benzofurane et leurs procédés de préparation

Publications (2)

Publication Number Publication Date
EP2807167A1 EP2807167A1 (fr) 2014-12-03
EP2807167A4 true EP2807167A4 (fr) 2016-01-20

Family

ID=48873918

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13741381.1A Withdrawn EP2807167A4 (fr) 2012-01-25 2013-01-24 Dérivés d'isoquinuclidène réunis par fusion à de l'indole et du benzofurane et leurs procédés de préparation

Country Status (3)

Country Link
EP (1) EP2807167A4 (fr)
CA (1) CA2858105A1 (fr)
WO (1) WO2013112757A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016086158A1 (fr) * 2014-11-26 2016-06-02 The Trustees Of Columbia University In The City Of New York Modulateurs du récepteur opioïde
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
TW202103699A (zh) 2019-04-17 2021-02-01 英商康派斯百事威公司 賽洛西賓（ｐｓｉｌｏｃｙｂｉｎ）於憂鬱及其他各種失調症之治療

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220737B1 (en) * 1997-09-04 2007-05-22 Novoneuron, Inc Noribogaine in the treatment of pain and drug addiction
WO2011103007A2 (fr) * 2010-02-22 2011-08-25 The Scripps Research Institute Vinca-alcaloïdes 10'-fluorés dotés d'une activité biologique augmentée contre les cellules cancéreuses multirésistantes
WO2012012764A1 (fr) * 2010-07-23 2012-01-26 Demerx, Inc. Compositions de noribogaïne
WO2013085850A2 (fr) * 2011-12-08 2013-06-13 Demerx, Inc. Synthèse stéréosélective totale de la noribogaïne
WO2013112673A1 (fr) * 2012-01-25 2013-08-01 Demerx, Inc. Voacangine synthétique

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220737B1 (en) * 1997-09-04 2007-05-22 Novoneuron, Inc Noribogaine in the treatment of pain and drug addiction
WO2011103007A2 (fr) * 2010-02-22 2011-08-25 The Scripps Research Institute Vinca-alcaloïdes 10'-fluorés dotés d'une activité biologique augmentée contre les cellules cancéreuses multirésistantes
WO2012012764A1 (fr) * 2010-07-23 2012-01-26 Demerx, Inc. Compositions de noribogaïne
WO2013085850A2 (fr) * 2011-12-08 2013-06-13 Demerx, Inc. Synthèse stéréosélective totale de la noribogaïne
WO2013112673A1 (fr) * 2012-01-25 2013-08-01 Demerx, Inc. Voacangine synthétique

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GOUTAM KUMAR JANA ET AL: "Progress in the Synthesis of Iboga-alkaloids and their Congeners", ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, vol. 43, no. 6, 1 January 2011 (2011-01-01), pages 541 - 573, XP055160017, ISSN: 0030-4948, DOI: 10.1080/00304948.2011.629563 *
GOUTAM KUMAR JANA ET AL: "Reductive Heck coupling: an efficient approach toward the iboga alkaloids. Synthesis of ibogamine, epiibogamine and iboga analogs", TETRAHEDRON LETTERS, PERGAMON, GB, vol. 53, no. 13, 22 January 2012 (2012-01-22), pages 1671 - 1674, XP028459581, ISSN: 0040-4039, [retrieved on 20120128], DOI: 10.1016/J.TETLET.2012.01.097 *
See also references of WO2013112757A1 *
STEFAN HÖCK ET AL: "Enantioselective Synthesis of (-)-(19R)-Ibogamin-19-ol", HELVETICA CHIMICA ACTA, vol. 89, no. 3, 1 March 2006 (2006-03-01), pages 542 - 557, XP055165486, ISSN: 0018-019X, DOI: 10.1002/hlca.200690058 *
WHITE J D ET AL: "Catalyzed asymmetric Diels - Alder reactions of benzoquinone. Total synthesis of (-)-ibogamine", HELVETICA CHIMICA ACTA 2002 CH, vol. 85, no. 12, 2002, pages 4306 - 4327, XP002751997, ISSN: 0018-019X *

Also Published As

Publication number Publication date
WO2013112757A1 (fr) 2013-08-01
EP2807167A1 (fr) 2014-12-03
CA2858105A1 (fr) 2013-08-01

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Ipc: C07D 451/04 20060101AFI20151210BHEP

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