CA2855826A1 - Immunogenic complexes of polyanionic carbomers and env polypeptides and methods of manufacture and use thereof - Google Patents
Immunogenic complexes of polyanionic carbomers and env polypeptides and methods of manufacture and use thereof Download PDFInfo
- Publication number
- CA2855826A1 CA2855826A1 CA2855826A CA2855826A CA2855826A1 CA 2855826 A1 CA2855826 A1 CA 2855826A1 CA 2855826 A CA2855826 A CA 2855826A CA 2855826 A CA2855826 A CA 2855826A CA 2855826 A1 CA2855826 A1 CA 2855826A1
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- Prior art keywords
- polypeptide
- env
- env polypeptide
- immunogenic composition
- polyanionic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Landscapes
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Applications Claiming Priority (3)
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| US201161559512P | 2011-11-14 | 2011-11-14 | |
| US61/559,512 | 2011-11-14 | ||
| PCT/US2012/065113 WO2013074696A1 (en) | 2011-11-14 | 2012-11-14 | Immunogenic complexes of polyanionic carbomers and env polypeptides and methods of manufacture and use thereof |
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| CA2855826A1 true CA2855826A1 (en) | 2013-05-23 |
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| EP (1) | EP2780035A1 (https=) |
| JP (1) | JP2014533290A (https=) |
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| RU (1) | RU2014124154A (https=) |
| WO (1) | WO2013074696A1 (https=) |
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| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2625189B1 (en) | 2010-10-01 | 2018-06-27 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DE19216461T1 (de) | 2011-10-03 | 2021-10-07 | Modernatx, Inc. | Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon |
| CA3018046A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| WO2013151665A2 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| US12070495B2 (en) | 2019-03-15 | 2024-08-27 | Modernatx, Inc. | HIV RNA vaccines |
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| US2909462A (en) | 1955-12-08 | 1959-10-20 | Bristol Myers Co | Acrylic acid polymer laxative compositions |
| US3790665A (en) | 1968-02-23 | 1974-02-05 | Haver Lockhart Labor Inc | Injectable adjuvant,method of preparing same and compositions including such adjuvant |
| US4431739A (en) | 1979-11-05 | 1984-02-14 | Genentech, Inc. | Transformant bacterial culture capable of expressing heterologous protein |
| US4425437A (en) | 1979-11-05 | 1984-01-10 | Genentech, Inc. | Microbial polypeptide expression vehicle |
| US4338397A (en) | 1980-04-11 | 1982-07-06 | President And Fellows Of Harvard College | Mature protein synthesis |
| JPH0832637B2 (ja) * | 1985-02-14 | 1996-03-29 | アクゾ・エヌ・ヴエー | 合成免疫原 |
| US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
| ATE112687T1 (de) | 1988-09-13 | 1994-10-15 | Chiron Corp | Mutanten des hiv-1 hüllproteins mit fehlenden hypervariabelen domänen. |
| CA2017507C (en) | 1989-05-25 | 1996-11-12 | Gary Van Nest | Adjuvant formulation comprising a submicron oil droplet emulsion |
| US5840313A (en) | 1990-09-27 | 1998-11-24 | Syntello Vaccine Development Kb | Peptides for use in vaccination and induction of neutralizing antibodies against human immunodeficiency virus |
| IL101715A (en) | 1991-05-02 | 2005-06-19 | Amgen Inc | Recombinant dna-derived cholera toxin subunit analogs |
| IT1253009B (it) | 1991-12-31 | 1995-07-10 | Sclavo Ricerca S R L | Mutanti immunogenici detossificati della tossina colerica e della tossina lt, loro preparazione ed uso per la preparazione di vaccini |
| EP0688205A1 (en) * | 1993-03-11 | 1995-12-27 | Secretech, Inc. | Polymeric mucoadhesives in the delivery of immunogens at mucosal surfaces |
| CN1111540C (zh) | 1993-06-09 | 2003-06-18 | 康诺特实验室有限公司 | 串联的合成hiv-1肽类 |
| US5741492A (en) | 1996-01-23 | 1998-04-21 | St. Jude Children's Research Hospital | Preparation and use of viral vectors for mixed envelope protein vaccines against human immunodeficiency viruses |
| US7935805B1 (en) | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
| AU2487300A (en) | 1998-12-31 | 2000-07-31 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| AU2221600A (en) | 1998-12-31 | 2000-07-31 | Chiron Corporation | Improved expression of hiv polypeptides and production of virus-like particles |
| JP4776075B2 (ja) | 1998-12-31 | 2011-09-21 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 改変hivenvポリペプチド |
| JP2006509039A (ja) * | 2002-12-03 | 2006-03-16 | ユニバーシティ オブ マサチューセッツ | 多価初代hiv−1糖タンパク質dnaワクチンおよびワクチン接種方法 |
| AU2006304725B2 (en) * | 2005-10-17 | 2012-03-15 | Novartis Ag | Multiclade HIV vaccines |
| JP2009536653A (ja) * | 2006-05-09 | 2009-10-15 | ザ ヘンリー エム. ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド | Hiv−1免疫原性組成物 |
| WO2011003138A1 (en) * | 2009-07-06 | 2011-01-13 | The Australian National University | Immunomodulating compositions comprising interleukin 13 inhibitors and uses therefor |
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| WO2013074696A1 (en) | 2013-05-23 |
| MX2014005548A (es) | 2014-08-21 |
| BR112014011560A2 (pt) | 2017-05-09 |
| RU2014124154A (ru) | 2015-12-27 |
| AU2012340035A1 (en) | 2014-04-17 |
| EP2780035A1 (en) | 2014-09-24 |
| ZA201402910B (en) | 2015-12-23 |
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