CA2851383A1 - 2 - carboxamide cycloamino urea derivatives in combination with hsp90 inhibitors for the treatment of proliferative diseases - Google Patents
2 - carboxamide cycloamino urea derivatives in combination with hsp90 inhibitors for the treatment of proliferative diseases Download PDFInfo
- Publication number
- CA2851383A1 CA2851383A1 CA2851383A CA2851383A CA2851383A1 CA 2851383 A1 CA2851383 A1 CA 2851383A1 CA 2851383 A CA2851383 A CA 2851383A CA 2851383 A CA2851383 A CA 2851383A CA 2851383 A1 CA2851383 A1 CA 2851383A1
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- Prior art keywords
- compound
- alkyl
- pharmaceutically acceptable
- combination
- substituted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161547308P | 2011-10-14 | 2011-10-14 | |
| US61/547,308 | 2011-10-14 | ||
| PCT/EP2012/070171 WO2013053833A1 (en) | 2011-10-14 | 2012-10-11 | 2 - carboxamide cycloamino urea derivatives in combination with hsp90 inhibitors for the treatment of proliferative diseases |
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| RU (2) | RU2624493C2 (OSRAM) |
| WO (1) | WO2013053833A1 (OSRAM) |
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| AU2012331125A1 (en) * | 2011-11-02 | 2014-05-22 | Novartis Ag | 2-carboxamide cycloamino urea derivatives for use in treating VEGF - dependent diseases |
| JP2020507605A (ja) | 2017-02-17 | 2020-03-12 | フレッド ハッチンソン キャンサー リサーチ センター | Ｂｃｍａ関連癌および自己免疫疾患の治療のための併用療法 |
| CN111214473B (zh) * | 2020-02-14 | 2022-02-01 | 中国人民解放军陆军军医大学 | Hsp990在制备抗轮状病毒药物中的应用 |
| CN121712509A (zh) | 2023-05-04 | 2026-03-20 | 锐新医药公司 | 用于ras相关疾病或病症的组合疗法 |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| IL327306A (en) | 2023-10-12 | 2026-05-01 | Revolution Medicines Inc | Macrocyclic RAS inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
| WO2026090116A2 (en) | 2024-10-21 | 2026-04-30 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026090245A1 (en) | 2024-10-22 | 2026-04-30 | Revolution Medicines, Inc. | Use of ras inhibitors for treating cancer |
| US20260108528A1 (en) | 2024-10-22 | 2026-04-23 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4261989A (en) | 1979-02-19 | 1981-04-14 | Kaken Chemical Co. Ltd. | Geldanamycin derivatives and antitumor drug |
| SI1611112T1 (sl) | 2003-02-11 | 2012-12-31 | Vernalis (R&D) Limited | Izoksazolne spojine kot inhibitorji vroäśinskih ĺ ok proteinov |
| JO2783B1 (en) | 2005-09-30 | 2014-03-15 | نوفارتيس ايه جي | Compounds 2-Amino-7, 8-dihydro-6H-Bayredo (3,4-D) Pyrimidine-5-Ones |
| PL2182948T3 (pl) * | 2007-07-24 | 2013-07-31 | Novartis Ag | Zastosowanie imidazochinolin do leczenia chorób EGFR-zależnych albo chorób wykazujących nabytą oporność wobec środków ukierunkowanych na członków rodziny EGFR |
| TW200922595A (en) * | 2007-10-12 | 2009-06-01 | Novartis Ag | Organic compounds |
| UA104147C2 (uk) * | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| MX2011005664A (es) * | 2008-11-28 | 2011-06-16 | Novartis Ag | Inhibidores de hsp90 para tratamiento terapeutico. |
| DE102009012631B4 (de) | 2009-03-11 | 2011-07-28 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Filter für einen Computertomographen sowie Computertomograph |
| TR201802943T4 (tr) * | 2010-11-08 | 2018-03-21 | Novartis Ag | (S)-pirolidin-1,2-dikarboksilik asit 2-amid 1-({4-metil-5-[2-(2,2,2-trifloro-1,1-dimetil-etil)-piridin-4-il]-tiyazol-2-il}amid)'in egfr'ye bağlı hastalıkların veya egfr familya üyelerini hedefleyen ajanlara karşı direnç edinmiş hastalıkların tedavisinde kullanımı. |
-
2012
- 2012-10-11 CA CA2851383A patent/CA2851383A1/en not_active Abandoned
- 2012-10-11 MX MX2014004559A patent/MX2014004559A/es unknown
- 2012-10-11 WO PCT/EP2012/070171 patent/WO2013053833A1/en not_active Ceased
- 2012-10-11 RU RU2014119339A patent/RU2624493C2/ru not_active IP Right Cessation
- 2012-10-11 KR KR1020147009376A patent/KR20140078656A/ko not_active Ceased
- 2012-10-11 US US14/350,577 patent/US20140275089A1/en not_active Abandoned
- 2012-10-11 AU AU2012322976A patent/AU2012322976B2/en not_active Ceased
- 2012-10-11 JP JP2014535077A patent/JP6180420B2/ja not_active Expired - Fee Related
- 2012-10-11 CN CN201280050535.9A patent/CN103857392A/zh active Pending
- 2012-10-11 EP EP12772316.1A patent/EP2766015A1/en not_active Withdrawn
- 2012-10-11 CN CN201610906456.3A patent/CN106474127A/zh active Pending
- 2012-10-11 BR BR112014008400A patent/BR112014008400A2/pt not_active IP Right Cessation
- 2012-10-11 RU RU2017119219A patent/RU2017119219A/ru unknown
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2016
- 2016-03-03 US US15/059,395 patent/US20160199365A1/en not_active Abandoned
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2017
- 2017-06-09 JP JP2017114659A patent/JP2017214387A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012322976A1 (en) | 2014-05-01 |
| RU2014119339A (ru) | 2015-11-20 |
| RU2624493C2 (ru) | 2017-07-04 |
| RU2017119219A (ru) | 2018-11-02 |
| KR20140078656A (ko) | 2014-06-25 |
| BR112014008400A2 (pt) | 2017-04-04 |
| CN106474127A (zh) | 2017-03-08 |
| US20140275089A1 (en) | 2014-09-18 |
| WO2013053833A1 (en) | 2013-04-18 |
| AU2012322976B2 (en) | 2016-05-12 |
| US20160199365A1 (en) | 2016-07-14 |
| EP2766015A1 (en) | 2014-08-20 |
| JP2014528464A (ja) | 2014-10-27 |
| JP6180420B2 (ja) | 2017-08-16 |
| JP2017214387A (ja) | 2017-12-07 |
| RU2017119219A3 (OSRAM) | 2018-11-02 |
| CN103857392A (zh) | 2014-06-11 |
| MX2014004559A (es) | 2014-08-01 |
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