AU2012322976B2 - 2 - carboxamide cycloamino urea derivatives in combination with Hsp90 inhibitors for the treatment of proliferative diseases - Google Patents

2 - carboxamide cycloamino urea derivatives in combination with Hsp90 inhibitors for the treatment of proliferative diseases Download PDF

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Publication number
AU2012322976B2
AU2012322976B2 AU2012322976A AU2012322976A AU2012322976B2 AU 2012322976 B2 AU2012322976 B2 AU 2012322976B2 AU 2012322976 A AU2012322976 A AU 2012322976A AU 2012322976 A AU2012322976 A AU 2012322976A AU 2012322976 B2 AU2012322976 B2 AU 2012322976B2
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compound
combination
auy922
pharmaceutically acceptable
phenyl
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AU2012322976A
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AU2012322976A1 (en
Inventor
Christine Fritsch
Xizhong Huang
Cornelia Quadt
Christian Schnell
Hui-qin WANG
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Novartis AG
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Novartis AG
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2012322976A 2011-10-14 2012-10-11 2 - carboxamide cycloamino urea derivatives in combination with Hsp90 inhibitors for the treatment of proliferative diseases Ceased AU2012322976B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161547308P 2011-10-14 2011-10-14
US61/547,308 2011-10-14
PCT/EP2012/070171 WO2013053833A1 (en) 2011-10-14 2012-10-11 2 - carboxamide cycloamino urea derivatives in combination with hsp90 inhibitors for the treatment of proliferative diseases

Publications (2)

Publication Number Publication Date
AU2012322976A1 AU2012322976A1 (en) 2014-05-01
AU2012322976B2 true AU2012322976B2 (en) 2016-05-12

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AU2012322976A Ceased AU2012322976B2 (en) 2011-10-14 2012-10-11 2 - carboxamide cycloamino urea derivatives in combination with Hsp90 inhibitors for the treatment of proliferative diseases

Country Status (11)

Country Link
US (2) US20140275089A1 (OSRAM)
EP (1) EP2766015A1 (OSRAM)
JP (2) JP6180420B2 (OSRAM)
KR (1) KR20140078656A (OSRAM)
CN (2) CN103857392A (OSRAM)
AU (1) AU2012322976B2 (OSRAM)
BR (1) BR112014008400A2 (OSRAM)
CA (1) CA2851383A1 (OSRAM)
MX (1) MX2014004559A (OSRAM)
RU (2) RU2624493C2 (OSRAM)
WO (1) WO2013053833A1 (OSRAM)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2014122198A (ru) * 2011-11-02 2015-12-10 Новартис Аг Производные 2-карбоксамид циклоамино мочевины для применения в лечении vegf-зависимых заболеваний
WO2018151836A1 (en) 2017-02-17 2018-08-23 Fred Hutchinson Cancer Research Center Combination therapies for treatment of bcma-related cancers and autoimmune disorders
CN111214473B (zh) * 2020-02-14 2022-02-01 中国人民解放军陆军军医大学 Hsp990在制备抗轮状病毒药物中的应用
AU2024265078A1 (en) 2023-05-04 2025-12-11 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
WO2025034702A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Rmc-6291 for use in the treatment of ras protein-related disease or disorder
WO2025080946A2 (en) 2023-10-12 2025-04-17 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010029082A1 (en) * 2008-09-10 2010-03-18 Novartis Ag Organic compounds
WO2010060940A2 (en) * 2008-11-28 2010-06-03 Novartis Ag Hsp90 inhibitors for therapeutic treatment
WO2012062694A1 (en) * 2010-11-08 2012-05-18 Novartis Ag Use of 2-carboxamide cycloamino urea derivatives in the treatment of egfr dependent diseases or diseases that have acquired resistance to agents that target egfr family members

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261989A (en) 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
SI1611112T1 (sl) 2003-02-11 2012-12-31 Vernalis (R&D) Limited Izoksazolne spojine kot inhibitorji vroäśinskih ĺ ok proteinov
JO2783B1 (en) 2005-09-30 2014-03-15 نوفارتيس ايه جي Compounds 2-Amino-7, 8-dihydro-6H-Bayredo (3,4-D) Pyrimidine-5-Ones
PT2182948E (pt) * 2007-07-24 2013-04-30 Novartis Ag Utilização de imidazoquinolinas para o tratamento de doenças dependentes do egfr ou doenças que adquiriram resistência a agentes que têm como alvo membros da família egfr
TW200922595A (en) * 2007-10-12 2009-06-01 Novartis Ag Organic compounds
DE102009012631B4 (de) 2009-03-11 2011-07-28 Bayer Schering Pharma Aktiengesellschaft, 13353 Filter für einen Computertomographen sowie Computertomograph

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010029082A1 (en) * 2008-09-10 2010-03-18 Novartis Ag Organic compounds
WO2010060940A2 (en) * 2008-11-28 2010-06-03 Novartis Ag Hsp90 inhibitors for therapeutic treatment
WO2012062694A1 (en) * 2010-11-08 2012-05-18 Novartis Ag Use of 2-carboxamide cycloamino urea derivatives in the treatment of egfr dependent diseases or diseases that have acquired resistance to agents that target egfr family members

Also Published As

Publication number Publication date
MX2014004559A (es) 2014-08-01
CN106474127A (zh) 2017-03-08
BR112014008400A2 (pt) 2017-04-04
CA2851383A1 (en) 2013-04-18
AU2012322976A1 (en) 2014-05-01
JP6180420B2 (ja) 2017-08-16
JP2014528464A (ja) 2014-10-27
RU2017119219A3 (OSRAM) 2018-11-02
US20160199365A1 (en) 2016-07-14
RU2014119339A (ru) 2015-11-20
KR20140078656A (ko) 2014-06-25
RU2624493C2 (ru) 2017-07-04
CN103857392A (zh) 2014-06-11
US20140275089A1 (en) 2014-09-18
EP2766015A1 (en) 2014-08-20
JP2017214387A (ja) 2017-12-07
WO2013053833A1 (en) 2013-04-18
RU2017119219A (ru) 2018-11-02

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