CA2849330C - Slide scanner with a tilted image - Google Patents
Slide scanner with a tilted image Download PDFInfo
- Publication number
- CA2849330C CA2849330C CA2849330A CA2849330A CA2849330C CA 2849330 C CA2849330 C CA 2849330C CA 2849330 A CA2849330 A CA 2849330A CA 2849330 A CA2849330 A CA 2849330A CA 2849330 C CA2849330 C CA 2849330C
- Authority
- CA
- Canada
- Prior art keywords
- specimen
- scan
- detector array
- instrument
- scanning
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 claims abstract description 27
- 238000003384 imaging method Methods 0.000 claims description 17
- 230000033001 locomotion Effects 0.000 claims description 9
- 238000000799 fluorescence microscopy Methods 0.000 claims description 8
- 238000012935 Averaging Methods 0.000 claims description 7
- 238000005286 illumination Methods 0.000 description 19
- 238000003491 array Methods 0.000 description 13
- 230000003287 optical effect Effects 0.000 description 7
- 238000010586 diagram Methods 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 230000005540 biological transmission Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 238000002073 fluorescence micrograph Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000000018 DNA microarray Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 238000002493 microarray Methods 0.000 description 2
- 238000005424 photoluminescence Methods 0.000 description 2
- 238000003498 protein array Methods 0.000 description 2
- 239000004065 semiconductor Substances 0.000 description 2
- 241000252506 Characiformes Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 238000000399 optical microscopy Methods 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/06—Means for illuminating specimens
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y35/00—Methods or apparatus for measurement or analysis of nanostructures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/365—Control or image processing arrangements for digital or video microscopes
- G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Health & Medical Sciences (AREA)
- Multimedia (AREA)
- Crystallography & Structural Chemistry (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Microscoopes, Condenser (AREA)
- Automatic Focus Adjustment (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161537460P | 2011-09-21 | 2011-09-21 | |
| US61/537,460 | 2011-09-21 | ||
| PCT/CA2012/000868 WO2013040686A1 (en) | 2011-09-21 | 2012-09-21 | Slide scanner with a tilted image plane |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2849330A1 CA2849330A1 (en) | 2013-03-28 |
| CA2849330C true CA2849330C (en) | 2020-11-03 |
Family
ID=47913706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2849330A Active CA2849330C (en) | 2011-09-21 | 2012-09-21 | Slide scanner with a tilted image |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9632301B2 (OSRAM) |
| EP (1) | EP2758825B1 (OSRAM) |
| CA (1) | CA2849330C (OSRAM) |
| IN (1) | IN2014DN03134A (OSRAM) |
| WO (1) | WO2013040686A1 (OSRAM) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2868263C (en) * | 2012-03-23 | 2021-04-13 | Huron Technologies International Inc. | Slide scanner with dynamic focus and specimen tilt and method of operation |
| JP6211063B2 (ja) | 2012-05-02 | 2017-10-11 | ライカ バイオシステムズ イメージング インコーポレイテッド | ライン走査イメージングにおけるリアルタイムフォーカシング |
| JP6027875B2 (ja) * | 2012-12-07 | 2016-11-16 | オリンパス株式会社 | 撮像装置及び顕微鏡システム |
| WO2014179269A2 (en) * | 2013-04-30 | 2014-11-06 | Molecular Devices, Llc | Apparatus and method for generating in-focus images using parallel imaging in a microscopy system |
| CN105814883B (zh) * | 2013-12-16 | 2019-06-18 | 皇家飞利浦有限公司 | 具有带有用于电子电路的间隙的新型成像传感器的扫描成像系统 |
| CA2981348C (en) * | 2015-04-02 | 2023-05-23 | Huron Technologies International Inc. | High resolution pathology scanner with improved signal to noise ratio |
| US10244149B2 (en) | 2015-06-09 | 2019-03-26 | Lockheed Martin Corporation | Imaging system with scan line titled off focal plane |
| US10634894B2 (en) | 2015-09-24 | 2020-04-28 | Leica Biosystems Imaging, Inc. | Real-time focusing in line scan imaging |
| CA3002319C (en) * | 2015-12-09 | 2022-06-14 | Ventana Medical Systems, Inc. | An image scanning apparatus and methods of operating an image scanning apparatus |
| EP3420393B1 (en) | 2016-02-22 | 2024-04-10 | Koninklijke Philips N.V. | System for generating a synthetic 2d image with an enhanced depth of field of a biological sample |
| WO2018089839A1 (en) | 2016-11-10 | 2018-05-17 | The Trustees Of Columbia University In The City Of New York | Rapid high-resolution imaging methods for large samples |
| DE102017107348B4 (de) * | 2017-04-05 | 2019-03-14 | Olympus Soft Imaging Solutions Gmbh | Verfahren zur zytometrischen Analyse von Zellproben |
| US11106026B2 (en) * | 2017-04-24 | 2021-08-31 | Huron Technologies International Inc. | Scanning microscope for 3D imaging using MSIA |
| US10823952B2 (en) * | 2017-06-22 | 2020-11-03 | Huron Technologies International Inc. | MSIA scanning instrument with increased dynamic range |
| ES2928577T3 (es) * | 2017-09-29 | 2022-11-21 | Leica Biosystems Imaging Inc | Barrido en Z fijo bidimensional y tridimensional |
| EP3798711A1 (en) * | 2019-09-27 | 2021-03-31 | Leica Microsystems CMS GmbH | Imaging device and method for imaging an object using a microscope |
| US12099178B2 (en) * | 2020-12-16 | 2024-09-24 | Singular Genomics Systems, Inc. | Kinematic imaging system |
| WO2025072582A1 (en) * | 2023-09-27 | 2025-04-03 | Leica Biosystems Imaging, Inc. | Automatic tilt compensation in a digital scanning system |
| US12452530B2 (en) | 2023-12-20 | 2025-10-21 | Illumina, Inc. | Intelligent sample tilt adjustment with zones having variable size |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0843059A (ja) * | 1994-07-27 | 1996-02-16 | Nikon Corp | 近接場走査型顕微鏡 |
| US7095032B2 (en) * | 1998-03-20 | 2006-08-22 | Montagu Jean I | Focusing of microscopes and reading of microarrays |
| US7518652B2 (en) * | 2000-05-03 | 2009-04-14 | Aperio Technologies, Inc. | Method and apparatus for pre-focus in a linear array based slide scanner |
| US6583865B2 (en) * | 2000-08-25 | 2003-06-24 | Amnis Corporation | Alternative detector configuration and mode of operation of a time delay integration particle analyzer |
| DE10234756B3 (de) * | 2002-07-30 | 2004-02-12 | Leica Microsystems Semiconductor Gmbh | Autofokusmodul für mikroskopbasierte Systeme |
| WO2005010495A2 (en) * | 2003-07-22 | 2005-02-03 | Trestle Corporation | System and method for generating digital images of a microscope slide |
| JP4759277B2 (ja) * | 2005-01-21 | 2011-08-31 | オリンパス株式会社 | 観察方法および観察補助具 |
| US8059336B2 (en) * | 2007-05-04 | 2011-11-15 | Aperio Technologies, Inc. | Rapid microscope scanner for volume image acquisition |
| US10353190B2 (en) * | 2009-12-30 | 2019-07-16 | Koninklijke Philips N.V. | Sensor for microscopy |
-
2012
- 2012-09-21 WO PCT/CA2012/000868 patent/WO2013040686A1/en not_active Ceased
- 2012-09-21 IN IN3134DEN2014 patent/IN2014DN03134A/en unknown
- 2012-09-21 CA CA2849330A patent/CA2849330C/en active Active
- 2012-09-21 EP EP12833485.1A patent/EP2758825B1/en active Active
- 2012-09-21 US US14/346,661 patent/US9632301B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2758825A4 (en) | 2015-04-15 |
| EP2758825A1 (en) | 2014-07-30 |
| WO2013040686A1 (en) | 2013-03-28 |
| US9632301B2 (en) | 2017-04-25 |
| EP2758825B1 (en) | 2016-05-18 |
| US20140231638A1 (en) | 2014-08-21 |
| IN2014DN03134A (OSRAM) | 2015-05-22 |
| CA2849330A1 (en) | 2013-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20170921 |