IN2014DN03134A - - Google Patents
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- Publication number
- IN2014DN03134A IN2014DN03134A IN3134DEN2014A IN2014DN03134A IN 2014DN03134 A IN2014DN03134 A IN 2014DN03134A IN 3134DEN2014 A IN3134DEN2014 A IN 3134DEN2014A IN 2014DN03134 A IN2014DN03134 A IN 2014DN03134A
- Authority
- IN
- India
- Prior art keywords
- scan
- detector array
- focus
- specimen
- maintain
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/06—Means for illuminating specimens
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y35/00—Methods or apparatus for measurement or analysis of nanostructures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/365—Control or image processing arrangements for digital or video microscopes
- G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Multimedia (AREA)
- Health & Medical Sciences (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Microscoopes, Condenser (AREA)
- Automatic Focus Adjustment (AREA)
Abstract
An instrument and method for scanning a large microscope specimen uses a light source and at least one lens to focus light from the specimen onto a detector array. The specimen holder is located on a scanning stage and the detector array is dynamically tilted about a scan direction during the scan to maintain focus across the width of the scan strip as the scan proceeds. A degree of tilt varies during the scan as is required to maintain lateral focus relative to the detector array.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161537460P | 2011-09-21 | 2011-09-21 | |
| PCT/CA2012/000868 WO2013040686A1 (en) | 2011-09-21 | 2012-09-21 | Slide scanner with a tilted image plane |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN03134A true IN2014DN03134A (en) | 2015-05-22 |
Family
ID=47913706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN3134DEN2014 IN2014DN03134A (en) | 2011-09-21 | 2012-09-21 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9632301B2 (en) |
| EP (1) | EP2758825B1 (en) |
| CA (1) | CA2849330C (en) |
| IN (1) | IN2014DN03134A (en) |
| WO (1) | WO2013040686A1 (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013138911A1 (en) * | 2012-03-23 | 2013-09-26 | Huron Technologies International Inc. | Slide scanner with dynamic focus and specimen tilt and method of operation |
| ES2953897T3 (en) | 2012-05-02 | 2023-11-16 | Leica Biosystems Imaging Inc | Real-time focus in line scan imaging |
| JP6027875B2 (en) * | 2012-12-07 | 2016-11-16 | オリンパス株式会社 | Imaging apparatus and microscope system |
| EP3019905B1 (en) * | 2013-04-30 | 2020-06-03 | Molecular Devices, LLC | Apparatus and method for generating in-focus images using parallel imaging in a microscopy system |
| EP3264745B1 (en) * | 2013-12-16 | 2019-07-17 | Koninklijke Philips N.V. | Scanning imaging system with a novel imaging sensor with gaps for electronic circuitry |
| EP3278167B1 (en) * | 2015-04-02 | 2023-09-06 | Huron Technologies International Inc. | High resolution pathology scanner with improved signal to noise ratio |
| US10244149B2 (en) | 2015-06-09 | 2019-03-26 | Lockheed Martin Corporation | Imaging system with scan line titled off focal plane |
| CN108139650B (en) | 2015-09-24 | 2020-10-30 | 徕卡生物系统公司 | Real-time focusing in line scan imaging |
| CA3002319C (en) * | 2015-12-09 | 2022-06-14 | Ventana Medical Systems, Inc. | An image scanning apparatus and methods of operating an image scanning apparatus |
| RU2734447C2 (en) | 2016-02-22 | 2020-10-16 | Конинклейке Филипс Н.В. | System for forming a synthesized two-dimensional image of a biological sample with high depth of field |
| JP2020502558A (en) | 2016-11-10 | 2020-01-23 | ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク | High-speed, high-resolution imaging method for large samples |
| DE102017107348B4 (en) | 2017-04-05 | 2019-03-14 | Olympus Soft Imaging Solutions Gmbh | Method for the cytometric analysis of cell samples |
| EP3615916A4 (en) * | 2017-04-24 | 2020-12-30 | Technologies International Inc. Huron | Scanning microscope for 3d imaging using msia |
| CA3067870A1 (en) * | 2017-06-22 | 2018-12-27 | Arthur Edward Dixon | Msia scanning instrument with increased dynamic range |
| ES2928577T3 (en) * | 2017-09-29 | 2022-11-21 | Leica Biosystems Imaging Inc | 2D and 3D Fixed Z-Scan |
| EP3798711A1 (en) * | 2019-09-27 | 2021-03-31 | Leica Microsystems CMS GmbH | Imaging device and method for imaging an object using a microscope |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0843059A (en) * | 1994-07-27 | 1996-02-16 | Nikon Corp | Near field-scanning microscope |
| US7095032B2 (en) * | 1998-03-20 | 2006-08-22 | Montagu Jean I | Focusing of microscopes and reading of microarrays |
| US7518652B2 (en) * | 2000-05-03 | 2009-04-14 | Aperio Technologies, Inc. | Method and apparatus for pre-focus in a linear array based slide scanner |
| US6583865B2 (en) * | 2000-08-25 | 2003-06-24 | Amnis Corporation | Alternative detector configuration and mode of operation of a time delay integration particle analyzer |
| DE10234756B3 (en) * | 2002-07-30 | 2004-02-12 | Leica Microsystems Semiconductor Gmbh | Autofocus module for microscope employs prism to deflect measurement beam through cylindrical lens onto detector with two or more lines |
| US20050089208A1 (en) * | 2003-07-22 | 2005-04-28 | Rui-Tao Dong | System and method for generating digital images of a microscope slide |
| JP4759277B2 (en) * | 2005-01-21 | 2011-08-31 | オリンパス株式会社 | Observation method and observation aid |
| WO2008137746A1 (en) * | 2007-05-04 | 2008-11-13 | Aperio Technologies, Inc. | Rapid microscope scanner for volume image acquisition |
| BR112012015931A2 (en) * | 2009-12-30 | 2021-03-02 | Koninklijke Philips Eletronics N.V. | method for microscopically imaging a sample with a scanner, scanning microscope for imaging a sample, using a two-dimensional array sensor and arranging for imaging an oblique cross-section of a sample |
-
2012
- 2012-09-21 EP EP12833485.1A patent/EP2758825B1/en active Active
- 2012-09-21 US US14/346,661 patent/US9632301B2/en active Active
- 2012-09-21 IN IN3134DEN2014 patent/IN2014DN03134A/en unknown
- 2012-09-21 CA CA2849330A patent/CA2849330C/en active Active
- 2012-09-21 WO PCT/CA2012/000868 patent/WO2013040686A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP2758825B1 (en) | 2016-05-18 |
| EP2758825A1 (en) | 2014-07-30 |
| CA2849330C (en) | 2020-11-03 |
| CA2849330A1 (en) | 2013-03-28 |
| US9632301B2 (en) | 2017-04-25 |
| WO2013040686A1 (en) | 2013-03-28 |
| US20140231638A1 (en) | 2014-08-21 |
| EP2758825A4 (en) | 2015-04-15 |
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