CA2846460C - Aprepitant l-proline composition and cocrystal - Google Patents
Aprepitant l-proline composition and cocrystal Download PDFInfo
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- CA2846460C CA2846460C CA2846460A CA2846460A CA2846460C CA 2846460 C CA2846460 C CA 2846460C CA 2846460 A CA2846460 A CA 2846460A CA 2846460 A CA2846460 A CA 2846460A CA 2846460 C CA2846460 C CA 2846460C
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- aprepitant
- cocrystal
- proline
- disease
- itch
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Classifications
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Neurosurgery (AREA)
- Biomedical Technology (AREA)
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- Psychiatry (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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| US38574410P | 2010-09-23 | 2010-09-23 | |
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| US201161439654P | 2011-02-04 | 2011-02-04 | |
| US61/439,654 | 2011-02-04 | ||
| US201161498214P | 2011-06-17 | 2011-06-17 | |
| US61/498,214 | 2011-06-17 | ||
| PCT/IB2011/054210 WO2012038937A1 (en) | 2010-09-23 | 2011-09-23 | Aprepitant l-proline composition and cocrystal |
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| CA2846460A1 CA2846460A1 (en) | 2012-03-29 |
| CA2846460C true CA2846460C (en) | 2019-01-08 |
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| CN103221049B (zh) | 2010-09-23 | 2015-11-25 | 诺弗米克斯有限公司 | 阿瑞匹坦l-脯氨酸组合物和共晶 |
| WO2013076659A1 (en) | 2011-11-25 | 2013-05-30 | Nuformix Limited | Aprepitant l-proline solvates - compositions and cocrystals |
| US10098859B2 (en) | 2012-09-05 | 2018-10-16 | Amri Ssci, Llc | Cocrystals of p-coumaric acid |
| US20160324881A1 (en) * | 2013-12-30 | 2016-11-10 | Oncoprevent Gmbh | Neurokinin-1 Receptor Antagonists For Use In A Method Of Prevention Of Cancer |
| SG11202007530XA (en) * | 2018-02-07 | 2020-09-29 | Reata Pharmaceuticals Inc | Co-crystal forms of a novobiocin analog and proline |
| CN116283947A (zh) * | 2023-02-07 | 2023-06-23 | 成都医学院 | 一种阿瑞匹坦共晶及其制备方法和用途 |
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| US6048859A (en) | 1992-06-29 | 2000-04-11 | Merck & Co., Inc. | Morpholine and thiomorpholine tachykinin receptor antagonists |
| US5719147A (en) | 1992-06-29 | 1998-02-17 | Merck & Co., Inc. | Morpholine and thiomorpholine tachykinin receptor antagonists |
| IL111960A (en) | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
| ZA985765B (en) | 1997-07-02 | 1999-08-04 | Merck & Co Inc | Polymorphic form of a tachykinin receptor antagonist. |
| CA2489984A1 (en) * | 2002-06-21 | 2003-12-31 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
| JP4923182B2 (ja) * | 2003-02-28 | 2012-04-25 | マクニール−ピーピーシー・インコーポレーテツド | セレコキシブ及びニコチンアミド共結晶並びにこの共結晶を含む医薬組成物 |
| EP2034952A4 (en) * | 2006-06-16 | 2011-08-17 | Reddys Lab Ltd Dr | APREPITANT COMPOSITIONS |
| US20110009362A1 (en) * | 2008-02-27 | 2011-01-13 | Dr. Reddy's Laboratories Ltd. | Solubility-enhanced forms of aprepitant and pharmaceutical compositions thereof |
| CN103221049B (zh) | 2010-09-23 | 2015-11-25 | 诺弗米克斯有限公司 | 阿瑞匹坦l-脯氨酸组合物和共晶 |
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2011
- 2011-09-23 CN CN201180055997.5A patent/CN103221049B/zh active Active
- 2011-09-23 JP JP2013529758A patent/JP5997162B2/ja active Active
- 2011-09-23 KR KR1020137010228A patent/KR101833578B1/ko active Active
- 2011-09-23 US US13/825,380 patent/US9029369B2/en active Active
- 2011-09-23 ES ES11779217.6T patent/ES2616752T3/es active Active
- 2011-09-23 CA CA2846460A patent/CA2846460C/en active Active
- 2011-09-23 AR ARP110103486 patent/AR083095A1/es unknown
- 2011-09-23 AU AU2011306391A patent/AU2011306391B2/en active Active
- 2011-09-23 WO PCT/IB2011/054210 patent/WO2012038937A1/en not_active Ceased
- 2011-09-23 BR BR112013006651A patent/BR112013006651A2/pt not_active Application Discontinuation
- 2011-09-23 EP EP11779217.6A patent/EP2618828B1/en active Active
- 2011-09-23 TW TW100134362A patent/TWI540131B/zh active
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2012038937A1 (en) | 2012-03-29 |
| TW201217366A (en) | 2012-05-01 |
| EP2618828A1 (en) | 2013-07-31 |
| TWI540131B (zh) | 2016-07-01 |
| KR101833578B1 (ko) | 2018-02-28 |
| AR083095A1 (es) | 2013-01-30 |
| AU2011306391B2 (en) | 2016-12-15 |
| KR20140040671A (ko) | 2014-04-03 |
| JP2013537901A (ja) | 2013-10-07 |
| CN103221049B (zh) | 2015-11-25 |
| BR112013006651A2 (pt) | 2017-07-18 |
| CA2846460A1 (en) | 2012-03-29 |
| IL225443A0 (en) | 2013-06-27 |
| US20130252949A1 (en) | 2013-09-26 |
| JP5997162B2 (ja) | 2016-09-28 |
| EP2618828B1 (en) | 2016-11-23 |
| AU2011306391A1 (en) | 2013-04-11 |
| CN103221049A (zh) | 2013-07-24 |
| ES2616752T3 (es) | 2017-06-14 |
| HK1187554A1 (zh) | 2014-04-11 |
| US9029369B2 (en) | 2015-05-12 |
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