CA2844812C - Meta-substituted biphenyl peripherally restricted faah inhibitors - Google Patents
Meta-substituted biphenyl peripherally restricted faah inhibitors Download PDFInfo
- Publication number
- CA2844812C CA2844812C CA2844812A CA2844812A CA2844812C CA 2844812 C CA2844812 C CA 2844812C CA 2844812 A CA2844812 A CA 2844812A CA 2844812 A CA2844812 A CA 2844812A CA 2844812 C CA2844812 C CA 2844812C
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- CA
- Canada
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- pain
- faah
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
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- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Pharmacology & Pharmacy (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161525636P | 2011-08-19 | 2011-08-19 | |
| US61/525,636 | 2011-08-19 | ||
| PCT/US2012/051478 WO2013028570A2 (en) | 2011-08-19 | 2012-08-17 | Meta-substituted biphenyl peripherally restricted faah inhibitors |
Publications (2)
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| CA2844812A1 CA2844812A1 (en) | 2013-02-28 |
| CA2844812C true CA2844812C (en) | 2019-10-22 |
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| EP (1) | EP2744778B1 (OSRAM) |
| JP (1) | JP6092870B2 (OSRAM) |
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| WO (1) | WO2013028570A2 (OSRAM) |
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| KR100485727B1 (ko) * | 2004-06-24 | 2005-04-27 | 주식회사 바이오리더스 | 폴리감마글루탐산-비타민 복합체 및 그 용도 |
| MX354772B (es) | 2011-08-19 | 2018-03-21 | Univ California | Inhibidores de la amida de acidos grasos (faah) restringidos perifericamente por bifenil metasustituido. |
| WO2014023325A1 (en) * | 2012-08-06 | 2014-02-13 | Fondazione Istituto Italiano Di Tecnologia | Multitarget faah and cox inhibitors and therapeutical uses thereof |
| EP3988540A1 (en) * | 2014-04-07 | 2022-04-27 | The Regents of the University of California | Inhibitors of fatty acid amide hydrolase (faah) enzyme with improved oral bioavailability and their use as medicaments |
| CN116999410A (zh) * | 2015-08-11 | 2023-11-07 | Eyesiu医疗股份有限公司 | 具有生物活性亲脂性化合物的聚乙二醇化脂质纳米粒 |
| CA3024556A1 (en) * | 2016-05-12 | 2017-11-16 | The Regents Of The University Of Michigan | Ash1l inhibitors and methods of treatment therewith |
| PH12018000077B1 (en) | 2017-07-05 | 2021-07-09 | Frimline Private Ltd | A pharmaceutical composition for neuropathic pain |
| US10702487B2 (en) | 2017-08-19 | 2020-07-07 | Frimline Private Limited | Pharmaceutical composition for prevention of diet induced obesity |
| SG10201807034XA (en) | 2017-09-05 | 2019-04-29 | Frimline Private Ltd | A pharmaceutical composition for improving or preventing progression of Chronic Kidney Disease |
| GB201802326D0 (en) | 2018-02-13 | 2018-03-28 | Ucl Business Plc | Gene therapy |
| EP3762034B1 (en) | 2018-03-05 | 2025-08-27 | Wylder Nation Foundation | A fatty acid amide hydrolase (faahi) inhibitor for use in inhibiting the cellular accumulation of a sphingolipid in a subject that has lysosomal storage disease or disorder |
| EP3908375A1 (en) * | 2019-01-10 | 2021-11-17 | Travecta Therapeutics Pte. Ltd. | Anandamide compounds |
| CA3186853A1 (en) * | 2020-07-23 | 2022-01-27 | John Mansell | Compositions and methods for treating pain and anxiety disorders |
| CN120965462A (zh) * | 2025-10-17 | 2025-11-18 | 四川奥邦古得药业有限公司 | 用于生产3,5-二醚戊苯的方法及其在制备3,5-二羟基戊苯中的应用 |
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| JP4817495B2 (ja) | 1998-05-29 | 2011-11-16 | ニューロサイエンシーズ・リサーチ・ファウンデーション・インコーポレーテッド | 外因性カンナビノイドでの痛みの制御 |
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| FR2842808B1 (fr) | 2002-07-25 | 2004-09-10 | Sod Conseils Rech Applic | Nouveaux derives d'arylimidazoles, leur preparation et leurs applications therapeutiques |
| UA80841C2 (en) * | 2002-10-07 | 2007-11-12 | Univ California | Fatty acid amide hydrolase inhibitors, pharmaceutical composition (variants) and method to treat appetite disorders, glaucoma, pain, and related neurological disorders (variants) |
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| US20070155707A1 (en) | 2005-12-29 | 2007-07-05 | Kadmus Pharmaceuticals, Inc. | Ionizable inhibitors of fatty acid amide hydrolase |
| US9316633B2 (en) | 2006-11-16 | 2016-04-19 | The Regents Of The University Of California | Methods for identifying inhibitors of solute transporters |
| WO2008063714A1 (en) * | 2006-11-20 | 2008-05-29 | N.V. Organon | Metabolically-stabilized inhibitors of fatty acid amide hydrolase |
| TW200948805A (en) | 2008-03-07 | 2009-12-01 | Sigma Tau Ind Farmaceuti | Enol carbamate derivatives as modulators of fatty acid amide hydrolase |
| WO2011046954A1 (en) | 2009-10-13 | 2011-04-21 | Ligand Pharmaceuticals Inc. | Hematopoietic growth factor mimetic small molecule compounds and their uses |
| WO2012015704A2 (en) * | 2010-07-28 | 2012-02-02 | The Regents Of The University Of California | Peripherally restricted faah inhibitors |
| WO2012167133A2 (en) | 2011-06-01 | 2012-12-06 | The Regents Of The University Of California | Inhibitors of anandamide transport and their therapeutic uses |
| MX354772B (es) | 2011-08-19 | 2018-03-21 | Univ California | Inhibidores de la amida de acidos grasos (faah) restringidos perifericamente por bifenil metasustituido. |
| EP3988540A1 (en) | 2014-04-07 | 2022-04-27 | The Regents of the University of California | Inhibitors of fatty acid amide hydrolase (faah) enzyme with improved oral bioavailability and their use as medicaments |
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Also Published As
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| BR112014003886A2 (pt) | 2017-03-21 |
| KR20150100485A (ko) | 2015-09-02 |
| JP6092870B2 (ja) | 2017-03-08 |
| CN104203906A (zh) | 2014-12-10 |
| DK2744778T3 (en) | 2019-03-04 |
| US9745255B2 (en) | 2017-08-29 |
| AU2012299060A1 (en) | 2014-04-03 |
| EP2744778A2 (en) | 2014-06-25 |
| CN104203906B (zh) | 2018-03-13 |
| NZ622480A (en) | 2016-05-27 |
| CA2844812A1 (en) | 2013-02-28 |
| BR112014003886A8 (pt) | 2018-01-23 |
| US20140288170A1 (en) | 2014-09-25 |
| MX2014001966A (es) | 2015-04-08 |
| MX354772B (es) | 2018-03-21 |
| BR112014003886B1 (pt) | 2022-04-19 |
| WO2013028570A3 (en) | 2013-04-18 |
| ES2708723T3 (es) | 2019-04-10 |
| JP2014527532A (ja) | 2014-10-16 |
| EP2744778B1 (en) | 2019-01-16 |
| KR102079404B1 (ko) | 2020-02-19 |
| HK1198644A1 (en) | 2015-05-22 |
| AU2012299060B2 (en) | 2017-06-01 |
| WO2013028570A2 (en) | 2013-02-28 |
| EP2744778A4 (en) | 2015-04-08 |
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