CA2842183A1 - Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto - Google Patents

Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto Download PDF

Info

Publication number
CA2842183A1
CA2842183A1 CA2842183A CA2842183A CA2842183A1 CA 2842183 A1 CA2842183 A1 CA 2842183A1 CA 2842183 A CA2842183 A CA 2842183A CA 2842183 A CA2842183 A CA 2842183A CA 2842183 A1 CA2842183 A1 CA 2842183A1
Authority
CA
Canada
Prior art keywords
formula
compound
alkyl
me0h
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CA2842183A
Other languages
English (en)
French (fr)
Inventor
Roland E. Dolle
Bertrand Le Bourdonnec
Pierre Martin
Christian Steffen MOESSNER
Felix Herbert Spindler
Dirk Jost Spielvogel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adolor Corp
Original Assignee
Adolor Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adolor Corp filed Critical Adolor Corp
Publication of CA2842183A1 publication Critical patent/CA2842183A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2842183A 2011-07-18 2012-07-17 Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto Withdrawn CA2842183A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161508817P 2011-07-18 2011-07-18
US61/508,817 2011-07-18
PCT/US2012/047082 WO2013012871A1 (en) 2011-07-18 2012-07-17 Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto

Publications (1)

Publication Number Publication Date
CA2842183A1 true CA2842183A1 (en) 2013-01-24

Family

ID=47558430

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2842183A Withdrawn CA2842183A1 (en) 2011-07-18 2012-07-17 Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto

Country Status (9)

Country Link
US (1) US20150045556A1 (en, 2012)
EP (1) EP2734041A4 (en, 2012)
CN (1) CN103917096A (en, 2012)
AU (1) AU2012284127A1 (en, 2012)
CA (1) CA2842183A1 (en, 2012)
HK (1) HK1199794A1 (en, 2012)
IL (1) IL230506A0 (en, 2012)
IN (1) IN2014DN00137A (en, 2012)
WO (1) WO2013012871A1 (en, 2012)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103804431A (zh) * 2014-02-25 2014-05-21 中国人民解放军第四军医大学 一种手性二茂铁双膦配体及其制备方法
EP3421455B1 (en) * 2017-06-29 2019-03-27 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Improved process for the preparation of chiral 3-amino-piperidins, useful intermediates for the preparation of tofacitinib
CN111051280B (zh) 2017-08-02 2023-12-22 弗特克斯药品有限公司 制备吡咯烷化合物的方法
US11465985B2 (en) 2017-12-08 2022-10-11 Vertex Pharmaceuticals Incorporated Processes for making modulators of cystic fibrosis transmembrane conductance regulator

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0287339B1 (en) * 1987-04-16 1994-08-17 Eli Lilly And Company Piperidine opioid antagonists
US5536858A (en) * 1994-02-12 1996-07-16 Hoffmann-La Roche Inc. Tetrasulfonated diphosphine compounds and metal complexes thereof for asymmetric catalytic reactions
US5553858A (en) * 1995-06-28 1996-09-10 Mckoon; Carl T. Golf putter
US6057456A (en) * 1997-10-16 2000-05-02 Yale University Transition metal-catalyzed process for preparing alpha-arylated carbonyl-containing compounds
US6900228B1 (en) * 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
TWI254043B (en) * 1999-06-08 2006-05-01 Hoffmann La Roche Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor
US6794510B2 (en) * 2002-08-08 2004-09-21 Adolor Corporation Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto
JP5431496B2 (ja) * 2008-12-18 2014-03-05 エフ．ホフマン−ラ ロシュ アーゲー アミノ−メチルテトラリン誘導体の合成方法

Also Published As

Publication number Publication date
AU2012284127A1 (en) 2013-05-02
EP2734041A4 (en) 2015-03-25
HK1199794A1 (en) 2015-07-24
IN2014DN00137A (en, 2012) 2015-05-22
US20150045556A1 (en) 2015-02-12
IL230506A0 (en) 2014-03-31
WO2013012871A1 (en) 2013-01-24
EP2734041A1 (en) 2014-05-28
CN103917096A (zh) 2014-07-09

Similar Documents

Publication Publication Date Title
ES2667054T3 (es) Nuevas imidazoquinolinas sustituidas
US6794510B2 (en) Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto
US10544175B2 (en) Crystalline fosaprepitant dicyclohexylamine salt and its preparation
CA2842183A1 (en) Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto
CN111574533B (zh) 柠檬苦素a环开环胺化衍生物或其药学上可接受的盐、制备方法及用途
EP1973895A1 (en) Process for isolation of desired isomers of nebivolol intermediates
ES2741505T3 (es) Procedimiento para la preparación de acetato de abiraterona y sus productos intermedios
CA3113391A1 (en) Aminophosphinic derivatives as aminopeptidase a inhibitors
JP2020070296A (ja) リナグリプチンの製造法
WO2010053944A1 (en) Improved method of making piperidine derivatives
JP2013529687A (ja) キナーゼインヒビターの合成および使用
CN113683613B (zh) 一种多环吡啶肟基化合物及其药物组合物和用途
US11834463B2 (en) High affinity macrocyclic FKB51-inhibitors for treatment of psychiatric disorders
CN118994208B (zh) 一种联苯类衍生物的制备方法
KR940003292B1 (ko) 광학적 활성 2-메틸-1-(4-트리플루오로메틸페닐)-3-피롤리디노-1-프로파논 및 그 제조방법
CN103755624B (zh) 一种哌啶衍生物的合成方法
CN103450164B (zh) 格尔德霉素衍生物及其制备方法和用途
KR102184129B1 (ko) 의약품 합성용 중간체 화합물의 제조 방법
WO2025012756A1 (en) Amphiphilic tlr7/8 adjuvants and uses thereof
EP3031800B1 (en) Process for the preparation of high purity miglustat
EA050094B1 (ru) Синтез (2s,5r)-5-(2-хлорфенил)-1-(2'-метокси-[1,1'-бифенил]-4-карбонил)пирролидин-2-карбоновой кислоты
CN113583022A (zh) 多环化合物及其药物组合物和用途
CN119859132A (zh) 一种环烃类白杨素衍生物及其制备方法
CN117480170A (zh) 用于合成缬苯那嗪的方法
JPH0567149B2 (en, 2012)

Legal Events

Date Code Title Description
AZWI Withdrawn application

Effective date: 20140801