IN2014DN00137A - - Google Patents
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- Publication number
- IN2014DN00137A IN2014DN00137A IN137DEN2014A IN2014DN00137A IN 2014DN00137 A IN2014DN00137 A IN 2014DN00137A IN 137DEN2014 A IN137DEN2014 A IN 137DEN2014A IN 2014DN00137 A IN2014DN00137 A IN 2014DN00137A
- Authority
- IN
- India
- Prior art keywords
- useful
- intermediates
- preparation
- present processes
- processes
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 230000002093 peripheral effect Effects 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 208000017228 Gastrointestinal motility disease Diseases 0.000 abstract 1
- 101100244562 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) oprD gene Proteins 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 108700023159 delta Opioid Receptors Proteins 0.000 abstract 1
- 102000048124 delta Opioid Receptors Human genes 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 102000048260 kappa Opioid Receptors Human genes 0.000 abstract 1
- 229940127240 opiate Drugs 0.000 abstract 1
- 239000003401 opiate antagonist Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 108020001588 κ-opioid receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161508817P | 2011-07-18 | 2011-07-18 | |
| PCT/US2012/047082 WO2013012871A1 (en) | 2011-07-18 | 2012-07-17 | Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN00137A true IN2014DN00137A (en, 2012) | 2015-05-22 |
Family
ID=47558430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN137DEN2014 IN2014DN00137A (en, 2012) | 2011-07-18 | 2012-07-17 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20150045556A1 (en, 2012) |
| EP (1) | EP2734041A4 (en, 2012) |
| CN (1) | CN103917096A (en, 2012) |
| AU (1) | AU2012284127A1 (en, 2012) |
| CA (1) | CA2842183A1 (en, 2012) |
| HK (1) | HK1199794A1 (en, 2012) |
| IL (1) | IL230506A0 (en, 2012) |
| IN (1) | IN2014DN00137A (en, 2012) |
| WO (1) | WO2013012871A1 (en, 2012) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103804431A (zh) * | 2014-02-25 | 2014-05-21 | 中国人民解放军第四军医大学 | 一种手性二茂铁双膦配体及其制备方法 |
| EP3421455B1 (en) * | 2017-06-29 | 2019-03-27 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Improved process for the preparation of chiral 3-amino-piperidins, useful intermediates for the preparation of tofacitinib |
| CN111051280B (zh) | 2017-08-02 | 2023-12-22 | 弗特克斯药品有限公司 | 制备吡咯烷化合物的方法 |
| US11465985B2 (en) | 2017-12-08 | 2022-10-11 | Vertex Pharmaceuticals Incorporated | Processes for making modulators of cystic fibrosis transmembrane conductance regulator |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0287339B1 (en) * | 1987-04-16 | 1994-08-17 | Eli Lilly And Company | Piperidine opioid antagonists |
| US5536858A (en) * | 1994-02-12 | 1996-07-16 | Hoffmann-La Roche Inc. | Tetrasulfonated diphosphine compounds and metal complexes thereof for asymmetric catalytic reactions |
| US5553858A (en) * | 1995-06-28 | 1996-09-10 | Mckoon; Carl T. | Golf putter |
| US6057456A (en) * | 1997-10-16 | 2000-05-02 | Yale University | Transition metal-catalyzed process for preparing alpha-arylated carbonyl-containing compounds |
| US6900228B1 (en) * | 1998-03-10 | 2005-05-31 | Research Triangle Institute | Opiate compounds, methods of making and methods of use |
| TWI254043B (en) * | 1999-06-08 | 2006-05-01 | Hoffmann La Roche | Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor |
| US6794510B2 (en) * | 2002-08-08 | 2004-09-21 | Adolor Corporation | Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto |
| JP5431496B2 (ja) * | 2008-12-18 | 2014-03-05 | エフ．ホフマン−ラ ロシュ アーゲー | アミノ−メチルテトラリン誘導体の合成方法 |
-
2012
- 2012-07-17 US US14/233,670 patent/US20150045556A1/en not_active Abandoned
- 2012-07-17 EP EP12814994.5A patent/EP2734041A4/en not_active Withdrawn
- 2012-07-17 AU AU2012284127A patent/AU2012284127A1/en not_active Abandoned
- 2012-07-17 WO PCT/US2012/047082 patent/WO2013012871A1/en active Application Filing
- 2012-07-17 CN CN201280045401.8A patent/CN103917096A/zh active Pending
- 2012-07-17 CA CA2842183A patent/CA2842183A1/en not_active Withdrawn
- 2012-07-17 HK HK15100253.5A patent/HK1199794A1/xx unknown
- 2012-07-17 IN IN137DEN2014 patent/IN2014DN00137A/en unknown
-
2014
- 2014-01-16 IL IL230506A patent/IL230506A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012284127A1 (en) | 2013-05-02 |
| EP2734041A4 (en) | 2015-03-25 |
| CA2842183A1 (en) | 2013-01-24 |
| HK1199794A1 (en) | 2015-07-24 |
| US20150045556A1 (en) | 2015-02-12 |
| IL230506A0 (en) | 2014-03-31 |
| WO2013012871A1 (en) | 2013-01-24 |
| EP2734041A1 (en) | 2014-05-28 |
| CN103917096A (zh) | 2014-07-09 |
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