CA2841954C - 5-hydroxymethyl-2furfural (5-hmf) as treatment for hypoxia - Google Patents

5-hydroxymethyl-2furfural (5-hmf) as treatment for hypoxia Download PDF

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Publication number
CA2841954C
CA2841954C CA2841954A CA2841954A CA2841954C CA 2841954 C CA2841954 C CA 2841954C CA 2841954 A CA2841954 A CA 2841954A CA 2841954 A CA2841954 A CA 2841954A CA 2841954 C CA2841954 C CA 2841954C
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CA
Canada
Prior art keywords
hmf
hypoxia
subject
dose
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2841954A
Other languages
English (en)
French (fr)
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CA2841954A1 (en
Inventor
Warren Stern
Original Assignee
AesRX LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AesRX LLC filed Critical AesRX LLC
Publication of CA2841954A1 publication Critical patent/CA2841954A1/en
Application granted granted Critical
Publication of CA2841954C publication Critical patent/CA2841954C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2841954A 2011-07-15 2012-07-12 5-hydroxymethyl-2furfural (5-hmf) as treatment for hypoxia Expired - Fee Related CA2841954C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161508260P 2011-07-15 2011-07-15
US61/508,260 2011-07-15
PCT/US2012/046427 WO2013012670A1 (en) 2011-07-15 2012-07-12 Treatment for hypoxia

Publications (2)

Publication Number Publication Date
CA2841954A1 CA2841954A1 (en) 2013-01-24
CA2841954C true CA2841954C (en) 2020-05-05

Family

ID=46551919

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2841954A Expired - Fee Related CA2841954C (en) 2011-07-15 2012-07-12 5-hydroxymethyl-2furfural (5-hmf) as treatment for hypoxia

Country Status (7)

Country Link
US (1) US9918958B2 (https=)
EP (1) EP2731602A1 (https=)
JP (1) JP2014520854A (https=)
AU (1) AU2012284361B2 (https=)
BR (1) BR112014000889A2 (https=)
CA (1) CA2841954C (https=)
WO (1) WO2013012670A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016043849A2 (en) 2014-07-24 2016-03-24 Global Blood Therapeutics, Inc. Compounds for treating acute respiratory distress syndrome or a negative effect thereof
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
JP7265237B2 (ja) * 2017-07-27 2023-04-26 共栄化学工業株式会社 毛髪用組成物及び皮膚外用組成物
WO2023061554A1 (en) * 2021-10-11 2023-04-20 Mitocai Ltd. 5-hydroxymethylfurfural for the treatment of mitochondrial dysfunction
US11458144B1 (en) 2021-12-23 2022-10-04 King Abdulaziz University Methods for using 5-HMF analogs with increased solubility to inhibit or reverse RBC sickling
CN117085005A (zh) * 2023-10-08 2023-11-21 山东省科学院生物研究所 5-羟甲基-2-呋喃甲酸在制备促血管生成相关产品中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2507545C (en) 2002-12-04 2011-06-21 Virginia Commonwealth University Use of furfural derivatives as anti-sickling agents
EP2255623A1 (en) * 2009-05-26 2010-12-01 Volker Wagner-Solbach Plant nutriments
WO2011146471A1 (en) * 2010-05-18 2011-11-24 Aesrx Llc Treatment for altitudinal hypoxia

Also Published As

Publication number Publication date
BR112014000889A2 (pt) 2017-10-31
AU2012284361B2 (en) 2016-11-17
CA2841954A1 (en) 2013-01-24
US20130018092A1 (en) 2013-01-17
JP2014520854A (ja) 2014-08-25
US9918958B2 (en) 2018-03-20
AU2012284361A2 (en) 2014-02-13
AU2012284361A1 (en) 2014-01-30
WO2013012670A1 (en) 2013-01-24
EP2731602A1 (en) 2014-05-21

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EEER Examination request

Effective date: 20140313

MKLA Lapsed

Effective date: 20220301

MKLA Lapsed

Effective date: 20200831