CA2832979C - Production of acetyl-coenzyme a derived compounds - Google Patents

Production of acetyl-coenzyme a derived compounds Download PDF

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Publication number
CA2832979C
CA2832979C CA2832979A CA2832979A CA2832979C CA 2832979 C CA2832979 C CA 2832979C CA 2832979 A CA2832979 A CA 2832979A CA 2832979 A CA2832979 A CA 2832979A CA 2832979 C CA2832979 C CA 2832979C
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Canada
Prior art keywords
pantothenate
production
hacd
cell
enzyme
Prior art date
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CA2832979A
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English (en)
French (fr)
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CA2832979A1 (en
Inventor
Adam MEADOWS
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Amyris Inc
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Amyris Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2832979A 2011-05-09 2012-05-09 Production of acetyl-coenzyme a derived compounds Active CA2832979C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161483896P 2011-05-09 2011-05-09
US61/483,896 2011-05-09
PCT/US2012/037127 WO2012154854A1 (en) 2011-05-09 2012-05-09 Production of acetyl-coenzyme a derived compounds

Publications (2)

Publication Number Publication Date
CA2832979A1 CA2832979A1 (en) 2012-11-15
CA2832979C true CA2832979C (en) 2020-04-14

Family

ID=47139628

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2832979A Active CA2832979C (en) 2011-05-09 2012-05-09 Production of acetyl-coenzyme a derived compounds

Country Status (11)

Country Link
US (1) US9670518B2 (https=)
EP (1) EP2707475B1 (https=)
JP (1) JP5989098B2 (https=)
CN (1) CN103502428A (https=)
AU (1) AU2012253564A1 (https=)
BR (1) BR112013028544B1 (https=)
CA (1) CA2832979C (https=)
DK (1) DK2707475T3 (https=)
MX (1) MX2013012871A (https=)
WO (1) WO2012154854A1 (https=)
ZA (1) ZA201308393B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140057314A1 (en) * 2011-05-13 2014-02-27 Amyris, Inc. Methods and compositions for detecting microbial production of water-immiscible compounds
WO2013181647A2 (en) 2012-06-01 2013-12-05 Danisco Us Inc. Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms
WO2014087184A1 (en) * 2012-12-03 2014-06-12 Metabolic Explorer Neopentyl glycol fermentative production by a recombinant microorganism
CN104120148A (zh) * 2013-04-28 2014-10-29 中国科学院青岛生物能源与过程研究所 一种生物法合成α-或β-蒎烯的方法
EP3741865B1 (en) 2014-09-18 2024-03-13 Genomatica, Inc. Non-natural microbial organisms with improved energetic efficiency
KR101782891B1 (ko) * 2015-07-08 2017-09-29 한국과학기술연구원 미어신 생산용 벡터 및 균주, 및 이를 이용한 미어신의 생산방법
CN107083338A (zh) * 2017-05-15 2017-08-22 天津大学 重组菌株及其构建方法与在产菜油甾醇中的应用
WO2019113387A1 (en) 2017-12-07 2019-06-13 Zymergen Inc. Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation
JP2021506316A (ja) 2017-12-21 2021-02-22 ザイマージェン インコーポレイテッド ネペタラクトールオキシドレダクターゼ、ネペタラクトールシンターゼ、及びネペタラクトンを産生する能力がある微生物
CN110656056B (zh) * 2019-10-31 2021-07-27 江南大学 一种高浓度蒎烯耐受性产蒎烯工程菌的构建方法
CN112402401B (zh) * 2020-12-18 2022-03-22 中国农业科学院兰州畜牧与兽药研究所 桧烯在制备杀灭或预防寄生虫病药物中的应用
CN116926092B (zh) * 2022-10-28 2024-04-26 昆明理工大学 一种泛酸激酶基因RkPank及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4579415B2 (ja) * 1998-07-06 2010-11-10 ディーシーブイ・インコーポレイテッド・ドゥーイング・ビジネス・アズ・バイオ−テクニカル・リソーシィズ ビタミン製造方法
US6531303B1 (en) * 1998-07-06 2003-03-11 Arkion Life Sciences Llc Method of producing geranylgeraniol
DK1303629T3 (da) 2000-07-25 2006-10-30 Emmaus Foundation Inc Fremgangsmåde til forögelse af ethanolproduktion fra mikrobiel fermetering
US20040199941A1 (en) * 2003-03-24 2004-10-07 Rice University Increased bacterial CoA and acetyl-CoA pools
WO2008039177A2 (en) * 2006-09-22 2008-04-03 Rice University Pantothenate kinase expressing cells
EP2066778B1 (en) * 2006-09-26 2016-01-27 The Regents of The University of California Production of isoprenoids and isoprenoid precursors
AU2008305655B2 (en) * 2007-09-20 2013-10-31 Amyris, Inc. Production of isoprenoids
WO2010019696A2 (en) * 2008-08-12 2010-02-18 Allylix, Inc. Method for production of isoprenoids

Also Published As

Publication number Publication date
MX2013012871A (es) 2014-02-17
WO2012154854A1 (en) 2012-11-15
CA2832979A1 (en) 2012-11-15
BR112013028544B1 (pt) 2020-10-27
ZA201308393B (en) 2014-08-27
EP2707475A4 (en) 2014-12-03
US9670518B2 (en) 2017-06-06
JP2014513542A (ja) 2014-06-05
DK2707475T3 (en) 2016-01-11
US20120288891A1 (en) 2012-11-15
CN103502428A (zh) 2014-01-08
AU2012253564A1 (en) 2013-10-31
EP2707475B1 (en) 2015-09-30
EP2707475A1 (en) 2014-03-19
BR112013028544A2 (pt) 2016-09-20
JP5989098B2 (ja) 2016-09-07

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