CA2832556A1 - Formulations with reduced viscosity - Google Patents
Formulations with reduced viscosity Download PDFInfo
- Publication number
- CA2832556A1 CA2832556A1 CA2832556A CA2832556A CA2832556A1 CA 2832556 A1 CA2832556 A1 CA 2832556A1 CA 2832556 A CA2832556 A CA 2832556A CA 2832556 A CA2832556 A CA 2832556A CA 2832556 A1 CA2832556 A1 CA 2832556A1
- Authority
- CA
- Canada
- Prior art keywords
- formulation
- viscosity
- less
- concentration
- citrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000011287 therapeutic dose Methods 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 229940035024 thioglycerol Drugs 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 150000003577 thiophenes Chemical class 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161473121P | 2011-04-07 | 2011-04-07 | |
| US61/473,121 | 2011-04-07 | ||
| PCT/US2012/032462 WO2012138958A1 (en) | 2011-04-07 | 2012-04-06 | Formulations with reduced viscosity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2832556A1 true CA2832556A1 (en) | 2012-10-11 |
Family
ID=46969561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2832556A Abandoned CA2832556A1 (en) | 2011-04-07 | 2012-04-06 | Formulations with reduced viscosity |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20140023655A1 (enExample) |
| EP (2) | EP3058952A1 (enExample) |
| JP (1) | JP2014516924A (enExample) |
| KR (1) | KR20140018966A (enExample) |
| CN (1) | CN103596585A (enExample) |
| AU (2) | AU2012240050B2 (enExample) |
| BR (1) | BR112013025866A2 (enExample) |
| CA (1) | CA2832556A1 (enExample) |
| EA (1) | EA201391488A1 (enExample) |
| IL (1) | IL228591A0 (enExample) |
| SG (1) | SG193963A1 (enExample) |
| WO (1) | WO2012138958A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2523688T3 (enExample) * | 2010-01-15 | 2018-03-10 | ||
| EP3578203A1 (en) | 2011-10-28 | 2019-12-11 | Integritybio Inc. | Protein formulations containing amino acids |
| FR2994390B1 (fr) | 2012-08-10 | 2014-08-15 | Adocia | Procede d'abaissement de la viscosite de solutions de proteines a concentration elevee |
| WO2014141149A1 (en) * | 2013-03-15 | 2014-09-18 | Glaxosmithkline Intellectual Property (No.2) Limited | Formulations with reduced viscosity |
| WO2014169153A1 (en) * | 2013-04-10 | 2014-10-16 | Echogen, Inc. | Peptide complexes and therapeutic uses |
| JP6179939B2 (ja) * | 2013-07-09 | 2017-08-16 | 国立大学法人 筑波大学 | 高濃度γグロブリン製剤の粘度低下方法 |
| IL312865B2 (en) | 2013-09-11 | 2025-06-01 | Eagle Biologics Inc | Liquid protein formulations containing viscosity-lowering agents |
| SG11201702614SA (en) | 2014-10-01 | 2017-04-27 | Eagle Biolog Inc | Polysaccharide and nucleic acid formulations containing viscosity-lowering agents |
| US20180264081A1 (en) * | 2015-01-18 | 2018-09-20 | Gloriana Therapeutics Sarl | Therapeutic protein formulations |
| CN116327921A (zh) | 2015-08-24 | 2023-06-27 | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 生物医药组合物 |
| US11603407B2 (en) * | 2017-04-06 | 2023-03-14 | Regeneron Pharmaceuticals, Inc. | Stable antibody formulation |
| WO2018211517A1 (en) | 2017-05-16 | 2018-11-22 | Bhami's Research Laboratory, Pvt. Ltd. | High concentration protein formulations with reduced viscosity |
| CA3134401A1 (en) | 2019-03-29 | 2020-10-08 | Jiangsu Hengrui Medicine Co., Ltd. | Pharmaceutical composition containing antibody against il-5 and use thereof |
| BR112022026670A2 (pt) * | 2020-07-13 | 2023-01-24 | Merck Patent Gmbh | Excipientes de redução da viscosidade e combinações dos mesmos para formulações de proteína altamente concentradas |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57106673A (en) | 1980-12-24 | 1982-07-02 | Chugai Pharmaceut Co Ltd | Dibenzo(b,f)(1,4)oxazepin derivative |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5747447A (en) * | 1992-04-30 | 1998-05-05 | Cor Therapeutics | Stable polypeptide composition |
| IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
| IL155002A0 (en) * | 2000-10-12 | 2003-10-31 | Genentech Inc | Reduced-viscosity concentrated protein formulations |
| JP5133494B2 (ja) | 2001-08-10 | 2013-01-30 | アバディーン ユニバーシティ | 抗原結合ドメイン |
| SI1556477T1 (sl) * | 2002-11-01 | 2017-12-29 | Glaxosmithkline Biologicals S.A. | Sušilni postopek |
| WO2004060343A1 (en) * | 2002-12-31 | 2004-07-22 | Nektar Therapeutics | Antibody-containing particles and compositions |
| WO2004091658A1 (en) * | 2003-04-04 | 2004-10-28 | Genentech, Inc. | High concentration antibody and protein formulations |
| EP1532983A1 (en) * | 2003-11-18 | 2005-05-25 | ZLB Bioplasma AG | Immunoglobulin preparations having increased stability |
| BRPI0620316A2 (pt) * | 2005-12-21 | 2011-11-08 | Wyeth Corp | formulações de proteìnas com viscosidades reduzida e seus usos |
| EP1977763A4 (en) * | 2005-12-28 | 2010-06-02 | Chugai Pharmaceutical Co Ltd | STABILIZER PREPARATION CONTAINING ANTIBODIES |
| JP5577098B2 (ja) * | 2006-12-21 | 2014-08-20 | アムジエン・インコーポレーテツド | ポリペプチドを含有する安定な緩衝化された製剤 |
| CA2701032C (en) * | 2007-09-27 | 2021-01-26 | Amgen Inc. | Pharmaceutical formulations |
| AR069495A1 (es) * | 2007-11-30 | 2010-01-27 | Glaxo Group Ltd | Construcciones de union de antigenos para el tratamiento de cancer o enfermedades inflamatorias (asma, artritis o artrosis) |
| PE20091174A1 (es) * | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| NO2523688T3 (enExample) * | 2010-01-15 | 2018-03-10 | ||
| PL2531218T3 (pl) * | 2010-02-04 | 2019-05-31 | Csl Behring Ag | Preparat immunoglobuliny |
| US20110223208A1 (en) * | 2010-03-09 | 2011-09-15 | Beth Hill | Non-Aqueous High Concentration Reduced Viscosity Suspension Formulations |
| JP2014510152A (ja) * | 2011-04-07 | 2014-04-24 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 粘度が低減された処方物 |
-
2012
- 2012-04-06 JP JP2014504013A patent/JP2014516924A/ja active Pending
- 2012-04-06 CN CN201280026486.5A patent/CN103596585A/zh active Pending
- 2012-04-06 BR BR112013025866A patent/BR112013025866A2/pt not_active IP Right Cessation
- 2012-04-06 KR KR1020137029163A patent/KR20140018966A/ko not_active Withdrawn
- 2012-04-06 EP EP16154327.7A patent/EP3058952A1/en not_active Withdrawn
- 2012-04-06 EP EP12768307.6A patent/EP2694100A4/en not_active Withdrawn
- 2012-04-06 SG SG2013072426A patent/SG193963A1/en unknown
- 2012-04-06 US US14/110,182 patent/US20140023655A1/en not_active Abandoned
- 2012-04-06 EA EA201391488A patent/EA201391488A1/ru unknown
- 2012-04-06 WO PCT/US2012/032462 patent/WO2012138958A1/en not_active Ceased
- 2012-04-06 CA CA2832556A patent/CA2832556A1/en not_active Abandoned
- 2012-04-06 AU AU2012240050A patent/AU2012240050B2/en not_active Ceased
-
2013
- 2013-09-29 IL IL228591A patent/IL228591A0/en unknown
-
2016
- 2016-04-14 AU AU2016202355A patent/AU2016202355A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3058952A1 (en) | 2016-08-24 |
| BR112013025866A2 (pt) | 2016-12-20 |
| SG193963A1 (en) | 2013-11-29 |
| EA201391488A1 (ru) | 2014-01-30 |
| AU2016202355A1 (en) | 2016-05-05 |
| AU2012240050B2 (en) | 2016-01-21 |
| IL228591A0 (en) | 2013-12-31 |
| WO2012138958A1 (en) | 2012-10-11 |
| CN103596585A (zh) | 2014-02-19 |
| EP2694100A4 (en) | 2014-10-01 |
| EP2694100A1 (en) | 2014-02-12 |
| KR20140018966A (ko) | 2014-02-13 |
| US20140023655A1 (en) | 2014-01-23 |
| JP2014516924A (ja) | 2014-07-17 |
| AU2012240050A1 (en) | 2013-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20150408 |
|
| FZDE | Discontinued |
Effective date: 20170725 |