CA2828878C - Predicting gastroenteropancreatic neuroendocrine neoplasms (gep-nens) - Google Patents

Predicting gastroenteropancreatic neuroendocrine neoplasms (gep-nens) Download PDF

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CA2828878C
CA2828878C CA2828878A CA2828878A CA2828878C CA 2828878 C CA2828878 C CA 2828878C CA 2828878 A CA2828878 A CA 2828878A CA 2828878 A CA2828878 A CA 2828878A CA 2828878 C CA2828878 C CA 2828878C
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gep
nen
biomarkers
seq
expression
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CA2828878A1 (en
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Irvin M. Modlin
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Yale University
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Yale University
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57438Specifically defined cancers of liver, pancreas or kidney
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
CA2828878A 2011-03-01 2012-03-01 Predicting gastroenteropancreatic neuroendocrine neoplasms (gep-nens) Active CA2828878C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161448137P 2011-03-01 2011-03-01
US61/448,137 2011-03-01
PCT/US2012/027351 WO2012119013A1 (en) 2011-03-01 2012-03-01 PREDICTING GASTROENTEROPANCREATIC NEUROENDOCRINE NEOPLASMS (GEP-NENs)

Publications (2)

Publication Number Publication Date
CA2828878A1 CA2828878A1 (en) 2012-09-07
CA2828878C true CA2828878C (en) 2020-08-25

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Application Number Title Priority Date Filing Date
CA2828878A Active CA2828878C (en) 2011-03-01 2012-03-01 Predicting gastroenteropancreatic neuroendocrine neoplasms (gep-nens)

Country Status (14)

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US (1) US9988684B2 (ja)
EP (1) EP2681333B1 (ja)
JP (2) JP6159662B2 (ja)
KR (2) KR102023584B1 (ja)
CN (1) CN103502473B (ja)
AU (2) AU2012223288B2 (ja)
CA (1) CA2828878C (ja)
DK (1) DK2681333T3 (ja)
ES (1) ES2656487T3 (ja)
IL (1) IL228224A (ja)
MX (1) MX351779B (ja)
PL (1) PL2681333T3 (ja)
WO (1) WO2012119013A1 (ja)
ZA (1) ZA201306686B (ja)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013329356B2 (en) 2012-10-09 2018-11-29 Five3 Genomics, Llc Systems and methods for tumor clonality analysis
DK3194618T3 (da) * 2014-09-15 2021-07-12 Clifton Life Sciences LLC Sammensætninger, fremgangsmåder og kits til diagnosticering af et gastroenteropankreatisk neuroendokrin neoplasma
CN107194137B (zh) * 2016-01-31 2023-05-23 北京万灵盘古科技有限公司 一种基于医疗数据建模的坏死性小肠结肠炎分类预测方法
CN105938521A (zh) * 2016-07-04 2016-09-14 苏州大学附属儿童医院 一种强直性脊柱炎预警模型建立方法及装置
WO2018160925A1 (en) * 2017-03-02 2018-09-07 President And Fellows Of Harvard College Methods and systems for predicting treatment responses in subjects
WO2018214249A1 (zh) * 2017-05-22 2018-11-29 立森印迹诊断技术(无锡)有限公司 一种印记基因分级模型及其组成的系统和应用
CN111479931B (zh) * 2017-11-30 2024-08-16 液体活检研究有限责任公司 使用基因表达测定预测肽受体放射治疗
CA3087978A1 (en) * 2017-12-19 2019-06-27 Chase Therapeutics Corporation Methods for developing pharmaceuticals for treating neurodegenerative conditions
CN108048564B (zh) * 2018-02-09 2021-03-05 中国科学院昆明动物研究所 人glt8d1基因的新用途
JP7061768B2 (ja) * 2018-03-09 2022-05-02 国立大学法人 東京大学 生物応答の解析方法、解析プログラム、及び解析装置
CA3003032A1 (en) * 2018-04-27 2019-10-27 Nanostics Inc. Methods of diagnosing disease using microflow cytometry
KR102141246B1 (ko) * 2018-05-25 2020-08-04 주식회사 엠디헬스케어 qPCR 분석을 통한 대장암 진단방법
WO2019226035A1 (ko) * 2018-05-25 2019-11-28 주식회사 엠디헬스케어 Qpcr 분석을 통한 대장암 진단방법
JP7133411B2 (ja) * 2018-09-19 2022-09-08 テルモ株式会社 Ctc採取システム及びctc採取システムの作動方法
CN109190713A (zh) * 2018-09-29 2019-01-11 王海燕 基于血清质谱自适应稀疏特征选择的卵巢癌微创快检技术
US11875903B2 (en) 2018-12-31 2024-01-16 Tempus Labs, Inc. Method and process for predicting and analyzing patient cohort response, progression, and survival
CA3125449A1 (en) 2018-12-31 2020-07-09 Tempus Labs A method and process for predicting and analyzing patient cohort response, progression, and survival
CN109652550B (zh) * 2019-01-21 2022-08-02 首都医科大学附属北京朝阳医院 circ-HUWE1作为胃癌和结直肠癌诊断生物标志物和治疗靶点的应用
CN109949268A (zh) * 2019-01-24 2019-06-28 郑州大学第一附属医院 一种基于机器学习的肝细胞癌分化水平分级方法
SE543275C2 (en) * 2019-03-07 2020-11-10 Tx Medic Ab Treatment efficiency evaluation
US11995127B2 (en) * 2019-04-02 2024-05-28 Aspentech Corporation Validation of operating plans and schedules using machine learning
EP4041886A1 (en) 2019-10-10 2022-08-17 Liquid Biopsy Research LLC Compositions, methods and kits for biological sample and rna stabilization
WO2022026642A2 (en) * 2020-07-29 2022-02-03 The Children's Hospital Of Philadelphia Compositions and methods for hemoglobin production
KR102438608B1 (ko) * 2021-06-15 2022-08-31 재단법인 아산사회복지재단 췌장 신경내분비 종양 감별진단용 바이오마커 조성물 및 이를 이용한 췌장 신경내분비 종양 감별진단에 필요한 정보를 제공하는 방법
KR102519913B1 (ko) * 2021-06-15 2023-04-10 재단법인 아산사회복지재단 췌장 신경내분비 종양 진단용 바이오마커 조성물 및 이를 이용한 췌장 신경내분비 종양 진단에 필요한 정보를 제공하는 방법
CN113637750A (zh) * 2021-07-16 2021-11-12 宁波市第一医院 急性髓系白血病的辅助诊断、预后诊断或危险度分层标记物及其应用
WO2024073652A1 (en) * 2022-09-30 2024-04-04 Liquid Biopsy Research LLC Methods for neuroendocrine cancer detection in saliva

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060194265A1 (en) 2001-10-23 2006-08-31 Morris David W Novel therapeutic targets in cancer
US20050084883A1 (en) * 2003-08-25 2005-04-21 The Johns Hopkins University School Of Medicine Method of diagnosis and treatment of pancreatic endocrine neoplasms based on differential gene expression analysis

Also Published As

Publication number Publication date
US20140066328A1 (en) 2014-03-06
IL228224A0 (en) 2013-12-31
AU2017204086B2 (en) 2019-05-16
AU2017204086A1 (en) 2017-07-06
KR20140042793A (ko) 2014-04-07
CA2828878A1 (en) 2012-09-07
JP6159662B2 (ja) 2017-07-05
KR102023584B1 (ko) 2019-09-24
EP2681333B1 (en) 2017-11-15
KR102114412B1 (ko) 2020-06-18
ES2656487T3 (es) 2018-02-27
CN103502473A (zh) 2014-01-08
JP2017104116A (ja) 2017-06-15
DK2681333T3 (en) 2018-01-08
US9988684B2 (en) 2018-06-05
MX2013010035A (es) 2014-08-27
JP2014512172A (ja) 2014-05-22
KR20180116483A (ko) 2018-10-24
ZA201306686B (en) 2015-03-25
MX351779B (es) 2017-10-27
AU2012223288A1 (en) 2013-09-19
EP2681333A1 (en) 2014-01-08
JP6321233B2 (ja) 2018-05-09
AU2012223288B2 (en) 2017-03-30
PL2681333T3 (pl) 2018-03-30
CN103502473B (zh) 2016-03-09
WO2012119013A1 (en) 2012-09-07
IL228224A (en) 2017-11-30

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