CA2825124A1 - Fused dihydrofurans as gpr119 modulators for the treatment of diabetes, obesity and related disorders - Google Patents
Fused dihydrofurans as gpr119 modulators for the treatment of diabetes, obesity and related disorders Download PDFInfo
- Publication number
- CA2825124A1 CA2825124A1 CA2825124A CA2825124A CA2825124A1 CA 2825124 A1 CA2825124 A1 CA 2825124A1 CA 2825124 A CA2825124 A CA 2825124A CA 2825124 A CA2825124 A CA 2825124A CA 2825124 A1 CA2825124 A1 CA 2825124A1
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- Canada
- Prior art keywords
- group
- alkyl
- ring
- dihydro
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 26
- 208000008589 Obesity Diseases 0.000 title claims description 17
- 235000020824 obesity Nutrition 0.000 title claims description 17
- 238000011282 treatment Methods 0.000 title description 31
- 125000004852 dihydrofuranyl group Chemical group O1C(CC=C1)* 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 253
- 101000996752 Homo sapiens Glucose-dependent insulinotropic receptor Proteins 0.000 claims abstract description 30
- 102100033839 Glucose-dependent insulinotropic receptor Human genes 0.000 claims abstract description 29
- 238000000034 method Methods 0.000 claims description 262
- 125000001072 heteroaryl group Chemical group 0.000 claims description 110
- 125000001424 substituent group Chemical group 0.000 claims description 73
- -1 1,2,3,6-tetrahydropyridin-4-yl ring Chemical group 0.000 claims description 69
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 57
- 125000003118 aryl group Chemical group 0.000 claims description 50
- 229910052731 fluorine Inorganic materials 0.000 claims description 49
- 150000003839 salts Chemical class 0.000 claims description 47
- 125000005842 heteroatom Chemical group 0.000 claims description 33
- 125000000623 heterocyclic group Chemical group 0.000 claims description 33
- 229910052739 hydrogen Inorganic materials 0.000 claims description 30
- 239000003814 drug Substances 0.000 claims description 27
- 125000000217 alkyl group Chemical group 0.000 claims description 26
- 229910052717 sulfur Inorganic materials 0.000 claims description 24
- 201000010099 disease Diseases 0.000 claims description 23
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 23
- 229940124597 therapeutic agent Drugs 0.000 claims description 21
- 229910052794 bromium Inorganic materials 0.000 claims description 19
- 239000008194 pharmaceutical composition Substances 0.000 claims description 18
- 229910052760 oxygen Inorganic materials 0.000 claims description 17
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 16
- 230000001404 mediated effect Effects 0.000 claims description 15
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- 125000000753 cycloalkyl group Chemical group 0.000 claims description 12
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 12
- 229910052740 iodine Inorganic materials 0.000 claims description 12
- 229910052757 nitrogen Inorganic materials 0.000 claims description 12
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 10
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- 239000000969 carrier Substances 0.000 claims description 8
- 125000001624 naphthyl group Chemical group 0.000 claims description 8
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 7
- 239000003085 diluting agent Substances 0.000 claims description 7
- 125000000304 alkynyl group Chemical group 0.000 claims description 6
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- 125000001153 fluoro group Chemical group F* 0.000 claims description 5
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- 125000002837 carbocyclic group Chemical group 0.000 claims description 4
- 230000003213 activating effect Effects 0.000 claims description 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 4
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 40
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- 238000006243 chemical reaction Methods 0.000 description 23
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- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 21
- 229910000027 potassium carbonate Inorganic materials 0.000 description 20
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- 150000003254 radicals Chemical class 0.000 description 15
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- WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical compound Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 description 14
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- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 14
- 229910052723 transition metal Inorganic materials 0.000 description 14
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- BGLLZQRUXJGTAD-UHFFFAOYSA-N 2-chloro-5-ethylpyrimidine Chemical compound CCC1=CN=C(Cl)N=C1 BGLLZQRUXJGTAD-UHFFFAOYSA-N 0.000 description 12
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- 101100145039 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) RNT1 gene Proteins 0.000 description 12
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- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 10
- 229940100607 GPR119 agonist Drugs 0.000 description 10
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 10
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- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 1
- 229930195734 saturated hydrocarbon Natural products 0.000 description 1
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- 238000000926 separation method Methods 0.000 description 1
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- 150000003378 silver Chemical class 0.000 description 1
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- XGVXKJKTISMIOW-ZDUSSCGKSA-N simurosertib Chemical compound N1N=CC(C=2SC=3C(=O)NC(=NC=3C=2)[C@H]2N3CCC(CC3)C2)=C1C XGVXKJKTISMIOW-ZDUSSCGKSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 230000000707 stereoselective effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
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- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- INUWDZDWSJJFSQ-UHFFFAOYSA-N tert-butyl 4-ethynylpiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(C#C)CC1 INUWDZDWSJJFSQ-UHFFFAOYSA-N 0.000 description 1
- QKSQWQOAUQFORH-UHFFFAOYSA-N tert-butyl n-[(2-methylpropan-2-yl)oxycarbonylimino]carbamate Chemical compound CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C QKSQWQOAUQFORH-UHFFFAOYSA-N 0.000 description 1
- RQCNHUCCQJMSRG-UHFFFAOYSA-N tert-butyl piperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCCC1 RQCNHUCCQJMSRG-UHFFFAOYSA-N 0.000 description 1
- 125000002873 tetrahydrofuranonyl group Chemical group 0.000 description 1
- 125000002673 tetrahydropyranonyl group Chemical group O1C(C(CCC1)*)=O 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
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- 210000001519 tissue Anatomy 0.000 description 1
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- 230000001988 toxicity Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- TUQOTMZNTHZOKS-UHFFFAOYSA-N tributylphosphine Chemical compound CCCCP(CCCC)CCCC TUQOTMZNTHZOKS-UHFFFAOYSA-N 0.000 description 1
- WLPUWLXVBWGYMZ-UHFFFAOYSA-N tricyclohexylphosphine Chemical compound C1CCCCC1P(C1CCCCC1)C1CCCCC1 WLPUWLXVBWGYMZ-UHFFFAOYSA-N 0.000 description 1
- PBIMIGNDTBRRPI-UHFFFAOYSA-N trifluoro borate Chemical compound FOB(OF)OF PBIMIGNDTBRRPI-UHFFFAOYSA-N 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
- 235000019798 tripotassium phosphate Nutrition 0.000 description 1
- COIOYMYWGDAQPM-UHFFFAOYSA-N tris(2-methylphenyl)phosphane Chemical class CC1=CC=CC=C1P(C=1C(=CC=CC=1)C)C1=CC=CC=C1C COIOYMYWGDAQPM-UHFFFAOYSA-N 0.000 description 1
- DLQYXUGCCKQSRJ-UHFFFAOYSA-N tris(furan-2-yl)phosphane Chemical class C1=COC(P(C=2OC=CC=2)C=2OC=CC=2)=C1 DLQYXUGCCKQSRJ-UHFFFAOYSA-N 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11151688.6 | 2011-01-21 | ||
| EP11151688 | 2011-01-21 | ||
| EP11191903 | 2011-12-05 | ||
| EP11191903.1 | 2011-12-05 | ||
| PCT/EP2012/050841 WO2012098217A1 (en) | 2011-01-21 | 2012-01-20 | Fused dihydrofurans as gpr119 modulators for the treatment of diabetes, obesity and related disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2825124A1 true CA2825124A1 (en) | 2012-07-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2825124A Abandoned CA2825124A1 (en) | 2011-01-21 | 2012-01-20 | Fused dihydrofurans as gpr119 modulators for the treatment of diabetes, obesity and related disorders |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8778926B2 (enExample) |
| EP (1) | EP2665719B1 (enExample) |
| JP (1) | JP5703393B2 (enExample) |
| KR (1) | KR20140003496A (enExample) |
| CN (1) | CN103443097A (enExample) |
| AP (1) | AP2013006985A0 (enExample) |
| AR (1) | AR084905A1 (enExample) |
| AU (1) | AU2012208530A1 (enExample) |
| BR (1) | BR112013017669A2 (enExample) |
| CA (1) | CA2825124A1 (enExample) |
| CO (1) | CO6781501A2 (enExample) |
| EA (1) | EA201300846A1 (enExample) |
| EC (1) | ECSP13012800A (enExample) |
| MA (1) | MA34839B1 (enExample) |
| MX (1) | MX2013008083A (enExample) |
| PH (1) | PH12013501515A1 (enExample) |
| SG (1) | SG192036A1 (enExample) |
| UY (1) | UY33871A (enExample) |
| WO (1) | WO2012098217A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8481731B2 (en) | 2009-06-24 | 2013-07-09 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical composition and methods relating thereto |
| UY33805A (es) | 2010-12-17 | 2012-07-31 | Boehringer Ingelheim Int | ?Derivados de dihidrobenzofuranil-piperidinilo, aza-dihidrobenzofuranilpiperidinilo y diaza-dihidrobenzofuranil-piperidinilo, composiciones farmacéuticas que los contienen y usos de los mismos?. |
| WO2012123449A1 (en) | 2011-03-14 | 2012-09-20 | Boehringer Ingelheim International Gmbh | N- cyclopropyl - n- piperidinylbenzamides as gpr119 modulators |
| US8921398B2 (en) | 2011-06-09 | 2014-12-30 | Boehringer Ingelheim International Gmbh | N-cyclopropyl-N-piperidinyl-amide derivatives, pharmaceutical compositions and uses thereof |
| US8853239B2 (en) * | 2011-12-09 | 2014-10-07 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
| US9012456B2 (en) * | 2012-02-28 | 2015-04-21 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
| EP2847196B1 (en) * | 2012-05-07 | 2017-10-25 | Boehringer Ingelheim International GmbH | New 2,3-dihydro-furo[2,3-c]pyridines, their use as modulators of the g-protein-coupled receptor gpr119 and pharmaceutical compositions comprising them |
| AU2013290100A1 (en) | 2012-07-11 | 2015-01-29 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| US10526345B2 (en) | 2016-04-08 | 2020-01-07 | Mankind Pharma Ltd. | Compounds as GPR119 agonists |
| US10954229B2 (en) | 2016-04-08 | 2021-03-23 | Mankind Pharma Ltd. | GPR119 agonist compounds |
| US10208030B2 (en) * | 2016-04-08 | 2019-02-19 | Mankind Pharma Ltd. | GPR119 agonist compounds |
| JP7095288B2 (ja) * | 2018-01-24 | 2022-07-05 | 富士フイルムビジネスイノベーション株式会社 | 定着装置および画像形成装置 |
| MX2022010548A (es) | 2020-02-28 | 2022-09-23 | Kallyope Inc | Agonistas de gpr40. |
| MX2022014505A (es) | 2020-05-19 | 2022-12-13 | Kallyope Inc | Activadores de la ampk. |
| CA3183575A1 (en) | 2020-06-26 | 2021-12-30 | Iyassu Sebhat | Ampk activators |
| CN121909017A (zh) * | 2023-08-11 | 2026-04-21 | 人类制药有限公司 | Gpr119激动剂的药物制剂及其用途 |
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| JP2003221386A (ja) * | 2001-11-26 | 2003-08-05 | Takeda Chem Ind Ltd | 二環性誘導体、その製造法およびその用途 |
| JP2008545008A (ja) * | 2005-06-30 | 2008-12-11 | プロシディオン・リミテッド | Ｇｐｃｒアゴニスト |
| AR064416A1 (es) * | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas. |
| EP2390254A1 (en) * | 2009-01-22 | 2011-11-30 | Mitsubishi Tanabe Pharma Corporation | NOVEL PYRROLOÝ2,3-d¨PYRIMIDINE COMPOUND |
| US8293729B2 (en) | 2009-06-24 | 2012-10-23 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical composition and methods relating thereto |
| US8481731B2 (en) | 2009-06-24 | 2013-07-09 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical composition and methods relating thereto |
| WO2011022692A2 (en) * | 2009-08-20 | 2011-02-24 | University Of Tennessee Research Foundation, The | Furanopyridine cannabinoid compounds and related methods of use |
| CN102971311B (zh) * | 2010-05-06 | 2015-07-08 | 百时美施贵宝公司 | 作为gpr119调节剂的二环杂芳基化合物 |
| EP2566862B1 (en) * | 2010-05-06 | 2015-09-16 | Bristol-Myers Squibb Company | Benzofuranyl analogues as gpr119 modulators |
| JP5794297B2 (ja) | 2010-05-07 | 2015-10-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｇｐｒ１１９アゴニストとしてのピリダジノン |
| UY33805A (es) * | 2010-12-17 | 2012-07-31 | Boehringer Ingelheim Int | ?Derivados de dihidrobenzofuranil-piperidinilo, aza-dihidrobenzofuranilpiperidinilo y diaza-dihidrobenzofuranil-piperidinilo, composiciones farmacéuticas que los contienen y usos de los mismos?. |
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- 2012-01-20 AR ARP120100198A patent/AR084905A1/es unknown
- 2012-01-20 WO PCT/EP2012/050841 patent/WO2012098217A1/en not_active Ceased
- 2012-01-20 CA CA2825124A patent/CA2825124A1/en not_active Abandoned
- 2012-01-20 US US13/354,356 patent/US8778926B2/en active Active
- 2012-01-20 AP AP2013006985A patent/AP2013006985A0/xx unknown
-
2013
- 2013-07-26 CO CO13177678A patent/CO6781501A2/es not_active Application Discontinuation
- 2013-07-29 EC ECSP13012800 patent/ECSP13012800A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MA34839B1 (fr) | 2014-01-02 |
| JP2014502988A (ja) | 2014-02-06 |
| UY33871A (es) | 2012-07-31 |
| EP2665719A1 (en) | 2013-11-27 |
| JP5703393B2 (ja) | 2015-04-15 |
| US20130018030A1 (en) | 2013-01-17 |
| AR084905A1 (es) | 2013-07-10 |
| CO6781501A2 (es) | 2013-10-31 |
| EP2665719B1 (en) | 2016-05-04 |
| WO2012098217A1 (en) | 2012-07-26 |
| BR112013017669A2 (pt) | 2018-09-18 |
| KR20140003496A (ko) | 2014-01-09 |
| PH12013501515A1 (en) | 2013-09-16 |
| US8778926B2 (en) | 2014-07-15 |
| AP2013006985A0 (en) | 2013-07-31 |
| SG192036A1 (en) | 2013-08-30 |
| CN103443097A (zh) | 2013-12-11 |
| EA201300846A1 (ru) | 2013-12-30 |
| ECSP13012800A (es) | 2013-10-31 |
| MX2013008083A (es) | 2013-09-13 |
| AU2012208530A1 (en) | 2013-07-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20160120 |