CA2818684C - Traitements modulant les cellules tueuses naturelles et methodes de traitement d'hemopathies malignes - Google Patents

Traitements modulant les cellules tueuses naturelles et methodes de traitement d'hemopathies malignes Download PDF

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Publication number
CA2818684C
CA2818684C CA2818684A CA2818684A CA2818684C CA 2818684 C CA2818684 C CA 2818684C CA 2818684 A CA2818684 A CA 2818684A CA 2818684 A CA2818684 A CA 2818684A CA 2818684 C CA2818684 C CA 2818684C
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antibody
antigen
binding fragment
seq
nkcir
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CA2818684A1 (fr
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Pascale Andre
Renaud Buffet
Marcel Rozencweig
Jerome Tiollier
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Innate Pharma SA
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Innate Pharma SA
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Cette invention concerne des compositions comprenant des composés neutralisant les récepteurs d'inhibition des cellules tueuses naturelles ; l'invention concerne également des méthodes d'utilisation de ces compositions dans le traitement d'hémopathies malignes.
CA2818684A 2010-11-22 2011-11-22 Traitements modulant les cellules tueuses naturelles et methodes de traitement d'hemopathies malignes Active CA2818684C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41597310P 2010-11-22 2010-11-22
US61/415,973 2010-11-22
PCT/US2011/061840 WO2012071411A2 (fr) 2010-11-22 2011-11-22 Traitements modulant les cellules tueuses naturelles et méthodes de traitement d'hémopathies malignes

Publications (2)

Publication Number Publication Date
CA2818684A1 CA2818684A1 (fr) 2012-05-31
CA2818684C true CA2818684C (fr) 2023-02-21

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CA2818684A Active CA2818684C (fr) 2010-11-22 2011-11-22 Traitements modulant les cellules tueuses naturelles et methodes de traitement d'hemopathies malignes

Country Status (11)

Country Link
US (1) US9844593B2 (fr)
EP (1) EP2643350A4 (fr)
JP (2) JP6224457B2 (fr)
CN (2) CN106963947A (fr)
AR (1) AR083957A1 (fr)
BR (1) BR112013012138B1 (fr)
CA (1) CA2818684C (fr)
EA (1) EA035033B1 (fr)
MX (1) MX355483B (fr)
TW (1) TWI664191B (fr)
WO (1) WO2012071411A2 (fr)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090191213A9 (en) * 2003-07-02 2009-07-30 Novo Nordisk A/S Compositions and methods for regulating NK cell activity
JP5855326B2 (ja) * 2005-01-06 2016-02-09 ノヴォ ノルディスク アー/エス 抗kir組み合わせ治療および方法
KR102046666B1 (ko) * 2011-05-25 2019-11-19 이나뜨 파르마 염증성 장애의 치료를 위한 항-kir 항체
US11471486B2 (en) 2012-09-04 2022-10-18 Inven2 As Selective and controlled expansion of educated NK cells
KR102130865B1 (ko) 2012-10-02 2020-08-05 브리스톨-마이어스 스큅 컴퍼니 암을 치료하기 위한 항-kir 항체와 항-pd-1 항체의 조합물
CN105188749B (zh) 2012-12-21 2017-12-19 西雅图基因公司 抗ntb‑a抗体及相关组合物和方法
WO2014117121A1 (fr) 2013-01-28 2014-07-31 St. Jude Children's Research Hospital, Inc. Récepteur chimérique à spécificité nkg2d adapté pour être utilisé en thérapie cellulaire contre le cancer et les maladies infectieuses
PL2992020T3 (pl) 2013-05-03 2020-06-01 Ohio State Innovation Foundation Odpornościowe komórki efektorowe wyrażające inżynierowane chimeryczne receptory antygenu swoiste dla CS1
EP3066128B1 (fr) 2013-11-06 2018-10-31 Bristol-Myers Squibb Company Combinaison d'anticorps anti-kir et d'anticorps anti-cs1 pour traiter un myélome multiple
EP3143134B1 (fr) 2014-05-15 2020-10-28 National University of Singapore Lymphocytes tueurs naturels modifiés et leurs utilisations
WO2015195555A1 (fr) * 2014-06-16 2015-12-23 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Blocage de cd38 à l'aide d'anticorps anti-cd38 conjugué à la protéine g pour protéger des cellules nk
WO2016022589A2 (fr) 2014-08-08 2016-02-11 The Regents Of The University Of California Méthodes de traitement du myélome multiple
AU2016219785B2 (en) 2015-02-20 2021-10-28 Ohio State Innovation Foundation Bivalent antibody directed against NKG2D and tumor associated antigens
RU2571551C1 (ru) * 2015-04-16 2015-12-20 Закрытое акционерное общество "ПЕПТЕК" Специфическая сочетанная терапия злокачественных опухолей цитостатиком и его модификатором
EA201792273A1 (ru) 2015-04-17 2018-04-30 Бристол-Маерс Сквибб Компани Композиции, содержащие комбинацию анти-pd-1 антитела и другого антитела
WO2016177682A1 (fr) 2015-05-06 2016-11-10 Snipr Technologies Limited Altération de populations microbiennes et modification de microbiote
CN107850596B (zh) 2015-07-24 2020-12-04 先天制药公司 用于检测组织浸润nk细胞的方法
CA3004530A1 (fr) 2015-11-07 2017-05-11 Multivir Inc. Methodes et compositions comprenant une therapie genique suppressive de tumeur et le blocage du point de controle immunitaire pour le traitement du cancer
AU2017266951B2 (en) 2016-05-20 2021-05-27 Biohaven Pharmaceutical Holding Company Ltd. Use of Glutamate modulating agents with Immunotherapies to treat cancer
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
KR101926166B1 (ko) * 2016-05-24 2018-12-06 재단법인 아산사회복지재단 수용체 시너지 활성을 이용한 nk 세포의 활성도 검사 방법 및 이를 이용한 nk 세포의 활성도가 관련된 질환의 진단 방법
GB201609811D0 (en) 2016-06-05 2016-07-20 Snipr Technologies Ltd Methods, cells, systems, arrays, RNA and kits
AU2017335732A1 (en) 2016-09-27 2019-04-04 Board Of Regents, The University Of Texas System Methods for enhancing immune checkpoint blockade therapy by modulating the microbiome
US11278592B2 (en) 2016-10-12 2022-03-22 Board Of Regents, The University Of Texas System Methods and compositions for TUSC2 immunotherapy
AU2017375958A1 (en) 2016-12-12 2019-07-04 Multivir Inc. Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases
CN110520157A (zh) 2017-02-09 2019-11-29 纪念斯隆凯特琳癌症中心 抗-kir3dl1抗体
SG11201908337VA (en) 2017-03-27 2019-10-30 Nat Univ Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
WO2018183385A1 (fr) 2017-03-27 2018-10-04 National University Of Singapore Récepteurs chimériques de nkg2d tronqués et leurs utilisations dans une immunothérapie de cellules tueuses naturelles
EP3601355A1 (fr) 2017-03-31 2020-02-05 Bristol-Myers Squibb Company Procédés de traitement de tumeur
CN110891974B (zh) 2017-05-12 2021-08-06 哈普恩治疗公司 间皮素结合蛋白质
EP3694884A1 (fr) 2017-10-15 2020-08-19 Bristol-Myers Squibb Company Procédés de traitement de tumeur
KR20200135986A (ko) 2018-03-19 2020-12-04 멀티비르 인코포레이티드 종양 억제인자 유전자 치료 및 cd122/cd132 작용제를 포함하는 암 치료를 위한 방법 및 조성물
AU2019236865A1 (en) 2018-03-23 2020-10-01 Bristol-Myers Squibb Company Antibodies against MICA and/or MICB and uses thereof
SG11202009504YA (en) 2018-03-25 2020-10-29 Snipr Biome Aps Treating & preventing microbial infections
US10760075B2 (en) 2018-04-30 2020-09-01 Snipr Biome Aps Treating and preventing microbial infections
CN111971306A (zh) 2018-03-30 2020-11-20 百时美施贵宝公司 治疗肿瘤的方法
WO2019195769A1 (fr) * 2018-04-06 2019-10-10 The Brigham And Women's Hospital, Inc. Méthodes de diagnostic et de traitement de lymphomes à lymphocytes t cutanés agressifs
CN108728527B (zh) * 2018-06-06 2020-06-09 青岛泱深生物医药有限公司 Hcst基因作为诊治子痫前期的靶标
MA52889A (fr) 2018-06-15 2021-04-21 Flagship Pioneering Innovations V Inc Augmentation de l'activité immunitaire par modulation de facteurs de signalisation post-cellulaires
IL281683B2 (en) 2018-09-25 2023-04-01 Harpoon Therapeutics Inc dll3 binding proteins and methods of use
JP7450622B2 (ja) 2018-12-21 2024-03-15 ヴァレリオ・セラピューティクス 新規のコンジュゲートされた核酸分子及びその使用
KR102210455B1 (ko) * 2019-02-28 2021-02-02 사회복지법인 삼성생명공익재단 자연살해세포 활성 검출용 미세입자 및 이를 이용한 검출 방법
EP3773918A4 (fr) 2019-03-05 2022-01-05 Nkarta, Inc. Récepteurs d'antigènes chimériques anti-cd19 et leurs utilisations en immunothérapie
EP3962493A2 (fr) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V, Inc. Métodes de modulation de l'activité immunitaire
CN111973739B (zh) * 2019-05-23 2024-02-13 正大天晴药业集团股份有限公司 抗pd-l1单克隆抗体治疗癌症的用途
CN114174538A (zh) 2019-05-30 2022-03-11 百时美施贵宝公司 适合于免疫肿瘤学疗法的多肿瘤基因特征
US20220233691A1 (en) 2019-05-30 2022-07-28 Bristol-Myers Squibb Company Cell localization signature and combination therapy
EP3976832A1 (fr) 2019-05-30 2022-04-06 Bristol-Myers Squibb Company Procédés d'identification d'un sujet approprié pour une thérapie d'immuno-oncologie (i-o)
WO2021024020A1 (fr) 2019-08-06 2021-02-11 Astellas Pharma Inc. Polythérapie impliquant des anticorps dirigés contre la claudine 18.2 et inhibiteurs de point de contrôle immunitaire pour le traitement du cancer
WO2021113644A1 (fr) 2019-12-05 2021-06-10 Multivir Inc. Combinaisons comprenant un activateur de lymphocytes t cd8+, un inhibiteur de point de contrôle immunitaire et une radiothérapie en vue d'obtenir des effets ciblés et abscopal pour le traitement du cancer
JP2023509359A (ja) 2019-12-17 2023-03-08 フラグシップ パイオニアリング イノベーションズ ブイ,インコーポレーテッド 鉄依存性細胞分解の誘導物質との併用抗癌療法
TW202214857A (zh) 2020-06-19 2022-04-16 法商昂席歐公司 新型結合核酸分子及其用途
WO2022006179A1 (fr) 2020-06-29 2022-01-06 Flagship Pioneering Innovations V, Inc. Virus modifiés pour favoriser la thanotransmission et leur utilisation dans le traitement du cancer
IL298993A (en) 2020-07-07 2023-02-01 BioNTech SE Therapeutic RNA for HPV positive cancer
WO2022011531A1 (fr) * 2020-07-14 2022-01-20 浙江道尔生物科技有限公司 Anticorps à domaine unique anti-cld18a2
MX2023002326A (es) 2020-08-31 2023-03-21 Bristol Myers Squibb Co Firma de localizacion celular e inmunoterapia.
WO2022120179A1 (fr) 2020-12-03 2022-06-09 Bristol-Myers Squibb Company Signatures géniques multi-tumorales et leurs utilisations
WO2022135666A1 (fr) 2020-12-21 2022-06-30 BioNTech SE Programme de traitement faisant intervenir des protéines cytokines
TW202245808A (zh) 2020-12-21 2022-12-01 德商拜恩迪克公司 用於治療癌症之治療性rna
WO2022135667A1 (fr) 2020-12-21 2022-06-30 BioNTech SE Arn thérapeutique pour le traitement du cancer
EP4267172A1 (fr) 2020-12-28 2023-11-01 Bristol-Myers Squibb Company Administration sous-cutanée d'anticorps pd1/pd-l1
WO2022146947A1 (fr) 2020-12-28 2022-07-07 Bristol-Myers Squibb Company Compositions d'anticorps et leurs procédés d'utilisation
AU2022218137A1 (en) 2021-02-03 2023-08-24 Mozart Therapeutics, Inc. Binding agents and methods of using the same
EP4314068A1 (fr) 2021-04-02 2024-02-07 The Regents Of The University Of California Anticorps dirigés contre un cdcp1 clivé et leurs utilisations
AU2022312698A1 (en) 2021-07-13 2024-01-25 BioNTech SE Multispecific binding agents against cd40 and cd137 in combination therapy for cancer
AU2022318734A1 (en) * 2021-07-28 2024-02-08 Merck Sharp & Dohme Llc Methods for treating acute myeloid leukemia with anti-ilt3 antibodies
TW202333802A (zh) 2021-10-11 2023-09-01 德商拜恩迪克公司 用於肺癌之治療性rna(二)
WO2023076876A1 (fr) 2021-10-26 2023-05-04 Mozart Therapeutics, Inc. Modulation de réponses immunitaires à des vecteurs viraux
WO2023111203A1 (fr) 2021-12-16 2023-06-22 Onxeo Nouvelles molécules d'acide nucléique conjuguées et leurs utilisations
WO2023178329A1 (fr) 2022-03-18 2023-09-21 Bristol-Myers Squibb Company Procédés d'isolement de polypeptides
WO2023235847A1 (fr) 2022-06-02 2023-12-07 Bristol-Myers Squibb Company Compositions d'anticorps et leurs procédés d'utilisation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030105294A1 (en) * 1998-02-25 2003-06-05 Stephen Gillies Enhancing the circulating half life of antibody-based fusion proteins
KR101059041B1 (ko) 2002-05-17 2011-08-24 셀진 코포레이션 암과 다른 질병의 치료 및 처리를 위한 선택적 사이토카인억제 약물을 사용하는 방법 및 조성물
US7968569B2 (en) * 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
CN1852924A (zh) * 2003-07-02 2006-10-25 依奈特制药公司 Pan-kir2dl nk-受体的抗体及其在诊断及治疗中的应用
BRPI0412153B8 (pt) 2003-07-02 2021-05-25 Innate Pharma Sas anticorpo monoclonal e fragmento de ligação a antígeno do anticorpo monoclonal
BRPI0412890B8 (pt) * 2003-07-24 2021-05-25 Innate Pharma método de selecionar um anticorpo anti kir2dl1 ou fragmento de anticorpo de ligação de antígeno
CA2601417C (fr) * 2004-07-01 2018-10-30 Novo Nordisk A/S Anticorps humains anti-kir
JP5855326B2 (ja) 2005-01-06 2016-02-09 ノヴォ ノルディスク アー/エス 抗kir組み合わせ治療および方法
PT1836225E (pt) * 2005-01-06 2012-01-10 Novo Nordisk As Agentes de ligação a kir e métodos de utilização dos mesmos
ES2627923T3 (es) * 2007-01-11 2017-08-01 Novo Nordisk A/S Anticuerpos anti-KIR, formulaciones y usos de los mismos
US20100099084A1 (en) 2008-10-17 2010-04-22 Maher Albitar Detection of npm1 nucleic acid in acellular body fluids

Also Published As

Publication number Publication date
JP2016199549A (ja) 2016-12-01
TW201305210A (zh) 2013-02-01
CN103298831A (zh) 2013-09-11
CN106963947A (zh) 2017-07-21
CA2818684A1 (fr) 2012-05-31
JP2014501729A (ja) 2014-01-23
WO2012071411A2 (fr) 2012-05-31
WO2012071411A3 (fr) 2012-08-16
EP2643350A2 (fr) 2013-10-02
EA201390756A1 (ru) 2014-11-28
JP6224457B2 (ja) 2017-11-01
EP2643350A4 (fr) 2015-01-07
MX355483B (es) 2018-04-19
EA035033B1 (ru) 2020-04-20
BR112013012138B1 (pt) 2022-02-22
US9844593B2 (en) 2017-12-19
MX2013005673A (es) 2013-12-06
US20130251711A1 (en) 2013-09-26
BR112013012138A2 (pt) 2020-09-01
AR083957A1 (es) 2013-04-10
TWI664191B (zh) 2019-07-01

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