CA2811001A1 - Treatment of constipation-predominant irritable bowel syndrome - Google Patents
Treatment of constipation-predominant irritable bowel syndrome Download PDFInfo
- Publication number
- CA2811001A1 CA2811001A1 CA2811001A CA2811001A CA2811001A1 CA 2811001 A1 CA2811001 A1 CA 2811001A1 CA 2811001 A CA2811001 A CA 2811001A CA 2811001 A CA2811001 A CA 2811001A CA 2811001 A1 CA2811001 A1 CA 2811001A1
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- Prior art keywords
- linaclotide
- patient
- administering
- week
- treatment
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
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- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38193610P | 2010-09-11 | 2010-09-11 | |
| US61/381,936 | 2010-09-11 | ||
| US38246910P | 2010-09-13 | 2010-09-13 | |
| US61/382,469 | 2010-09-13 | ||
| US39426710P | 2010-10-18 | 2010-10-18 | |
| US61/394,267 | 2010-10-18 | ||
| US40850910P | 2010-10-29 | 2010-10-29 | |
| US61/408,509 | 2010-10-29 | ||
| US40899410P | 2010-11-01 | 2010-11-01 | |
| US61/408,994 | 2010-11-01 | ||
| PCT/US2011/051080 WO2012034068A1 (en) | 2010-09-11 | 2011-09-09 | Treatment of constipation-predominant irritable bowel syndrome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2811001A1 true CA2811001A1 (en) | 2012-03-15 |
Family
ID=44654514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2811001A Abandoned CA2811001A1 (en) | 2010-09-11 | 2011-09-09 | Treatment of constipation-predominant irritable bowel syndrome |
Country Status (7)
| Country | Link |
|---|---|
| US (9) | US20140162963A1 (https=) |
| EP (1) | EP2613794A1 (https=) |
| JP (1) | JP2013540732A (https=) |
| CN (1) | CN103702678A (https=) |
| CA (1) | CA2811001A1 (https=) |
| MX (1) | MX2013002747A (https=) |
| WO (1) | WO2012034068A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA119335C2 (uk) * | 2013-12-11 | 2019-06-10 | Айронвуд Фармасьютикалз, Інк. | Композиції лінаклотиду з затриманим вивільненням |
| CN105412904A (zh) * | 2014-06-17 | 2016-03-23 | 深圳翰宇药业股份有限公司 | 利那洛肽肠溶缓释微丸胶囊制剂及其制备方法和用途 |
| WO2016024291A1 (en) * | 2014-08-11 | 2016-02-18 | Sun Pharmaceutical Industries Ltd. | Linaclotide stable composition |
| US20180008547A1 (en) * | 2015-02-02 | 2018-01-11 | Aurobindo Pharma Ltd | Stable Compositions comprising Linaclotide |
| US20220241367A1 (en) * | 2019-06-10 | 2022-08-04 | Ironwood Pharmaceutical, Inc. | Treatment of Abdominal Pain Associated with Diarrhea-Predominant Irritable Bowel Syndrome |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| IL115592A (en) * | 1994-10-13 | 2000-07-26 | Novo Nordisk As | Stabilized pharmaceutical formulation comprising a growth hormone and leucine |
| US7304036B2 (en) * | 2003-01-28 | 2007-12-04 | Microbia, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| CN117530912A (zh) * | 2008-08-15 | 2024-02-09 | 硬木药品公司 | 适合口服给药的鸟苷酸环化酶-c受体激动剂多肽的稳定的固体制剂 |
| CA2770334A1 (en) * | 2009-08-12 | 2011-02-17 | Forest Laboratories Holdings Limited | Orally disintegrating compositions of linaclotide |
| WO2011020054A1 (en) * | 2009-08-13 | 2011-02-17 | Ironwood Pharmaceuticals Inc. | Method for modulating the pharmacodynamic effect of orally administered guanylate cyclase receptor agonists |
| US8933030B2 (en) * | 2010-02-17 | 2015-01-13 | Ironwwod Pharmaceuticals, Inc. | Treatments for gastrointestinal disorders |
-
2011
- 2011-09-09 EP EP11758343.5A patent/EP2613794A1/en not_active Withdrawn
- 2011-09-09 MX MX2013002747A patent/MX2013002747A/es not_active Application Discontinuation
- 2011-09-09 CA CA2811001A patent/CA2811001A1/en not_active Abandoned
- 2011-09-09 WO PCT/US2011/051080 patent/WO2012034068A1/en not_active Ceased
- 2011-09-09 US US13/821,761 patent/US20140162963A1/en not_active Abandoned
- 2011-09-09 CN CN201180054408.1A patent/CN103702678A/zh active Pending
- 2011-09-09 JP JP2013528350A patent/JP2013540732A/ja active Pending
-
2016
- 2016-03-31 US US15/086,483 patent/US20160206686A1/en not_active Abandoned
-
2017
- 2017-06-16 US US15/624,862 patent/US20170281722A1/en not_active Abandoned
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2018
- 2018-01-25 US US15/879,670 patent/US20180147253A1/en not_active Abandoned
- 2018-09-20 US US16/136,523 patent/US20190022173A1/en not_active Abandoned
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2019
- 2019-05-17 US US16/414,946 patent/US20190282655A1/en not_active Abandoned
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2021
- 2021-12-20 US US17/556,274 patent/US20220111001A1/en not_active Abandoned
-
2023
- 2023-03-16 US US18/184,888 patent/US20230263854A1/en not_active Abandoned
- 2023-12-15 US US18/541,323 patent/US20240115656A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20190282655A1 (en) | 2019-09-19 |
| US20170281722A1 (en) | 2017-10-05 |
| JP2013540732A (ja) | 2013-11-07 |
| US20180147253A1 (en) | 2018-05-31 |
| US20160206686A1 (en) | 2016-07-21 |
| WO2012034068A1 (en) | 2012-03-15 |
| US20230263854A1 (en) | 2023-08-24 |
| US20190022173A1 (en) | 2019-01-24 |
| US20140162963A1 (en) | 2014-06-12 |
| US20240115656A1 (en) | 2024-04-11 |
| US20220111001A1 (en) | 2022-04-14 |
| MX2013002747A (es) | 2013-10-25 |
| CN103702678A (zh) | 2014-04-02 |
| EP2613794A1 (en) | 2013-07-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20160826 |
|
| FZDE | Discontinued |
Effective date: 20190107 |