CA2803998A1 - Antibody formulations - Google Patents
Antibody formulations Download PDFInfo
- Publication number
- CA2803998A1 CA2803998A1 CA2803998A CA2803998A CA2803998A1 CA 2803998 A1 CA2803998 A1 CA 2803998A1 CA 2803998 A CA2803998 A CA 2803998A CA 2803998 A CA2803998 A CA 2803998A CA 2803998 A1 CA2803998 A1 CA 2803998A1
- Authority
- CA
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- Prior art keywords
- formulation
- antibody
- antibody fragment
- rsa
- sucrose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- C—CHEMISTRY; METALLURGY
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- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
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Landscapes
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| US8221753B2 (en) | 2009-09-30 | 2012-07-17 | Tracon Pharmaceuticals, Inc. | Endoglin antibodies |
| TW201241008A (en) * | 2010-10-01 | 2012-10-16 | Alexion Pharma Inc | Polypeptides that bind to human complement component C5 |
| US20140004131A1 (en) | 2012-05-04 | 2014-01-02 | Novartis Ag | Antibody formulation |
| HK1205146A1 (en) * | 2012-06-21 | 2015-12-11 | Ucb医药有限公司 | Pharmaceutical formulation |
| UA115789C2 (uk) * | 2012-09-05 | 2017-12-26 | Трейкон Фармасутікалз, Інк. | Композиція антитіла до cd105 та її застосування |
| EP4285928A3 (en) * | 2013-09-27 | 2024-03-13 | F. Hoffmann-La Roche AG | Anti-pdl1 antibody formulations |
| JP6799904B2 (ja) * | 2014-07-31 | 2020-12-16 | キユーピー株式会社 | 含水エタノール製剤及びその製造方法、並びに、リゾチーム加工品及び／又はその塩並びにその製造方法 |
| US9926375B2 (en) | 2014-11-12 | 2018-03-27 | Tracon Pharmaceuticals, Inc. | Anti-endoglin antibodies and uses thereof |
| US10155820B2 (en) | 2014-11-12 | 2018-12-18 | Tracon Pharmaceuticals, Inc. | Anti-endoglin antibodies and uses thereof |
| JP2019501139A (ja) | 2015-11-25 | 2019-01-17 | イミュノジェン・インコーポレーテッド | 医薬製剤及びその使用 |
| JP2018535242A (ja) | 2015-11-30 | 2018-11-29 | メディミューン，エルエルシー | 高濃度のタンパク質ベースの治療剤を含有する医薬組成物中の非晶質安定化化合物としてのアミノ酸と糖との最適比 |
| MY200764A (en) | 2015-12-16 | 2024-01-14 | Regeneron Pharma | Compositions and methods of manufacturing protein microparticles |
| CN105920600A (zh) * | 2016-04-19 | 2016-09-07 | 上海景泽生物技术有限公司 | 一种稳定的抗vegf抗体制剂及其用途 |
| JP7266108B2 (ja) | 2019-02-18 | 2023-04-27 | イーライ リリー アンド カンパニー | 治療用抗体製剤 |
| EP4271412A4 (en) * | 2020-12-30 | 2024-12-04 | Ammax Bio, Inc | Extended local release of antibodies |
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| US5468468A (en) | 1989-02-09 | 1995-11-21 | The United States Of America, As Represented By The Secretary Of The Department Of Health & Human Services | Method for making a monoclonal antibody, monoclonal antibodies to α PD |
| ATE179457T1 (de) | 1989-02-09 | 1999-05-15 | Us Health | Zuwachsfaktorrezeptorgen deriviert von platten des typs oc |
| ATE193553T1 (de) | 1991-01-31 | 2000-06-15 | Cor Therapeutics Inc | Domänen von extrazellulären bereichen von menschlichen blutplättchen abstammenden wachstumsfaktor rezeptor-polypeptiden |
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| US5444151A (en) | 1992-05-15 | 1995-08-22 | Ludwig Institute For Cancer Research | Platelet derived growth factor antagonists |
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| ES2190087T3 (es) * | 1997-06-13 | 2003-07-16 | Genentech Inc | Formulacion estabilizada de un anticuerpo. |
| US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| US20030165831A1 (en) | 2000-03-21 | 2003-09-04 | John Lee | Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer |
| JP4340062B2 (ja) * | 2000-10-12 | 2009-10-07 | ジェネンテック・インコーポレーテッド | 粘度の減少した濃縮タンパク質製剤 |
| US20030113316A1 (en) * | 2001-07-25 | 2003-06-19 | Kaisheva Elizabet A. | Stable lyophilized pharmaceutical formulation of IgG antibodies |
| MXPA04007924A (es) * | 2002-02-14 | 2005-05-17 | Chugai Pharmaceutical Co Ltd | Formulaciones en solucion que contienen anticuerpo. |
| WO2004050850A2 (en) | 2002-12-02 | 2004-06-17 | Abgenix, Inc. | Antibodies directed to phospholipase a2 and uses thereof |
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| AU2007260769A1 (en) * | 2006-06-14 | 2007-12-21 | Imclone Llc | Lyophilized formulations of anti-EGFR antibodies |
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| ES2827180T3 (es) * | 2006-10-06 | 2021-05-20 | Amgen Inc | Formulaciones de anticuerpos estables |
| US20080153818A1 (en) * | 2006-12-21 | 2008-06-26 | Bingaman David P | Methods for preventing inflammation during surgery |
-
2011
- 2011-07-01 WO PCT/US2011/042838 patent/WO2012003470A2/en not_active Ceased
- 2011-07-01 US US13/175,522 patent/US8754195B2/en not_active Expired - Fee Related
- 2011-07-01 CN CN201180042125.5A patent/CN103108658B/zh not_active Expired - Fee Related
- 2011-07-01 SG SG2012094074A patent/SG186421A1/en unknown
- 2011-07-01 BR BR112012033457A patent/BR112012033457A2/pt not_active IP Right Cessation
- 2011-07-01 JP JP2013518765A patent/JP2013531679A/ja active Pending
- 2011-07-01 AU AU2011274363A patent/AU2011274363A1/en not_active Abandoned
- 2011-07-01 EP EP11801508.0A patent/EP2588141A4/en not_active Withdrawn
- 2011-07-01 CA CA2803998A patent/CA2803998A1/en not_active Abandoned
-
2015
- 2015-08-26 JP JP2015166305A patent/JP2016026164A/ja active Pending
-
2016
- 2016-02-29 AU AU2016201291A patent/AU2016201291A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN103108658B (zh) | 2015-08-19 |
| WO2012003470A2 (en) | 2012-01-05 |
| SG186421A1 (en) | 2013-01-30 |
| JP2013531679A (ja) | 2013-08-08 |
| CN103108658A (zh) | 2013-05-15 |
| EP2588141A4 (en) | 2014-12-03 |
| BR112012033457A2 (pt) | 2017-04-04 |
| AU2011274363A1 (en) | 2013-01-24 |
| US20120009199A1 (en) | 2012-01-12 |
| US8754195B2 (en) | 2014-06-17 |
| EP2588141A2 (en) | 2013-05-08 |
| JP2016026164A (ja) | 2016-02-12 |
| AU2016201291A1 (en) | 2016-03-17 |
| WO2012003470A3 (en) | 2012-02-23 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |
Effective date: 20170704 |