CA2803787C - Adenovirus ad36 e4orf1 protein for prevention and treatment of non-alcoholic fatty liver disease - Google Patents

Adenovirus ad36 e4orf1 protein for prevention and treatment of non-alcoholic fatty liver disease Download PDF

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Publication number
CA2803787C
CA2803787C CA2803787A CA2803787A CA2803787C CA 2803787 C CA2803787 C CA 2803787C CA 2803787 A CA2803787 A CA 2803787A CA 2803787 A CA2803787 A CA 2803787A CA 2803787 C CA2803787 C CA 2803787C
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CA
Canada
Prior art keywords
adenovirus
nucleic acid
e4orf1
protein
e4orf1 protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2803787A
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English (en)
French (fr)
Other versions
CA2803787A1 (en
Inventor
Nikhil Dhurandhar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Louisiana State University
Original Assignee
Louisiana State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Louisiana State University filed Critical Louisiana State University
Publication of CA2803787A1 publication Critical patent/CA2803787A1/en
Application granted granted Critical
Publication of CA2803787C publication Critical patent/CA2803787C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10311Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10333Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2803787A 2010-07-08 2011-07-08 Adenovirus ad36 e4orf1 protein for prevention and treatment of non-alcoholic fatty liver disease Expired - Fee Related CA2803787C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36244310P 2010-07-08 2010-07-08
US61/362,443 2010-07-08
PCT/US2011/043338 WO2012006512A1 (en) 2010-07-08 2011-07-08 Adenovirus ad36 e4orf1 protein for prevention and treatment of non-alcoholic fatty liver disease

Publications (2)

Publication Number Publication Date
CA2803787A1 CA2803787A1 (en) 2012-01-12
CA2803787C true CA2803787C (en) 2018-12-04

Family

ID=44629893

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2803787A Expired - Fee Related CA2803787C (en) 2010-07-08 2011-07-08 Adenovirus ad36 e4orf1 protein for prevention and treatment of non-alcoholic fatty liver disease

Country Status (11)

Country Link
US (2) US8951980B2 (cg-RX-API-DMAC7.html)
EP (1) EP2590665B1 (cg-RX-API-DMAC7.html)
JP (1) JP5965397B2 (cg-RX-API-DMAC7.html)
KR (1) KR101831638B1 (cg-RX-API-DMAC7.html)
CN (1) CN103052397B (cg-RX-API-DMAC7.html)
AU (1) AU2011274537B9 (cg-RX-API-DMAC7.html)
CA (1) CA2803787C (cg-RX-API-DMAC7.html)
ES (1) ES2550962T3 (cg-RX-API-DMAC7.html)
NZ (1) NZ606236A (cg-RX-API-DMAC7.html)
TW (1) TWI531650B (cg-RX-API-DMAC7.html)
WO (1) WO2012006512A1 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2887679C (en) 2012-10-17 2020-12-29 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compositions and methods for improving glucose uptake
US9354963B2 (en) * 2014-02-26 2016-05-31 Microsoft Technology Licensing, Llc Service metric analysis from structured logging schema of usage data
EP3134417B1 (en) 2014-04-23 2019-07-31 Board of Supervisors of Louisiana State University and Agricultural and Mechanical College Small molecule analogs of e4orf1
GB201910299D0 (en) * 2019-07-18 2019-09-04 Aouadi Myriam Medical uses, methods and uses

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2282780T3 (es) * 2004-08-12 2007-10-16 F. Hoffmann-La Roche Ag Metodo para el diagnostico de la fibrosis hepatica.
US20060045919A1 (en) 2004-08-27 2006-03-02 Samueli Institute Homeopathic compositions and methods for the treatment of cancer
JP2008105945A (ja) * 2005-02-07 2008-05-08 Ajinomoto Co Inc アディポネクチンの分泌促進又は誘導作用を有するアシルアミド化合物
ES2472325T3 (es) 2005-11-30 2014-06-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Gen y proteína del adenovirus 36 E4 orf 1 y sus usos
JP2009521707A (ja) * 2005-12-27 2009-06-04 オーベテック, エルエルシー 疾患のバイオマーカーとしての脂肪生成アデノウイルス
JP2008273938A (ja) * 2007-03-30 2008-11-13 Shiseido Co Ltd アディポネクチン産生促進剤

Also Published As

Publication number Publication date
EP2590665B1 (en) 2015-09-16
KR101831638B1 (ko) 2018-02-23
ES2550962T3 (es) 2015-11-13
CN103052397A (zh) 2013-04-17
EP2590665A1 (en) 2013-05-15
AU2011274537B9 (en) 2017-02-23
CN103052397B (zh) 2017-09-19
TWI531650B (zh) 2016-05-01
US8951980B2 (en) 2015-02-10
AU2011274537B2 (en) 2016-12-15
TW201217529A (en) 2012-05-01
JP2013531681A (ja) 2013-08-08
US20170340699A1 (en) 2017-11-30
NZ606236A (en) 2014-09-26
WO2012006512A1 (en) 2012-01-12
US20120027845A1 (en) 2012-02-02
KR20130100262A (ko) 2013-09-10
JP5965397B2 (ja) 2016-08-03
HK1185261A1 (en) 2014-02-14
CA2803787A1 (en) 2012-01-12
AU2011274537A1 (en) 2013-02-14

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